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Characterization of CNPY5 and its family members.

Schildknegt D, Lodder N, Pandey A, Egmond M, Pena F, Braakman I, van der Sluijs P.

Protein Sci. 2019 Jul;28(7):1276-1289. doi: 10.1002/pro.3635. Epub 2019 May 16.


Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase.

McCaul N, Yeoh HY, van Zadelhoff G, Lodder N, Kleizen B, Braakman I.

J Vis Exp. 2019 Feb 12;(144). doi: 10.3791/58952.


Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants.

van Willigen M, Vonk AM, Yeoh HY, Kruisselbrink E, Kleizen B, van der Ent CK, Egmond MR, de Jonge HR, Braakman I, Beekman JM, van der Sluijs P.

Life Sci Alliance. 2019 Jan 18;2(1). pii: e201800172. doi: 10.26508/lsa.201800172. Print 2019 Feb.


Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman's summary.

Mall MA, Hwang TC, Braakman I.

J Cyst Fibros. 2018 Mar;17(2S):S1-S4. doi: 10.1016/j.jcf.2017.11.008. Epub 2017 Dec 9. Review.


Analysis of Disulfide Bond Formation.

Braakman I, Lamriben L, van Zadelhoff G, Hebert DN.

Curr Protoc Protein Sci. 2017 Nov 1;90:14.1.1-14.1.21. doi: 10.1002/cpps.43.


Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis.

Mijnders M, Kleizen B, Braakman I.

Curr Opin Pharmacol. 2017 Jun;34:83-90. doi: 10.1016/j.coph.2017.09.014. Epub 2017 Oct 18. Review.


Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide.

Snapp EL, McCaul N, Quandte M, Cabartova Z, Bontjer I, Källgren C, Nilsson I, Land A, von Heijne G, Sanders RW, Braakman I.

Elife. 2017 Jul 28;6. pii: e26067. doi: 10.7554/eLife.26067.


Alteration of protein function by a silent polymorphism linked to tRNA abundance.

Kirchner S, Cai Z, Rauscher R, Kastelic N, Anding M, Czech A, Kleizen B, Ostedgaard LS, Braakman I, Sheppard DN, Ignatova Z.

PLoS Biol. 2017 May 16;15(5):e2000779. doi: 10.1371/journal.pbio.2000779. eCollection 2017 May.


Protein quality control at the endoplasmic reticulum.

McCaffrey K, Braakman I.

Essays Biochem. 2016 Oct 15;60(2):227-235. Review.


Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.

Kakkar V, Kuiper EF, Pandey A, Braakman I, Kampinga HH.

Sci Rep. 2016 Oct 7;6:34830. doi: 10.1038/srep34830.


Co- and Post-Translational Protein Folding in the ER.

Ellgaard L, McCaul N, Chatsisvili A, Braakman I.

Traffic. 2016 Jun;17(6):615-38. doi: 10.1111/tra.12392. Epub 2016 Apr 22. Review.


Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus.

Shen S, Wang M, Li X, Li S, van Oers MM, Vlak JM, Braakman I, Hu Z, Deng F, Wang H.

J Gen Virol. 2016 Apr;97(4):988-99. doi: 10.1099/jgv.0.000404. Epub 2016 Jan 14.


TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules.

Jevtov I, Zacharogianni M, van Oorschot MM, van Zadelhoff G, Aguilera-Gomez A, Vuillez I, Braakman I, Hafen E, Stocker H, Rabouille C.

J Cell Sci. 2015 Jul 15;128(14):2497-508. doi: 10.1242/jcs.168724. Epub 2015 Jun 8.


Folding of influenza virus hemagglutinin in insect cells is fast and efficient.

Li X, van Oers MM, Vlak JM, Braakman I.

J Biotechnol. 2015 Jun 10;203:77-83. doi: 10.1016/j.jbiotec.2015.03.018. Epub 2015 Mar 28.


Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity.

Mathys L, François KO, Quandte M, Braakman I, Balzarini J.

PLoS One. 2014 Jun 26;9(6):e101181. doi: 10.1371/journal.pone.0101181. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110202.


