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Items: 1 to 50 of 148

1.

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.

Dziekan JM, Yu H, Chen D, Dai L, Wirjanata G, Larsson A, Prabhu N, Sobota RM, Bozdech Z, Nordlund P.

Sci Transl Med. 2019 Jan 2;11(473). pii: eaau3174. doi: 10.1126/scitranslmed.aau3174.

PMID:
30602534
2.

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.

Zhu L, Tripathi J, Rocamora FM, Miotto O, van der Pluijm R, Voss TS, Mok S, Kwiatkowski DP, Nosten F, Day NPJ, White NJ, Dondorp AM, Bozdech Z; Tracking Resistance to Artemisinin Collaboration I.

Nat Commun. 2018 Dec 4;9(1):5158. doi: 10.1038/s41467-018-07588-x.

3.

Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa.

Simam J, Rono M, Ngoi J, Nyonda M, Mok S, Marsh K, Bozdech Z, Mackinnon M.

BMC Genomics. 2018 May 21;19(1):372. doi: 10.1186/s12864-018-4689-7.

4.

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.

Rocamora F, Zhu L, Liong KY, Dondorp A, Miotto O, Mok S, Bozdech Z.

PLoS Pathog. 2018 Mar 14;14(3):e1006930. doi: 10.1371/journal.ppat.1006930. eCollection 2018 Mar.

5.

Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites.

Fraschka SA, Filarsky M, Hoo R, Niederwieser I, Yam XY, Brancucci NMB, Mohring F, Mushunje AT, Huang X, Christensen PR, Nosten F, Bozdech Z, Russell B, Moon RW, Marti M, Preiser PR, Bártfai R, Voss TS.

Cell Host Microbe. 2018 Mar 14;23(3):407-420.e8. doi: 10.1016/j.chom.2018.01.008. Epub 2018 Mar 1.

6.

Adaptation of Plasmodium falciparum to its transmission environment.

Rono MK, Nyonda MA, Simam JJ, Ngoi JM, Mok S, Kortok MM, Abdullah AS, Elfaki MM, Waitumbi JN, El-Hassan IM, Marsh K, Bozdech Z, Mackinnon MJ.

Nat Ecol Evol. 2018 Feb;2(2):377-387. doi: 10.1038/s41559-017-0419-9. Epub 2017 Dec 18.

PMID:
29255304
7.

Histone 4 lysine 8 acetylation regulates proliferation and host-pathogen interaction in Plasmodium falciparum.

Gupta AP, Zhu L, Tripathi J, Kucharski M, Patra A, Bozdech Z.

Epigenetics Chromatin. 2017 Aug 22;10(1):40. doi: 10.1186/s13072-017-0147-z.

8.

Singapore Malaria Network Meeting (SingMalNet) 2016.

Preiser P, Renia L, Bozdech Z, Tan K, Russell B, Cooke BM.

Int J Parasitol. 2017 Jun;47(7):369-370. doi: 10.1016/j.ijpara.2017.05.001. No abstract available.

PMID:
28622798
9.

Epigenetic landscapes underlining global patterns of gene expression in the human malaria parasite, Plasmodium falciparum.

Gupta AP, Bozdech Z.

Int J Parasitol. 2017 Jun;47(7):399-407. doi: 10.1016/j.ijpara.2016.10.008. Epub 2017 Apr 13. Review.

PMID:
28414071
10.

Integrated analysis of the Plasmodium species transcriptome.

Hoo R, Zhu L, Amaladoss A, Mok S, Natalang O, Lapp SA, Hu G, Liew K, Galinski MR, Bozdech Z, Preiser PR.

EBioMedicine. 2016 May;7:255-66. doi: 10.1016/j.ebiom.2016.04.011. Epub 2016 Apr 22.

11.

Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai-Myanmar Border (2003-2013): The Role of Parasite Genetic Factors.

Phyo AP, Ashley EA, Anderson TJC, Bozdech Z, Carrara VI, Sriprawat K, Nair S, White MM, Dziekan J, Ling C, Proux S, Konghahong K, Jeeyapant A, Woodrow CJ, Imwong M, McGready R, Lwin KM, Day NPJ, White NJ, Nosten F.

Clin Infect Dis. 2016 Sep 15;63(6):784-791. doi: 10.1093/cid/ciw388. Epub 2016 Jun 16.

12.

