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The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family.

Parker KER, Fairweather SJ, Rajendran E, Blume M, McConville MJ, Bröer S, Kirk K, van Dooren GG.

PLoS Pathog. 2019 Feb 11;15(2):e1007577. doi: 10.1371/journal.ppat.1007577. eCollection 2019 Feb.


Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets.

Jing W, Yabas M, Bröer A, Coupland L, Gardiner EE, Enders A, Bröer S.

Blood Adv. 2019 Feb 12;3(3):219-229. doi: 10.1182/bloodadvances.2018023473.


Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.

Bröer A, Gauthier-Coles G, Rahimi F, van Geldermalsen M, Dorsch D, Wegener A, Holst J, Bröer S.

J Biol Chem. 2019 Mar 15;294(11):4012-4026. doi: 10.1074/jbc.RA118.006378. Epub 2019 Jan 11.


Amino Acid Transport Across the Mammalian Intestine.

Bröer S, Fairweather SJ.

Compr Physiol. 2018 Dec 13;9(1):343-373. doi: 10.1002/cphy.c170041.


Development of Biomarkers for Inhibition of SLC6A19 (B⁰AT1)-A Potential Target to Treat Metabolic Disorders.

Javed K, Cheng Q, Carroll AJ, Truong TT, Bröer S.

Int J Mol Sci. 2018 Nov 14;19(11). pii: E3597. doi: 10.3390/ijms19113597.


Automated quantification of EEG spikes and spike clusters as a new read out in Theiler's virus mouse model of encephalitis-induced epilepsy.

Anjum SMM, Käufer C, Hopfengärtner R, Waltl I, Bröer S, Löscher W.

Epilepsy Behav. 2018 Nov;88:189-204. doi: 10.1016/j.yebeh.2018.09.016. Epub 2018 Oct 3.


Anticonvulsant effects after grafting of rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus.

Backofen-Wehrhahn B, Gey L, Bröer S, Petersen B, Schiff M, Handreck A, Stanslowsky N, Scharrenbroich J, Weißing M, Staege S, Wegner F, Niemann H, Löscher W, Gernert M.

Exp Neurol. 2018 Dec;310:70-83. doi: 10.1016/j.expneurol.2018.09.004. Epub 2018 Sep 8.


Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures.

Käufer C, Chhatbar C, Bröer S, Waltl I, Ghita L, Gerhauser I, Kalinke U, Löscher W.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8929-E8938. doi: 10.1073/pnas.1806754115. Epub 2018 Sep 4.


Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets.

Bröer A, Fairweather S, Bröer S.

Front Pharmacol. 2018 Jul 19;9:785. doi: 10.3389/fphar.2018.00785. eCollection 2018.


Does AMH relate to timing of menopause? Results of an Individual Patient Data meta- analysis.

Depmann M, Eijkemans MJC, Broer SL, Tehrani FR, Solaymani-Dodaran M, Azizi F, Lambalk CB, Randolph JF Jr, Harlow SD, Freeman EW, Sammel MD, Verschuren WMM, van der Schouw YT, Mol BW, Broekmans FJM.

J Clin Endocrinol Metab. 2018 Jul 18. doi: 10.1210/jc.2018-00724. [Epub ahead of print]


PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter Function at Synapses in Situ.

Dong W, Todd AC, Bröer A, Hulme SR, Bröer S, Billups B.

Int J Mol Sci. 2018 Mar 21;19(4). pii: E924. doi: 10.3390/ijms19040924.


Amino Acid Transporters as Disease Modifiers and Drug Targets.

Bröer S.

SLAS Discov. 2018 Apr;23(4):303-320. doi: 10.1177/2472555218755629.


Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis.

Waltl I, Käufer C, Bröer S, Chhatbar C, Ghita L, Gerhauser I, Anjum M, Kalinke U, Löscher W.

Neurobiol Dis. 2018 Feb;110:192-205. doi: 10.1016/j.nbd.2017.12.001. Epub 2017 Dec 5.


A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.

Schidlitzki A, Twele F, Klee R, Waltl I, Römermann K, Bröer S, Meller S, Gerhauser I, Rankovic V, Li D, Brandt C, Bankstahl M, Töllner K, Löscher W.

Sci Rep. 2017 Sep 22;7(1):12191. doi: 10.1038/s41598-017-12368-6.


Gene therapy decreases seizures in a model of Incontinentia pigmenti.

Dogbevia GK, Töllner K, Körbelin J, Bröer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Löscher W, Schwaninger M.

Ann Neurol. 2017 Jul;82(1):93-104. doi: 10.1002/ana.24981.


ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.

Masle-Farquhar E, Bröer A, Yabas M, Enders A, Bröer S.

Front Immunol. 2017 May 12;8:549. doi: 10.3389/fimmu.2017.00549. eCollection 2017.


Amino acid homeostasis and signalling in mammalian cells and organisms.

Bröer S, Bröer A.

Biochem J. 2017 May 25;474(12):1935-1963. doi: 10.1042/BCJ20160822. Review.


