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Items: 1 to 50 of 161

1.

Targeting PLK1 as a novel chemopreventive approach to eradicate preneoplastic mucosal changes in the head and neck.

de Boer DV, Martens-de Kemp SR, Buijze M, Stigter-van Walsum M, Bloemena E, Dietrich R, Leemans CR, van Beusechem VW, Braakhuis BJM, Brakenhoff RH.

Oncotarget. 2017 May 16;8(58):97928-97940. doi: 10.18632/oncotarget.17880. eCollection 2017 Nov 17.

2.

Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review.

Hussein AA, Helder MN, de Visscher JG, Leemans CR, Braakhuis BJ, de Vet HCW, Forouzanfar T.

Eur J Cancer. 2017 Sep;82:115-127. doi: 10.1016/j.ejca.2017.05.026. Epub 2017 Jun 24. Review.

PMID:
28654785
3.

The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics.

Martens-de Kemp SR, Brink A, van der Meulen IH, de Menezes RX, Te Beest DE, Leemans CR, van Beusechem VW, Braakhuis BJ, Brakenhoff RH.

Mol Cancer Ther. 2017 Mar;16(3):540-550. doi: 10.1158/1535-7163.MCT-16-0457. Epub 2016 Dec 15.

4.

Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.

Giefing M, Wierzbicka M, Szyfter K, Brenner JC, Braakhuis BJ, Brakenhoff RH, Bradford CR, Sorensen JA, Rinaldo A, Rodrigo JP, Takes RP, Ferlito A.

Eur J Cancer. 2016 Mar;55:147-57. doi: 10.1016/j.ejca.2015.10.070. Epub 2016 Feb 4. Review.

5.

Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.

Braakhuis BJ, Nieuwint AW, Oostra AB, Joenje H, Flach GB, Graveland AP, Brakenhoff RH, Leemans CR.

J Oral Pathol Med. 2016 Mar;45(3):189-92. doi: 10.1111/jop.12349. Epub 2015 Aug 26.

PMID:
26306924
6.

Noninvasive molecular screening for oral precancer in Fanconi anemia patients.

Smetsers SE, Velleuer E, Dietrich R, Wu T, Brink A, Buijze M, Deeg DJ, Soulier J, Leemans CR, Braakhuis BJ, Brakenhoff RH.

Cancer Prev Res (Phila). 2015 Nov;8(11):1102-11. doi: 10.1158/1940-6207.CAPR-15-0220. Epub 2015 Aug 14.

7.

Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs. secondary primary tumor.

Gleber-Netto FO, Braakhuis BJ, Triantafyllou A, Takes RP, Kelner N, Rodrigo JP, Strojan P, Vander Poorten V, Rapidis AD, Rinaldo A, Brakenhoff RH, Ferlito A, Kowalski LP.

Oral Oncol. 2015 Aug;51(8):738-44. doi: 10.1016/j.oraloncology.2015.04.016. Epub 2015 May 16. Review.

PMID:
25987307
8.

Quantitative diffusion-weighted MRI parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.

Schouten CS, de Graaf P, Bloemena E, Witte BI, Braakhuis BJ, Brakenhoff RH, Leemans CR, Castelijns JA, de Bree R.

AJNR Am J Neuroradiol. 2015 Apr;36(4):763-7. doi: 10.3174/ajnr.A4271. Epub 2015 Feb 26.

9.

Interaction of quantitative (18)F-FDG-PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.

Schouten CS, Hakim S, Boellaard R, Bloemena E, Doornaert PA, Witte BI, Braakhuis BJ, Brakenhoff RH, Leemans CR, Hoekstra OS, de Bree R.

Head Neck. 2016 Apr;38(4):529-35. doi: 10.1002/hed.23920. Epub 2015 May 26.

PMID:
25352335
10.

A comprehensive assessment protocol including patient reported outcomes, physical tests, and biological sampling in newly diagnosed patients with head and neck cancer: is it feasible?

van Nieuwenhuizen AJ, Buffart LM, Smit JH, Brakenhoff RH, Braakhuis BJ, de Bree R, Leemans CR, Verdonck-de Leeuw IM.

Support Care Cancer. 2014 Dec;22(12):3321-30. doi: 10.1007/s00520-014-2359-0. Epub 2014 Aug 12.

11.

Incidence and survival trends of head and neck squamous cell carcinoma in the Netherlands between 1989 and 2011.

Braakhuis BJ, Leemans CR, Visser O.

Oral Oncol. 2014 Jul;50(7):670-5. doi: 10.1016/j.oraloncology.2014.03.008. Epub 2014 Apr 13.

12.

Genetic susceptibility to head and neck squamous cell carcinoma.

Lacko M, Braakhuis BJ, Sturgis EM, Boedeker CC, Suárez C, Rinaldo A, Ferlito A, Takes RP.

