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Items: 1 to 50 of 62

1.

IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation.

Impellizzieri D, Ridder F, Raeber ME, Egholm C, Woytschak J, Kolios AGA, Legler DF, Boyman O.

J Allergy Clin Immunol. 2019 Feb 12. pii: S0091-6749(19)30203-9. doi: 10.1016/j.jaci.2019.01.042. [Epub ahead of print]

PMID:
30768990
2.

Development of a novel class of interleukin-2 immunotherapies for metastatic cancer.

Boyman O, Arenas-Ramirez N.

Swiss Med Wkly. 2019 Jan 23;149:w14697. doi: 10.4414/smw.2019.14697. eCollection 2019 Jan 14.

3.

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response.

Keller N, Woytschak J, Heeb LEM, Marques Maggio E, Mairpady Shambat S, Snäll J, Hyldegaard O, Boyman O, Norrby-Teglund A, Zinkernagel AS.

J Invest Dermatol. 2019 Jun;139(6):1284-1293. doi: 10.1016/j.jid.2018.11.027. Epub 2018 Dec 10.

PMID:
30543898
4.

Editorial overview: Allergy and hypersensitivity: Emerging concepts in allergy and type 2 immunity.

Boyman O, Eggel A, Noti M.

Curr Opin Immunol. 2018 Oct;54:iii-v. doi: 10.1016/j.coi.2018.10.002. No abstract available.

PMID:
30342706
5.

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Jelcic I, Al Nimer F, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, Martin R.

Cell. 2018 Sep 20;175(1):85-100.e23. doi: 10.1016/j.cell.2018.08.011. Epub 2018 Aug 30.

6.

Epigenetic mechanisms of tumor resistance to immunotherapy.

Arenas-Ramirez N, Sahin D, Boyman O.

Cell Mol Life Sci. 2018 Nov;75(22):4163-4176. doi: 10.1007/s00018-018-2908-7. Epub 2018 Aug 23. Review.

PMID:
30140960
7.

Regulation of neutrophils in type 2 immune responses.

Heeb LEM, Egholm C, Impellizzieri D, Ridder F, Boyman O.

Curr Opin Immunol. 2018 Oct;54:115-122. doi: 10.1016/j.coi.2018.06.009. Epub 2018 Jul 14. Review.

PMID:
30015087
8.

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.

Castro W, Chelbi ST, Niogret C, Ramon-Barros C, Welten SPM, Osterheld K, Wang H, Rota G, Morgado L, Vivier E, Raeber ME, Boyman O, Delorenzi M, Barras D, Ho PC, Oxenius A, Guarda G.

Nat Immunol. 2018 Aug;19(8):809-820. doi: 10.1038/s41590-018-0144-9. Epub 2018 Jul 2.

9.

The role of cytokines in T-cell memory in health and disease.

Raeber ME, Zurbuchen Y, Impellizzieri D, Boyman O.

Immunol Rev. 2018 May;283(1):176-193. doi: 10.1111/imr.12644. Review.

PMID:
29664568
10.

The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation.

Wang Y, de Vallière C, Imenez Silva PH, Leonardi I, Gruber S, Gerstgrasser A, Melhem H, Weber A, Leucht K, Wolfram L, Hausmann M, Krieg C, Thomasson K, Boyman O, Frey-Wagner I, Rogler G, Wagner CA.

J Crohns Colitis. 2018 Feb 28;12(3):355-368. doi: 10.1093/ecco-jcc/jjx147.

11.

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy.

Zingg D, Arenas-Ramirez N, Sahin D, Rosalia RA, Antunes AT, Haeusel J, Sommer L, Boyman O.

Cell Rep. 2017 Jul 25;20(4):854-867. doi: 10.1016/j.celrep.2017.07.007.

12.

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.

Arenas-Ramirez N, Zou C, Popp S, Zingg D, Brannetti B, Wirth E, Calzascia T, Kovarik J, Sommer L, Zenke G, Woytschak J, Regnier CH, Katopodis A, Boyman O.

Sci Transl Med. 2016 Nov 30;8(367):367ra166.

PMID:
27903862
13.

Endogenous polyclonal anti-IL-1 antibody responses potentiate IL-1 activity during pathogenic inflammation.

Spohn G, Arenas-Ramirez N, Bouchaud G, Boyman O.