Anti-Müllerian hormone does not predict time to pregnancy: results of a prospective cohort study.

Depmann M, Broer SL, Eijkemans MJC, van Rooij IAJ, Scheffer GJ, Heimensem J, Mol BW, Broekmans FJM.

Gynecol Endocrinol. 2017 Aug;33(8):644-648. doi: 10.1080/09513590.2017.1306848. Epub 2017 Apr 10.


SNAT3-mediated glutamine transport in perisynaptic astrocytes in situ is regulated by intracellular sodium.

Todd AC, Marx MC, Hulme SR, Bröer S, Billups B.

Glia. 2017 Jun;65(6):900-916. doi: 10.1002/glia.23133. Epub 2017 Mar 8.


Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites.

Rajendran E, Hapuarachchi SV, Miller CM, Fairweather SJ, Cai Y, Smith NC, Cockburn IA, Bröer S, Kirk K, van Dooren GG.

Nat Commun. 2017 Feb 16;8:14455. doi: 10.1038/ncomms14455.


Identification of novel inhibitors of the amino acid transporter B0 AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes.

Cheng Q, Shah N, Bröer A, Fairweather S, Jiang Y, Schmoll D, Corry B, Bröer S.

Br J Pharmacol. 2017 Mar;174(6):468-482. doi: 10.1111/bph.13711. Epub 2017 Feb 14.


Viral mouse models of multiple sclerosis and epilepsy: Marked differences in neuropathogenesis following infection with two naturally occurring variants of Theiler's virus BeAn strain.

Bröer S, Hage E, Käufer C, Gerhauser I, Anjum M, Li L, Baumgärtner W, Schulz TF, Löscher W.

Neurobiol Dis. 2017 Mar;99:121-132. doi: 10.1016/j.nbd.2016.12.020. Epub 2016 Dec 22.


Brain transporters: From genes and genetic disorders to function and drug discovery.

Vandenberg RJ, Ryan R, Broer S.

Neurochem Int. 2016 Sep;98:1-3. doi: 10.1016/j.neuint.2016.07.005. No abstract available.


Refinement of a model of acquired epilepsy for identification and validation of biomarkers of epileptogenesis in rats.

Brandt C, Rankovic V, Töllner K, Klee R, Bröer S, Löscher W.

Epilepsy Behav. 2016 Aug;61:120-131. doi: 10.1016/j.yebeh.2016.05.012. Epub 2016 Jun 22.


Does anti-Müllerian hormone predict menopause in the general population? Results of a prospective ongoing cohort study.

Depmann M, Eijkemans MJ, Broer SL, Scheffer GJ, van Rooij IA, Laven JS, Broekmans FJ.

Hum Reprod. 2016 Jul;31(7):1579-87. doi: 10.1093/humrep/dew112. Epub 2016 May 13.


Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.

Bröer A, Rahimi F, Bröer S.

J Biol Chem. 2016 Jun 17;291(25):13194-205. doi: 10.1074/jbc.M115.700534. Epub 2016 Apr 26.


Fluctuations in anti-Müllerian hormone levels throughout the menstrual cycle parallel fluctuations in the antral follicle count: a cohort study.

Depmann M, van Disseldorp J, Broer SL, Eijkemans MJ, Laven JS, Visser JA, de Rijke YB, Mol BW, Broekmans FJ.

Acta Obstet Gynecol Scand. 2016 Jul;95(7):820-8. doi: 10.1111/aogs.12886. Epub 2016 Apr 3.


Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains.

Bröer S, Käufer C, Haist V, Li L, Gerhauser I, Anjum M, Bankstahl M, Baumgärtner W, Löscher W.

Exp Neurol. 2016 May;279:57-74. doi: 10.1016/j.expneurol.2016.02.011. Epub 2016 Feb 15.


ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes.

Yabas M, Jing W, Shafik S, Bröer S, Enders A.

PLoS One. 2016 Jan 22;11(1):e0146774. doi: 10.1371/journal.pone.0146774. eCollection 2016.


Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.

Bröer S, Löscher W.

Epilepsy Behav. 2015 Dec;53:98-107. doi: 10.1016/j.yebeh.2015.09.028. Epub 2015 Nov 2.


Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney.

Chan K, Busque SM, Sailer M, Stoeger C, Bröer S, Daniel H, Rubio-Aliaga I, Wagner CA.

Pflugers Arch. 2016 Feb;468(2):213-27. doi: 10.1007/s00424-015-1742-0. Epub 2015 Oct 21.


Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes.

Elso CM, Chu EP, Alsayb MA, Mackin L, Ivory ST, Ashton MP, Bröer S, Silveira PA, Brodnicki TC.

G3 (Bethesda). 2015 Oct 4;5(12):2903-11. doi: 10.1534/g3.115.021709.


Can we predict age at natural menopause using ovarian reserve tests or mother's age at menopause? A systematic literature review.

Depmann M, Broer SL, van der Schouw YT, Tehrani FR, Eijkemans MJ, Mol BW, Broekmans FJ.