Int J Radiat Oncol Biol Phys. 2014 May 1;89(1):38-48. doi: 10.1016/j.ijrobp.2013.09.034. Review.

PMID:
24725688
13.

Cancer stem cell enrichment marker CD98: a prognostic factor for survival in patients with human papillomavirus-positive oropharyngeal cancer.

Rietbergen MM, Martens-de Kemp SR, Bloemena E, Witte BI, Brink A, Baatenburg de Jong RJ, Leemans CR, Braakhuis BJ, Brakenhoff RH.

Eur J Cancer. 2014 Mar;50(4):765-73. doi: 10.1016/j.ejca.2013.11.010. Epub 2013 Dec 4.

14.

Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas.

Rietbergen MM, Snijders PJ, Beekzada D, Braakhuis BJ, Brink A, Heideman DA, Hesselink AT, Witte BI, Bloemena E, Baatenburg-De Jong RJ, Leemans CR, Brakenhoff RH.

Int J Cancer. 2014 May 15;134(10):2366-72. doi: 10.1002/ijc.28580. Epub 2013 Nov 19.

15.

Molecular screening of oral precancer.

Graveland AP, Bremmer JF, de Maaker M, Brink A, Cobussen P, Zwart M, Braakhuis BJ, Bloemena E, van der Waal I, Leemans CR, Brakenhoff RH.

Oral Oncol. 2013 Dec;49(12):1129-35. doi: 10.1016/j.oraloncology.2013.09.005. Epub 2013 Oct 9.

PMID:
24120275
16.

No evidence for active human papillomavirus (HPV) in fields surrounding HPV-positive oropharyngeal tumors.

Rietbergen MM, Braakhuis BJ, Moukhtari N, Bloemena E, Brink A, Sie D, Ylstra B, Baatenburg de Jong RJ, Snijders PJ, Brakenhoff RH, Leemans CR.

J Oral Pathol Med. 2014 Feb;43(2):137-42. doi: 10.1111/jop.12123. Epub 2013 Oct 11.

PMID:
24118314
17.

TP53 mutation and human papilloma virus status of oral squamous cell carcinomas in young adult patients.

Braakhuis BJ, Rietbergen MM, Buijze M, Snijders PJ, Bloemena E, Brakenhoff RH, Leemans CR.

Oral Dis. 2014 Sep;20(6):602-8. doi: 10.1111/odi.12178. Epub 2013 Sep 23.

PMID:
24112103
18.

Identification of lethal microRNAs specific for head and neck cancer.

Lindenbergh-van der Plas M, Martens-de Kemp SR, de Maaker M, van Wieringen WN, Ylstra B, Agami R, Cerisoli F, Leemans CR, Braakhuis BJ, Brakenhoff RH.

Clin Cancer Res. 2013 Oct 15;19(20):5647-57. doi: 10.1158/1078-0432.CCR-12-2295. Epub 2013 Aug 13.

19.

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.

Martens-de Kemp SR, Dalm SU, Wijnolts FM, Brink A, Honeywell RJ, Peters GJ, Braakhuis BJ, Brakenhoff RH.

PLoS One. 2013 Apr 17;8(4):e61555. doi: 10.1371/journal.pone.0061555. Print 2013.

20.

Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines.

Nagel R, Martens-de Kemp SR, Buijze M, Jacobs G, Braakhuis BJ, Brakenhoff RH.

Oral Oncol. 2013 Jun;49(6):560-6. doi: 10.1016/j.oraloncology.2013.03.446. Epub 2013 Apr 8.

21.

CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties.

Martens-de Kemp SR, Brink A, Stigter-van Walsum M, Damen JM, Rustenburg F, Wu T, van Wieringen WN, Schuurhuis GJ, Braakhuis BJ, Slijper M, Brakenhoff RH.

Stem Cell Res. 2013 May;10(3):477-88. doi: 10.1016/j.scr.2013.02.004. Epub 2013 Feb 18.

22.

Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.

Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ, Brakenhoff RH.

Clin Cancer Res. 2013 Apr 15;19(8):1994-2003. doi: 10.1158/1078-0432.CCR-12-2539. Epub 2013 Feb 26.

23.

Immunotherapy for head and neck cancer patients: shifting the balance.

Turksma AW, Braakhuis BJ, Bloemena E, Meijer CJ, Leemans CR, Hooijberg E.

Immunotherapy. 2013 Jan;5(1):49-61. doi: 10.2217/imt.12.135. Review.

PMID:
23256798
24.

Effector memory T-cell frequencies in relation to tumour stage, location and HPV status in HNSCC patients.

Turksma AW, Bontkes HJ, van den Heuvel H, de Gruijl TD, von Blomberg BM, Braakhuis BJ, Leemans CR, Bloemena E, Meijer CJ, Hooijberg E.

