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Items: 1 to 50 of 353

1.

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization.

Astakhova A, Chistyakov D, Thomas D, Geisslinger G, Brüne B, Sergeeva M, Namgaladze D.

Cells. 2019 Oct 1;8(10). pii: E1185. doi: 10.3390/cells8101185.

2.

ER-Mitochondria Communication in Cells of the Innate Immune System.

Namgaladze D, Khodzhaeva V, Brüne B.

Cells. 2019 Sep 15;8(9). pii: E1088. doi: 10.3390/cells8091088. Review.

3.

Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells.

Trümper V, von Knethen A, Preuß A, Ermilov E, Hackbarth S, Kuchler L, Gunne S, Schäfer A, Bornhütter T, Vereb G, Ujlaky-Nagy L, Brüne B, Röder B, Schindler M, Parnham MJ, Knape T.

Theranostics. 2019 Jul 28;9(19):5444-5463. doi: 10.7150/thno.29367. eCollection 2019.

4.

uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames.

Scholz A, Eggenhofer F, Gelhausen R, Grüning B, Zarnack K, Brüne B, Backofen R, Schmid T.

PLoS One. 2019 Sep 12;14(9):e0222459. doi: 10.1371/journal.pone.0222459. eCollection 2019.

5.

Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development.

Elwakeel E, Brüggemann M, Fink AF, Schulz MH, Schmid T, Savai R, Brüne B, Zarnack K, Weigert A.

Int J Mol Sci. 2019 Sep 9;20(18). pii: E4438. doi: 10.3390/ijms20184438.

6.

Macrophage HIF-2α regulates tumor-suppressive Spint1 in the tumor microenvironment.

Susen RM, Bauer R, Olesch C, Fuhrmann DC, Fink AF, Dehne N, Jain A, Ebersberger I, Schmid T, Brüne B.

Mol Carcinog. 2019 Nov;58(11):2127-2138. doi: 10.1002/mc.23103. Epub 2019 Aug 22.

PMID:
31436357
7.

Translation of TNFAIP2 is tightly controlled by upstream open reading frames.

Scholz A, Rappl P, Böffinger N, Mota AC, Brüne B, Schmid T.

Cell Mol Life Sci. 2019 Aug 7. doi: 10.1007/s00018-019-03265-4. [Epub ahead of print]

PMID:
31392347
8.

Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater.

Weigert A, Olesch C, Brüne B.

Front Immunol. 2019 Jul 19;10:1706. doi: 10.3389/fimmu.2019.01706. eCollection 2019. Review.

9.

Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation.

Syed SN, Raue R, Weigert A, von Knethen A, Brüne B.

Cells. 2019 Jul 28;8(8). pii: E785. doi: 10.3390/cells8080785.

10.

Regulation and Functions of 15-Lipoxygenases in Human Macrophages.

Snodgrass RG, Brüne B.

Front Pharmacol. 2019 Jul 4;10:719. doi: 10.3389/fphar.2019.00719. eCollection 2019. Review.

11.

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I.

EMBO J. 2019 Sep 2;38(17):e100938. doi: 10.15252/embj.2018100938. Epub 2019 Jul 22.

PMID:
31328803
12.

PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology.

von Knethen A, Brüne B.

Signal Transduct Target Ther. 2019 Jun 7;4:18. doi: 10.1038/s41392-019-0053-x. eCollection 2019. No abstract available.

13.

Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.

Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1235-1246. doi: 10.1016/j.bbalip.2019.05.008. Epub 2019 May 23.

14.

PGE2 in fibrosis and cancer: Insights into fibroblast activation.

Elwakeel E, Brüne B, Weigert A.

Prostaglandins Other Lipid Mediat. 2019 Aug;143:106339. doi: 10.1016/j.prostaglandins.2019.106339. Epub 2019 May 14. Review.

PMID:
31100473
15.

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.

Ortmann CA, Dorsheimer L, Abou-El-Ardat K, Hoffrichter J, Assmus B, Bonig H, Scholz A, Pfeifer H, Martin H, Schmid T, Brüne B, Scheich S, Steffen B, Riemann J, Hermann S, Dukat A, Bug G, Brandts CH, Wagner S, Serve H, Rieger MA.

Cell Rep. 2019 May 14;27(7):2022-2028.e3. doi: 10.1016/j.celrep.2019.04.064.

16.

Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity.

Mora J, Mertens C, Meier JK, Fuhrmann DC, Brüne B, Jung M.

Cells. 2019 May 11;8(5). pii: E445. doi: 10.3390/cells8050445. Review.

17.

GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.