DNA damage regulation and its role in drug-related phenotypes in the malaria parasites.

Gupta DK, Patra AT, Zhu L, Gupta AP, Bozdech Z.

Sci Rep. 2016 Apr 1;6:23603. doi: 10.1038/srep23603.

13.

New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Zhu L, Mok S, Imwong M, Jaidee A, Russell B, Nosten F, Day NP, White NJ, Preiser PR, Bozdech Z.

Sci Rep. 2016 Feb 9;6:20498. doi: 10.1038/srep20498.

14.

A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum.

Bozdech Z, Ferreira PE, Mok S.

Trends Parasitol. 2015 Aug;31(8):345-6. doi: 10.1016/j.pt.2015.06.004. Epub 2015 Jul 11.

PMID:
26169358
15.

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.

Josling GA, Petter M, Oehring SC, Gupta AP, Dietz O, Wilson DW, Schubert T, Längst G, Gilson PR, Crabb BS, Moes S, Jenoe P, Lim SW, Brown GV, Bozdech Z, Voss TS, Duffy MF.

Cell Host Microbe. 2015 Jun 10;17(6):741-51. doi: 10.1016/j.chom.2015.05.009.

16.

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

Dogovski C, Xie SC, Burgio G, Bridgford J, Mok S, McCaw JM, Chotivanich K, Kenny S, Gnädig N, Straimer J, Bozdech Z, Fidock DA, Simpson JA, Dondorp AM, Foote S, Klonis N, Tilley L.

PLoS Biol. 2015 Apr 22;13(4):e1002132. doi: 10.1371/journal.pbio.1002132. eCollection 2015 Apr.

17.

Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures.

Lapp SA, Mok S, Zhu L, Wu H, Preiser PR, Bozdech Z, Galinski MR.

Malar J. 2015 Mar 13;14:110. doi: 10.1186/s12936-015-0612-8.

18.

Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.

Mok S, Ashley EA, Ferreira PE, Zhu L, Lin Z, Yeo T, Chotivanich K, Imwong M, Pukrittayakamee S, Dhorda M, Nguon C, Lim P, Amaratunga C, Suon S, Hien TT, Htut Y, Faiz MA, Onyamboko MA, Mayxay M, Newton PN, Tripura R, Woodrow CJ, Miotto O, Kwiatkowski DP, Nosten F, Day NP, Preiser PR, White NJ, Dondorp AM, Fairhurst RM, Bozdech Z.

Science. 2015 Jan 23;347(6220):431-5. doi: 10.1126/science.1260403. Epub 2014 Dec 11.

19.

Genome-wide analysis in Plasmodium falciparum reveals early and late phases of RNA polymerase II occupancy during the infectious cycle.

Rai R, Zhu L, Chen H, Gupta AP, Sze SK, Zheng J, Ruedl C, Bozdech Z, Featherstone M.

BMC Genomics. 2014 Nov 6;15:959. doi: 10.1186/1471-2164-15-959.

20.

Heterochromatin protein 1 secures survival and transmission of malaria parasites.

Brancucci NMB, Bertschi NL, Zhu L, Niederwieser I, Chin WH, Wampfler R, Freymond C, Rottmann M, Felger I, Bozdech Z, Voss TS.

Cell Host Microbe. 2014 Aug 13;16(2):165-176. doi: 10.1016/j.chom.2014.07.004.

21.

Spread of artemisinin resistance in Plasmodium falciparum malaria.

Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, Runcharoen R, Hien TT, Thuy-Nhien NT, Thanh NV, Phu NH, Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M, Khanthavong M, Hongvanthong B, Newton PN, Onyamboko MA, Fanello CI, Tshefu AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S, Bashraheil M, Peshu J, Faiz MA, Ghose A, Hossain MA, Samad R, Rahman MR, Hasan MM, Islam A, Miotto O, Amato R, MacInnis B, Stalker J, Kwiatkowski DP, Bozdech Z, Jeeyapant A, Cheah PY, Sakulthaew T, Chalk J, Intharabut B, Silamut K, Lee SJ, Vihokhern B, Kunasol C, Imwong M, Tarning J, Taylor WJ, Yeung S, Woodrow CJ, Flegg JA, Das D, Smith J, Venkatesan M, Plowe CV, Stepniewska K, Guerin PJ, Dondorp AM, Day NP, White NJ; Tracking Resistance to Artemisinin Collaboration (TRAC).

