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Items: 1 to 50 of 55

1.

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M.

Cell. 2019 Aug 22;178(5):1102-1114.e17. doi: 10.1016/j.cell.2019.07.050.

PMID:
31442403
2.

Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.

Xie C, Takahashi S, Brocker CN, He S, Chen L, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1396-1411. doi: 10.1016/j.bbalip.2019.05.014. Epub 2019 Jun 10.

PMID:
31195146
3.

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ.

Gastroenterology. 2019 Sep;157(3):744-759.e4. doi: 10.1053/j.gastro.2019.05.057. Epub 2019 May 30.

PMID:
31154022
4.

Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.

Kim D, Brocker CN, Takahashi S, Yagai T, Kim T, Xie G, Wang H, Qu A, Gonzalez FJ.

Hepatology. 2019 Jul;70(1):154-167. doi: 10.1002/hep.30530. Epub 2019 Mar 20.

PMID:
30697791
5.

Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice.

Xie G, Yin S, Zhang Z, Qi D, Wang X, Kim D, Yagai T, Brocker CN, Wang Y, Gonzalez FJ, Wang H, Qu A.

Am J Pathol. 2019 Feb;189(2):272-282. doi: 10.1016/j.ajpath.2018.10.009. Epub 2018 Nov 16.

PMID:
30448405
6.

REVERBa couples the circadian clock to hepatic glucocorticoid action.

Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW.

J Clin Invest. 2018 Oct 1;128(10):4454-4471. doi: 10.1172/JCI96138. Epub 2018 Sep 4.

7.

Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

Brocker CN, Patel DP, Velenosi TJ, Kim D, Yan T, Yue J, Li G, Krausz KW, Gonzalez FJ.

J Lipid Res. 2018 Nov;59(11):2140-2152. doi: 10.1194/jlr.M088419. Epub 2018 Aug 29.

PMID:
30158201
8.

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ.

Mol Metab. 2018 Mar;9:217-219. doi: 10.1016/j.molmet.2018.01.008. Epub 2018 Feb 2. No abstract available.

9.

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ.

Mol Metab. 2018 Jan;7:80-89. doi: 10.1016/j.molmet.2017.10.011. Epub 2017 Nov 6. Erratum in: Mol Metab. 2018 Jan 23;:.

10.

Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

Li G, Brocker CN, Xie C, Yan T, Noguchi A, Krausz KW, Xiang R, Gonzalez FJ.

J Gastroenterol Hepatol. 2018 May;33(5):1138-1145. doi: 10.1111/jgh.14046. Epub 2018 Feb 19.

11.

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Nov 7;26(5):801. doi: 10.1016/j.cmet.2017.10.007. No abstract available.

12.

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ.

Cell Metab. 2017 Oct 3;26(4):672-685.e4. doi: 10.1016/j.cmet.2017.08.019. Epub 2017 Sep 14. Erratum in: Cell Metab. 2017 Nov 7;26(5):801.

13.

Heteromer Nanostars by Spontaneous Self-Assembly.

Brocker C, Kim H, Smith D, Barua S.

Nanomaterials (Basel). 2017 May 31;7(6). pii: E127. doi: 10.3390/nano7060127.

14.

Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.

Brocker CN, Yue J, Kim D, Qu A, Bonzo JA, Gonzalez FJ.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G283-G299. doi: 10.1152/ajpgi.00205.2016. Epub 2017 Jan 12.

15.

Bioresponsive polymer coated drug nanorods for breast cancer treatment.

Laemthong T, Kim HH, Dunlap K, Brocker C, Barua D, Forciniti D, Huang YW, Barua S.

Nanotechnology. 2017 Jan 27;28(4):045601. doi: 10.1088/1361-6528/28/4/045601. Epub 2016 Dec 15.

PMID:
27977417
16.

Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.

Burdin DV, Kolobov AA, Brocker C, Soshnev AA, Samusik N, Demyanov AV, Brilloff S, Jarzebska N, Martens-Lobenhoffer J, Mieth M, Maas R, Bornstein SR, Bode-Böger SM, Gonzalez F, Weiss N, Rodionov RN.

Sci Rep. 2016 Oct 18;6:35503. doi: 10.1038/srep35503.

17.

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ.

J Lipid Res. 2016 Dec;57(12):2130-2137. Epub 2016 Sep 16.

18.

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.

Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, Hao H.

