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Items: 1 to 50 of 108

1.

Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Bianco G.

Mar Drugs. 2019 Feb 12;17(2). pii: E114. doi: 10.3390/md17020114.

2.

Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A.

García-Salcedo R, Álvarez-Álvarez R, Olano C, Cañedo L, Braña AF, Méndez C, de la Calle F, Salas JA.

Mar Drugs. 2018 Jul 31;16(8). pii: E259. doi: 10.3390/md16080259.

3.

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches.

Becerril A, Álvarez S, Braña AF, Rico S, Díaz M, Santamaría RI, Salas JA, Méndez C.

PLoS One. 2018 May 24;13(5):e0198145. doi: 10.1371/journal.pone.0198145. eCollection 2018.

4.

Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.

Sarmiento-Vizcaíno A, Espadas J, Martín J, Braña AF, Reyes F, García LA, Blanco G.

Front Microbiol. 2018 Apr 23;9:773. doi: 10.3389/fmicb.2018.00773. eCollection 2018.

5.

A Novel Growth Method To Improve the Quality of GaAs Nanowires Grown by Ga-Assisted Chemical Beam Epitaxy.

García Núñez C, Braña AF, López N, García BJ.

Nano Lett. 2018 Jun 13;18(6):3608-3615. doi: 10.1021/acs.nanolett.8b00702. Epub 2018 May 11.

PMID:
29739187
6.

New Insights into the Biosynthesis Pathway of Polyketide Alkaloid Argimycins P in Streptomyces argillaceus.

Ye S, Braña AF, González-Sabín J, Morís F, Olano C, Salas JA, Méndez C.

Front Microbiol. 2018 Feb 16;9:252. doi: 10.3389/fmicb.2018.00252. eCollection 2018.

7.

Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.

Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA.

Front Microbiol. 2018 Jan 30;9:39. doi: 10.3389/fmicb.2018.00039. eCollection 2018.

8.

Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea.

Sarmiento-Vizcaíno A, Braña AF, Pérez-Victoria I, Martín J, de Pedro N, Cruz M, Díaz C, Vicente F, Acuña JL, Reyes F, García LA, Blanco G.

Mar Drugs. 2017 Aug 28;15(9). pii: E271. doi: 10.3390/md15090271.

9.

Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa.

Braña AF, Sarmiento-Vizcaíno A, Osset M, Pérez-Victoria I, Martín J, de Pedro N, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G.

Mar Drugs. 2017 May 19;15(5). pii: E144. doi: 10.3390/md15050144.

10.

Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937.

Losada AA, Cano-Prieto C, García-Salcedo R, Braña AF, Méndez C, Salas JA, Olano C.

Microb Biotechnol. 2017 Jul;10(4):873-885. doi: 10.1111/1751-7915.12716. Epub 2017 Apr 18.

11.

Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P.

Ye S, Molloy B, Braña AF, Zabala D, Olano C, Cortés J, Morís F, Salas JA, Méndez C.

Front Microbiol. 2017 Feb 10;8:194. doi: 10.3389/fmicb.2017.00194. eCollection 2017.

12.

Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227.

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G.

J Nat Prod. 2017 Feb 24;80(2):569-573. doi: 10.1021/acs.jnatprod.6b01107. Epub 2017 Feb 7.

PMID:
28169531
13.

Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.

Salcedo RG, Olano C, Fernández R, Braña AF, Méndez C, de la Calle F, Salas JA.

Microb Cell Fact. 2016 Nov 9;15(1):187.

14.

Pharmacological Potential of Phylogenetically Diverse Actinobacteria Isolated from Deep-Sea Coral Ecosystems of the Submarine Avilés Canyon in the Cantabrian Sea.

Sarmiento-Vizcaíno A, González V, Braña AF, Palacios JJ, Otero L, Fernández J, Molina A, Kulik A, Vázquez F, Acuña JL, García LA, Blanco G.

Microb Ecol. 2017 Feb;73(2):338-352. doi: 10.1007/s00248-016-0845-2. Epub 2016 Sep 10.