N Engl J Med. 2014 Jul 31;371(5):411-23. doi: 10.1056/NEJMoa1314981. Erratum in: N Engl J Med. 2014 Aug 21;371(8):786.

22.

Epigenetic memory takes center stage in the survival strategy of malaria parasites.

Voss TS, Bozdech Z, Bártfai R.

Curr Opin Microbiol. 2014 Aug;20:88-95. doi: 10.1016/j.mib.2014.05.007. Epub 2014 Jun 17. Review.

PMID:
24945736
23.

Role of calcium signaling in the transcriptional regulation of the apicoplast genome of Plasmodium falciparum.

Cheemadan S, Ramadoss R, Bozdech Z.

Biomed Res Int. 2014;2014:869401. doi: 10.1155/2014/869401. Epub 2014 Apr 27.

24.

Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs.

Mok S, Liong KY, Lim EH, Huang X, Zhu L, Preiser PR, Bozdech Z.

Mol Microbiol. 2014 Mar;91(5):918-34. doi: 10.1111/mmi.12505. Epub 2014 Jan 23.

25.

A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.

Ch'ng JH, Mok S, Bozdech Z, Lear MJ, Boudhar A, Russell B, Nosten F, Tan KS.

Sci Rep. 2013;3:1734. doi: 10.1038/srep01734.

26.

Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum.

Gupta AP, Chin WH, Zhu L, Mok S, Luah YH, Lim EH, Bozdech Z.

PLoS Pathog. 2013 Feb;9(2):e1003170. doi: 10.1371/journal.ppat.1003170. Epub 2013 Feb 28.

27.

H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum.

Petter M, Selvarajah SA, Lee CC, Chin WH, Gupta AP, Bozdech Z, Brown GV, Duffy MF.

Mol Microbiol. 2013 Mar;87(6):1167-82. doi: 10.1111/mmi.12154. Epub 2013 Feb 4.

28.

DNA microarray-based genome-wide analyses of Plasmodium parasites.

Bozdech Z, Mok S, Gupta AP.

Methods Mol Biol. 2013;923:189-211.

PMID:
22990779
29.

Identification of a new chemical class of antimalarials.

Brunner R, Aissaoui H, Boss C, Bozdech Z, Brun R, Corminboeuf O, Delahaye S, Fischli C, Heidmann B, Kaiser M, Kamber J, Meyer S, Papastogiannidis P, Siegrist R, Voss T, Welford R, Wittlin S, Binkert C.

J Infect Dis. 2012 Sep 1;206(5):735-43. doi: 10.1093/infdis/jis418. Epub 2012 Jun 25.

PMID:
22732921
30.

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.

Claessens A, Adams Y, Ghumra A, Lindergard G, Buchan CC, Andisi C, Bull PC, Mok S, Gupta AP, Wang CW, Turner L, Arman M, Raza A, Bozdech Z, Rowe JA.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1772-81. doi: 10.1073/pnas.1120461109. Epub 2012 May 22.

31.

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling.

Witmer K, Schmid CD, Brancucci NM, Luah YH, Preiser PR, Bozdech Z, Voss TS.

Mol Microbiol. 2012 Apr;84(2):243-59. doi: 10.1111/j.1365-2958.2012.08019.x. Epub 2012 Mar 22.

32.

Transcriptional variation in the malaria parasite Plasmodium falciparum.

Rovira-Graells N, Gupta AP, Planet E, Crowley VM, Mok S, Ribas de Pouplana L, Preiser PR, Bozdech Z, Cortés A.

Genome Res. 2012 May;22(5):925-38. doi: 10.1101/gr.129692.111. Epub 2012 Mar 13.

33.

Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors.

Andrews KT, Gupta AP, Tran TN, Fairlie DP, Gobert GN, Bozdech Z.

PLoS One. 2012;7(2):e31847. doi: 10.1371/journal.pone.0031847. Epub 2012 Feb 27.

34.

Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.

Kuss C, Gan CS, Gunalan K, Bozdech Z, Sze SK, Preiser PR.

Mol Cell Proteomics. 2012 Feb;11(2):M111.010645. doi: 10.1074/mcp.M111.010645. Epub 2011 Oct 24.

35.

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.