Wegner MS, Gruber L, Schömel N, Trautmann S, Brachtendorf S, Fuhrmann D, Schreiber Y, Olesch C, Brüne B, Geisslinger G, Grösch S.

Int J Biochem Cell Biol. 2019 Jul;112:95-106. doi: 10.1016/j.biocel.2019.05.002. Epub 2019 May 11.

PMID:
31082617
18.

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.

von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B.

Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057. eCollection 2019.

19.

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A.

Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082.

20.

IL-22 and IL-22-Binding Protein Are Associated With Development of and Mortality From Acute-on-Chronic Liver Failure.

Schwarzkopf K, Rüschenbaum S, Barat S, Cai C, Mücke MM, Fitting D, Weigert A, Brüne B, Zeuzem S, Welsch C, Lange CM.

Hepatol Commun. 2019 Jan 17;3(3):392-405. doi: 10.1002/hep4.1303. eCollection 2019 Mar.

21.

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype.

Frank AC, Ebersberger S, Fink AF, Lampe S, Weigert A, Schmid T, Ebersberger I, Syed SN, Brüne B.

Nat Commun. 2019 Mar 8;10(1):1135. doi: 10.1038/s41467-019-08989-2.

22.

Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins.

Fuhrmann DC, Olesch C, Kurrle N, Schnütgen F, Zukunft S, Fleming I, Brüne B.

Cells. 2019 Feb 18;8(2). pii: E172. doi: 10.3390/cells8020172.

23.

Histone Deacetylation Inhibitors as Therapy Concept in Sepsis.

von Knethen A, Brüne B.

Int J Mol Sci. 2019 Jan 16;20(2). pii: E346. doi: 10.3390/ijms20020346. Review.

24.

Iron as a Central Player and Promising Target in Cancer Progression.

Jung M, Mertens C, Tomat E, Brüne B.

Int J Mol Sci. 2019 Jan 11;20(2). pii: E273. doi: 10.3390/ijms20020273. Review.

25.

Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation.

Winslow S, Scholz A, Rappl P, Brauß TF, Mertens C, Jung M, Weigert A, Brüne B, Schmid T.

PLoS One. 2019 Jan 7;14(1):e0209694. doi: 10.1371/journal.pone.0209694. eCollection 2019.

26.

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.

Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, Brüne B.

Front Immunol. 2018 Dec 4;9:2858. doi: 10.3389/fimmu.2018.02858. eCollection 2018.

27.

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.

Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Ecke A, Abou-El-Ardat K, Schmid T, Brüne B, Wagner S, Serve H, Hoffmann J, Seeger F, Dimmeler S, Zeiher AM, Rieger MA.

JAMA Cardiol. 2019 Jan 1;4(1):25-33. doi: 10.1001/jamacardio.2018.3965.

28.

TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression.

Fuhrmann DC, Wittig I, Brüne B.

Redox Biol. 2019 Jan;20:204-216. doi: 10.1016/j.redox.2018.10.007. Epub 2018 Oct 19.

29.

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.

Kern K, Schäfer SMG, Cohnen J, Pierre S, Osthues T, Tarighi N, Hohmann S, Ferreiros N, Brüne B, Weigert A, Geisslinger G, Sisignano M, Scholich K.

Front Immunol. 2018 Oct 1;9:2261. doi: 10.3389/fimmu.2018.02261. eCollection 2018.

30.

IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors.

Gupta S, Jain A, Syed SN, Snodgrass RG, Pflüger-Müller B, Leisegang MS, Weigert A, Brandes RP, Ebersberger I, Brüne B, Namgaladze D.

Oncoimmunology. 2018 Jul 30;7(10):e1494110. doi: 10.1080/2162402X.2018.1494110. eCollection 2018.

31.

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.

Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, Brüne B.

Front Immunol. 2018 Aug 24;9:1906. doi: 10.3389/fimmu.2018.01906. eCollection 2018.

32.

Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition.

Jung M, Brüne B, von Knethen A, Guiteras R, Cruzado JM, Hotter G, Sola A.

Lab Invest. 2018 Nov;98(11):1408-1422. doi: 10.1038/s41374-018-0098-4. Epub 2018 Aug 7.

PMID:
30087458
33.

The portal vein as a distinct immunological compartment - A comprehensive immune phenotyping study.

Queck A, Rueschenbaum S, Kubesch A, Cai C, Zeuzem S, Weigert A, Brüne B, Nour-Eldin NA, Gruber-Rouh T, Vogl T, Lange CM.

Hum Immunol. 2018 Oct;79(10):716-723. doi: 10.1016/j.humimm.2018.07.233. Epub 2018 Jul 30.

PMID:
30071249
34.