PMID:
27614749
15.

New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis.

González A, Rodríguez M, Braña AF, Méndez C, Salas JA, Olano C.

Microb Cell Fact. 2016 Mar 21;15:56. doi: 10.1186/s12934-016-0452-4.

16.

Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative.

Salcedo RG, Olano C, Gómez C, Fernández R, Braña AF, Méndez C, de la Calle F, Salas JA.

Microb Cell Fact. 2016 Feb 22;15:44. doi: 10.1186/s12934-016-0443-5.

17.

Increasing antibiotic production yields by favoring the biosynthesis of precursor metabolites glucose-1-phosphate and/or malonyl-CoA in Streptomyces producer strains.

Zabala D, Braña AF, Salas JA, Méndez C.

J Antibiot (Tokyo). 2016 Mar;69(3):179-82. doi: 10.1038/ja.2015.104. Epub 2015 Oct 14. No abstract available.

PMID:
26464013
18.

Atmospheric Dispersal of Bioactive Streptomyces albidoflavus Strains Among Terrestrial and Marine Environments.

Sarmiento-Vizcaíno A, Braña AF, González V, Nava H, Molina A, Llera E, Fiedler HP, Rico JM, García-Flórez L, Acuña JL, García LA, Blanco G.

Microb Ecol. 2016 Feb;71(2):375-86. doi: 10.1007/s00248-015-0654-z. Epub 2015 Jul 30.

PMID:
26224165
19.

Crosstalk of Nataxazole Pathway with Chorismate-Derived Ionophore Biosynthesis Pathways in Streptomyces sp. Tü 6176.

Cano-Prieto C, Losada AA, Braña AF, Méndez C, Salas JA, Olano C.

Chembiochem. 2015 Sep 7;16(13):1925-1932. doi: 10.1002/cbic.201500261. Epub 2015 Jul 14.

PMID:
26083234
20.

Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway.

Cano-Prieto C, García-Salcedo R, Sánchez-Hidalgo M, Braña AF, Fiedler HP, Méndez C, Salas JA, Olano C.

Chembiochem. 2015 Jul 6;16(10):1461-73. doi: 10.1002/cbic.201500153. Epub 2015 May 26.

PMID:
25892546
21.

Myceligenerans cantabricum sp. nov., a barotolerant actinobacterium isolated from a deep cold-water coral.

Sarmiento-Vizcaíno A, González V, Braña AF, Molina A, Acuña JL, García LA, Blanco G.

Int J Syst Evol Microbiol. 2015 Apr;65(Pt 4):1328-34. doi: 10.1099/ijs.0.000107. Epub 2015 Feb 9.

PMID:
25667397
22.

Transcriptional regulation of mithramycin biosynthesis in Streptomyces argillaceus: dual role as activator and repressor of the PadR-like regulator MtrY.

Flórez AB, Álvarez S, Zabala D, Braña AF, Salas JA, Méndez C.

Microbiology. 2015 Feb;161(Pt 2):272-84.

PMID:
25416691
23.

Erratum to: Two Streptomyces Species Producing Antibiotic, Antitumor, and Anti-Inflammatory Compounds Are Widespread Among Intertidal Macroalgae and Deep-Sea Coral Reef Invertebrates from the Central Cantabrian Sea.

Braña AF, Fiedler HP, Nava H, González V, Sarmiento-Vizcaíno A, Molina A, Acuña JL, García LA, Blanco G.

Microb Ecol. 2015 Jul;70(1):298. doi: 10.1007/s00248-014-0529-8. No abstract available.

PMID:
25391238
24.

Two Streptomyces species producing antibiotic, antitumor, and anti-inflammatory compounds are widespread among intertidal macroalgae and deep-sea coral reef invertebrates from the central Cantabrian Sea.

Braña AF, Fiedler HP, Nava H, González V, Sarmiento-Vizcaíno A, Molina A, Acuña JL, García LA, Blanco G.

