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Items: 1 to 50 of 109

1.

Novel Point Mutations in cyp51A and cyp51B Genes Associated with Itraconazole and Posaconazole Resistance in Aspergillus clavatus Isolates.

Abastabar M, Hosseini T, Valadan R, Lagzian M, Haghani I, Aslani N, Badali H, Nouripour-Sisakht S, Nazeri M, Gholami S, Vakili M, Bowyer P, Shokohi T, Hedayati MT.

Microb Drug Resist. 2019 Jan 18. doi: 10.1089/mdr.2018.0300. [Epub ahead of print]

PMID:
30657433
2.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2018 Nov 20. pii: S0960-894X(18)30906-5. doi: 10.1016/j.bmcl.2018.11.039. [Epub ahead of print]

3.

Inducible Cell Fusion Permits Use of Competitive Fitness Profiling in the Human Pathogenic Fungus Aspergillus fumigatus.

Macdonald D, Thomson DD, Johns A, Contreras Valenzuela A, Gilsenan JM, Lord KM, Bowyer P, Denning DW, Read ND, Bromley MJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01615-18. doi: 10.1128/AAC.01615-18. Print 2019 Jan.

PMID:
30397071
4.

Pathophysiological aspects of Aspergillus colonization in disease.

Gago S, Denning DW, Bowyer P.

Med Mycol. 2018 Sep 15. doi: 10.1093/mmy/myy076. [Epub ahead of print]

PMID:
30239804
5.

Lung colonization by Aspergillus fumigatus is controlled by ZNF77.

Gago S, Overton NLD, Ben-Ghazzi N, Novak-Frazer L, Read ND, Denning DW, Bowyer P.

Nat Commun. 2018 Sep 20;9(1):3835. doi: 10.1038/s41467-018-06148-7.

6.

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).

Tsagris DJ, Birchall K, Bouloc N, Large JM, Merritt A, Smiljanic-Hurley E, Wheldon M, Ansell KH, Kettleborough C, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3168-3173. doi: 10.1016/j.bmcl.2018.08.028. Epub 2018 Aug 27.

PMID:
30174152
7.

Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.

Denning DW, Page ID, Chakaya J, Jabeen K, Jude CM, Cornet M, Alastruey-Izquierdo A, Bongomin F, Bowyer P, Chakrabarti A, Gago S, Guto J, Hochhegger B, Hoenigl M, Irfan M, Irurhe N, Izumikawa K, Kirenga B, Manduku V, Moazam S, Oladele RO, Richardson MD, Tudela JLR, Rozaliyani A, Salzer HJF, Sawyer R, Simukulwa NF, Skrahina A, Sriruttan C, Setianingrum F, Wilopo BAP, Cole DC, Getahun H.

Emerg Infect Dis. 2018 Aug;24(8). doi: 10.3201/eid2408.171312.

8.

Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.

Ubillos I, Jiménez A, Vidal M, Bowyer PW, Gaur D, Dutta S, Gamain B, Coppel R, Chauhan V, Lanar D, Chitnis C, Angov E, Beeson J, Cavanagh D, Campo JJ, Aguilar R, Dobaño C.

Malar J. 2018 Jun 1;17(1):219. doi: 10.1186/s12936-018-2369-3.

9.

Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle.

Stefanini I, Rizzetto L, Rivero D, Carbonell S, Gut M, Heath S, Gut IG, Trabocchi A, Guarna A, Ben Ghazzi N, Bowyer P, Kapushesky M, Cavalieri D.

Sci Rep. 2018 Apr 13;8(1):5964. doi: 10.1038/s41598-018-24341-y.

10.

Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages.

Overton NLD, Brakhage AA, Thywißen A, Denning DW, Bowyer P.

PLoS One. 2018 Mar 16;13(3):e0185706. doi: 10.1371/journal.pone.0185706. eCollection 2018.

11.

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species.

Kjærbølling I, Vesth TC, Frisvad JC, Nybo JL, Theobald S, Kuo A, Bowyer P, Matsuda Y, Mondo S, Lyhne EK, Kogle ME, Clum A, Lipzen A, Salamov A, Ngan CY, Daum C, Chiniquy J, Barry K, LaButti K, Haridas S, Simmons BA, Magnuson JK, Mortensen UH, Larsen TO, Grigoriev IV, Baker SE, Andersen MR.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E753-E761. doi: 10.1073/pnas.1715954115. Epub 2018 Jan 9.

