Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 147

1.

Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL.

Inflamm Res. 2019 Feb 9. doi: 10.1007/s00011-019-01218-y. [Epub ahead of print]

PMID:
30739130
2.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.

3.

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.

Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS.

Nat Commun. 2018 May 15;9(1):1921. doi: 10.1038/s41467-018-04310-9.

4.

Decreased photosynthetic rate under high temperature in wheat is due to lipid desaturation, oxidation, acylation, and damage of organelles.

Djanaguiraman M, Boyle DL, Welti R, Jagadish SVK, Prasad PVV.

BMC Plant Biol. 2018 Apr 5;18(1):55. doi: 10.1186/s12870-018-1263-z.

5.

Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.

Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS.

Biochem Pharmacol. 2018 May;151:282-290. doi: 10.1016/j.bcp.2018.01.041. Epub 2018 Feb 6.

PMID:
29408488
6.

Corrigendum: Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Goff BL, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Tas SW, Thurlings R, Fonseca JE, Veale DJ.

Nat Rev Rheumatol. 2017 Dec 19;14(1):60. doi: 10.1038/nrrheum.2017.206.

PMID:
29255214
7.

Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ.

Nat Rev Rheumatol. 2017 Sep 22;13(10):630. doi: 10.1038/nrrheum.2017.161.

PMID:
28935945
8.

Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene.

Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS.

J Immunol. 2017 Oct 1;199(7):2316-2322. doi: 10.4049/jimmunol.1700719. Epub 2017 Aug 14.

9.

Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ, Tas SW.

Nat Rev Rheumatol. 2017 Aug;13(8):463-475. doi: 10.1038/nrrheum.2017.115. Epub 2017 Jul 13. Review. Erratum in: Nat Rev Rheumatol. 2017 Sep 22;13(10 ):630. Nat Rev Rheumatol. 2017 Dec 19;14 (1):60.

PMID:
28701760
10.

LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.

Hammaker D, Whitaker JW, Maeshima K, Boyle DL, Ekwall AH, Wang W, Firestein GS.

Arthritis Rheumatol. 2016 Nov;68(11):2637-2645. doi: 10.1002/art.39746.

11.

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes.

Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W.

Nat Commun. 2016 Jun 10;7:11849. doi: 10.1038/ncomms11849.

12.

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.

Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS.

JCI Insight. 2016 May 19;1(7). pii: e86580.

13.

Multiple functions of Na/K-ATPase in dopamine-induced salivation of the Blacklegged tick, Ixodes scapularis.

Kim D, Urban J, Boyle DL, Park Y.

Sci Rep. 2016 Feb 10;6:21047. doi: 10.1038/srep21047.

14.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

15.

Glucosylceramides are critical for cell-type differentiation and organogenesis, but not for cell viability in Arabidopsis.

Msanne J, Chen M, Luttgeharm KD, Bradley AM, Mays ES, Paper JM, Boyle DL, Cahoon RE, Schrick K, Cahoon EB.

Plant J. 2015 Oct;84(1):188-201. doi: 10.1111/tpj.13000.

16.

Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets.

Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS.

PLoS One. 2015 Aug 19;10(8):e0136334. doi: 10.1371/journal.pone.0136334. eCollection 2015. No abstract available.

17.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

18.

Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.

Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS.

PLoS One. 2015 Apr 22;10(4):e0124254. doi: 10.1371/journal.pone.0124254. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136334.

19.

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis.

Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 Jul;67(7):1978-80. doi: 10.1002/art.39123. No abstract available.

20.

Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT.

Inflamm Bowel Dis. 2015 Feb;21(2):323-30. doi: 10.1097/MIB.0000000000000264.

21.

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.

Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, Kaplan I, Krishnaswami S, Luo Z, Bradley J, Firestein GS.

Ann Rheum Dis. 2015 Jun;74(6):1311-6. doi: 10.1136/annrheumdis-2014-206028. Epub 2014 Nov 14.

22.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N.

Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6.

23.

Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT.

Aliment Pharmacol Ther. 2014 Sep;40(5):477-85. doi: 10.1111/apt.12862. Epub 2014 Jul 13.

24.

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.

Gong W, Kolker SJ, Usachev Y, Walder RY, Boyle DL, Firestein GS, Sluka KA.

Arthritis Res Ther. 2014 Jun 12;16(3):R121. doi: 10.1186/ar4577.

25.

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6.

Hammaker D, Boyle DL, Topolewski K, Firestein GS.

J Inflamm (Lond). 2014 May 16;11:14. doi: 10.1186/1476-9255-11-14. eCollection 2014.

26.

Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels.

Jones JD, Hamilton BJ, Challener GJ, de Brum-Fernandes AJ, Cossette P, Liang P, Masetto A, Ménard HA, Carrier N, Boyle DL, Rosengren S, Boire G, Rigby WF.

Arthritis Res Ther. 2014 Apr 25;16(2):R103. doi: 10.1186/ar4552.

27.

Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain.

Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS.

Pain. 2014 Jun;155(6):1150-60. doi: 10.1016/j.pain.2014.03.003. Epub 2014 Mar 12.

28.

Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.

Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS.

PLoS One. 2014 Jan 6;9(1):e84818. doi: 10.1371/journal.pone.0084818. eCollection 2014. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/4fbfa4f0-cb27-4ec4-80d6-3b0ed5e9e8b8.

29.

Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis.

Boyle DL, Kim HR, Topolewski K, Bartok B, Firestein GS.

