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Items: 40

1.

"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.

Bua S, Lomelino C, Murray AB, Osman SM, ALOthman ZA, Bozdag M, Abdel-Aziz HA, Eldehna WM, McKenna R, Nocentini A, Supuran CT.

J Med Chem. 2020 Jan 9;63(1):321-333. doi: 10.1021/acs.jmedchem.9b01669. Epub 2019 Dec 18.

PMID:
31794211
2.

The effect of diosmin against lead exposure in rats.

Bozdağ M, Eraslan G.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec 12. doi: 10.1007/s00210-019-01758-4. [Epub ahead of print]

PMID:
31792554
3.

Estimating forensic age via magnetic resonance imaging of the distal radial epiphysis.

Er A, Bozdag M, Basa CD, Kacmaz IE, Ekizoglu O.

Int J Legal Med. 2020 Jan;134(1):375-380. doi: 10.1007/s00414-019-02189-9. Epub 2019 Nov 12.

PMID:
31713678
4.

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos.

Aspatwar A, Hammaren M, Parikka M, Parkkila S, Carta F, Bozdag M, Vullo D, Supuran CT.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):65-71. doi: 10.1080/14756366.2019.1683007.

5.

Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs.

Aspatwar A, Kairys V, Rala S, Parikka M, Bozdag M, Carta F, Supuran CT, Parkkila S.

Int J Mol Sci. 2019 Oct 17;20(20). pii: E5153. doi: 10.3390/ijms20205153. Review.

6.

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.

Bozdag M, Ferraroni M, Ward C, Carta F, Bua S, Angeli A, Langdon SP, Kunkler IH, Al-Tamimi AS, Supuran CT.

Eur J Med Chem. 2019 Nov 15;182:111600. doi: 10.1016/j.ejmech.2019.111600. Epub 2019 Aug 7.

PMID:
31419777
7.

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.

Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L, Ghelardini C, Supuran CT, Carta F.

J Med Chem. 2019 Aug 8;62(15):7233-7249. doi: 10.1021/acs.jmedchem.9b00845. Epub 2019 Jul 23.

PMID:
31287314
8.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.

Bozdag M, Poli G, Angeli A, Lucarini E, Tuccinardi T, Di Cesare Mannelli L, Selleri S, Ghelardini C, Winum JY, Carta F, Supuran CT.

Bioorg Chem. 2019 Aug;89:103033. doi: 10.1016/j.bioorg.2019.103033. Epub 2019 Jun 6.

PMID:
31212085
9.

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells.

Mboge MY, Chen Z, Khokhar D, Wolff A, Ai L, Heldermon CD, Bozdag M, Carta F, Supuran CT, Brown KD, McKenna R, Frost CJ, Frost SC.

Biochem J. 2019 May 28;476(10):1497-1513. doi: 10.1042/BCJ20190177.

PMID:
31072911
10.

Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Micheli L, Bozdag M, Akgul O, Carta F, Guccione C, Bergonzi MC, Bilia AR, Cinci L, Lucarini E, Parisio C, Supuran CT, Ghelardini C, Di Cesare Mannelli L.

Int J Mol Sci. 2019 Apr 18;20(8). pii: E1923. doi: 10.3390/ijms20081923.

11.

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC.

PLoS One. 2018 Nov 19;13(11):e0207417. doi: 10.1371/journal.pone.0207417. eCollection 2018.

12.

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding.

De Simone G, Angeli A, Bozdag M, Supuran CT, Winum JY, Monti SM, Alterio V.

Chem Commun (Camb). 2018 Sep 11;54(73):10312-10315. doi: 10.1039/c8cc05755a.

PMID:
30140816
13.

Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N'-aryl-N-hydroxy-ureas.

Berrino E, Bozdag M, Del Prete S, Alasmary FAS, Alqahtani LS, AlOthman Z, Capasso C, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1194-1198. doi: 10.1080/14756366.2018.1490733.

14.

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.

Bozdag M, Carta F, Ceruso M, Ferraroni M, McDonald PC, Dedhar S, Supuran CT.

