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Items: 1 to 50 of 183

1.

The role of ceramides in metabolic disorders: when size and localization matters.

Turpin-Nolan SM, Brüning JC.

Nat Rev Endocrinol. 2020 Feb 14. doi: 10.1038/s41574-020-0320-5. [Epub ahead of print] Review.

PMID:
32060415
2.

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.

Engström Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC.

Nat Commun. 2020 Jan 23;11(1):442. doi: 10.1038/s41467-020-14291-3.

3.

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.

MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T.

Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6.

PMID:
31695197
4.

m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.

Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG.

Cell Rep. 2019 Aug 13;28(7):1703-1716.e6. doi: 10.1016/j.celrep.2019.07.032.

5.

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.

Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA.

J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033. Epub 2019 Aug 8.

PMID:
31401286
6.

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.

Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC.

Cell Rep. 2019 Jun 11;27(11):3182-3198.e9. doi: 10.1016/j.celrep.2019.05.037.

7.

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC.

Cell. 2019 May 30;177(6):1536-1552.e23. doi: 10.1016/j.cell.2019.05.008.

PMID:
31150623
8.

The role of insulin sensitivity and intranasally applied insulin on olfactory perception.

Edwin Thanarajah S, Hoffstall V, Rigoux L, Hanssen R, Brüning JC, Tittgemeyer M.

Sci Rep. 2019 May 10;9(1):7222. doi: 10.1038/s41598-019-43693-7.

9.

Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions.

Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Brüning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H.

Cell Metab. 2019 Jul 2;30(1):111-128.e6. doi: 10.1016/j.cmet.2019.04.001. Epub 2019 Apr 25.

PMID:
31031093
10.

Modulation of midbrain neurocircuitry by intranasal insulin.

Edwin Thanarajah S, Iglesias S, Kuzmanovic B, Rigoux L, Stephan KE, Brüning JC, Tittgemeyer M.

Neuroimage. 2019 Jul 1;194:120-127. doi: 10.1016/j.neuroimage.2019.03.050. Epub 2019 Mar 23.

11.

Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.

Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G.

JCI Insight. 2019 Feb 7;4(3). pii: 123337. doi: 10.1172/jci.insight.123337. [Epub ahead of print]

12.

Time-dependent assessment of stimulus-evoked regional dopamine release.

Lippert RN, Cremer AL, Edwin Thanarajah S, Korn C, Jahans-Price T, Burgeno LM, Tittgemeyer M, Brüning JC, Walton ME, Backes H.

Nat Commun. 2019 Jan 18;10(1):336. doi: 10.1038/s41467-018-08143-4.

13.

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.

Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N.

Mol Metab. 2019 Mar;21:36-50. doi: 10.1016/j.molmet.2018.12.008. Epub 2019 Jan 2.

14.

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC.

Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031.

15.

Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans.

Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M.

Cell Metab. 2019 Mar 5;29(3):695-706.e4. doi: 10.1016/j.cmet.2018.12.006. Epub 2018 Dec 27.

PMID:
30595479
16.

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Brandt C, Nolte H, Henschke S, Engström Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC.

Cell. 2018 Nov 15;175(5):1321-1335.e20. doi: 10.1016/j.cell.2018.10.015.

17.

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.

Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC.

Cell Rep. 2018 Oct 9;25(2):383-397.e10. doi: 10.1016/j.celrep.2018.09.034.

18.

Insulin regulates POMC neuronal plasticity to control glucose metabolism.

Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T.

Elife. 2018 Sep 19;7. pii: e38704. doi: 10.7554/eLife.38704.

19.

Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma.

Mittenbühler MJ, Sprenger HG, Gruber S, Wunderlich CM, Kern L, Brüning JC, Wunderlich FT.

Mol Metab. 2018 Nov;17:122-133. doi: 10.1016/j.molmet.2018.08.010. Epub 2018 Sep 5.

20.

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.

Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R.

Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6.

21.

Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters.

Jiang H, Brüning JC.

Cell Metab. 2018 Jul 3;28(1):7-8. doi: 10.1016/j.cmet.2018.06.018.

22.

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC.

Exp Mol Med. 2018 Jun 28;50(6):75. doi: 10.1038/s12276-018-0108-z.

23.

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit.

Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Brüning JC, Hammerschmidt M.

Cell Rep. 2018 May 8;23(6):1728-1741. doi: 10.1016/j.celrep.2018.04.018.

24.

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.

Dodd GT, Lee-Young RS, Brüning JC, Tiganis T.

Diabetes. 2018 Jul;67(7):1246-1257. doi: 10.2337/db17-1485. Epub 2018 Apr 30.

25.

VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans.

Schüler R, Seebeck N, Osterhoff MA, Witte V, Flöel A, Busjahn A, Jais A, Brüning JC, Frahnow T, Kabisch S, Pivovarova O, Hornemann S, Kruse M, Pfeiffer AFH.

Mol Metab. 2018 May;11:129-136. doi: 10.1016/j.molmet.2018.02.004. Epub 2018 Feb 12.

26.

N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB.

Mol Cell. 2018 Feb 15;69(4):636-647.e7. doi: 10.1016/j.molcel.2018.01.019. Epub 2018 Feb 8.

27.

Corrigendum to "Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584].

Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Bruning JC, Cooney G, Neely GG, Herzog H.

Mol Metab. 2017 Nov;6(11):1562. doi: 10.1016/j.molmet.2017.06.017. Epub 2017 Jul 8. No abstract available.

28.

A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle.