Microb Ecol. 2015 Apr;69(3):512-24. doi: 10.1007/s00248-014-0508-0. Epub 2014 Oct 16. Erratum in: Microb Ecol. 2015 Jul;70(1):298. Braña, Afredo F [corrected to Braña, Alfredo F].

PMID:
25319239
25.

Activation and silencing of secondary metabolites in Streptomyces albus and Streptomyces lividans after transformation with cosmids containing the thienamycin gene cluster from Streptomyces cattleya.

Braña AF, Rodríguez M, Pahari P, Rohr J, García LA, Blanco G.

Arch Microbiol. 2014 May;196(5):345-55. doi: 10.1007/s00203-014-0977-z. Epub 2014 Mar 15.

PMID:
24633227
26.

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.

Olano C, García I, González A, Rodriguez M, Rozas D, Rubio J, Sánchez-Hidalgo M, Braña AF, Méndez C, Salas JA.

Microb Biotechnol. 2014 May;7(3):242-56. doi: 10.1111/1751-7915.12116. Epub 2014 Mar 4.

27.

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus.

Zabala D, Braña AF, Flórez AB, Salas JA, Méndez C.

Metab Eng. 2013 Nov;20:187-97. doi: 10.1016/j.ymben.2013.10.002. Epub 2013 Oct 19.

PMID:
24148183
28.

Generation by mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A.

Sialer C, García I, González-Sabín J, Braña AF, Méndez C, Morís F, Salas JA.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5707-9. doi: 10.1016/j.bmcl.2013.08.017. Epub 2013 Aug 12.

PMID:
23993774
29.

Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping.

Alvarez-Álvarez R, Martínez-Burgo Y, Pérez-Redondo R, Braña AF, Martín JF, Liras P.

Appl Microbiol Biotechnol. 2013 Nov;97(21):9451-63. doi: 10.1007/s00253-013-5148-7. Epub 2013 Aug 22.

PMID:
23974366
30.

Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity.

Garcia I, Vior NM, González-Sabín J, Braña AF, Rohr J, Moris F, Méndez C, Salas JA.

Chem Biol. 2013 Aug 22;20(8):1022-32. doi: 10.1016/j.chembiol.2013.06.014. Epub 2013 Aug 1.

31.

High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of Streptomyces lividans.

Díaz M, Sevillano L, Rico S, Lombo F, Braña AF, Salas JA, Mendez C, Santamaría RI.

FEMS Microbiol Lett. 2013 May;342(2):123-9. doi: 10.1111/1574-6968.12098. Epub 2013 Feb 28.

32.

Lipase-catalyzed preparation of chromomycin A₃ analogues and biological evaluation for anticancer activity.

González-Sabín J, Núñez LE, Menéndez N, Braña AF, Méndez C, Salas JA, Gotor V, Morís F.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4310-3. doi: 10.1016/j.bmcl.2012.05.015. Epub 2012 May 11.

PMID:
22647722
33.

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Núñez LE, Nybo SE, González-Sabín J, Pérez M, Menéndez N, Braña AF, Shaaban KA, He M, Morís F, Salas JA, Rohr J, Méndez C.

J Med Chem. 2012 Jun 28;55(12):5813-25. doi: 10.1021/jm300234t. Epub 2012 Jun 7.

34.

Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin.

Gómez C, Olano C, Palomino-Schätzlein M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

J Antibiot (Tokyo). 2012 Jul;65(7):341-8. doi: 10.1038/ja.2012.37. Epub 2012 May 9.

PMID:
22569159
35.

Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring.

Garcia I, Vior NM, Braña AF, González-Sabin J, Rohr J, Moris F, Méndez C, Salas JA.

Chem Biol. 2012 Mar 23;19(3):399-413. doi: 10.1016/j.chembiol.2012.01.014.

36.

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.

Gómez C, Horna DH, Olano C, Palomino-Schätzlein M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

J Bacteriol. 2011 Aug;193(16):4214-23. doi: 10.1128/JB.05062-11. Epub 2011 Jun 10.