Drug Metab Dispos. 2016 May;44(5):720-31. doi: 10.1124/dmd.116.069419. Epub 2016 Mar 10.

19.

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ.

Nat Commun. 2015 Dec 15;6:10166. doi: 10.1038/ncomms10166.

20.

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29.

Cicchini C, de Nonno V, Battistelli C, Cozzolino AM, De Santis Puzzonia M, Ciafrè SA, Brocker C, Gonzalez FJ, Amicone L, Tripodi M.

Biochim Biophys Acta. 2015 Aug;1849(8):919-29. doi: 10.1016/j.bbagrm.2015.05.005. Epub 2015 May 21.

21.

The Habc domain of the SNARE Vam3 interacts with the HOPS tethering complex to facilitate vacuole fusion.

Lürick A, Kuhlee A, Bröcker C, Kümmel D, Raunser S, Ungermann C.

J Biol Chem. 2015 Feb 27;290(9):5405-13. doi: 10.1074/jbc.M114.631465. Epub 2015 Jan 6.

22.

Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function.

Behrmann H, Lürick A, Kuhlee A, Balderhaar HK, Bröcker C, Kümmel D, Engelbrecht-Vandré S, Gohlke U, Raunser S, Heinemann U, Ungermann C.

J Biol Chem. 2014 Nov 28;289(48):33503-12. doi: 10.1074/jbc.M114.602714. Epub 2014 Oct 16.

23.

Improved drug therapy: triangulating phenomics with genomics and metabolomics.

Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V.

Hum Genomics. 2014 Sep 1;8:16. doi: 10.1186/s40246-014-0016-9. Review.

24.

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G564-73. doi: 10.1152/ajpgi.00153.2014. Epub 2014 Jul 17.

25.

aldh7a1 regulates eye and limb development in zebrafish.

Babcock HE, Dutta S, Alur RP, Brocker C, Vasiliou V, Vitale S, Abu-Asab M, Brooks BP.

PLoS One. 2014 Jul 8;9(7):e101782. doi: 10.1371/journal.pone.0101782. eCollection 2014.

26.

Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo.

Bonzo JA, Brocker C, Jiang C, Wang RH, Deng CX, Gonzalez FJ.

Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E824-37. doi: 10.1152/ajpendo.00175.2013. Epub 2014 Feb 4.

27.

Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity.

Liu A, Krausz KW, Fang ZZ, Brocker C, Qu A, Gonzalez FJ.

Arch Toxicol. 2014 Apr;88(4):983-96. doi: 10.1007/s00204-013-1188-0. Epub 2014 Jan 3.

28.

Subunit organisation of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes.

Guo Z, Johnston W, Kovtun O, Mureev S, Bröcker C, Ungermann C, Alexandrov K.

PLoS One. 2013 Dec 2;8(12):e81534. doi: 10.1371/journal.pone.0081534. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/3b445e95-4f8c-4238-9895-e05f49949f20.

29.

The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.

Balderhaar HJ, Lachmann J, Yavavli E, Bröcker C, Lürick A, Ungermann C.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3823-8. doi: 10.1073/pnas.1221785110. Epub 2013 Feb 15.

30.

Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress.

Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V.

Free Radic Biol Med. 2013 Mar;56:89-101. doi: 10.1016/j.freeradbiomed.2012.11.010. Epub 2012 Nov 27. Review.

31.

Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics.

Brocker C, Vasiliou M, Carpenter S, Carpenter C, Zhang Y, Wang X, Kotchoni SO, Wood AJ, Kirch HH, Kopečný D, Nebert DW, Vasiliou V.

Planta. 2013 Jan;237(1):189-210. doi: 10.1007/s00425-012-1749-0. Epub 2012 Sep 25.

32.

The role of hyperosmotic stress in inflammation and disease.

Brocker C, Thompson DC, Vasiliou V.

Biomol Concepts. 2012 Aug;3(4):345-364.

33.

Genome-wide identification and analysis of grape aldehyde dehydrogenase (ALDH) gene superfamily.

Zhang Y, Mao L, Wang H, Brocker C, Yin X, Vasiliou V, Fei Z, Wang X.

PLoS One. 2012;7(2):e32153. doi: 10.1371/journal.pone.0032153. Epub 2012 Feb 15.

34.

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.

