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Items: 1 to 50 of 105

1.

Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers.

Merugu S, Chen L, Gavens E, Gabra H, Brougham M, Makin G, Ng A, Murphy D, Gabriel AS, Robinson ML, Wright JH, Burchill SA, Humphreys A, Bown N, Jamieson D, Tweddle DA.

Clin Cancer Res. 2019 Nov 25. doi: 10.1158/1078-0432.CCR-19-0656. [Epub ahead of print]

PMID:
31767563
2.

Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells.

Ciardullo C, Aptullahoglu E, Woodhouse L, Lin WY, Wallis JP, Marr H, Marshall S, Bown N, Willmore E, Lunec J.

Haematologica. 2019 Dec;104(12):2429-2442. doi: 10.3324/haematol.2018.206631. Epub 2019 Apr 19.

3.

Characterization and drug sensitivity of a novel human ovarian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor.

Franklin M, Gentles L, Matheson E, Bown N, Cross P, Ralte A, Gilkes-Immeson C, Bradbury A, Zanjirband M, Lunec J, Drew Y, O'Donnell R, Curtin NJ.

Cancer Med. 2018 Sep;7(9):4744-4754. doi: 10.1002/cam4.1724. Epub 2018 Aug 14.

4.

Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study.

Berbegall AP, Bogen D, Pötschger U, Beiske K, Bown N, Combaret V, Defferrari R, Jeison M, Mazzocco K, Varesio L, Vicha A, Ash S, Castel V, Coze C, Ladenstein R, Owens C, Papadakis V, Ruud E, Amann G, Sementa AR, Navarro S, Ambros PF, Noguera R, Ambros IM.

Br J Cancer. 2018 May;118(11):1502-1512. doi: 10.1038/s41416-018-0098-6. Epub 2018 May 14.

5.

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 109 /L - RESPONSE to Yan et al.

Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A, Marsh JCW; British Society for Standards in Haematology AA Guidelines Committee.

Br J Haematol. 2018 Jul;182(2):286-287. doi: 10.1111/bjh.14766. Epub 2017 May 23. No abstract available.

PMID:
28542907
6.

Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse.

Chen L, Humphreys A, Turnbull L, Bellini A, Schleiermacher G, Salwen H, Cohn SL, Bown N, Tweddle DA.

Oncotarget. 2016 Dec 27;7(52):87301-87311. doi: 10.18632/oncotarget.13541.

7.

Factors associated with recurrence and survival length following relapse in patients with neuroblastoma.

Basta NO, Halliday GC, Makin G, Birch J, Feltbower R, Bown N, Elliott M, Moreno L, Barone G, Pearson AD, James PW, Tweddle DA, McNally RJ.

Br J Cancer. 2016 Oct 25;115(9):1048-1057. doi: 10.1038/bjc.2016.302. Epub 2016 Oct 4.

8.

The clinical utility of genetic testing of tissues from pregnancy losses.

Waterman CA, Batstone P, Bown N, Cresswell L, Delmege C, English CJ, Fews G, Grimsley L, Imrie S, Kulkarni A, Mann K, Johnson R, Morgan SM, Roberts P, Simonic I, Trueman S, Wall M, McMullan D.

BJOG. 2018 Jun;125(7):867-873. doi: 10.1111/1471-0528.14229. Epub 2016 Sep 5.

9.

The role of the RAS pathway in iAMP21-ALL.

Ryan SL, Matheson E, Grossmann V, Sinclair P, Bashton M, Schwab C, Towers W, Partington M, Elliott A, Minto L, Richardson S, Rahman T, Keavney B, Skinner R, Bown N, Haferlach T, Vandenberghe P, Haferlach C, Santibanez-Koref M, Moorman AV, Kohlmann A, Irving JA, Harrison CJ.

Leukemia. 2016 Sep;30(9):1824-31. doi: 10.1038/leu.2016.80. Epub 2016 Apr 22.