Mok S, Imwong M, Mackinnon MJ, Sim J, Ramadoss R, Yi P, Mayxay M, Chotivanich K, Liong KY, Russell B, Socheat D, Newton PN, Day NP, White NJ, Preiser PR, Nosten F, Dondorp AM, Bozdech Z.

BMC Genomics. 2011 Aug 3;12:391. doi: 10.1186/1471-2164-12-391.

37.

Quantitative time-course profiling of parasite and host cell proteins in the human malaria parasite Plasmodium falciparum.

Foth BJ, Zhang N, Chaal BK, Sze SK, Preiser PR, Bozdech Z.

Mol Cell Proteomics. 2011 Aug;10(8):M110.006411. doi: 10.1074/mcp.M110.006411. Epub 2011 May 10.

38.

A moonlighting function of Plasmodium falciparum histone 3, mono-methylated at lysine 9?

Luah YH, Chaal BK, Ong EZ, Bozdech Z.

PLoS One. 2010 Apr 19;5(4):e10252. doi: 10.1371/journal.pone.0010252.

39.

A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology.

Flueck C, Bartfai R, Niederwieser I, Witmer K, Alako BT, Moes S, Bozdech Z, Jenoe P, Stunnenberg HG, Voss TS.

PLoS Pathog. 2010 Feb 26;6(2):e1000784. doi: 10.1371/journal.ppat.1000784.

40.

Defining species specific genome differences in malaria parasites.

Liew KJ, Hu G, Bozdech Z, Peter PR.

BMC Genomics. 2010 Feb 23;11:128. doi: 10.1186/1471-2164-11-128.

41.

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle.

Chaal BK, Gupta AP, Wastuwidyaningtyas BD, Luah YH, Bozdech Z.

PLoS Pathog. 2010 Jan 22;6(1):e1000737. doi: 10.1371/journal.ppat.1000737.

42.

Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum.

Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z.

Nat Biotechnol. 2010 Jan;28(1):91-8. doi: 10.1038/nbt.1597. Epub 2009 Dec 27.

PMID:
20037583
43.

Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates.

Mackinnon MJ, Li J, Mok S, Kortok MM, Marsh K, Preiser PR, Bozdech Z.

PLoS Pathog. 2009 Oct;5(10):e1000644. doi: 10.1371/journal.ppat.1000644. Epub 2009 Oct 30.

44.

Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.

Flueck C, Bartfai R, Volz J, Niederwieser I, Salcedo-Amaya AM, Alako BT, Ehlgen F, Ralph SA, Cowman AF, Bozdech Z, Stunnenberg HG, Voss TS.

PLoS Pathog. 2009 Sep;5(9):e1000569. doi: 10.1371/journal.ppat.1000569. Epub 2009 Sep 4.

45.

Quantitative protein expression profiling reveals extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites.

Foth BJ, Zhang N, Mok S, Preiser PR, Bozdech Z.

Genome Biol. 2008;9(12):R177. doi: 10.1186/gb-2008-9-12-r177. Epub 2008 Dec 17.

46.

The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites.

Bozdech Z, Mok S, Hu G, Imwong M, Jaidee A, Russell B, Ginsburg H, Nosten F, Day NP, White NJ, Carlton JM, Preiser PR.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16290-5. doi: 10.1073/pnas.0807404105. Epub 2008 Oct 13.

47.

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.

Gao X, Yeo KP, Aw SS, Kuss C, Iyer JK, Genesan S, Rajamanonmani R, Lescar J, Bozdech Z, Preiser PR.

PLoS Pathog. 2008 Jul 11;4(7):e1000104. doi: 10.1371/journal.ppat.1000104.

48.

Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and located in the surface membranes of infected red blood cells and the apical tips of merozoites.

Blythe JE, Yam XY, Kuss C, Bozdech Z, Holder AA, Marsh K, Langhorne J, Preiser PR.

Infect Immun. 2008 Jul;76(7):3329-36. doi: 10.1128/IAI.01460-07. Epub 2008 May 12.

49.

Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506.

Kotaka M, Ye H, Alag R, Hu G, Bozdech Z, Preiser PR, Yoon HS, Lescar J.

Biochemistry. 2008 Jun 3;47(22):5951-61. doi: 10.1021/bi800004u. Epub 2008 May 9.

PMID:
18465874
50.

Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy.

Hu G, Llinás M, Li J, Preiser PR, Bozdech Z.

BMC Bioinformatics. 2007 Sep 19;8:350.

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