Oral Dis. 2013 Sep;19(6):577-84. doi: 10.1111/odi.12037. Epub 2012 Nov 26.

PMID:
23176702
25.

Expression signature in peripheral blood cells for molecular diagnosis of head and neck squamous cell carcinoma.

Braakhuis BJ, Graveland AP, Dijk F, Ylstra B, van Wieringen WN, Leemans CR, Brakenhoff RH.

Oral Dis. 2013 Jul;19(5):452-5. doi: 10.1111/odi.12019. Epub 2012 Oct 3.

PMID:
23034102
26.

Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors.

Braakhuis BJ, Brakenhoff RH, Leemans CR.

Ann Oncol. 2012 Sep;23 Suppl 10:x173-7.

PMID:
22987957
27.

Increasing prevalence rates of HPV attributable oropharyngeal squamous cell carcinomas in the Netherlands as assessed by a validated test algorithm.

Rietbergen MM, Leemans CR, Bloemena E, Heideman DA, Braakhuis BJ, Hesselink AT, Witte BI, Baatenburg de Jong RJ, Meijer CJ, Snijders PJ, Brakenhoff RH.

Int J Cancer. 2013 Apr 1;132(7):1565-71. doi: 10.1002/ijc.27821. Epub 2012 Nov 23.

28.

Molecular diagnosis of minimal residual disease in head and neck cancer patients.

Graveland AP, Braakhuis BJ, Eerenstein SE, de Bree R, Bloemena E, de Maaker M, van den Brekel MW, Dijk F, Mesker WE, Tanke HJ, Leemans CR, Brakenhoff RH.

Cell Oncol (Dordr). 2012 Oct;35(5):367-75. Epub 2012 Sep 4.

PMID:
22945509
29.

Generation of precursor cell lines from preneoplastic fields surrounding head and neck cancers.

van Zeeburg HJ, Graveland AP, Brink A, Nguyen M, Leemans CR, Bloemena E, Braakhuis BJ, Brakenhoff RH.

Head Neck. 2013 Apr;35(4):568-74. doi: 10.1002/hed.23004. Epub 2012 Jun 19.

PMID:
22714984
30.

Prognostic value of DNA ploidy status in patients with oral leukoplakia.

Bremmer JF, Brakenhoff RH, Broeckaert MA, Beliën JA, Leemans CR, Bloemena E, van der Waal I, Braakhuis BJ.

Oral Oncol. 2011 Oct;47(10):956-60. doi: 10.1016/j.oraloncology.2011.07.025. Epub 2011 Aug 30.

PMID:
21880540
31.

Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma.

Lindenbergh-van der Plas M, Brakenhoff RH, Kuik DJ, Buijze M, Bloemena E, Snijders PJ, Leemans CR, Braakhuis BJ.

Clin Cancer Res. 2011 Jun 1;17(11):3733-41. doi: 10.1158/1078-0432.CCR-11-0183. Epub 2011 Apr 5.

32.

The molecular biology of head and neck cancer.

Leemans CR, Braakhuis BJ, Brakenhoff RH.

Nat Rev Cancer. 2011 Jan;11(1):9-22. doi: 10.1038/nrc2982. Epub 2010 Dec 16. Review.

PMID:
21160525
33.

Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma.

Graveland AP, Golusinski PJ, Buijze M, Douma R, Sons N, Kuik DJ, Bloemena E, Leemans CR, Brakenhoff RH, Braakhuis BJ.

Int J Cancer. 2011 Apr 15;128(8):1852-9. doi: 10.1002/ijc.25523.

34.

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.

Smeets SJ, van der Plas M, Schaaij-Visser TB, van Veen EA, van Meerloo J, Braakhuis BJ, Steenbergen RD, Brakenhoff RH.

Int J Cancer. 2011 Apr 1;128(7):1596-605. doi: 10.1002/ijc.25474. Epub 2010 May 24.

35.

Molecular analysis of surgical margins in head and neck cancer: more than a marginal issue.

Braakhuis BJ, Bloemena E, Leemans CR, Brakenhoff RH.

Oral Oncol. 2010 Jul;46(7):485-91. doi: 10.1016/j.oraloncology.2010.01.019. Epub 2010 Feb 26. Review.

PMID:
20189442
36.

Gene expression profiling in head and neck squamous cell carcinoma.

Braakhuis BJ, Brakenhoff RH, Leemans CR.

Curr Opin Otolaryngol Head Neck Surg. 2010 Apr;18(2):67-71. doi: 10.1097/MOO.0b013e32833693ce. Review.

PMID:
20084003
37.

Evaluation of cornulin, keratin 4, keratin 13 expression and grade of dysplasia for predicting malignant progression of oral leukoplakia.

