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Items: 34

1.

Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.

Agarabi CD, Chavez BK, Lute SC, Read EK, Rogstad S, Awotwe-Otoo D, Brown MR, Boyne MT 2nd, Brorson KA.

Biotechnol Prog. 2017 Jan;33(1):163-170. doi: 10.1002/btpr.2402. Epub 2016 Nov 21.

PMID:
27813291
2.

The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model.

Chockalingam AK, Hamed S, Goodwin DG, Rosenzweig BA, Pang E, Boyne MT 2nd, Patel V.

Dis Markers. 2016;2016:9296457. doi: 10.1155/2016/9296457. Epub 2016 Mar 8.

3.

Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations.

Chavez BK, Agarabi CD, Read EK, Boyne MT 2nd, Khan MA, Brorson KA.

Biomed Res Int. 2016;2016:2074149. doi: 10.1155/2016/2074149. Epub 2016 Mar 3.

4.

Modern analytics for synthetically derived complex drug substances: NMR, AFFF-MALS, and MS tests for glatiramer acetate.

Rogstad S, Pang E, Sommers C, Hu M, Jiang X, Keire DA, Boyne MT 2nd.

Anal Bioanal Chem. 2015 Nov;407(29):8647-59. doi: 10.1007/s00216-015-9057-8. Epub 2015 Oct 12.

PMID:
26458562
5.

Marketplace Analysis of Conjugated Estrogens: Determining the Consistently Present Steroidal Content with LC-MS.

Levy MJ, Boyne MT 2nd, Rogstad S, Skanchy DJ, Jiang X, Geerlof-Vidavsky I.

AAPS J. 2015 Nov;17(6):1438-45. doi: 10.1208/s12248-015-9805-x. Epub 2015 Aug 5.

6.
7.

Primary Sequence Confirmation of a Protein Therapeutic Using Top Down MS/MS and MS(3).

Levy MJ, Gucinski AC, Boyne MT 2nd.

Anal Chem. 2015 Jul 21;87(14):6995-9. doi: 10.1021/acs.analchem.5b01113. Epub 2015 Jul 6.

PMID:
26086621
8.

Comparison of Traditional 2-AB Fluorescence LC-MS/MS and Automated LC-MS for the Comparative Glycan Analysis of Monoclonal Antibodies.

Schiel JE, Rogstad SM, Boyne MT 2nd.

J Pharm Sci. 2015 Aug;104(8):2464-72. doi: 10.1002/jps.24522. Epub 2015 Jun 5.

PMID:
26053232
9.

Bioreactor process parameter screening utilizing a Plackett-Burman design for a model monoclonal antibody.

Agarabi CD, Schiel JE, Lute SC, Chavez BK, Boyne MT 2nd, Brorson KA, Khan M, Read EK.

J Pharm Sci. 2015 Jun;104(6):1919-1928. doi: 10.1002/jps.24420. Epub 2015 Mar 11.

PMID:
25762022
10.

Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control.

Zeng K, Geerlof-Vidavisky I, Gucinski A, Jiang X, Boyne MT 2nd.

AAPS J. 2015 May;17(3):643-51. doi: 10.1208/s12248-015-9730-z. Epub 2015 Feb 26.

11.

Direct site-specific glycoform identification and quantitative comparison of glycoprotein therapeutics: imiglucerase and velaglucerase alfa.

Ye H, Hill J, Gucinski AC, Boyne MT 2nd, Buhse LF.

AAPS J. 2015 Mar;17(2):405-15. doi: 10.1208/s12248-014-9706-4. Epub 2014 Dec 13.

12.

Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release.

Chimalakonda KC, Pang E, Weaver JL, Howard KE, Patel V, Boyne MT 2nd.

J Pharm Biomed Anal. 2015 Jan;102:494-9. doi: 10.1016/j.jpba.2014.10.016. Epub 2014 Oct 23.

PMID:
25459949
13.

Pharmacodynamic evaluation of the activities of six parenteral vancomycin products available in the United States.

Louie A, Boyne MT 2nd, Patel V, Huntley C, Liu W, Fikes S, Kurhanewicz S, Rodriquez J, Robbins N, Brown D, Baluya D, Drusano GL.

Antimicrob Agents Chemother. 2015 Jan;59(1):622-32. doi: 10.1128/AAC.03710-14. Epub 2014 Nov 10.

14.

Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon.

Gucinski AC, Boyne MT 2nd, Keire DA.

Anal Bioanal Chem. 2015 Jan;407(3):749-59. doi: 10.1007/s00216-014-8172-2. Epub 2014 Sep 27.

PMID:
25260409
15.

Post-translational structural modifications of immunoglobulin G and their effect on biological activity.

Hmiel LK, Brorson KA, Boyne MT 2nd.

Anal Bioanal Chem. 2015 Jan;407(1):79-94. doi: 10.1007/s00216-014-8108-x. Epub 2014 Sep 10. Review.

PMID:
25200070
16.

More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems.

Hartman NR, Mao JJ, Zhou H, Boyne MT 2nd, Wasserman AM, Taylor K, Racoosin JA, Patel V, Colatsky T.

Regul Toxicol Pharmacol. 2014 Oct;70(1):182-8. doi: 10.1016/j.yrtph.2014.07.002. Epub 2014 Jul 8.