Awazawa M, Gabel P, Tsaousidou E, Nolte H, Krüger M, Schmitz J, Ackermann PJ, Brandt C, Altmüller J, Motameny S, Wunderlich FT, Kornfeld JW, Blüher M, Brüning JC.

Nat Med. 2017 Dec;23(12):1466-1473. doi: 10.1038/nm.4420. Epub 2017 Nov 6.

PMID:
29106399
29.

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T.

Cell Metab. 2017 Sep 5;26(3):577. doi: 10.1016/j.cmet.2017.08.001. No abstract available.

30.

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T.

Cell Metab. 2017 Aug 1;26(2):375-393.e7. doi: 10.1016/j.cmet.2017.07.013. Erratum in: Cell Metab. 2017 Sep 5;26(3):577.

31.

Energy imbalance alters Ca2+ handling and excitability of POMC neurons.

Paeger L, Pippow A, Hess S, Paehler M, Klein AC, Husch A, Pouzat C, Brüning JC, Kloppenburg P.

Elife. 2017 Aug 1;6. pii: e25641. doi: 10.7554/eLife.25641.

32.

The Sense of Smell Impacts Metabolic Health and Obesity.

Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.

Cell Metab. 2017 Jul 5;26(1):198-211.e5. doi: 10.1016/j.cmet.2017.06.015.

33.

IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis.

Theurich S, Tsaousidou E, Hanssen R, Lempradl AM, Mauer J, Timper K, Schilbach K, Folz-Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC.

Cell Metab. 2017 Jul 5;26(1):171-184.e6. doi: 10.1016/j.cmet.2017.05.018.

34.

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.

Timper K, Brüning JC.

Dis Model Mech. 2017 Jun 1;10(6):679-689. doi: 10.1242/dmm.026609. Review.

35.

Insulin controls food intake and energy balance via NPY neurons.

Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Brüning JC, Cooney G, Neely GG, Herzog H.

Mol Metab. 2017 Apr 12;6(6):574-584. doi: 10.1016/j.molmet.2017.03.013. eCollection 2017 Jun. Erratum in: Mol Metab. 2017 Nov;6(11):1562. Neely, Greg [corrected to Neely, Greg G].

36.

Neuronal control of peripheral insulin sensitivity and glucose metabolism.

Ruud J, Steculorum SM, Brüning JC.

Nat Commun. 2017 May 4;8:15259. doi: 10.1038/ncomms15259. Review. No abstract available.

37.

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance.

Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC.

Nat Commun. 2017 May 3;8:14803. doi: 10.1038/ncomms14803.

38.

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.

Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC.

Cell Rep. 2017 Apr 11;19(2):267-280. doi: 10.1016/j.celrep.2017.03.043.

39.

Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity.

Steculorum SM, Timper K, Engström Ruud L, Evers N, Paeger L, Bremser S, Kloppenburg P, Brüning JC.

Cell Rep. 2017 Feb 14;18(7):1587-1597. doi: 10.1016/j.celrep.2017.01.047.

40.

IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity.

Braune J, Weyer U, Hobusch C, Mauer J, Brüning JC, Bechmann I, Gericke M.

J Immunol. 2017 Apr 1;198(7):2927-2934. doi: 10.4049/jimmunol.1600476. Epub 2017 Feb 13.

41.

Hypothalamic inflammation in obesity and metabolic disease.

Jais A, Brüning JC.

J Clin Invest. 2017 Jan 3;127(1):24-32. doi: 10.1172/JCI88878. Epub 2017 Jan 3. Review.

42.

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity.

Hausen AC, Ruud J, Jiang H, Hess S, Varbanov H, Kloppenburg P, Brüning JC.

Cell Rep. 2016 Dec 6;17(10):2512-2521. doi: 10.1016/j.celrep.2016.11.030.

43.

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.

Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R.

Cell Rep. 2016 Oct 18;17(4):1008-1021. doi: 10.1016/j.celrep.2016.09.053.

44.

Hunger-Driven Motivational State Competition.

Burnett CJ, Li C, Webber E, Tsaousidou E, Xue SY, Brüning JC, Krashes MJ.

Neuron. 2016 Oct 5;92(1):187-201. doi: 10.1016/j.neuron.2016.08.032. Epub 2016 Sep 29.

45.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC.

Cell. 2016 Aug 25;166(5):1338-1340. doi: 10.1016/j.cell.2016.08.010. No abstract available.

46.

Neuroendocrinology: Electromagnetogenetic Control over Feeding and Glucose Metabolism.

Ruud J, Brüning JC.

Curr Biol. 2016 Jun 6;26(11):R470-3. doi: 10.1016/j.cub.2016.04.044.

47.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC.

Cell. 2016 May 5;165(4):882-95. doi: 10.1016/j.cell.2016.03.033. Epub 2016 Apr 28. Erratum in: Cell. 2016 Aug 25;166(5):1338-1340.

48.

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss.

Schmitz J, Evers N, Awazawa M, Nicholls HT, Brönneke HS, Dietrich A, Mauer J, Blüher M, Brüning JC.

Mol Metab. 2016 Jan 11;5(5):328-339. doi: 10.1016/j.molmet.2015.12.001. eCollection 2016 May.

49.

Sweet Mitochondrial Dynamics in VMH Neurons.

Steculorum SM, Brüning JC.

Cell Metab. 2016 Apr 12;23(4):577-9. doi: 10.1016/j.cmet.2016.03.014.

50.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC.

Cell. 2016 Mar 24;165(1):125-138. doi: 10.1016/j.cell.2016.02.044.

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