Schaaij-Visser TB, Bremmer JF, Braakhuis BJ, Heck AJ, Slijper M, van der Waal I, Brakenhoff RH.

Oral Oncol. 2010 Feb;46(2):123-7. doi: 10.1016/j.oraloncology.2009.11.012. Epub 2009 Dec 29.

PMID:
20036603
38.

Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas.

Schaaij-Visser TB, Graveland AP, Gauci S, Braakhuis BJ, Buijze M, Heck AJ, Kuik DJ, Bloemena E, Leemans CR, Slijper M, Brakenhoff RH.

Clin Cancer Res. 2009 Dec 15;15(24):7666-7675.

39.

Human papilloma virus in head and neck cancer: the need for a standardised assay to assess the full clinical importance.

Braakhuis BJ, Brakenhoff RH, Meijer CJ, Snijders PJ, Leemans CR.

Eur J Cancer. 2009 Nov;45(17):2935-9. doi: 10.1016/j.ejca.2009.08.018. Epub 2009 Sep 18.

PMID:
19766476
40.

Molecular detection of minimal residual cancer in surgical margins of head and neck cancer patients.

Graveland AP, de Maaker M, Braakhuis BJ, de Bree R, Eerenstein SE, Bloemena E, Leemans CR, Brakenhoff RH.

Cell Oncol. 2009;31(4):317-28. doi: 10.3233/CLO-2009-0474.

41.

Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis.

Smeets SJ, Brakenhoff RH, Ylstra B, van Wieringen WN, van de Wiel MA, Leemans CR, Braakhuis BJ.

Cell Oncol. 2009;31(4):291-300. doi: 10.3233/CLO-2009-0471.

42.

Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck.

Wilting SM, Smeets SJ, Snijders PJ, van Wieringen WN, van de Wiel MA, Meijer GA, Ylstra B, Leemans CR, Meijer CJ, Brakenhoff RH, Braakhuis BJ, Steenbergen RD.

BMC Med Genomics. 2009 Jun 1;2:32. doi: 10.1186/1755-8794-2-32.

43.

Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: Increasing incidence, but not in young adults.

Braakhuis BJ, Visser O, Leemans CR.

Oral Oncol. 2009 Sep;45(9):e85-9. doi: 10.1016/j.oraloncology.2009.03.010. Epub 2009 May 19.

PMID:
19457708
44.

Screening for oral precancer with noninvasive genetic cytology.

Bremmer JF, Graveland AP, Brink A, Braakhuis BJ, Kuik DJ, Leemans CR, Bloemena E, van der Waal I, Brakenhoff RH.

Cancer Prev Res (Phila). 2009 Feb;2(2):128-33. doi: 10.1158/1940-6207.CAPR-08-0128. Epub 2009 Jan 27.

45.

Comparative evaluation of genetic assays to identify oral pre-cancerous fields.

Bremmer JF, Braakhuis BJ, Brink A, Broeckaert MA, Beliën JA, Meijer GA, Kuik DJ, Leemans CR, Bloemena E, van der Waal I, Brakenhoff RH.

J Oral Pathol Med. 2008 Nov;37(10):599-606. doi: 10.1111/j.1600-0714.2008.00682.x. Epub 2008 Aug 14.

PMID:
18705641
46.

Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer.

Wilting SM, de Wilde J, Meijer CJ, Berkhof J, Yi Y, van Wieringen WN, Braakhuis BJ, Meijer GA, Ylstra B, Snijders PJ, Steenbergen RD.

Genes Chromosomes Cancer. 2008 Oct;47(10):890-905. doi: 10.1002/gcc.20590.

47.

Human papillomavirus and oropharyngeal cancer.

Braakhuis BJ, Snijders PJ, Leemans CR.

N Engl J Med. 2007 Sep 13;357(11):1157; author reply 1157-8. No abstract available.

PMID:
17874473
48.

A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.

Smeets SJ, Hesselink AT, Speel EJ, Haesevoets A, Snijders PJ, Pawlita M, Meijer CJ, Braakhuis BJ, Leemans CR, Brakenhoff RH.

Int J Cancer. 2007 Dec 1;121(11):2465-72.

49.

Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma.

Braakhuis BJ, Senft A, de Bree R, de Vries J, Ylstra B, Cloos J, Kuik DJ, Leemans CR, Brakenhoff RH.

J Clin Pathol. 2006 Dec;59(12):1254-60. Epub 2006 May 5.

50.

Microarray analysis of bleomycin-exposed lymphoblastoid cells for identifying cancer susceptibility genes.

Cloos J, de Boer WP, Snel MH, van den Ijssel P, Ylstra B, Leemans CR, Brakenhoff RH, Braakhuis BJ.

Mol Cancer Res. 2006 Feb;4(2):71-7.

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