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.

Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, Grösch S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1214-1227. doi: 10.1016/j.bbalip.2018.07.011. Epub 2018 Jul 27.

PMID:
30059758
35.

mPGES-1 and ALOX5/-15 in tumor-associated macrophages.

Weigert A, Strack E, Snodgrass RG, Brüne B.

Cancer Metastasis Rev. 2018 Sep;37(2-3):317-334. doi: 10.1007/s10555-018-9731-3. Review.

PMID:
29808459
36.

AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages.

Kirchner J, Brüne B, Namgaladze D.

Sci Rep. 2018 May 17;8(1):7801. doi: 10.1038/s41598-018-26102-3.

37.

The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.

Treutlein EM, Kern K, Weigert A, Tarighi N, Schuh CD, Nüsing RM, Schreiber Y, Ferreirós N, Brüne B, Geisslinger G, Pierre S, Scholich K.

J Biol Chem. 2018 Jun 22;293(25):9685-9695. doi: 10.1074/jbc.RA118.002492. Epub 2018 May 11.

38.

8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model.

Shirsath N, Wagner K, Tangermann S, Schlederer M, Ringel C, Kenner L, Brüne B, Wolf P.

Acta Derm Venereol. 2018 Jun 8;98(6):576-584. doi: 10.2340/00015555-2905.

39.

Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma.

Sekar D, Govene L, Del Río ML, Sirait-Fischer E, Fink AF, Brüne B, Rodriguez-Barbosa JI, Weigert A.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E752. doi: 10.3390/ijms19030752.

40.

VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.

Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, Abdel Malik R, Bothur S, Wingert S, Bremer R, Rieger MA, Brüne B, Brandes RP, Fleming I, Benz PM.

J Cell Biol. 2018 Apr 2;217(4):1503-1519. doi: 10.1083/jcb.201702048. Epub 2018 Mar 5.

41.

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia.

Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B.

Cell Mol Life Sci. 2018 Aug;75(16):3051-3067. doi: 10.1007/s00018-018-2779-y. Epub 2018 Feb 20.

PMID:
29464284
42.

Selective targeting of tumor associated macrophages in different tumor models.

Kakoschky B, Pleli T, Schmithals C, Zeuzem S, Brüne B, Vogl TJ, Korf HW, Weigert A, Piiper A.

PLoS One. 2018 Feb 15;13(2):e0193015. doi: 10.1371/journal.pone.0193015. eCollection 2018.

43.

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment.

Mertens C, Mora J, Ören B, Grein S, Winslow S, Scholich K, Weigert A, Malmström P, Forsare C, Fernö M, Schmid T, Brüne B, Jung M.

Oncoimmunology. 2017 Dec 22;7(3):e1408751. doi: 10.1080/2162402X.2017.1408751. eCollection 2018.

44.

Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors.

Lampe S, Kunze M, Scholz A, Brauß TF, Winslow S, Simm S, Keller M, Heidler J, Wittig I, Brüne B, Schmid T.

Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):147-157. doi: 10.1016/j.bbagrm.2018.01.010. Epub 2018 Jan 31. No abstract available.

PMID:
29378331
45.

Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses.

Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):433-446. doi: 10.1016/j.bbalip.2018.01.009.

PMID:
29360568
46.

Redox-signals and macrophage biology.

Weigert A, von Knethen A, Fuhrmann D, Dehne N, Brüne B.

Mol Aspects Med. 2018 Oct;63:70-87. doi: 10.1016/j.mam.2018.01.003. Epub 2018 Jan 12. Review.

PMID:
29329794
47.

C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice.

Syed SN, Rau E, Ziegelmann M, Sogkas G, Brüne B, Schmidt RE.

Eur J Immunol. 2018 Apr;48(4):696-704. doi: 10.1002/eji.201747238. Epub 2018 Jan 15.

48.

Nrf2, the Master Regulator of Anti-Oxidative Responses.

Vomund S, Schäfer A, Parnham MJ, Brüne B, von Knethen A.

Int J Mol Sci. 2017 Dec 20;18(12). pii: E2772. doi: 10.3390/ijms18122772. Review.

49.

Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.

Ringleb J, Strack E, Angioni C, Geisslinger G, Steinhilber D, Weigert A, Brüne B.

J Immunol. 2018 Jan 15;200(2):857-868. doi: 10.4049/jimmunol.1700609. Epub 2017 Dec 11.

50.

Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2?

Jung M, Weigert A, Mertens C, Rehwald C, Brüne B.

Front Immunol. 2017 Sep 20;8:1171. doi: 10.3389/fimmu.2017.01171. eCollection 2017. Review.

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