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Items: 1 to 50 of 66

1.

Erector Spinae Plane Blocks in Major Hepatopancreaticobiliary Surgery: A Case Series.

Nair S, McGuinness S, Masood F, Boylan JF, Conlon NP.

A A Pract. 2019 Nov 1;13(9):332-334. doi: 10.1213/XAA.0000000000001069.

2.

Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.

Riggs JR, Elsner J, Cashion D, Robinson D, Tehrani L, Nagy M, Fultz KE, Krishna Narla R, Peng X, Tran T, Kulkarni A, Bahmanyar S, Condroski K, Pagarigan B, Fenalti G, LeBrun L, Leftheris K, Zhu D, Boylan JF.

J Med Chem. 2019 May 9;62(9):4401-4410. doi: 10.1021/acs.jmedchem.8b01869. Epub 2019 Apr 30.

PMID:
30998356
3.

Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint.

Zhu D, Xu S, Deyanat-Yazdi G, Peng SX, Barnes LA, Narla RK, Tran T, Mikolon D, Ning Y, Shi T, Jiang N, Raymon HK, Riggs JR, Boylan JF.

Mol Cancer Ther. 2018 Aug;17(8):1727-1738. doi: 10.1158/1535-7163.MCT-17-1084. Epub 2018 Jun 4.

4.

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, Katz J, Tang Y, Chen M, Moghaddam MF, Bahmanyar S, Pagarigan B, Delker S, LeBrun L, Chamberlain PP, Calabrese A, Canan SS, Leftheris K, Zhu D, Boylan JF.

J Med Chem. 2017 Nov 9;60(21):8989-9002. doi: 10.1021/acs.jmedchem.7b01223. Epub 2017 Oct 27.

PMID:
28991472
5.

What do we treat when we treat ARDS?

Yoshida T, Boylan JF, Kavanagh BP.

Intensive Care Med. 2016 Feb;42(2):284-6. doi: 10.1007/s00134-015-4150-1. Epub 2015 Dec 14. No abstract available.

PMID:
26667028
6.

Utility of near infrared light to determine tissue oxygenation during hepato-biliary surgery.

Murphy N, Fröhlich S, Kong T, Boylan JF, Conlon N.

J Clin Monit Comput. 2015 Oct;29(5):613-9. doi: 10.1007/s10877-014-9642-y. Epub 2014 Dec 11.

PMID:
25516160
7.

Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.

Dantas-Barbosa C, Bergthold G, Daudigeos-Dubus E, Blockus H, Boylan JF, Ferreira C, Puget S, Abely M, Vassal G, Grill J, Geoerger B.

Anticancer Drugs. 2015 Mar;26(3):272-83. doi: 10.1097/CAD.0000000000000190.

PMID:
25486598
8.

Alcoholic liver disease in the intensive care unit: outcomes and predictors of prognosis.

Fröhlich S, Murphy N, Kong T, Ffrench-O'Carroll R, Conlon N, Ryan D, Boylan JF.

J Crit Care. 2014 Dec;29(6):1131.e7-1131.e13. doi: 10.1016/j.jcrc.2014.06.002. Epub 2014 Jun 7.

PMID:
25070938
9.

Extreme heatstroke causing fulminant hepatic failure requiring liver transplantation: a case report.

Heneghan HM, Nazirawan F, Dorcaratto D, Fiore B, Boylan JF, Maguire D, Hoti E.

Transplant Proc. 2014 Sep;46(7):2430-2. doi: 10.1016/j.transproceed.2013.12.055. Epub 2014 Jul 3.

PMID:
24998305
10.

ARDS: progress unlikely with non-biological definition.

Fröhlich S, Murphy N, Boylan JF.

Br J Anaesth. 2013 Nov;111(5):696-9. doi: 10.1093/bja/aet165. No abstract available.

11.

Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability.

He W, Bennett MJ, Luistro L, Carvajal D, Nevins T, Smith M, Tyagi G, Cai J, Wei X, Lin TA, Heimbrook DC, Packman K, Boylan JF.

Mol Ther. 2014 Feb;22(2):359-370. doi: 10.1038/mt.2013.210. Epub 2013 Sep 3.

12.

Acute respiratory distress syndrome: current concepts and future directions.

Fröhlich S, Murphy N, Ryan D, Boylan JF.

Anaesth Intensive Care. 2013 Jul;41(4):463-72. Review.

13.

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.

Chen B, Tardell C, Higgins B, Packman K, Boylan JF, Niu H.

PLoS One. 2012;7(8):e42598. doi: 10.1371/journal.pone.0042598. Epub 2012 Aug 3.

14.

Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.

Tolcher AW, Messersmith WA, Mikulski SM, Papadopoulos KP, Kwak EL, Gibbon DG, Patnaik A, Falchook GS, Dasari A, Shapiro GI, Boylan JF, Xu ZX, Wang K, Koehler A, Song J, Middleton SA, Deutsch J, Demario M, Kurzrock R, Wheler JJ.