J Allergy Clin Immunol. 2017 Jun;139(6):1957-1965.e3. doi: 10.1016/j.jaci.2016.09.033. Epub 2016 Nov 7.

PMID:
27833025
14.

Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Woytschak J, Keller N, Krieg C, Impellizzieri D, Thompson RW, Wynn TA, Zinkernagel AS, Boyman O.

Immunity. 2016 Jul 19;45(1):172-84. doi: 10.1016/j.immuni.2016.06.025.

15.

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.

Hauser MA, Schaeuble K, Kindinger I, Impellizzieri D, Krueger WA, Hauck CR, Boyman O, Legler DF.

Immunity. 2016 Jan 19;44(1):59-72. doi: 10.1016/j.immuni.2015.12.010.

16.

IL-17 receptor A and adenosine deaminase 2 deficiency in siblings with recurrent infections and chronic inflammation.

Fellmann F, Angelini F, Wassenberg J, Perreau M, Arenas Ramirez N, Simon G, Boyman O, Demaria O, Christen-Zaech S, Hohl D, Belfiore M, von Scheven-Gete A, Gilliet M, Bochud PY, Perrin Y, Beck Popovic M, Bart PA, Beckmann JS, Martinet D, Hofer M.

J Allergy Clin Immunol. 2016 Apr;137(4):1189-1196.e2. doi: 10.1016/j.jaci.2015.07.053. Epub 2015 Nov 20.

PMID:
26607704
17.

Interleukin-2: Biology, Design and Application.

Arenas-Ramirez N, Woytschak J, Boyman O.

Trends Immunol. 2015 Dec;36(12):763-777. doi: 10.1016/j.it.2015.10.003. Epub 2015 Nov 10. Review.

18.

Modulation of T cell responses by IL-2 and IL-2 complexes.

Boyman O, Kolios AG, Raeber ME.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S54-7. Epub 2015 Oct 12. Review.

19.

The Swiss National Registry for Primary Immunodeficiencies: report on the first 6 years' activity from 2008 to 2014.

Marschall K, Hoernes M, Bitzenhofer-Grüber M, Jandus P, Duppenthaler A, Wuillemin WA, Rischewski J, Boyman O, Heininger U, Hauser T, Steiner U, Posfay-Barbe K, Seebach J, Recher M, Hess C, Helbling A, Reichenbach J; Swiss PID Registry Working Group.

Clin Exp Immunol. 2015 Oct;182(1):45-50. doi: 10.1111/cei.12661. Epub 2015 Jul 29.

20.

EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders.

Boyman O, Kaegi C, Akdis M, Bavbek S, Bossios A, Chatzipetrou A, Eiwegger T, Firinu D, Harr T, Knol E, Matucci A, Palomares O, Schmidt-Weber C, Simon HU, Steiner UC, Vultaggio A, Akdis CA, Spertini F.

Allergy. 2015 Jul;70(7):727-54. doi: 10.1111/all.12616. Epub 2015 Apr 24. Review.

PMID:
25819018
21.

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

Zingg D, Debbache J, Schaefer SM, Tuncer E, Frommel SC, Cheng P, Arenas-Ramirez N, Haeusel J, Zhang Y, Bonalli M, McCabe MT, Creasy CL, Levesque MP, Boyman O, Santoro R, Shakhova O, Dummer R, Sommer L.

Nat Commun. 2015 Jan 22;6:6051. doi: 10.1038/ncomms7051.

PMID:
25609585
22.

Use of enhanced interleukin-2 formulations for improved immunotherapy against cancer.

Rosalia RA, Arenas-Ramirez N, Bouchaud G, Raeber ME, Boyman O.

Curr Opin Chem Biol. 2014 Dec;23:39-46. doi: 10.1016/j.cbpa.2014.09.006. Epub 2014 Sep 29. Review.

23.

Adverse reactions to biologic agents and their medical management.

Boyman O, Comte D, Spertini F.

Nat Rev Rheumatol. 2014 Oct;10(10):612-27. doi: 10.1038/nrrheum.2014.123. Epub 2014 Aug 12. Review.

PMID:
25112605
24.

Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection.

Chijioke O, Müller A, Feederle R, Barros MH, Krieg C, Emmel V, Marcenaro E, Leung CS, Antsiferova O, Landtwing V, Bossart W, Moretta A, Hassan R, Boyman O, Niedobitek G, Delecluse HJ, Capaul R, Münz C.