12.

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

Fraczek MG, Chishimba L, Niven RM, Bromley M, Simpson A, Smyth L, Denning DW, Bowyer P.

J Allergy Clin Immunol. 2018 Aug;142(2):407-414. doi: 10.1016/j.jaci.2017.09.039. Epub 2017 Nov 6.

PMID:
29122659
13.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA.

Nat Commun. 2017 Sep 5;8(1):430. doi: 10.1038/s41467-017-00572-x.

14.

The establishment of a WHO Reference Reagent for anti-malaria (Plasmodium falciparum) human serum.

Bryan D, Silva N, Rigsby P, Dougall T, Corran P, Bowyer PW, Ho MM; Collaborative study group.

Malar J. 2017 Aug 5;16(1):314. doi: 10.1186/s12936-017-1958-x.

15.

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.

Beattie SR, Mark KMK, Thammahong A, Ries LNA, Dhingra S, Caffrey-Carr AK, Cheng C, Black CC, Bowyer P, Bromley MJ, Obar JJ, Goldman GH, Cramer RA.

PLoS Pathog. 2017 Apr 19;13(4):e1006340. doi: 10.1371/journal.ppat.1006340. eCollection 2017 Apr.

16.

Genetic susceptibility to severe asthma with fungal sensitization.

Overton NL, Simpson A, Bowyer P, Denning DW.

Int J Immunogenet. 2017 Jun;44(3):93-106. doi: 10.1111/iji.12312. Epub 2017 Mar 31.

PMID:
28371335
17.

Correction: Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.

Bromley M, Johns A, Davies E, Fraczek M, Gilsenan JM, Kurbatova N, Keays M, Kapushesky M, Gut M, Gut I, Denning DW, Bowyer P.

PLoS One. 2017 Feb 2;12(2):e0171787. doi: 10.1371/journal.pone.0171787. eCollection 2017.

18.

Correction: Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ.

PLoS Pathog. 2016 Dec 14;12(12):e1006106. doi: 10.1371/journal.ppat.1006106. eCollection 2016 Dec.

19.

Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study.

Overton NL, Denning DW, Bowyer P, Simpson A.

Allergy Asthma Clin Immunol. 2016 Sep 27;12:47. eCollection 2016.

20.

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ.

PLoS Pathog. 2016 Jul 20;12(7):e1005775. doi: 10.1371/journal.ppat.1005775. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2016 Dec 14;12 (12 ):e1006106.

21.

Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.

Bromley M, Johns A, Davies E, Fraczek M, Mabey Gilsenan J, Kurbatova N, Keays M, Kapushesky M, Gut M, Gut I, Denning DW, Bowyer P.

PLoS One. 2016 Jul 20;11(7):e0158724. doi: 10.1371/journal.pone.0158724. eCollection 2016. Erratum in: PLoS One. 2017 Feb 2;12 (2):e0171787.

22.

Determining the Internal Validity of the Inventory of Reading Occupations: An Assessment Tool of Children's Reading Participation.

Grajo LC, Candler C, Bowyer P, Schultz S, Thomson J, Fong K.

Am J Occup Ther. 2016 May-Jun;70(3):7003220010p1-9. doi: 10.5014/ajot.2016.017582.

23.

A Study of the Amputee Experience of Viewing Self in the Mirror.

Freysteinson W, Thomas L, Sebastian-Deutsch A, Douglas D, Melton D, Celia T, Reeves K, Bowyer P.

Rehabil Nurs. 2017 Jan/Feb;42(1):22-32. doi: 10.1002/rnj.256.

24.

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.

Green JL, Moon RW, Whalley D, Bowyer PW, Wallace C, Rochani A, Nageshan RK, Howell SA, Grainger M, Jones HM, Ansell KH, Chapman TM, Taylor DL, Osborne SA, Baker DA, Tatu U, Holder AA.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1464-75. doi: 10.1128/AAC.01748-15.

25.