Two phases of disulfide bond formation have differing requirements for oxygen.

Koritzinsky M, Levitin F, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG.

J Cell Biol. 2013 Nov 25;203(4):615-27. doi: 10.1083/jcb.201307185. Epub 2013 Nov 18.


Quantifying Changes in the Cellular Thiol-Disulfide Status during Differentiation of B Cells into Antibody-Secreting Plasma Cells.

Hansen RE, Otsu M, Braakman I, Winther JR.

Int J Cell Biol. 2013;2013:898563. doi: 10.1155/2013/898563. Epub 2013 Sep 24.


ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor.

Oka OB, Pringle MA, Schopp IM, Braakman I, Bulleid NJ.

Mol Cell. 2013 Jun 27;50(6):793-804. doi: 10.1016/j.molcel.2013.05.014. Epub 2013 Jun 13.


Cell biology. A sweet send-off.

Kleizen B, Braakman I.

Science. 2013 May 24;340(6135):930-1. doi: 10.1126/science.1239294. No abstract available.


Protein folding in the endoplasmic reticulum.

Braakman I, Hebert DN.

Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a013201. doi: 10.1101/cshperspect.a013201. Review.


Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum.

Benham AM, van Lith M, Sitia R, Braakman I.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110403. doi: 10.1098/rstb.2011.0403. Print 2013 May 5.


Peroxisome formation and maintenance are dependent on the endoplasmic reticulum.

Tabak HF, Braakman I, van der Zand A.

Annu Rev Biochem. 2013;82:723-44. doi: 10.1146/annurev-biochem-081111-125123. Epub 2013 Feb 14. Review.


Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes.

van der Zand A, Gent J, Braakman I, Tabak HF.

Cell. 2012 Apr 13;149(2):397-409. doi: 10.1016/j.cell.2012.01.054.


CFTR Folding Consortium: methods available for studies of CFTR folding and correction.

Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA.

Methods Mol Biol. 2011;742:335-53. doi: 10.1007/978-1-61779-120-8_20.


Protein folding and modification in the mammalian endoplasmic reticulum.

Braakman I, Bulleid NJ.

Annu Rev Biochem. 2011;80:71-99. doi: 10.1146/annurev-biochem-062209-093836. Review.


The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain.

Hoelen H, Kleizen B, Schmidt A, Richardson J, Charitou P, Thomas PJ, Braakman I.

PLoS One. 2010 Nov 30;5(11):e15458. doi: 10.1371/journal.pone.0015458.


Peroxisomal membrane proteins insert into the endoplasmic reticulum.

van der Zand A, Braakman I, Tabak HF.

Mol Biol Cell. 2010 Jun 15;21(12):2057-65. doi: 10.1091/mbc.E10-02-0082. Epub 2010 Apr 28.


Regulated increase in folding capacity prevents unfolded protein stress in the ER.

Christis C, Fullaondo A, Schildknegt D, Mkrtchian S, Heck AJ, Braakman I.

J Cell Sci. 2010 Mar 1;123(Pt 5):787-94. doi: 10.1242/jcs.041111. Epub 2010 Feb 9.


Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum.

Pena F, Jansens A, van Zadelhoff G, Braakman I.

J Biol Chem. 2010 Mar 19;285(12):8656-64. doi: 10.1074/jbc.M110.105718. Epub 2010 Jan 20.


Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.

van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17019-24. doi: 10.1073/pnas.0903036106. Epub 2009 Sep 17.


Entering a new era with Ero.

Braakman I.

Nat Rev Mol Cell Biol. 2009 Aug;10(8):503. doi: 10.1038/nrm2741. No abstract available.


Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.

Bontjer I, Land A, Eggink D, Verkade E, Tuin K, Baldwin C, Pollakis G, Paxton WA, Braakman I, Berkhout B, Sanders RW.

J Virol. 2009 Jan;83(1):368-83. doi: 10.1128/JVI.01404-08. Epub 2008 Oct 15.


Evolution rescues folding of human immunodeficiency virus-1 envelope glycoprotein GP120 lacking a conserved disulfide bond.