J Med Chem. 2018 Jul 26;61(14):6328-6338. doi: 10.1021/acs.jmedchem.8b00770. Epub 2018 Jul 17.

PMID:
29962205
15.

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes.

Bozdag M, Altamimi ASA, Vullo D, Supuran CT, Carta F.

Curr Med Chem. 2019;26(15):2558-2573. doi: 10.2174/0929867325666180622120625. Review.

PMID:
29932025
16.

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors.

Abdoli M, Bozdag M, Angeli A, Supuran CT.

Metabolites. 2018 Jun 1;8(2). pii: E37. doi: 10.3390/metabo8020037.

17.

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii.

Bua S, Bozdag M, Del Prete S, Carta F, Donald WA, Capasso C, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):707-713. doi: 10.1080/14756366.2018.1450400.

18.

Synthesis of N'-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human carbonic anhydrases.

Bozdag M, Carta F, Angeli A, Osman SM, Alasmary FAS, AlOthman Z, Supuran CT.

Bioorg Chem. 2018 Aug;78:1-6. doi: 10.1016/j.bioorg.2018.02.029. Epub 2018 Mar 1.

PMID:
29524665
19.

Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX.

Peperidou A, Bua S, Bozdag M, Hadjipavlou-Litina D, Supuran CT.

Molecules. 2018 Jan 12;23(1). pii: E153. doi: 10.3390/molecules23010153.

20.

Sex estimation in a contemporary Turkish population based on CT scans of the calcaneus.

Ekizoglu O, Inci E, Palabiyik FB, Can IO, Er A, Bozdag M, Kacmaz IE, Kranioti EF.

Forensic Sci Int. 2017 Oct;279:310.e1-310.e6. doi: 10.1016/j.forsciint.2017.07.038. Epub 2017 Aug 4.

PMID:
28912044
21.

MRI assessment of pituitary iron accumulation by using pituitary-R2 in β-thalassemia patients.

Bozdağ M, Bayraktaroğlu S, Aydınok Y, Çallı MC.

Acta Radiol. 2018 Jun;59(6):732-739. doi: 10.1177/0284185117730099. Epub 2017 Sep 7.

PMID:
28882060
22.

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides.

Abdoli M, Angeli A, Bozdag M, Carta F, Kakanejadifard A, Saeidian H, Supuran CT.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1071-1078. doi: 10.1080/14756366.2017.1356295.

23.

Carbonic anhydrase I, II, IV and IX inhibition with a series of 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives.

Bozdag M, Bua S, Osman SM, AlOthman Z, Supuran CT.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):885-892. doi: 10.1080/14756366.2017.1337759.

24.

Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.

Bozdag M, Alafeefy AM, Altamimi AM, Carta F, Supuran CT, Vullo D.

Bioorg Med Chem. 2017 May 15;25(10):2782-2788. doi: 10.1016/j.bmc.2017.03.054. Epub 2017 Mar 29.

PMID:
28389112
25.

Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.

Vullo D, Del Prete S, Nocentini A, Osman SM, AlOthman Z, Capasso C, Bozdag M, Carta F, Gratteri P, Supuran CT.

Bioorg Med Chem. 2017 Feb 1;25(3):1260-1265. doi: 10.1016/j.bmc.2016.12.040. Epub 2016 Dec 27.

PMID:
28057408
26.

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.

Bozdag M, Alafeefy AM, Altamimi AM, Vullo D, Carta F, Supuran CT.

Bioorg Med Chem. 2017 Jan 15;25(2):677-683. doi: 10.1016/j.bmc.2016.11.039. Epub 2016 Nov 29.

PMID:
27939347
27.

Sex estimation of the tibia in modern Turkish: A computed tomography study.

Ekizoglu O, Er A, Bozdag M, Akcaoglu M, Can IO, García-Donas JG, Kranioti EF.

Leg Med (Tokyo). 2016 Nov;23:89-94. doi: 10.1016/j.legalmed.2016.10.004. Epub 2016 Oct 14.

PMID:
27890111
28.

Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties.

Bozdag M, Alafeefy AM, Carta F, Ceruso M, Al-Tamimi AS, Al-Kahtani AA, Alasmary FAS, Supuran CT.