J Clin Oncol. 2012 Jul 1;30(19):2348-53. doi: 10.1200/JCO.2011.36.8282. Epub 2012 Apr 23.

15.

Identification of novel, potent and selective inhibitors of Polo-like kinase 1.

Chen S, Bartkovitz D, Cai J, Chen Y, Chen Z, Chu XJ, Le K, Le NT, Luk KC, Mischke S, Naderi-Oboodi G, Boylan JF, Nevins T, Qing W, Chen Y, Wovkulich PM.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1247-50. doi: 10.1016/j.bmcl.2011.11.052. Epub 2011 Dec 1.

PMID:
22172702
16.

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.

Huynh C, Poliseno L, Segura MF, Medicherla R, Haimovic A, Menendez S, Shang S, Pavlick A, Shao Y, Darvishian F, Boylan JF, Osman I, Hernando E.

PLoS One. 2011;6(9):e25264. doi: 10.1371/journal.pone.0025264. Epub 2011 Sep 29. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/a89c089f-ae9d-4453-a314-37efd5efb126.

17.

Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.

Ewton DZ, Hu J, Vilenchik M, Deng X, Luk KC, Polonskaia A, Hoffman AF, Zipf K, Boylan JF, Friedman EA.

Mol Cancer Ther. 2011 Nov;10(11):2104-14. doi: 10.1158/1535-7163.MCT-11-0498. Epub 2011 Aug 30.

18.

Consent in emergency care research.

Boylan JF, Conlon NP, Jaigirdar MJ.

Lancet. 2011 Jul 2;378(9785):25; author reply 27. doi: 10.1016/S0140-6736(11)61010-6. No abstract available.

PMID:
21724029
19.

Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.

Wang H, Daouti S, Li WH, Wen Y, Rizzo C, Higgins B, Packman K, Rosen N, Boylan JF, Heimbrook D, Niu H.

Cancer Res. 2011 Aug 15;71(16):5535-45. doi: 10.1158/0008-5472.CAN-10-4351. Epub 2011 Jun 24.

20.

Randomised controlled trials: important but overrated?

Boylan JF, Kavanagh BP, Armitage J.

J R Coll Physicians Edinb. 2011 Jun;41(2):126-31. doi: 10.4997/JRCPE.2011.216.

PMID:
21677918
21.

High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097.

He W, Luistro L, Carvajal D, Smith M, Nevins T, Yin X, Cai J, Higgins B, Kolinsky K, Rizzo C, Packman K, Heimbrook D, Boylan JF.

Mol Oncol. 2011 Jun;5(3):292-301. doi: 10.1016/j.molonc.2011.01.001. Epub 2011 Jan 21.

22.

Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

Luistro L, He W, Smith M, Packman K, Vilenchik M, Carvajal D, Roberts J, Cai J, Berkofsky-Fessler W, Hilton H, Linn M, Flohr A, Jakob-Røtne R, Jacobsen H, Glenn K, Heimbrook D, Boylan JF.

Cancer Res. 2009 Oct 1;69(19):7672-80. doi: 10.1158/0008-5472.CAN-09-1843. Epub 2009 Sep 22. Erratum in: Cancer Res. 2012 Apr 15;72(8):2151.

23.

Emergency airway management: competence versus expertise?

Boylan JF, Kavanagh BP.

Anesthesiology. 2008 Dec;109(6):945-7. doi: 10.1097/ALN.0b013e31818e3f8f. No abstract available.

PMID:
19034086
24.

The name of the game: no transfusion (or nontransfusion) by cookbook.

Boylan JF, Kavanagh BP.

Anesthesiology. 2008 Oct;109(4):745-6; author reply 747. doi: 10.1097/ALN.0b013e31818631d4. No abstract available.

PMID:
18813056
25.

Fatal fibrinolysis during orthotopic liver transplantation in patients receiving solvent/detergent-treated plasma (Octaplas).

Magner JJ, Crowley KJ, Boylan JF.

J Cardiothorac Vasc Anesth. 2007 Jun;21(3):410-3. Epub 2006 Dec 22. No abstract available.

PMID:
17544896
26.

Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury.

O'Croinin DF, Hopkins NO, Moore MM, Boylan JF, McLoughlin P, Laffey JG.

Crit Care Med. 2005 Nov;33(11):2606-12.

PMID:
16276187
27.

Airway management in the lateral position: a randomized controlled trial.

McCaul CL, Harney D, Ryan M, Moran C, Kavanagh BP, Boylan JF.

Anesth Analg. 2005 Oct;101(4):1221-5, table of contents.

PMID:
16192549
28.
29.

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.

Bowers AJ, Boylan JF.