Using magnetic coupling to implement (1)H, (19)F, (13)C experiments in routine high resolution NMR probes.

Bowyer P, Finnigan J, Marsden B, Taber B, Zens A.

J Magn Reson. 2015 Dec;261:190-8. doi: 10.1016/j.jmr.2015.10.010. Epub 2015 Nov 10.

PMID:
26619074
26.

Workshop report: Malaria vaccine development in Europe--preparing for the future.

Viebig NK, D'Alessio F, Draper SJ, Sim BK, Mordmüller B, Bowyer PW, Luty AJ, Jungbluth S, Chitnis CE, Hill AV, Kremsner P, Craig AG, Kocken CH, Leroy O.

Vaccine. 2015 Nov 17;33(46):6137-44. doi: 10.1016/j.vaccine.2015.09.074. Epub 2015 Oct 1. Review.

PMID:
26431986
27.

Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity.

Bowyer PW, Stewart LB, Aspeling-Jones H, Mensah-Brown HE, Ahouidi AD, Amambua-Ngwa A, Awandare GA, Conway DJ.

Infect Immun. 2015 Jun;83(6):2575-82. doi: 10.1128/IAI.03009-14. Epub 2015 Apr 13.

28.

Occurrence of azole-resistant species of Aspergillus in the UK environment.

Bromley MJ, van Muijlwijk G, Fraczek MG, Robson G, Verweij PE, Denning DW, Bowyer P.

J Glob Antimicrob Resist. 2014 Dec;2(4):276-279. doi: 10.1016/j.jgar.2014.05.004. Epub 2014 Jun 21.

PMID:
27873687
29.

A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.

Alcazar-Fuoli L, Cairns T, Lopez JF, Zonja B, Pérez S, Barceló D, Igarashi Y, Bowyer P, Bignell E.

PLoS One. 2014 Nov 5;9(11):e111875. doi: 10.1371/journal.pone.0111875. eCollection 2014.

30.

Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model.

Namvar S, Warn P, Farnell E, Bromley M, Fraczek M, Bowyer P, Herrick S.

Clin Exp Allergy. 2015 May;45(5):982-993. doi: 10.1111/cea.12426.

PMID:
25270353
31.

Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis.

Smith NL, Bromley MJ, Denning DW, Simpson A, Bowyer P.

J Infect Dis. 2015 Feb 15;211(4):651-60. doi: 10.1093/infdis/jiu490. Epub 2014 Sep 5.

PMID:
25193981
32.

A novel antifungal is active against Candida albicans biofilms and inhibits mutagenic acetaldehyde production in vitro.

Nieminen MT, Novak-Frazer L, Rautemaa W, Rajendran R, Sorsa T, Ramage G, Bowyer P, Rautemaa R.

PLoS One. 2014 Jul 3;9(7):e101859. doi: 10.1371/journal.pone.0101859. eCollection 2014.

33.

DL-2-hydroxyisocaproic acid attenuates inflammatory responses in a murine Candida albicans biofilm model.

Nieminen MT, Hernandez M, Novak-Frazer L, Kuula H, Ramage G, Bowyer P, Warn P, Sorsa T, Rautemaa R.

Clin Vaccine Immunol. 2014 Sep;21(9):1240-5. doi: 10.1128/CVI.00339-14. Epub 2014 Jul 2.

34.

A novel antifungal is active against Candida albicans biofilms and inhibits mutagenic acetaldehyde production in vitro.

Nieminen MT, Novak-Frazer L, Rautemaa V, Rajendran R, Sorsa T, Ramage G, Bowyer P, Rautemaa R.

PLoS One. 2014 May 27;9(5):e97864. doi: 10.1371/journal.pone.0097864. eCollection 2014. Corrected and republished in: PLoS One. 2014;9(7):e101859.

35.

Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.

Smith NL, Hankinson J, Simpson A, Denning DW, Bowyer P.

Clin Microbiol Infect. 2014 Nov;20(11):O960-8. doi: 10.1111/1469-0691.12643. Epub 2014 May 15.

36.

A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.

Smith NL, Hankinson J, Simpson A, Bowyer P, Denning DW.

Clin Microbiol Infect. 2014 Aug;20(8):O480-8. doi: 10.1111/1469-0691.12473. Epub 2014 Apr 2.