Cell Rep. 2013 Dec 26;5(6):1489-98. doi: 10.1016/j.celrep.2013.11.041. Epub 2013 Dec 19. Erratum in: Cell Rep. 2015 Aug 4;12(5):901.

25.

Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.

Bouchaud G, Gehrke S, Krieg C, Kolios A, Hafner J, Navarini AA, French LE, Boyman O.

J Exp Med. 2013 Sep 23;210(10):2105-17. doi: 10.1084/jem.20130291. Epub 2013 Sep 9.

26.

Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage.

Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Häner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C.

Blood. 2013 Sep 26;122(13):2271-81. doi: 10.1182/blood-2013-01-478073. Epub 2013 Aug 20.

27.

Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes.

Baeyens A, Pérol L, Fourcade G, Cagnard N, Carpentier W, Woytschak J, Boyman O, Hartemann A, Piaggio E.

Diabetes. 2013 Sep;62(9):3120-31. doi: 10.2337/db13-0214. Epub 2013 May 13.

28.

Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.

Jungraithmayr W, Codarri L, Bouchaud G, Krieg C, Boyman O, Gyülvészi G, Becher B, Weder W, Münz C.

Am J Respir Crit Care Med. 2013 Jun 15;187(12):1349-59. doi: 10.1164/rccm.201209-1749OC.

29.

Research needs in allergy: an EAACI position paper, in collaboration with EFA.

Papadopoulos NG, Agache I, Bavbek S, Bilo BM, Braido F, Cardona V, Custovic A, Demonchy J, Demoly P, Eigenmann P, Gayraud J, Grattan C, Heffler E, Hellings PW, Jutel M, Knol E, Lötvall J, Muraro A, Poulsen LK, Roberts G, Schmid-Grendelmeier P, Skevaki C, Triggiani M, Vanree R, Werfel T, Flood B, Palkonen S, Savli R, Allegri P, Annesi-Maesano I, Annunziato F, Antolin-Amerigo D, Apfelbacher C, Blanca M, Bogacka E, Bonadonna P, Bonini M, Boyman O, Brockow K, Burney P, Buters J, Butiene I, Calderon M, Cardell LO, Caubet JC, Celenk S, Cichocka-Jarosz E, Cingi C, Couto M, Dejong N, Del Giacco S, Douladiris N, Fassio F, Fauquert JL, Fernandez J, Rivas MF, Ferrer M, Flohr C, Gardner J, Genuneit J, Gevaert P, Groblewska A, Hamelmann E, Hoffmann HJ, Hoffmann-Sommergruber K, Hovhannisyan L, Hox V, Jahnsen FL, Kalayci O, Kalpaklioglu AF, Kleine-Tebbe J, Konstantinou G, Kurowski M, Lau S, Lauener R, Lauerma A, Logan K, Magnan A, Makowska J, Makrinioti H, Mangina P, Manole F, Mari A, Mazon A, Mills C, Mingomataj E, Niggemann B, Nilsson G, Ollert M, O'Mahony L, O'Neil S, Pala G, Papi A, Passalacqua G, Perkin M, Pfaar O, Pitsios C, Quirce S, Raap U, Raulf-Heimsoth M, Rhyner C, Robson-Ansley P, Alves RR, Roje Z, Rondon C, Rudzeviciene O, Ruëff F, Rukhadze M, Rumi G, Sackesen C, Santos AF, Santucci A, Scharf C, Schmidt-Weber C, Schnyder B, Schwarze J, Senna G, Sergejeva S, Seys S, Siracusa A, Skypala I, Sokolowska M, Spertini F, Spiewak R, Sprikkelman A, Sturm G, Swoboda I, Terreehorst I, Toskala E, Traidl-Hoffmann C, Venter C, Vlieg-Boerstra B, Whitacker P, Worm M, Xepapadaki P, Akdis CA.

Clin Transl Allergy. 2012 Nov 2;2(1):21. doi: 10.1186/2045-7022-2-21.

30.

Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

Boyman O, Krieg C, Letourneau S, Webster K, Surh CD, Sprent J.

Transplant Proc. 2012 May;44(4):1032-4. doi: 10.1016/j.transproceed.2012.01.093. Review.

PMID:
22564618
31.

Homeostatic maintenance of T cells and natural killer cells.

Boyman O, Krieg C, Homann D, Sprent J.