J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. doi: 10.1124/jpet.113.205955. Epub 2013 Nov 15.

PMID:
24244039
30.

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype.

Whitaker JW, Shoemaker R, Boyle DL, Hillman J, Anderson D, Wang W, Firestein GS.

Genome Med. 2013 Apr 30;5(4):40. doi: 10.1186/gm444. eCollection 2013.

31.

Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.

Sluka KA, Rasmussen LA, Edgar MM, O'Donnell JM, Walder RY, Kolker SJ, Boyle DL, Firestein GS.

Arthritis Rheum. 2013 May;65(5):1194-202. doi: 10.1002/art.37862.

32.

Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.

Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N.

Arthritis Rheum. 2013 May;65(5):1171-80. doi: 10.1002/art.37872.

33.

Regulation of DNA methylation in rheumatoid arthritis synoviocytes.

Nakano K, Boyle DL, Firestein GS.

J Immunol. 2013 Feb 1;190(3):1297-303. doi: 10.4049/jimmunol.1202572. Epub 2012 Dec 31.

34.

DNA methylome signature in rheumatoid arthritis.

Nakano K, Whitaker JW, Boyle DL, Wang W, Firestein GS.

Ann Rheum Dis. 2013 Jan;72(1):110-7. doi: 10.1136/annrheumdis-2012-201526. Epub 2012 Jun 26.

35.

Transmission electron microscopy reveals distinct macrophage- and tick cell-specific morphological stages of Ehrlichia chaffeensis.

Dedonder SE, Cheng C, Willard LH, Boyle DL, Ganta RR.

PLoS One. 2012;7(5):e36749. doi: 10.1371/journal.pone.0036749. Epub 2012 May 15.

36.

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6.

Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS.

Arthritis Rheum. 2012 Sep;64(9):2887-95. doi: 10.1002/art.34489.

37.

Effects of manipulating apoptosis on Sindbis virus infection of Aedes aegypti mosquitoes.

Wang H, Gort T, Boyle DL, Clem RJ.

J Virol. 2012 Jun;86(12):6546-54. doi: 10.1128/JVI.00125-12. Epub 2012 Mar 21.

38.

PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.

Bartok B, Boyle DL, Liu Y, Ren P, Ball ST, Bugbee WD, Rommel C, Firestein GS.

Am J Pathol. 2012 May;180(5):1906-16. doi: 10.1016/j.ajpath.2012.01.030. Epub 2012 Mar 17.

PMID:
22433439
39.

Development and mineralization of embryonic avian scleral ossicles.

Zhang G, Boyle DL, Zhang Y, Rogers AR, Conrad GW.

Mol Vis. 2012;18:348-61. Epub 2012 Feb 5.

40.

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.

Lee SI, Boyle DL, Berdeja A, Firestein GS.

Arthritis Res Ther. 2012 Feb 21;14(1):R38. doi: 10.1186/ar3750.

41.

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon.

Rosengren S, Corr M, Firestein GS, Boyle DL.

Ann Rheum Dis. 2012 Mar;71(3):440-7. doi: 10.1136/ard.2011.150284. Epub 2011 Nov 25.

PMID:
22121136
42.

Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice.

Hammaker D, Topolewski K, Edgar M, Yoshizawa T, Fukushima A, Boyle DL, Burak EC, Sah RL, Firestein GS.

Arthritis Rheum. 2012 Mar;64(3):678-87. doi: 10.1002/art.33359.

43.

Knickkopf protein protects and organizes chitin in the newly synthesized insect exoskeleton.

Chaudhari SS, Arakane Y, Specht CA, Moussian B, Boyle DL, Park Y, Kramer KJ, Beeman RW, Muthukrishnan S.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17028-33. doi: 10.1073/pnas.1112288108. Epub 2011 Sep 19.

44.

CXCL13 as a marker for outcome of rheumatoid arthritis: comment on the article by Meeuwisse et al.

Rosengren S, Kalunian KC, Kavanaugh A, Boyle DL.

Arthritis Rheum. 2011 Nov;63(11):3646-7. doi: 10.1002/art.30585. No abstract available.

45.

Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice.

Luo Y, Boyle DL, Hammaker D, Edgar M, Franzoso G, Firestein GS.

Arthritis Rheum. 2011 Oct;63(10):2949-55. doi: 10.1002/art.30497.

46.

Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis.

Hammaker D, Boyle DL, Firestein GS.

Rheumatology (Oxford). 2012 Apr;51(4):610-8. doi: 10.1093/rheumatology/ker154. Epub 2011 May 25.

47.

Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis.

Corr M, Boyle DL, Ronacher LM, Lew BR, van Baarsen LG, Tak PP, Firestein GS.

Ann Rheum Dis. 2011 May;70(5):858-63. doi: 10.1136/ard.2010.141077. Epub 2011 Jan 7.

48.

CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis.

Rosengren S, Wei N, Kalunian KC, Kavanaugh A, Boyle DL.

Rheumatology (Oxford). 2011 Mar;50(3):603-10. doi: 10.1093/rheumatology/keq337. Epub 2010 Nov 23.

PMID:
21098574
49.
50.

Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release.

Kolker SJ, Walder RY, Usachev Y, Hillman J, Boyle DL, Firestein GS, Sluka KA.

Ann Rheum Dis. 2010 May;69(5):903-9. doi: 10.1136/ard.2009.117168. Epub 2009 Nov 23.

Supplemental Content

Loading ...
Support Center