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Items: 1 to 50 of 172

1.

Publisher Correction: Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment.

Kumar P, Efstathopoulos P, Millischer V, Olsson E, Wei YB, Brüstle O, Schalling M, Villaescusa JC, Ösby U, Lavebratt C.

Sci Rep. 2019 Nov 5;9(1):16377. doi: 10.1038/s41598-019-53159-5.

2.

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation.

Flitsch LJ, Brüstle O.

F1000Res. 2019 Aug 30;8. pii: F1000 Faculty Rev-1548. doi: 10.12688/f1000research.18926.1. eCollection 2019. Review.

3.

In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells.

Ostermann L, Ladewig J, Müller FJ, Kesavan J, Tailor J, Smith A, Brüstle O, Koch P.

Stem Cells. 2019 Nov;37(11):1429-1440. doi: 10.1002/stem.3065. Epub 2019 Aug 24.

PMID:
31339593
4.

Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons.

Rehbach K, Kesavan J, Hauser S, Ritzenhofen S, Jungverdorben J, Schüle R, Schöls L, Peitz M, Brüstle O.

Sci Rep. 2019 Jul 3;9(1):9615. doi: 10.1038/s41598-019-45246-4.

5.

Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse.

Wiatr K, Piasecki P, Marczak Ł, Wojciechowski P, Kurkowiak M, Płoski R, Rydzanicz M, Handschuh L, Jungverdorben J, Brüstle O, Figlerowicz M, Figiel M.

Mol Neurobiol. 2019 Dec;56(12):8168-8202. doi: 10.1007/s12035-019-01643-4. Epub 2019 Jun 14.

6.

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.

Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, Brose N, Brüstle O, Rhee JS.

Cell Rep. 2019 May 14;27(7):2212-2228.e7. doi: 10.1016/j.celrep.2019.04.059.

7.

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.

Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, Peitz M, Toonen RF, Brüstle O, Verhage M.

Cell Rep. 2019 May 14;27(7):2199-2211.e6. doi: 10.1016/j.celrep.2019.04.058.

8.

Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons.

Vaswani AR, Weykopf B, Hagemann C, Fried HU, Brüstle O, Blaess S.

Elife. 2019 Jan 28;8. pii: e41623. doi: 10.7554/eLife.41623.

9.

Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease.

Weykopf B, Haupt S, Jungverdorben J, Flitsch LJ, Hebisch M, Liu GH, Suzuki K, Belmonte JCI, Peitz M, Blaess S, Till A, Brüstle O.

Eur J Neurosci. 2019 Feb;49(4):561-589. doi: 10.1111/ejn.14345. Review.

PMID:
30656775
10.

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis.

Stappert L, Klaus F, Brüstle O.

Front Neurosci. 2018 Nov 5;12:707. doi: 10.3389/fnins.2018.00707. eCollection 2018. Review.

11.

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.

Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch LJ, Eckert D, Hebisch M, Fischer J, Kesavan J, Weykopf B, Schneider L, Holtkamp D, Beck H, Till A, Wüllner U, Ziller MJ, Wagner W, Peitz M, Brüstle O.

Nat Commun. 2018 Oct 2;9(1):4047. doi: 10.1038/s41467-018-06398-5.

12.

Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment.

Kumar P, Efstathopoulos P, Millischer V, Olsson E, Wei YB, Brüstle O, Schalling M, Villaescusa JC, Ösby U, Lavebratt C.

Sci Rep. 2018 Aug 24;8(1):12743. doi: 10.1038/s41598-018-31122-0. Erratum in: Sci Rep. 2019 Nov 5;9(1):16377.

13.

Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.

Evert BO, Nalavade R, Jungverdorben J, Matthes F, Weber S, Rajput A, Bonn S, Brüstle O, Peitz M, Krauß S.

PLoS One. 2018 Aug 7;13(8):e0201794. doi: 10.1371/journal.pone.0201794. eCollection 2018.

14.

Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype.

Peitz M, Bechler T, Thiele CC, Veltel M, Bloschies M, Fliessbach K, Ramirez A, Brüstle O.

Stem Cell Res. 2018 May;29:250-253. doi: 10.1016/j.scr.2018.04.011. Epub 2018 Apr 23.

15.

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E.

Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5. doi: 10.1016/j.chembiol.2018.03.012. Epub 2018 Apr 26.

16.

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

Poppe D, Doerr J, Schneider M, Wilkens R, Steinbeck JA, Ladewig J, Tam A, Paschon DE, Gregory PD, Reik A, Müller CE, Koch P, Brüstle O.

Stem Cells Transl Med. 2018 Jun;7(6):477-486. doi: 10.1002/sctm.16-0272. Epub 2018 Mar 28.

17.

DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling.

de Boni L, Gasparoni G, Haubenreich C, Tierling S, Schmitt I, Peitz M, Koch P, Walter J, Wüllner U, Brüstle O.

Clin Epigenetics. 2018 Jan 29;10:13. doi: 10.1186/s13148-018-0440-0. eCollection 2018.