Bröcker C, Kuhlee A, Gatsogiannis C, Balderhaar HJ, Hönscher C, Engelbrecht-Vandré S, Ungermann C, Raunser S.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1991-6. doi: 10.1073/pnas.1117797109. Epub 2012 Jan 25.

35.

Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.

Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C.

Exp Hematol. 2012 Apr;40(4):318-29.e2. doi: 10.1016/j.exphem.2011.12.006. Epub 2011 Dec 20.

PMID:
22198153
36.

Update on the aldehyde dehydrogenase gene (ALDH) superfamily.

Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V.

Hum Genomics. 2011 May;5(4):283-303.

37.

Double reading of radiological examinations in Norway.

Husby JA, Espeland A, Kalyanpur A, Brocker C, Haldorsen IS.

Acta Radiol. 2011 Jun 1;52(5):516-21. doi: 10.1258/ar.2011.100347. Epub 2011 Mar 17.

PMID:
21498308
38.

Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity.

Brocker C, Cantore M, Failli P, Vasiliou V.

Chem Biol Interact. 2011 May 30;191(1-3):269-77. doi: 10.1016/j.cbi.2011.02.016. Epub 2011 Feb 19.

39.

Evolutionary divergence and functions of the human interleukin (IL) gene family.

Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V.

Hum Genomics. 2010 Oct;5(1):30-55.

40.

Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering.

Cabrera M, Langemeyer L, Mari M, Rethmeier R, Orban I, Perz A, Bröcker C, Griffith J, Klose D, Steinhoff HJ, Reggiori F, Engelbrecht-Vandré S, Ungermann C.

J Cell Biol. 2010 Nov 15;191(4):845-59. doi: 10.1083/jcb.201004092.

41.

The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome.

Balderhaar HJ, Arlt H, Ostrowicz C, Bröcker C, Sündermann F, Brandt R, Babst M, Ungermann C.

J Cell Sci. 2010 Dec 1;123(Pt 23):4085-94. doi: 10.1242/jcs.071977. Epub 2010 Nov 9.

42.

Multisubunit tethering complexes and their role in membrane fusion.

Bröcker C, Engelbrecht-Vandré S, Ungermann C.

Curr Biol. 2010 Nov 9;20(21):R943-52. doi: 10.1016/j.cub.2010.09.015. Review.

43.

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family.

Brocker C, Carpenter C, Nebert DW, Vasiliou V.

Hum Genomics. 2010 Aug;4(6):411-20.

44.

The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1.

Scharer G, Brocker C, Vasiliou V, Creadon-Swindell G, Gallagher RC, Spector E, Van Hove JL.

J Inherit Metab Dis. 2010 Oct;33(5):571-81. doi: 10.1007/s10545-010-9187-2. Epub 2010 Sep 3.

45.

The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.

Nordmann M, Cabrera M, Perz A, Bröcker C, Ostrowicz C, Engelbrecht-Vandré S, Ungermann C.

Curr Biol. 2010 Sep 28;20(18):1654-9. doi: 10.1016/j.cub.2010.08.002.

46.

Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues.

Marchitti SA, Orlicky DJ, Brocker C, Vasiliou V.

J Histochem Cytochem. 2010 Sep;58(9):765-83. doi: 10.1369/jhc.2009.955773.

47.

Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.

Marchitti SA, Brocker C, Orlicky DJ, Vasiliou V.

Free Radic Biol Med. 2010 Nov 15;49(9):1432-43. doi: 10.1016/j.freeradbiomed.2010.08.004. Epub 2010 Aug 10.

48.

Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme.

Stagos D, Chen Y, Brocker C, Donald E, Jackson BC, Orlicky DJ, Thompson DC, Vasiliou V.

Drug Metab Dispos. 2010 Oct;38(10):1679-87. doi: 10.1124/dmd.110.034678. Epub 2010 Jul 8.

49.

Defined subunit arrangement and rab interactions are required for functionality of the HOPS tethering complex.

Ostrowicz CW, Bröcker C, Ahnert F, Nordmann M, Lachmann J, Peplowska K, Perz A, Auffarth K, Engelbrecht-Vandré S, Ungermann C.

Traffic. 2010 Oct;11(10):1334-46. doi: 10.1111/j.1600-0854.2010.01097.x.

50.

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V.

J Biol Chem. 2010 Jun 11;285(24):18452-63. doi: 10.1074/jbc.M109.077925. Epub 2010 Mar 5.

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