10.

The effect of FLT3-ITD and NPM1 mutation on survival in intensively treated elderly patients with cytogenetically normal acute myeloid leukemia - Response to Rashidi et al.

McGregor AK, Moulton D, Bown N, Cuthbert G, Bourn D, Mathew S, Dang R, Mounter P, Jones G.

Leuk Lymphoma. 2016 Aug;57(8):1980-1. doi: 10.3109/10428194.2016.1169412. Epub 2016 Apr 19. No abstract available.

PMID:
27090743
11.

Incidence and outcomes for adults diagnosed with acute myeloid leukemia in the north of England: a real world study.

McGregor AK, Moulton D, Bown N, Cuthbert G, Bourn D, Mathew S, Dang R, Mounter P, Jones G.

Leuk Lymphoma. 2016 Jul;57(7):1575-84. doi: 10.3109/10428194.2015.1108413. Epub 2015 Dec 15.

PMID:
26666339
12.

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma.

Decock A, Ongenaert M, Cannoodt R, Verniers K, De Wilde B, Laureys G, Van Roy N, Berbegall AP, Bienertova-Vasku J, Bown N, Clément N, Combaret V, Haber M, Hoyoux C, Murray J, Noguera R, Pierron G, Schleiermacher G, Schulte JH, Stallings RL, Tweddle DA; Children’s Cancer and Leukaemia Group (CCLG), De Preter K, Speleman F, Vandesompele J.

Oncotarget. 2016 Jan 12;7(2):1960-72. doi: 10.18632/oncotarget.6477.

13.

Guidelines for the diagnosis and management of adult aplastic anaemia.

Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A, Marsh JC; British Society for Standards in Haematology.

Br J Haematol. 2016 Jan;172(2):187-207. doi: 10.1111/bjh.13853. Epub 2015 Nov 16. No abstract available. Erratum in: Br J Haematol. 2016 Nov;175(3):546.

PMID:
26568159
14.

Exome Sequencing of an Adult Pituitary Atypical Teratoid Rhabdoid Tumor.

Biswas S, Wood M, Joshi A, Bown N, Strain L, Martinsson T, Campbell J, Ashworth A, Swain A.

Front Oncol. 2015 Oct 23;5:236. doi: 10.3389/fonc.2015.00236. eCollection 2015.

15.

Response to the letter to the editor: 1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk satisfaction in the SIOP2009/Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) trial.

Pritchard-Jones K, Williams R, Segers H, van den Heuvel-Eibrink M, Pieters R, van Tinteren H, Vujanic G, Bown N.

Genes Chromosomes Cancer. 2015 Jun;54(6):397-9. doi: 10.1002/gcc.22250. Epub 2015 Mar 28. No abstract available.

PMID:
25820248
16.

Guidelines for cytogenetic investigations in tumours.

Hastings RJ, Bown N, Tibiletti MG, Debiec-Rychter M, Vanni R, Espinet B, van Roy N, Roberts P, van den Berg-de-Ruiter E, Bernheim A, Schoumans J, Chatters S, Zemanova Z, Stevens-Kroef M, Simons A, Heim S, Salido M, Ylstra B, Betts DR; Tumour Best Practice meeting; Eurogentest.

Eur J Hum Genet. 2016 Jan;24(1):6-13. doi: 10.1038/ejhg.2015.35. Epub 2015 Mar 25. No abstract available.

17.

c-MYC is a radiosensitive locus in human breast cells.

Wade MA, Sunter NJ, Fordham SE, Long A, Masic D, Russell LJ, Harrison CJ, Rand V, Elstob C, Bown N, Rowe D, Lowe C, Cuthbert G, Bennett S, Crosier S, Bacon CM, Onel K, Scott K, Scott D, Travis LB, May FE, Allan JM.

Oncogene. 2015 Sep 17;34(38):4985-94. doi: 10.1038/onc.2014.427. Epub 2014 Dec 22.

