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Items: 1 to 50 of 94


G-CSFR antagonism reduces neutrophilic inflammation during pneumococcal and influenza respiratory infections without compromising clearance.

Wang H, Aloe C, Wilson N, Bozinovski S.

Sci Rep. 2019 Nov 27;9(1):17732. doi: 10.1038/s41598-019-54053-w.


Sensitive molecular testing methods can demonstrate NSCLC driver mutations in malignant pleural effusion despite non-malignant cytology.

Steinfort DP, Kranz S, Dowers A, Leas L, Dimitriadis V, Pham K, Hsu A, Bozinovski S, Irving LB, Loveland P, Christie M.

Transl Lung Cancer Res. 2019 Aug;8(4):513-518. doi: 10.21037/tlcr.2019.07.05.


Cigarette Smoking Exacerbates Skeletal Muscle Injury Without Compromising its Regenerative Capacity.

Chan SM, Cerni C, Passey S, Seow HJ, Bernardo I, van der Poel C, Dobric A, Brassington K, Selemidis S, Bozinovski S, Vlahos R.

Am J Respir Cell Mol Biol. 2019 Aug 28. doi: 10.1165/rcmb.2019-0106OC. [Epub ahead of print]


Novel multiplex droplet digital PCR assay for scoring PD-L1 in non-small cell lung cancer biopsy specimens.

Vannitamby A, Hendry S, Irving L, Steinfort D, Bozinovski S.

Lung Cancer. 2019 Aug;134:233-237. doi: 10.1016/j.lungcan.2019.06.029. Epub 2019 Jul 2.


Mitochondrial Reactive Oxygen Species Contribute to Pathological Inflammation During Influenza A Virus Infection in Mice.

To EE, Erlich JR, Liong F, Luong R, Liong S, Esaq F, Oseghale O, Anthony D, McQualter J, Bozinovski S, Vlahos R, O'Leary JJ, Brooks DA, Selemidis S.

Antioxid Redox Signal. 2019 Jul 12. doi: 10.1089/ars.2019.7727. [Epub ahead of print]


Excessive Reactive Oxygen Species Inhibit IL-17A+ γδ T Cells and Innate Cellular Responses to Bacterial Lung Infection.

Anthony D, Papanicolaou A, Wang H, Seow HJ, To EE, Yatmaz S, Anderson GP, Wijburg O, Selemidis S, Vlahos R, Bozinovski S.

Antioxid Redox Signal. 2019 Jul 17. doi: 10.1089/ars.2018.7716. [Epub ahead of print]


New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease.

Brassington K, Selemidis S, Bozinovski S, Vlahos R.

Clin Sci (Lond). 2019 Apr 12;133(7):885-904. doi: 10.1042/CS20180316. Print 2019 Apr 15. Review.


ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.

Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.

EMBO Mol Med. 2019 Apr;11(4). pii: e9976. doi: 10.15252/emmm.201809976.


Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies.

Chan SMH, Selemidis S, Bozinovski S, Vlahos R.

Pharmacol Ther. 2019 Jun;198:160-188. doi: 10.1016/j.pharmthera.2019.02.013. Epub 2019 Feb 26.


Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice.

To EE, Erlich J, Liong F, Luong R, Liong S, Bozinovski S, Seow HJ, O'Leary JJ, Brooks DA, Vlahos R, Selemidis S.

Sci Rep. 2019 Feb 20;9(1):2366. doi: 10.1038/s41598-019-38864-5.


A Novel Approach to Detect Programed Death Ligand 1 (PD-L1) Status and Multiple Tumor Mutations Using a Single Non-Small-Cell Lung Cancer (NSCLC) Bronchoscopy Specimen.

Vannitamby A, Hendry S, Makadia T, Danks J, Slavin J, Irving L, Steinfort D, Bozinovski S.

J Mol Diagn. 2019 Mar;21(2):186-197. doi: 10.1016/j.jmoldx.2018.10.001. Epub 2019 Feb 13.


Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.

Yu X, Seow HJ, Wang H, Anthony D, Bozinovski S, Lin L, Ye JM, Vlahos R.

Clin Sci (Lond). 2019 Feb 18;133(4):551-564. doi: 10.1042/CS20180912. Print 2019 Feb 28.


Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review.

Wang H, Anthony D, Selemidis S, Vlahos R, Bozinovski S.

Front Immunol. 2018 Oct 16;9:2345. doi: 10.3389/fimmu.2018.02345. eCollection 2018. Review.


Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients.

Xu SS, Alexander PK, Lie Y, Dore V, Bozinovski S, Mulligan RS, Young K, Villemagne VL, Rowe CC.

BMJ Open. 2018 Nov 15;8(11):e025533. doi: 10.1136/bmjopen-2018-025533.


The transcriptomic response of Streptococcus pneumoniae following exposure to cigarette smoke extract.