Cell Mol Life Sci. 2012 May;69(10):1597-608. doi: 10.1007/s00018-012-0968-7. Epub 2012 Mar 30. Review.

32.

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC.

Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975.

33.

The role of interleukin-2 during homeostasis and activation of the immune system.

Boyman O, Sprent J.

Nat Rev Immunol. 2012 Feb 17;12(3):180-90. doi: 10.1038/nri3156. Review.

PMID:
22343569
34.

The suppressive role of IL-10 in contact and atopic dermatitis.

Boyman O, Werfel T, Akdis CA.

J Allergy Clin Immunol. 2012 Jan;129(1):160-1. doi: 10.1016/j.jaci.2011.10.046. No abstract available.

PMID:
22196528
35.

The role of interleukin-2 in memory CD8 cell differentiation.

Boyman O, Cho JH, Sprent J.

Adv Exp Med Biol. 2010;684:28-41.

36.

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells.

Krieg C, Létourneau S, Pantaleo G, Boyman O.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11906-11. doi: 10.1073/pnas.1002569107. Epub 2010 Jun 14. Erratum in: Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):345.

37.

Bystander activation of CD4+ T cells.

Boyman O.

Eur J Immunol. 2010 Apr;40(4):936-9. doi: 10.1002/eji.201040466.

38.

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.

Létourneau S, van Leeuwen EM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2171-6. doi: 10.1073/pnas.0909384107. Epub 2010 Jan 19.

39.

Homeostatic proliferation and survival of naïve and memory T cells.

Boyman O, Létourneau S, Krieg C, Sprent J.

Eur J Immunol. 2009 Aug;39(8):2088-94. doi: 10.1002/eji.200939444. Review.

40.

Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.

Schmutz S, Bosco N, Chappaz S, Boyman O, Acha-Orbea H, Ceredig R, Rolink AG, Finke D.

J Immunol. 2009 Aug 15;183(4):2217-21. doi: 10.4049/jimmunol.0802911. Epub 2009 Jul 27.

41.

IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets.

Létourneau S, Krieg C, Pantaleo G, Boyman O.

J Allergy Clin Immunol. 2009 Apr;123(4):758-62. doi: 10.1016/j.jaci.2009.02.011. Review.

PMID:
19348914
42.

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J.

J Exp Med. 2009 Apr 13;206(4):751-60. doi: 10.1084/jem.20082824. Epub 2009 Mar 30.

43.

The role of chemokines in cancer immune surveillance by the adaptive immune system.

Krieg C, Boyman O.

Semin Cancer Biol. 2009 Apr;19(2):76-83. doi: 10.1016/j.semcancer.2008.10.011. Epub 2008 Nov 7. Review.

PMID:
19038343
44.

IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia.

Boyman O, Ramsey C, Kim DM, Sprent J, Surh CD.

J Immunol. 2008 Jun 1;180(11):7265-75.

45.

T cell homeostasis.

Sprent J, Cho JH, Boyman O, Surh CD.

Immunol Cell Biol. 2008 May-Jun;86(4):312-9. doi: 10.1038/icb.2008.12. Epub 2008 Mar 25. Review.

PMID:
18362947
46.

GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.

Mantel PY, Kuipers H, Boyman O, Rhyner C, Ouaked N, Rückert B, Karagiannidis C, Lambrecht BN, Hendriks RW, Crameri R, Akdis CA, Blaser K, Schmidt-Weber CB.

PLoS Biol. 2007 Dec;5(12):e329.

47.

Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype.

Harari A, Cellerai C, Bellutti Enders F, Köstler J, Codarri L, Tapia G, Boyman O, Castro E, Gaudieri S, James I, John M, Wagner R, Mallal S, Pantaleo G.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16233-8. Epub 2007 Oct 2.

48.

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.

Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Ramsey C, Kim DM, Surh CD, Sprent J.

J Exp Med. 2007 Aug 6;204(8):1787-801. Epub 2007 Jul 30.

49.

Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A, Kotelianski V, Gardner H, Nestle FO.

Nat Med. 2007 Jul;13(7):836-42. Epub 2007 Jul 1.

PMID:
17603494
50.

Cytokines and T-cell homeostasis.

Boyman O, Purton JF, Surh CD, Sprent J.

Curr Opin Immunol. 2007 Jun;19(3):320-6. Epub 2007 Apr 12. Review.

PMID:
17433869

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