37.

2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species.

Sakko M, Moore C, Novak-Frazer L, Rautemaa V, Sorsa T, Hietala P, Järvinen A, Bowyer P, Tjäderhane L, Rautemaa R.

Mycoses. 2014 Apr;57(4):214-21. doi: 10.1111/myc.12145. Epub 2013 Oct 11.

PMID:
24125484
38.

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.

Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M.

Nat Chem Biol. 2013 Oct;9(10):651-6. doi: 10.1038/nchembio.1315. Epub 2013 Aug 11.

39.

Voriconazole resistance in Aspergillus fumigatus: should we be concerned?

Denning DW, Bowyer P.

Clin Infect Dis. 2013 Aug;57(4):521-3. doi: 10.1093/cid/cit321. Epub 2013 May 10. No abstract available.

40.

Environmental fungicides and triazole resistance in Aspergillus.

Bowyer P, Denning DW.

Pest Manag Sci. 2014 Feb;70(2):173-8. doi: 10.1002/ps.3567. Epub 2013 Dec 5.

PMID:
23616354
41.

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.

Fraczek MG, Bromley M, Buied A, Moore CB, Rajendran R, Rautemaa R, Ramage G, Denning DW, Bowyer P.

J Antimicrob Chemother. 2013 Jul;68(7):1486-96. doi: 10.1093/jac/dkt075. Epub 2013 Apr 10.

PMID:
23580559
42.

Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans.

Marttila E, Bowyer P, Sanglard D, Uittamo J, Kaihovaara P, Salaspuro M, Richardson M, Rautemaa R.

Mol Oral Microbiol. 2013 Aug;28(4):281-91. doi: 10.1111/omi.12024. Epub 2013 Feb 28.

PMID:
23445445
43.

Strain dependent variation of immune responses to A. fumigatus: definition of pathogenic species.

Rizzetto L, Giovannini G, Bromley M, Bowyer P, Romani L, Cavalieri D.

PLoS One. 2013;8(2):e56651. doi: 10.1371/journal.pone.0056651. Epub 2013 Feb 18.

44.

Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis.

Howard SJ, Pasqualotto AC, Anderson MJ, Leatherbarrow H, Albarrag AM, Harrison E, Gregson L, Bowyer P, Denning DW.

Mycoses. 2013 Jul;56(4):434-41. doi: 10.1111/myc.12047. Epub 2013 Feb 1.

PMID:
23369025
45.

Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.

Buchholz KR, Bowyer PW, Boothroyd JC.

Eukaryot Cell. 2013 Mar;12(3):399-410. doi: 10.1128/EC.00343-12. Epub 2013 Jan 4.

46.

High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.

Buied A, Moore CB, Denning DW, Bowyer P.

J Antimicrob Chemother. 2013 Mar;68(3):512-4. doi: 10.1093/jac/dks451. Epub 2012 Dec 2.

PMID:
23208831
47.

Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya.

Nieminen MT, Novak-Frazer L, Collins R, Dawsey SP, Dawsey SM, Abnet CC, White RE, Freedman ND, Mwachiro M, Bowyer P, Salaspuro M, Rautemaa R.

Cancer Epidemiol Biomarkers Prev. 2013 Jan;22(1):69-75. doi: 10.1158/1055-9965.EPI-12-0908. Epub 2012 Nov 15.

48.

Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates.

Farnell E, Rousseau K, Thornton DJ, Bowyer P, Herrick SE.

Fungal Biol. 2012 Sep;116(9):1003-12. doi: 10.1016/j.funbio.2012.07.004. Epub 2012 Jul 20.

49.

The role of cGMP signalling in regulating life cycle progression of Plasmodium.

Hopp CS, Bowyer PW, Baker DA.

Microbes Infect. 2012 Aug;14(10):831-7. doi: 10.1016/j.micinf.2012.04.011. Epub 2012 May 3. Review.

50.

Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.

Bowyer P, Mosquera J, Anderson M, Birch M, Bromley M, Denning DW.

FEMS Microbiol Lett. 2012 Jul;332(1):10-9. doi: 10.1111/j.1574-6968.2012.02575.x. Epub 2012 May 21.

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