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Items: 8

1.

Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing.

Arigoni-Affolter I, Scibona E, Lin CW, Brühlmann D, Souquet J, Broly H, Aebi M.

Sci Adv. 2019 Nov 27;5(11):eaax8930. doi: 10.1126/sciadv.aax8930. eCollection 2019 Nov.

2.

Generation of site-distinct N-glycan variants for in vitro bioactivity testing.

Brühlmann D, Vuillemin T, Satwekar A, Galano E, Palmese A, D'Angelo A, Manco Z, Souquet J, Broly H, Sauer M, Hemberger J, Jordan M.

Biotechnol Bioeng. 2019 May;116(5):1017-1028. doi: 10.1002/bit.26930. Epub 2019 Feb 27.

PMID:
30659587
3.

Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures.

Hutter S, Villiger TK, Brühlmann D, Stettler M, Broly H, Soos M, Gunawan R.

Metab Eng. 2017 Sep;43(Pt A):9-20. doi: 10.1016/j.ymben.2017.07.005. Epub 2017 Jul 25.

PMID:
28754360
4.

Cell culture media supplemented with raffinose reproducibly enhances high mannose glycan formation.

Brühlmann D, Muhr A, Parker R, Vuillemin T, Bucsella B, Kalman F, Torre S, La Neve F, Lembo A, Haas T, Sauer M, Souquet J, Broly H, Hemberger J, Jordan M.

J Biotechnol. 2017 Jun 20;252:32-42. doi: 10.1016/j.jbiotec.2017.04.026. Epub 2017 Apr 29.

PMID:
28465212
5.

Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.

Brühlmann D, Sokolov M, Butté A, Sauer M, Hemberger J, Souquet J, Broly H, Jordan M.

Biotechnol Bioeng. 2017 Jul;114(7):1448-1458. doi: 10.1002/bit.26269. Epub 2017 Mar 14.

PMID:
28197999
6.

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody.

Sokolov M, Ritscher J, MacKinnon N, Bielser JM, Brühlmann D, Rothenhäusler D, Thanei G, Soos M, Stettler M, Souquet J, Broly H, Morbidelli M, Butté A.

Biotechnol Prog. 2017 Jan;33(1):181-191. doi: 10.1002/btpr.2374. Epub 2016 Oct 31.

PMID:
27689949
7.

Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systems.

Rouiller Y, Bielser JM, Brühlmann D, Jordan M, Broly H, Stettler M.

Biotechnol Prog. 2016 Jan-Feb;32(1):160-70. doi: 10.1002/btpr.2186. Epub 2015 Nov 3.

PMID:
26489036
8.

Tailoring recombinant protein quality by rational media design.

Brühlmann D, Jordan M, Hemberger J, Sauer M, Stettler M, Broly H.

Biotechnol Prog. 2015 May-Jun;31(3):615-29. doi: 10.1002/btpr.2089. Epub 2015 Apr 29. Review.

PMID:
25864704

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