Bioorg Med Chem. 2016 Sep 15;24(18):4100-4107. doi: 10.1016/j.bmc.2016.06.052. Epub 2016 Jun 27.

PMID:
27396930
29.

Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity.

Bozdag M, Alafeefy AM, Vullo D, Carta F, Dedeoglu N, Al-Tamimi AM, Al-Jaber NA, Scozzafava A, Supuran CT.

Bioorg Med Chem. 2015 Dec 15;23(24):7751-64. doi: 10.1016/j.bmc.2015.11.023. Epub 2015 Nov 23.

PMID:
26639945
30.

Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.

Bragagni M, Bozdag M, Carta F, Scozzafava A, Lanzi C, Masini E, Mura P, Supuran CT.

Bioorg Med Chem. 2015 Sep 15;23(18):6223-7. doi: 10.1016/j.bmc.2015.07.047. Epub 2015 Jul 29.

PMID:
26319622
31.

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.

Bozdag M, Carta F, Vullo D, Akdemir A, Isik S, Lanzi C, Scozzafava A, Masini E, Supuran CT.

Bioorg Med Chem. 2015 May 15;23(10):2368-76. doi: 10.1016/j.bmc.2015.03.068. Epub 2015 Mar 31.

PMID:
25846066
32.

7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring.

Vullo D, Isik S, Bozdag M, Carta F, Supuran CT.

J Enzyme Inhib Med Chem. 2015;30(5):773-7. doi: 10.3109/14756366.2014.970185. Epub 2015 Feb 12.

PMID:
25672528
33.

Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase.

Bozdag M, Carta F, Vullo D, Isik S, AlOthman Z, Osman SM, Scozzafava A, Supuran CT.

J Enzyme Inhib Med Chem. 2016;31(1):132-6. doi: 10.3109/14756366.2015.1010529. Epub 2015 Feb 11.

PMID:
25669351
34.

A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.

Bozdag M, Pinard M, Carta F, Masini E, Scozzafava A, McKenna R, Supuran CT.

J Med Chem. 2014 Nov 26;57(22):9673-86. doi: 10.1021/jm501497m. Epub 2014 Nov 10.

35.

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

Bozdag M, Ferraroni M, Carta F, Vullo D, Lucarini L, Orlandini E, Rossello A, Nuti E, Scozzafava A, Masini E, Supuran CT.

J Med Chem. 2014 Nov 13;57(21):9152-67. doi: 10.1021/jm501314c. Epub 2014 Oct 17.

PMID:
25310626
36.

Synthesis of a novel affinity gel for the purification of carbonic anhydrases.

Bozdag M, Isik S, Beyaztas S, Arslan O, Supuran CT.

J Enzyme Inhib Med Chem. 2015 Apr;30(2):240-4. doi: 10.3109/14756366.2014.912216. Epub 2014 Jun 18.

PMID:
24939102
37.

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

Bozdag M, Ferraroni M, Nuti E, Vullo D, Rossello A, Carta F, Scozzafava A, Supuran CT.

Bioorg Med Chem. 2014 Jan 1;22(1):334-40. doi: 10.1016/j.bmc.2013.11.016. Epub 2013 Nov 18.

PMID:
24300919
38.

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.

Tanc M, Carta F, Bozdag M, Scozzafava A, Supuran CT.

Bioorg Med Chem. 2013 Aug 1;21(15):4502-10. doi: 10.1016/j.bmc.2013.05.032. Epub 2013 May 31.

PMID:
23769167
39.

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.

Bozdag M, Dreker T, Henry C, Tosco P, Vallaro M, Fruttero R, Scozzafava A, Carta F, Supuran CT.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):715-9. doi: 10.1016/j.bmcl.2012.11.102. Epub 2012 Dec 2.

40.

Reassessment of suicide attempters at home, shortly after discharge from hospital.

Verwey B, van Waarde JA, Bozdağ MA, van Rooij I, de Beurs E, Zitman FG.

Crisis. 2010;31(6):303-10. doi: 10.1027/0227-5910/a000041.

PMID:
21190928

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