Manna S, Waring A, Papanicolaou A, Hall NE, Bozinovski S, Dunne EM, Satzke C.

Sci Rep. 2018 Oct 24;8(1):15716. doi: 10.1038/s41598-018-34103-5.


CSF3R/CD114 mediates infection-dependent transition to severe asthma.

Wang H, FitzPatrick M, Wilson NJ, Anthony D, Reading PC, Satzke C, Dunne EM, Licciardi PV, Seow HJ, Nichol K, Adcock IM, Chung KF, Anderson GP, Vlahos R, Wark P, Bozinovski S.

J Allergy Clin Immunol. 2019 Feb;143(2):785-788.e6. doi: 10.1016/j.jaci.2018.10.001. Epub 2018 Oct 9. No abstract available.


Modelling COPD co-morbidities in preclinical models.

Vlahos R, Bozinovski S.

Respirology. 2018 Dec;23(12):1094-1095. doi: 10.1111/resp.13416. Epub 2018 Oct 4. Review. No abstract available.


Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production.

Wang H, Blackall M, Sominsky L, Spencer SJ, Vlahos R, Churchill M, Bozinovski S.

J Neuroinflammation. 2018 Jul 6;15(1):200. doi: 10.1186/s12974-018-1234-1.


Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice.

Vlahos R, Bozinovski S.

Methods Mol Biol. 2018;1725:53-63. doi: 10.1007/978-1-4939-7568-6_5.


Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo.

Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Kumlien Georén S, Adner M, Cardell LO, Lindén A.

PLoS One. 2017 Dec 5;12(12):e0188909. doi: 10.1371/journal.pone.0188909. eCollection 2017.


Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model.

Wang H, Anthony D, Yatmaz S, Wijburg O, Satzke C, Levy B, Vlahos R, Bozinovski S.

Clin Sci (Lond). 2017 Aug 24;131(18):2347-2362. doi: 10.1042/CS20171006. Print 2017 Sep 15.


Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.


Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia.

Dowman LM, McDonald CF, Bozinovski S, Vlahos R, Gillies R, Pouniotis D, Hill CJ, Goh NSL, Holland AE.

Respirology. 2017 Jul;22(5):957-964. doi: 10.1111/resp.13002. Epub 2017 Feb 22.


Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment.

Vannitamby A, Seow HJ, Anderson G, Vlahos R, Thompson M, Steinfort D, Irving LB, Bozinovski S.

Thorax. 2017 Dec;72(12):1140-1143. doi: 10.1136/thoraxjnl-2016-209389. Epub 2017 Feb 15.


Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505.


Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease.

Passey SL, Hansen MJ, Bozinovski S, McDonald CF, Holland AE, Vlahos R.

Pharmacol Ther. 2016 Oct;166:56-70. doi: 10.1016/j.pharmthera.2016.06.013. Epub 2016 Jun 29. Review.


COPD and stroke: are systemic inflammation and oxidative stress the missing links?

Austin V, Crack PJ, Bozinovski S, Miller AA, Vlahos R.

Clin Sci (Lond). 2016 Jul 1;130(13):1039-50. doi: 10.1042/CS20160043. Review.


Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice.

FitzPatrick M, Royce SG, Langenbach S, McQualter J, Reading PC, Wijburg O, Anderson GP, Stewart A, Bourke J, Bozinovski S.

Sci Rep. 2016 Mar 4;6:22751. doi: 10.1038/srep22751.


Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice.

Oostwoud LC, Gunasinghe P, Seow HJ, Ye JM, Selemidis S, Bozinovski S, Vlahos R.

Sci Rep. 2016 Feb 15;6:20983. doi: 10.1038/srep20983.


Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes.

Passey SL, Bozinovski S, Vlahos R, Anderson GP, Hansen MJ.

PLoS One. 2016 Jan 19;11(1):e0146882. doi: 10.1371/journal.pone.0146882. eCollection 2016.


Do anti-viral neutrophil responses exacerbate lung inflammation in asthma?

Vlahos R, Bozinovski S.

Respirology. 2016 Jan;21(1):10-1. doi: 10.1111/resp.12688. Epub 2015 Nov 20. No abstract available.


Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities.

Bernardo I, Bozinovski S, Vlahos R.

Pharmacol Ther. 2015 Nov;155:60-79. doi: 10.1016/j.pharmthera.2015.08.005. Epub 2015 Aug 19. Review.


Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice.

Bozinovski S, Seow HJ, Chan SP, Anthony D, McQualter J, Hansen M, Jenkins BJ, Anderson GP, Vlahos R.

Clin Sci (Lond). 2015 Nov;129(9):785-96. doi: 10.1042/CS20140703. Epub 2015 Jul 1.


Multifaceted Role for IL-17A in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Bozinovski S, Vlahos R.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1213-4. doi: 10.1164/rccm.201504-0714ED. No abstract available.


COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.

Bozinovski S, Vlahos R, Anthony D, McQualter J, Anderson G, Irving L, Steinfort D.

Br J Pharmacol. 2016 Feb;173(4):635-48. doi: 10.1111/bph.13198. Epub 2015 Jul 8. Review.


Preclinical murine models of Chronic Obstructive Pulmonary Disease.

Vlahos R, Bozinovski S.

Eur J Pharmacol. 2015 Jul 15;759:265-71. doi: 10.1016/j.ejphar.2015.03.029. Epub 2015 Mar 24. Review.


Vascular endothelial growth factor in peritoneal dialysis patients.

Jovanović N, Božinovski SŽ, Krstić S, Obrenović R, Trbojević-Stanković J, Stojimirović B.

Clin Lab. 2014;60(10):1695-701.


HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.

Lilja A, Weeden CE, McArthur K, Nguyen T, Donald A, Wong ZX, Dousha L, Bozinovski S, Vlahos R, Burns CJ, Asselin-Labat ML, Anderson GP.

PLoS One. 2015 Jan 23;10(1):e0114975. doi: 10.1371/journal.pone.0114975. eCollection 2015.


Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis.

Jones GW, McLeod L, Kennedy CL, Bozinovski S, Najdovska M, Jenkins BJ.

Atherosclerosis. 2015 Feb;238(2):321-8. doi: 10.1016/j.atherosclerosis.2014.12.037. Epub 2014 Dec 23.


Targeting pro-resolution pathways to combat chronic inflammation in COPD.

Bozinovski S, Anthony D, Vlahos R.

J Thorac Dis. 2014 Nov;6(11):1548-56. doi: 10.3978/j.issn.2072-1439.2014.08.08. Review.


Harnessing the potential of lung stem cells for regenerative medicine.

McQualter JL, Anthony D, Bozinovski S, Prêle CM, Laurent GJ.

Int J Biochem Cell Biol. 2014 Nov;56:82-91. doi: 10.1016/j.biocel.2014.10.012. Epub 2014 Oct 15. Review.


IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells.

Hansen MJ, Chan SP, Langenbach SY, Dousha LF, Jones JE, Yatmaz S, Seow HJ, Vlahos R, Anderson GP, Bozinovski S.

PLoS One. 2014 Nov 18;9(11):e113180. doi: 10.1371/journal.pone.0113180. eCollection 2014.


Role of alveolar macrophages in chronic obstructive pulmonary disease.

Vlahos R, Bozinovski S.

Front Immunol. 2014 Sep 10;5:435. doi: 10.3389/fimmu.2014.00435. eCollection 2014. Review.


SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling.

Anthony D, McQualter JL, Bishara M, Lim EX, Yatmaz S, Seow HJ, Hansen M, Thompson M, Hamilton JA, Irving LB, Levy BD, Vlahos R, Anderson GP, Bozinovski S.

FASEB J. 2014 Sep;28(9):3867-77. doi: 10.1096/fj.14-250332. Epub 2014 May 20.


IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice.

Ruwanpura SM, McLeod L, Brooks GD, Bozinovski S, Vlahos R, Longano A, Bardin PG, Anderson GP, Jenkins BJ.

Respirology. 2014 Apr;19(3):419-27. doi: 10.1111/resp.12243. Epub 2014 Feb 10.


Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice.

Ruwanpura SM, McLeod L, Lilja AR, Brooks G, Dousha LF, Seow HJ, Bozinovski S, Vlahos R, Hertzog PJ, Anderson GP, Jenkins BJ.

PLoS One. 2013 Oct 29;8(10):e78095. doi: 10.1371/journal.pone.0078095. eCollection 2013.


Recent advances in pre-clinical mouse models of COPD.

Vlahos R, Bozinovski S.

Clin Sci (Lond). 2014 Feb;126(4):253-65. doi: 10.1042/CS20130182. Review.


Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects.

Smith ME, Bozinovski S, Malmhäll C, Sjöstrand M, Glader P, Venge P, Hiemstra PS, Anderson GP, Lindén A, Qvarfordt I.

PLoS One. 2013 Sep 23;8(9):e75032. doi: 10.1371/journal.pone.0075032. eCollection 2013.


TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.

McQualter JL, McCarty RC, Van der Velden J, O'Donoghue RJ, Asselin-Labat ML, Bozinovski S, Bertoncello I.

Stem Cell Res. 2013 Nov;11(3):1222-33. doi: 10.1016/j.scr.2013.08.007. Epub 2013 Aug 28.


Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways.

Bozinovski S, Anthony D, Anderson GP, Irving LB, Levy BD, Vlahos R.

Pharmacol Ther. 2013 Dec;140(3):280-9. doi: 10.1016/j.pharmthera.2013.07.007. Epub 2013 Jul 21. Review.


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