Gene. 2004 Mar 17;328:135-42.

PMID:
15019993
30.

Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.

Laffey JG, Honan D, Hopkins N, Hyvelin JM, Boylan JF, McLoughlin P.

Am J Respir Crit Care Med. 2004 Jan 1;169(1):46-56. Epub 2003 Sep 4.

PMID:
12958048
31.

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.

Bowers AJ, Scully S, Boylan JF.

Oncogene. 2003 May 8;22(18):2823-35.

PMID:
12743605
32.

Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism.

Loughrey JP, Laffey JG, Moore BJ, Lynch F, Boylan JF, McLoughlin P.

Crit Care Med. 2003 Mar;31(3):910-5.

PMID:
12627004
33.

Assessment of a simple artificial neural network for predicting residual neuromuscular block.

Laffey JG, Tobin E, Boylan JF, McShane AJ.

Br J Anaesth. 2003 Jan;90(1):48-52.

34.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).

Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL.

J Med Chem. 2002 Nov 21;45(24):5233-48.

PMID:
12431051
35.

Decrease in bispectral index preceding intraoperative hemodynamic crisis: evidence of acute alteration of propofol pharmacokinetics.

Honan DM, Breen PJ, Boylan JF, McDonald NJ, Egan TD.

Anesthesiology. 2002 Nov;97(5):1303-5. No abstract available.

PMID:
12411818
36.

Atracurium is associated with postoperative residual curarization.

McCaul C, Tobin E, Boylan JF, McShane AJ.

Br J Anaesth. 2002 Nov;89(5):766-9.

37.

The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist.

Laffey JG, Boylan JF, Cheng DC.

Anesthesiology. 2002 Jul;97(1):215-52. Review. No abstract available.

PMID:
12131125
38.

Patient compliance with pre-operative day case instructions.

Laffey JG, Boylan JF.

Anaesthesia. 2001 Sep;56(9):910. No abstract available.

39.

Patient compliance with pre-operative day case instructions.

Laffey JG, Boylan JF.

Anaesthesia. 2001 Sep;56(9):906-924. No abstract available.

40.

Postoperative neurologic deficit despite normal cerebral oximetry during carotid endarterectomy.

Laffey JG, Mehigan D, Boylan JF.

J Clin Anesth. 2000 Nov;12(7):573-4. No abstract available.

PMID:
11221659
41.

Patients' knowledge of perioperative care.

Laffey JG, Coleman M, Boylan JF.

Ir J Med Sci. 2000 Apr-Jun;169(2):113-8.

PMID:
11006666
42.

Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation.

Sielecki TM, Boylan JF, Benfield PA, Trainor GL.

J Med Chem. 2000 Jan 13;43(1):1-18. Review. No abstract available.

PMID:
10633033
43.

Analysis of site-specific phosphorylation of the retinoblastoma protein during cell cycle progression.

Boylan JF, Sharp DM, Leffet L, Bowers A, Pan W.

Exp Cell Res. 1999 Apr 10;248(1):110-4.

PMID:
10094818
44.

Instructions for ambulatory surgery--patient comprehension and compliance.

Laffey JG, Carroll M, Donnelly N, Boylan JF.

Ir J Med Sci. 1998 Jul-Sep;167(3):160-3.

PMID:
9780565
45.

Reversibility of parkinsonism-induced acute upper airway obstruction by benztropine therapy.

Lydon AM, Boylan JF.

Anesth Analg. 1998 Oct;87(4):975-6. No abstract available.

PMID:
9768805
46.

Epidural bupivacaine-morphine analgesia versus patient-controlled analgesia following abdominal aortic surgery: analgesic, respiratory, and myocardial effects.

Boylan JF, Katz J, Kavanagh BP, Klinck JR, Cheng DC, DeMajo WC, Walker PM, Johnston KW, Sandler AN.

Anesthesiology. 1998 Sep;89(3):585-93.

PMID:
9743393
47.

Late-onset preemptive analgesia associated with preincisional large-dose alfentanil.

Griffin MJ, Hughes D, Knaggs A, Donnelly MB, Boylan JF.

Anesth Analg. 1997 Dec;85(6):1317-21.

PMID:
9390601
48.

Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation.

Boylan JF, Klinck JR, Sandler AN, Arellano R, Greig PD, Nierenberg H, Roger SL, Glynn MF.

Anesthesiology. 1996 Nov;85(5):1043-8; discussion 30A-31A.

PMID:
8916821
49.

Cocaine toxicity and isoflurane anesthesia: hemodynamic, myocardial metabolic, and regional blood flow effects in swine.

Boylan JF, Cheng DC, Sandler AN, Carmichael FJ, Koren G, Feindel C, Boylen P.

J Cardiothorac Vasc Anesth. 1996 Oct;10(6):772-7.

PMID:
8910158
50.

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