18.

In vitro segregation and isolation of human pluripotent stem cell-derived neural crest cells.

Münst S, Koch P, Kesavan J, Alexander-Mays M, Münst B, Blaess S, Brüstle O.

Methods. 2018 Jan 15;133:65-80. doi: 10.1016/j.ymeth.2017.09.012. Epub 2017 Oct 14.

PMID:
29037816
19.

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.

Jungverdorben J, Till A, Brüstle O.

J Mol Med (Berl). 2017 Jul;95(7):705-718. doi: 10.1007/s00109-017-1533-5. Epub 2017 Jun 7. Review.

20.

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation.

Roese-Koerner B, Stappert L, Brüstle O.

Neurogenesis (Austin). 2017 May 12;4(1):e1313647. doi: 10.1080/23262133.2017.1313647. eCollection 2017. Review.

21.

Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.

Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R.

Brain. 2017 Jun 1;140(6):1561-1578. doi: 10.1093/brain/awx095. Erratum in: Brain. 2017 Dec 9;:.

22.

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.

De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brüstle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolén G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE.

Stem Cell Res. 2017 Apr;20:105-114. doi: 10.1016/j.scr.2017.03.002. Epub 2017 Mar 7.

23.

Glycoconjugates reveal diversity of human neural stem cells (hNSCs) derived from human induced pluripotent stem cells (hiPSCs).

Kandasamy M, Roll L, Langenstroth D, Brüstle O, Faissner A.

Cell Tissue Res. 2017 Jun;368(3):531-549. doi: 10.1007/s00441-017-2594-z. Epub 2017 Mar 15.

PMID:
28299522
24.

Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli.

Tornero D, Tsupykov O, Granmo M, Rodriguez C, Grønning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brüstle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z.

Brain. 2017 Mar 1;140(3):692-706. doi: 10.1093/brain/aww347.

PMID:
28115364
25.

Whole-brain 3D mapping of human neural transplant innervation.

Doerr J, Schwarz MK, Wiedermann D, Leinhaas A, Jakobs A, Schloen F, Schwarz I, Diedenhofen M, Braun NC, Koch P, Peterson DA, Kubitscheck U, Hoehn M, Brüstle O.

Nat Commun. 2017 Jan 19;8:14162. doi: 10.1038/ncomms14162.

26.

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D.

EMBO J. 2016 Nov 2;35(21):2350-2370. Epub 2016 Sep 12.

27.

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma.

Reinartz R, Wang S, Kebir S, Silver DJ, Wieland A, Zheng T, Küpper M, Rauschenbach L, Fimmers R, Shepherd TM, Trageser D, Till A, Schäfer N, Glas M, Hillmer AM, Cichon S, Smith AA, Pietsch T, Liu Y, Reynolds BA, Yachnis A, Pincus DW, Simon M, Brüstle O, Steindler DA, Scheffler B.

Clin Cancer Res. 2017 Jan 15;23(2):562-574. doi: 10.1158/1078-0432.CCR-15-2089. Epub 2016 Aug 12.

28.

Reciprocal Regulation between Bifunctional miR-9/9(∗) and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation.

Roese-Koerner B, Stappert L, Berger T, Braun NC, Veltel M, Jungverdorben J, Evert BO, Peitz M, Borghese L, Brüstle O.

Stem Cell Reports. 2016 Aug 9;7(2):207-19. doi: 10.1016/j.stemcr.2016.06.008. Epub 2016 Jul 14.

29.

Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays.

Seidel D, Obendorf J, Englich B, Jahnke HG, Semkova V, Haupt S, Girard M, Peschanski M, Brüstle O, Robitzki AA.

Biosens Bioelectron. 2016 Dec 15;86:277-286. doi: 10.1016/j.bios.2016.06.056. Epub 2016 Jun 20.

30.

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S.

Mol Psychiatry. 2016 Sep;21(9):1321. doi: 10.1038/mp.2016.100. Epub 2016 Jun 21. No abstract available.

PMID:
27324182
31.

Modeling psychiatric disorders: from genomic findings to cellular phenotypes.

Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S.

Mol Psychiatry. 2016 Sep;21(9):1167-79. doi: 10.1038/mp.2016.89. Epub 2016 May 31. Review. Erratum in: Mol Psychiatry. 2016 Sep;21(9):1321.

32.

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.

Ben Halima S, Mishra S, Raja KMP, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L.

Cell Rep. 2016 Mar 8;14(9):2127-2141. doi: 10.1016/j.celrep.2016.01.076. Epub 2016 Feb 25.

33.

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

Kumar S, Wirths O, Stüber K, Wunderlich P, Koch P, Theil S, Rezaei-Ghaleh N, Zweckstetter M, Bayer TA, Brüstle O, Thal DR, Walter J.

Acta Neuropathol. 2016 Apr;131(4):525-37. doi: 10.1007/s00401-016-1546-0. Epub 2016 Feb 22.

34.

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

35.

Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals.

