Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 18

1.

De novo design of bioactive protein switches.

Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D.

Nature. 2019 Aug;572(7768):205-210. doi: 10.1038/s41586-019-1432-8. Epub 2019 Jul 24.

PMID:
31341284
2.

Modular and tunable biological feedback control using a de novo protein switch.

Ng AH, Nguyen TH, Gómez-Schiavon M, Dods G, Langan RA, Boyken SE, Samson JA, Waldburger LM, Dueber JE, Baker D, El-Samad H.

Nature. 2019 Aug;572(7768):265-269. doi: 10.1038/s41586-019-1425-7. Epub 2019 Jul 24.

PMID:
31341280
3.

De novo design of tunable, pH-driven conformational changes.

Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D.

Science. 2019 May 17;364(6441):658-664. doi: 10.1126/science.aav7897.

PMID:
31097662
4.

Self-Assembling 2D Arrays with de Novo Protein Building Blocks.

Chen Z, Johnson MC, Chen J, Bick MJ, Boyken SE, Lin B, De Yoreo JJ, Kollman JM, Baker D, DiMaio F.

J Am Chem Soc. 2019 Jun 5;141(22):8891-8895. doi: 10.1021/jacs.9b01978. Epub 2019 May 10.

PMID:
31050411
5.

Programmable design of orthogonal protein heterodimers.

Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D.

Nature. 2019 Jan;565(7737):106-111. doi: 10.1038/s41586-018-0802-y. Epub 2018 Dec 19.

6.

Correction to Rapid Sampling of Hydrogen Bond Networks for Computational Protein Design.

Maguire JB, Boyken SE, Baker D, Kuhlman B.

J Chem Theory Comput. 2018 Oct 9;14(10):5434. doi: 10.1021/acs.jctc.8b00883. Epub 2018 Sep 17. No abstract available.

PMID:
30221938
7.

Rapid Sampling of Hydrogen Bond Networks for Computational Protein Design.

Maguire JB, Boyken SE, Baker D, Kuhlman B.

J Chem Theory Comput. 2018 May 8;14(5):2751-2760. doi: 10.1021/acs.jctc.8b00033. Epub 2018 Apr 20. Erratum in: J Chem Theory Comput. 2018 Oct 9;14(10):5434.

8.

Accurate computational design of multipass transmembrane proteins.

Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D.

Science. 2018 Mar 2;359(6379):1042-1046. doi: 10.1126/science.aaq1739.

PMID:
29496880
9.

An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.

Devkota S, Joseph RE, Boyken SE, Fulton DB, Andreotti AH.

Biochemistry. 2017 Jun 13;56(23):2938-2949. doi: 10.1021/acs.biochem.6b01182. Epub 2017 May 25.

10.

Modeling oblong proteins and water-mediated interfaces with RosettaDock in CAPRI rounds 28-35.

Marze NA, Jeliazkov JR, Roy Burman SS, Boyken SE, DiMaio F, Gray JJ.

Proteins. 2017 Mar;85(3):479-486. doi: 10.1002/prot.25168. Epub 2016 Oct 24.

11.

The coming of age of de novo protein design.

Huang PS, Boyken SE, Baker D.

Nature. 2016 Sep 15;537(7620):320-7. doi: 10.1038/nature19946. Review.

PMID:
27629638
12.

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.

Boyken SE, Chen Z, Groves B, Langan RA, Oberdorfer G, Ford A, Gilmore JM, Xu C, DiMaio F, Pereira JH, Sankaran B, Seelig G, Zwart PH, Baker D.

Science. 2016 May 6;352(6286):680-7. doi: 10.1126/science.aad8865. Erratum in: Science. 2016 May 20;352(6288). pii: aag1318. doi: 10.1126/science.aag1318.

13.

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH.

PLoS Comput Biol. 2016 Mar 24;12(3):e1004826. doi: 10.1371/journal.pcbi.1004826. eCollection 2016 Mar.

14.

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH.

J Mol Biol. 2014 Oct 23;426(21):3656-69. doi: 10.1016/j.jmb.2014.08.018. Epub 2014 Sep 2.

15.

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.

Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH.

Sci Signal. 2014 Aug 5;7(337):ra74. doi: 10.1126/scisignal.2005147.

16.

Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.

Boyken SE, Fulton DB, Andreotti AH.

Protein Sci. 2012 Sep;21(9):1288-97. doi: 10.1002/pro.2114. Epub 2012 Jul 16.

17.

Rates of molecular evolution vary in vertebrates for insulin-like growth factor-1 (IGF-1), a pleiotropic locus that regulates life history traits.

Sparkman AM, Schwartz TS, Madden JA, Boyken SE, Ford NB, Serb JM, Bronikowski AM.

Gen Comp Endocrinol. 2012 Aug 1;178(1):164-73. doi: 10.1016/j.ygcen.2012.04.022. Epub 2012 Apr 30.

PMID:
22569170
18.

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport.

Long F, Su CC, Zimmermann MT, Boyken SE, Rajashankar KR, Jernigan RL, Yu EW.

Nature. 2010 Sep 23;467(7314):484-8. doi: 10.1038/nature09395.

Supplemental Content

Loading ...
Support Center