Sanders RW, Hsu ST, van Anken E, Liscaljet IM, Dankers M, Bontjer I, Land A, Braakman I, Bonvin AM, Berkhout B.

Mol Biol Cell. 2008 Nov;19(11):4707-16. doi: 10.1091/mbc.E08-07-0670. Epub 2008 Aug 27.


Protein folding includes oligomerization - examples from the endoplasmic reticulum and cytosol.

Christis C, Lubsen NH, Braakman I.

FEBS J. 2008 Oct;275(19):4700-27. doi: 10.1111/j.1742-4658.2008.06590.x. Epub 2008 Aug 1. Review.


Biochemistry. Cargo load reduction.

Braakman I, Otsu M.

Science. 2008 Jul 25;321(5888):499-500. doi: 10.1126/science.1162125. No abstract available.


Only five of 10 strictly conserved disulfide bonds are essential for folding and eight for function of the HIV-1 envelope glycoprotein.

van Anken E, Sanders RW, Liscaljet IM, Land A, Bontjer I, Tillemans S, Nabatov AA, Paxton WA, Berkhout B, Braakman I.

Mol Biol Cell. 2008 Oct;19(10):4298-309. doi: 10.1091/mbc.E07-12-1282. Epub 2008 Jul 23.


Peroxisomes: minted by the ER.

Tabak HF, van der Zand A, Braakman I.

Curr Opin Cell Biol. 2008 Aug;20(4):393-400. doi: 10.1016/ Epub 2008 Jul 9. Review.


Analysis of disulfide bond formation.

Braakman I, Hebert DN.

Curr Protoc Protein Sci. 2001 May;Chapter 14:Unit14.1. doi: 10.1002/0471140864.ps1401s03.


The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion.

Sanders RW, van Anken E, Nabatov AA, Liscaljet IM, Bontjer I, Eggink D, Melchers M, Busser E, Dankers MM, Groot F, Braakman I, Berkhout B, Paxton WA.

Retrovirology. 2008 Jan 31;5:10. doi: 10.1186/1742-4690-5-10.


Formation of peroxisomes: present and past.

Tabak HF, Hoepfner D, Zand Av, Geuze HJ, Braakman I, Huynen MA.

Biochim Biophys Acta. 2006 Dec;1763(12):1647-54. Epub 2006 Sep 3. Review.


The return of the peroxisome.

van der Zand A, Braakman I, Geuze HJ, Tabak HF.

J Cell Sci. 2006 Mar 15;119(Pt 6):989-94. Review.


A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients.

Piersma D, Berns EM, Verhoef-Post M, Uitterlinden AG, Braakman I, Pols HA, Themmen AP.

J Clin Endocrinol Metab. 2006 Apr;91(4):1470-6. Epub 2006 Feb 7.


Endoplasmic reticulum stress and the making of a professional secretory cell.

van Anken E, Braakman I.

Crit Rev Biochem Mol Biol. 2005 Sep-Oct;40(5):269-83. Review.


Folding of CFTR is predominantly cotranslational.

Kleizen B, van Vlijmen T, de Jonge HR, Braakman I.

Mol Cell. 2005 Oct 28;20(2):277-87.


Versatility of the endoplasmic reticulum protein folding factory.

van Anken E, Braakman I.

Crit Rev Biochem Mol Biol. 2005 Jul-Aug;40(4):191-228. Review.


Contribution of the endoplasmic reticulum to peroxisome formation.

Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF.

Cell. 2005 Jul 15;122(1):85-95.


A critical step in the folding of influenza virus HA determined with a novel folding assay.

Maggioni MC, Liscaljet IM, Braakman I.

Nat Struct Mol Biol. 2005 Mar;12(3):258-63. Epub 2005 Feb 6.


Synthesis and quality control of viral membrane proteins.

Maggioni C, Braakman I.

Curr Top Microbiol Immunol. 2005;285:175-98. Review.


Low-density lipoprotein receptor structure and folding.

Gent J, Braakman I.

Cell Mol Life Sci. 2004 Oct;61(19-20):2461-70. Review.


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