Heesen L, Peitz M, Torres-Benito L, Hölker I, Hupperich K, Dobrindt K, Jungverdorben J, Ritzenhofen S, Weykopf B, Eckert D, Hosseini-Barkooie SM, Storbeck M, Fusaki N, Lonigro R, Heller R, Kye MJ, Brüstle O, Wirth B.

Cell Mol Life Sci. 2016 May;73(10):2089-104. doi: 10.1007/s00018-015-2084-y. Epub 2015 Nov 16.

PMID:
26573968
36.

Regulation of oligodendrocyte precursor maintenance by chondroitin sulphate glycosaminoglycans.

Karus M, Ulc A, Ehrlich M, Czopka T, Hennen E, Fischer J, Mizhorova M, Qamar N, Brüstle O, Faissner A.

Glia. 2016 Feb;64(2):270-86. doi: 10.1002/glia.22928. Epub 2015 Oct 10.

PMID:
26454153
37.

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.

Fernandes TG, Duarte ST, Ghazvini M, Gaspar C, Santos DC, Porteira AR, Rodrigues GM, Haupt S, Rombo DM, Armstrong J, Sebastião AM, Gribnau J, Garcia-Cazorla À, Brüstle O, Henrique D, Cabral JM, Diogo MM.

Biotechnol J. 2015 Oct;10(10):1578-88. doi: 10.1002/biot.201400751. Epub 2015 Jun 30.

PMID:
26123315
38.

Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes.

Gorris R, Fischer J, Erwes KL, Kesavan J, Peterson DA, Alexander M, Nöthen MM, Peitz M, Quandel T, Karus M, Brüstle O.

Glia. 2015 Dec;63(12):2152-67. doi: 10.1002/glia.22882. Epub 2015 Jun 30.

PMID:
26123132
39.

A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension.

Elanzew A, Sommer A, Pusch-Klein A, Brüstle O, Haupt S.

Biotechnol J. 2015 Oct;10(10):1589-99. doi: 10.1002/biot.201400757. Epub 2015 Aug 11.

PMID:
26110829
40.

A 3D human neural cell culture system for modeling Alzheimer's disease.

Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY.

Nat Protoc. 2015 Jul;10(7):985-1006. doi: 10.1038/nprot.2015.065. Epub 2015 Jun 11.

41.

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy.

Doerr J, Böckenhoff A, Ewald B, Ladewig J, Eckhardt M, Gieselmann V, Matzner U, Brüstle O, Koch P.

Mol Ther. 2015 Sep;23(9):1519-31. doi: 10.1038/mt.2015.106. Epub 2015 Jun 10.

42.

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W.

Sci Rep. 2015 Jun 9;5:11126. doi: 10.1038/srep11126.

43.

Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment.

Miranda CC, Fernandes TG, Pascoal JF, Haupt S, Brüstle O, Cabral JM, Diogo MM.

Biotechnol J. 2015 Oct;10(10):1612-24. doi: 10.1002/biot.201400846. Epub 2015 Apr 28.

PMID:
25866360
44.

Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.

Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F.

Science. 2015 Apr 17;348(6232):347-52. doi: 10.1126/science.aaa2958. Epub 2015 Mar 12.

45.

Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).

Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang SM, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo SK, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh SK, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan BZ, Zeng F, Zhou Q.

Regen Med. 2015;10(2 Suppl):1-44. doi: 10.2217/rme.14.93. No abstract available.

PMID:
25675265
46.

Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.

Kadari A, Mekala S, Wagner N, Malan D, Köth J, Doll K, Stappert L, Eckert D, Peitz M, Matthes J, Sasse P, Herzig S, Brüstle O, Ergün S, Edenhofer F.

Stem Cell Rev Rep. 2015 Aug;11(4):560-9. doi: 10.1007/s12015-014-9564-6.

47.

Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors.

Avaliani N, Sørensen AT, Ledri M, Bengzon J, Koch P, Brüstle O, Deisseroth K, Andersson M, Kokaia M.

Stem Cells. 2014 Dec;32(12):3088-98. doi: 10.1002/stem.1823.

48.

The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification.

Stappert L, Roese-Koerner B, Brüstle O.

Cell Tissue Res. 2015 Jan;359(1):47-64. doi: 10.1007/s00441-014-1981-y. Epub 2014 Aug 30. Review.

49.

Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells.

Qin J, Sontag S, Lin Q, Mitzka S, Leisten I, Schneider RK, Wang X, Jauch A, Peitz M, Brüstle O, Wagner W, Zhao RC, Zenke M.

Stem Cells Dev. 2014 Dec 1;23(23):2875-82. doi: 10.1089/scd.2014.0120. Epub 2014 Aug 11.

50.

Human induced pluripotent stem cells improve recovery in stroke-injured aged rats.

Tatarishvili J, Oki K, Monni E, Koch P, Memanishvili T, Buga AM, Verma V, Popa-Wagner A, Brüstle O, Lindvall O, Kokaia Z.

Restor Neurol Neurosci. 2014;32(4):547-58. doi: 10.3233/RNN-140404.

PMID:
24916776

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