Menopause. 2016 Feb;23(2):224-32. doi: 10.1097/GME.0000000000000509. Review.


Creatine as a booster for human brain function. How might it work?

Rae CD, Bröer S.

Neurochem Int. 2015 Oct;89:249-59. doi: 10.1016/j.neuint.2015.08.010. Epub 2015 Aug 18. Review.


Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.

Fairweather SJ, Bröer A, Subramanian N, Tumer E, Cheng Q, Schmoll D, O'Mara ML, Bröer S.

J Biol Chem. 2015 Oct 2;290(40):24308-25. doi: 10.1074/jbc.M115.648519. Epub 2015 Aug 3.


Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control.

Jiang Y, Rose AJ, Sijmonsma TP, Bröer A, Pfenninger A, Herzig S, Schmoll D, Bröer S.

Mol Metab. 2015 Feb 16;4(5):406-17. doi: 10.1016/j.molmet.2015.02.003. eCollection 2015 May.


The Relationship Between Variation in Size of the Primordial Follicle Pool and Age at Natural Menopause.

Depmann M, Faddy MJ, van der Schouw YT, Peeters PH, Broer SL, Kelsey TW, Nelson SM, Broekmans FJ.

J Clin Endocrinol Metab. 2015 Jun;100(6):E845-51. doi: 10.1210/jc.2015-1298. Epub 2015 Apr 27.


Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.

Brandt C, Töllner K, Klee R, Bröer S, Löscher W.

Neurobiol Dis. 2015 Mar;75:78-90. doi: 10.1016/j.nbd.2014.12.015. Epub 2014 Dec 27.


Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice.

Morton SK, Chaston DJ, Howitt L, Heisler J, Nicholson BJ, Fairweather S, Bröer S, Ashton AW, Matthaei KI, Hill CE.

Hypertension. 2015 Mar;65(3):662-9. doi: 10.1161/HYPERTENSIONAHA.114.04578. Epub 2014 Dec 29.


Using individual patient data to adjust for indirectness did not successfully remove the bias in this case of comparative test accuracy.

Wang J, Bossuyt P, Geskus R, Zwinderman A, Dolleman M, Broer S, Broekmans F, Mol BW, Leeflang M; IMPORT Study Group.

J Clin Epidemiol. 2015 Mar;68(3):290-8. doi: 10.1016/j.jclinepi.2014.10.005. Epub 2014 Dec 2.


Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span.

Yabas M, Coupland LA, Cromer D, Winterberg M, Teoh NC, D'Rozario J, Kirk K, Bröer S, Parish CR, Enders A.

J Biol Chem. 2014 Jul 11;289(28):19531-7. doi: 10.1074/jbc.C114.570267. Epub 2014 Jun 4.


Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.

Balkrishna S, Bröer A, Welford SM, Hatzoglou M, Bröer S.

Cell Physiol Biochem. 2014;33(5):1591-606. doi: 10.1159/000358722. Epub 2014 May 16.


Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications.

Broer SL, Broekmans FJ, Laven JS, Fauser BC.

Hum Reprod Update. 2014 Sep-Oct;20(5):688-701. doi: 10.1093/humupd/dmu020. Epub 2014 May 12. Review.


Predicting menopausal age with anti-Müllerian hormone: a cross-validation study of two existing models.

Ramezani Tehrani F, Dólleman M, van Disseldorp J, Broer SL, Azizi F, Solaymani-Dodaran M, Fauser BC, Laven JS, Eijkemans MJ, Broekmans F.

Climacteric. 2014 Oct;17(5):583-90. doi: 10.3109/13697137.2014.898264. Epub 2014 Jun 10.


The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.


Anti-Mullerian hormone is a more accurate predictor of individual time to menopause than mother's age at menopause.

Dólleman M, Depmann M, Eijkemans MJ, Heimensem J, Broer SL, van der Stroom EM, Laven JS, Van Rooij IA, Scheffer GJ, Peeters PH, van der Schouw YT, Lambalk CB, Broekmans FJ.

Hum Reprod. 2014 Mar;29(3):584-91. doi: 10.1093/humrep/det446. Epub 2014 Jan 15.


Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy.

Töpfer M, Töllner K, Brandt C, Twele F, Bröer S, Löscher W.

Eur J Neurosci. 2014 Feb;39(4):673-87. doi: 10.1111/ejn.12424. Epub 2013 Nov 19.


The SLC38 family of sodium-amino acid co-transporters.

Bröer S.

Pflugers Arch. 2014 Jan;466(1):155-72. doi: 10.1007/s00424-013-1393-y. Epub 2013 Nov 6. Review.


Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks.

Tümer E, Bröer A, Balkrishna S, Jülich T, Bröer S.

J Biol Chem. 2013 Nov 22;288(47):33813-23. doi: 10.1074/jbc.M113.482760. Epub 2013 Oct 11.


Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat.

Bröer S, Zolkowska D, Gernert M, Rogawski MA.

Neuroscience. 2013 Nov 12;252:253-61. doi: 10.1016/j.neuroscience.2013.07.050. Epub 2013 Jul 29.

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