37.

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

Horna DH, Gómez C, Olano C, Palomino-Schätzlein M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

J Bacteriol. 2011 May;193(10):2647-51. doi: 10.1128/JB.00108-11. Epub 2011 Mar 11.

38.

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.

García B, González-Sabín J, Menéndez N, Braña AF, Núñez LE, Morís F, Salas JA, Méndez C.

Microb Biotechnol. 2011 Mar;4(2):226-38. doi: 10.1111/j.1751-7915.2010.00229.x. Epub 2010 Nov 18.

39.

Myxococcus xanthus induces actinorhodin overproduction and aerial mycelium formation by Streptomyces coelicolor.

Pérez J, Muñoz-Dorado J, Braña AF, Shimkets LJ, Sevillano L, Santamaría RI.

Microb Biotechnol. 2011 Mar;4(2):175-83. doi: 10.1111/j.1751-7915.2010.00208.x. Epub 2010 Sep 27.

40.

Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.

Rodríguez M, Núñez LE, Braña AF, Méndez C, Salas JA, Blanco G.

Antimicrob Agents Chemother. 2011 Apr;55(4):1638-49. doi: 10.1128/AAC.01366-10. Epub 2011 Jan 24.

41.

Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.

Bosserman MA, Flórez AB, Shaaban KA, Braña AF, Salas JA, Méndez C, Rohr J.

Biochemistry. 2011 Mar 1;50(8):1421-8. doi: 10.1021/bi1016205. Epub 2011 Feb 2.

42.

dltA gene mutation in the teichoic acids alanylation system of Lactococcus garvieae results in diminished proliferation in its natural host.

Reimundo P, Menéndez A, Méndez J, Pérez-Pascual D, Navais R, Gómez E, Braña AF, Guijarro JA.

Vet Microbiol. 2010 Jul 14;143(2-4):434-9. doi: 10.1016/j.vetmic.2009.12.004. Epub 2009 Dec 11.

PMID:
20042300
43.

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.

Olano C, Gómez C, Pérez M, Palomino M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

Chem Biol. 2009 Oct 30;16(10):1031-44. doi: 10.1016/j.chembiol.2009.09.015.

44.

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles.

Sánchez C, Salas AP, Braña AF, Palomino M, Pineda-Lucena A, Carbajo RJ, Méndez C, Moris F, Salas JA.

Chem Commun (Camb). 2009 Jul 21;(27):4118-20. doi: 10.1039/b905068j. Epub 2009 May 27.

PMID:
19568652
45.

Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.

Ramos A, Olano C, Braña AF, Méndez C, Salas JA.

J Bacteriol. 2009 Apr;191(8):2871-5. doi: 10.1128/JB.01747-08. Epub 2009 Feb 20.

46.

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya.

Rodríguez M, Núñez LE, Braña AF, Méndez C, Salas JA, Blanco G.

Mol Microbiol. 2008 Aug;69(3):633-45. doi: 10.1111/j.1365-2958.2008.06312.x.

47.

Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.

Lombó F, Abdelfattah MS, Braña AF, Salas JA, Rohr J, Méndez C.

Chembiochem. 2009 Jan 26;10(2):296-303. doi: 10.1002/cbic.200800425.

48.

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.

Pérez M, Baig I, Braña AF, Salas JA, Rohr J, Méndez C.

Chembiochem. 2008 Sep 22;9(14):2295-304. doi: 10.1002/cbic.200800299.

49.

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.

Ramos A, Lombó F, Braña AF, Rohr J, Méndez C, Salas JA.

Microbiology. 2008 Mar;154(Pt 3):781-8. doi: 10.1099/mic.0.2007/014035-0.

PMID:
18310024
50.

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity.

Olano C, Abdelfattah MS, Gullón S, Braña AF, Rohr J, Méndez C, Salas JA.

Chembiochem. 2008 Mar 3;9(4):624-33. doi: 10.1002/cbic.200700610.

PMID:
18224649

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