PMID:
25010377
17.

Identification of site-specific heterogeneity in peptide drugs using intact mass spectrometry with electron transfer dissociation.

Gucinski AC, Boyne MT 2nd.

Rapid Commun Mass Spectrom. 2014 Aug 15;28(15):1757-63. doi: 10.1002/rcm.6957.

PMID:
24975256
18.

Analytical techniques and bioactivity assays to compare the structure and function of filgrastim (granulocyte-colony stimulating factor) therapeutics from different manufacturers.

Levy MJ, Gucinski AC, Sommers CD, Ghasriani H, Wang B, Keire DA, Boyne MT 2nd.

Anal Bioanal Chem. 2014 Oct;406(26):6559-67. doi: 10.1007/s00216-013-7469-x. Epub 2013 Nov 22.

PMID:
24264620
19.

Analyses of marketplace tacrolimus drug product quality: bioactivity, NMR and LC-MS.

Sommers CD, Pang ES, Ghasriani H, Berendt RT, Vilker VL, Keire DA, Boyne MT 2nd.

J Pharm Biomed Anal. 2013 Nov;85:108-17. doi: 10.1016/j.jpba.2013.07.001. Epub 2013 Jul 12.

PMID:
23917038
20.

Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry.

Wang B, Gucinski AC, Keire DA, Buhse LF, Boyne MT 2nd.

Analyst. 2013 May 21;138(10):3058-65. doi: 10.1039/c3an36524g.

PMID:
23579346
21.
22.

Evaluation of intact mass spectrometry for the quantitative analysis of protein therapeutics.

Gucinski AC, Boyne MT 2nd.

Anal Chem. 2012 Sep 18;84(18):8045-51. doi: 10.1021/ac301949j. Epub 2012 Sep 4.

PMID:
22916992
23.

Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity.

Norcross MA, Luo S, Lu L, Boyne MT, Gomarteli M, Rennels AD, Woodcock J, Margulies DH, McMurtrey C, Vernon S, Hildebrand WH, Buchli R.

AIDS. 2012 Jul 17;26(11):F21-9. doi: 10.1097/QAD.0b013e328355fe8f.

24.

Quality assessment of U.S. marketplace vancomycin for injection products using high-resolution liquid chromatography-mass spectrometry and potency assays.

Hadwiger ME, Sommers CD, Mans DJ, Patel V, Boyne MT 2nd.

Antimicrob Agents Chemother. 2012 Jun;56(6):2824-30. doi: 10.1128/AAC.00164-12. Epub 2012 Feb 27.

25.

Product quality of parenteral vancomycin products in the United States.

Nambiar S, Madurawe RD, Zuk SM, Khan SR, Ellison CD, Faustino PJ, Mans DJ, Trehy ML, Hadwiger ME, Boyne MT 2nd, Biswas K, Cox EM.

Antimicrob Agents Chemother. 2012 Jun;56(6):2819-23. doi: 10.1128/AAC.05344-11. Epub 2012 Feb 6.

26.

Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval.

Boyne MT, Garcia BA, Li M, Zamdborg L, Wenger CD, Babai S, Kelleher NL.

J Proteome Res. 2009 Jan;8(1):374-9. doi: 10.1021/pr800635m.

27.

Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra.

Wenger CD, Boyne MT 2nd, Ferguson JT, Robinson DE, Kelleher NL.

Anal Chem. 2008 Nov 1;80(21):8055-63. doi: 10.1021/ac8010704. Epub 2008 Oct 8.

28.

"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry.

Roth MJ, Parks BA, Ferguson JT, Boyne MT 2nd, Kelleher NL.

Anal Chem. 2008 Apr 15;80(8):2857-66. doi: 10.1021/ac800141g. Epub 2008 Mar 20.

29.

Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers.

Parks BA, Jiang L, Thomas PM, Wenger CD, Roth MJ, Boyne MT 2nd, Burke PV, Kwast KE, Kelleher NL.

Anal Chem. 2007 Nov 1;79(21):7984-91. Epub 2007 Oct 5.

30.

Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.

Kelly WL, Boyne MT 2nd, Yeh E, Vosburg DA, Galonić DP, Kelleher NL, Walsh CT.

Biochemistry. 2007 Jan 16;46(2):359-68.

PMID:
17209546
31.

Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units.

Chan YA, Boyne MT 2nd, Podevels AM, Klimowicz AK, Handelsman J, Kelleher NL, Thomas MG.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14349-54. Epub 2006 Sep 18.

32.

Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster.

Gatto GJ Jr, Boyne MT 2nd, Kelleher NL, Walsh CT.

J Am Chem Soc. 2006 Mar 22;128(11):3838-47.

PMID:
16536560
33.

Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

Boyne MT 2nd, Pesavento JJ, Mizzen CA, Kelleher NL.

J Proteome Res. 2006 Feb;5(2):248-53.

PMID:
16457589
34.

Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry.

Roth MJ, Forbes AJ, Boyne MT 2nd, Kim YB, Robinson DE, Kelleher NL.

Mol Cell Proteomics. 2005 Jul;4(7):1002-8. Epub 2005 Apr 28.

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