18.

Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis.

Bomken S, Haigh S, Bown N, Carey P, Wood K, Windebank K.

Pediatr Blood Cancer. 2015 Jun;62(6):1055-7. doi: 10.1002/pbc.25318. Epub 2014 Nov 8.

PMID:
25382309
19.

Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification.

Defferrari R, Mazzocco K, Ambros IM, Ambros PF, Bedwell C, Beiske K, Bénard J, Berbegall AP, Bown N, Combaret V, Couturier J, Erminio G, Gambini C, Garaventa A, Gross N, Haupt R, Kohler J, Jeison M, Lunec J, Marques B, Martinsson T, Noguera R, Parodi S, Schleiermacher G, Tweddle DA, Valent A, Van Roy N, Vicha A, Villamon E, Tonini GP.

Br J Cancer. 2015 Jan 20;112(2):290-5. doi: 10.1038/bjc.2014.557. Epub 2014 Nov 4.

20.

Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors.

Thway K, Bown N, Miah A, Turner R, Fisher C.

Head Neck Pathol. 2015 Jun;9(2):273-9. doi: 10.1007/s12105-014-0556-2. Epub 2014 Jul 4.

21.

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia.

Li Y, Schwab C, Ryan S, Papaemmanuil E, Robinson HM, Jacobs P, Moorman AV, Dyer S, Borrow J, Griffiths M, Heerema NA, Carroll AJ, Talley P, Bown N, Telford N, Ross FM, Gaunt L, McNally RJQ, Young BD, Sinclair P, Rand V, Teixeira MR, Joseph O, Robinson B, Maddison M, Dastugue N, Vandenberghe P, Stephens PJ, Cheng J, Van Loo P, Stratton MR, Campbell PJ, Harrison CJ.

Nature. 2014 Apr 3;508(7494):98-102. doi: 10.1038/nature13115. Epub 2014 Mar 23.

22.

Gain of 1q is a marker of poor prognosis in Wilms' tumors.

Segers H, van den Heuvel-Eibrink MM, Williams RD, van Tinteren H, Vujanic G, Pieters R, Pritchard-Jones K, Bown N; Children's Cancer and Leukaemia Group and the UK Cancer Cytogenetics Group.

Genes Chromosomes Cancer. 2013 Nov;52(11):1065-74. doi: 10.1002/gcc.22101. Epub 2013 Sep 4.

PMID:
24038759
23.

Pediatric chronic myeloid leukemia with B-cell lymphoid blast crisis at presentation.

Iyer P, Carey P, Bown N, Samarasinghe S.

Blood Res. 2013 Jun;48(2):151-2. doi: 10.5045/br.2013.48.2.151. Epub 2013 Jun 25. No abstract available.

24.

Acute lymphoblastic leukemia associated with RCSD1-ABL1 novel fusion gene has a distinct gene expression profile from BCR-ABL1 fusion.

De Braekeleer E, Douet-Guilbert N, Guardiola P, Rowe D, Mustjoki S, Zamecnikova A, Al Bahar S, Jaramillo G, Berthou C, Bown N, Porkka K, Ochoa C, De Braekeleer M.

Leukemia. 2013 Jun;27(6):1422-4. doi: 10.1038/leu.2012.332. Epub 2012 Nov 20. No abstract available.

PMID:
23168614
25.

Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

Schleiermacher G, Michon J, Ribeiro A, Pierron G, Mosseri V, Rubie H, Munzer C, Bénard J, Auger N, Combaret V, Janoueix-Lerosey I, Pearson A, Tweddle DA, Bown N, Gerrard M, Wheeler K, Noguera R, Villamon E, Cañete A, Castel V, Marques B, de Lacerda A, Tonini GP, Mazzocco K, Defferrari R, de Bernardi B, di Cataldo A, van Roy N, Brichard B, Ladenstein R, Ambros I, Ambros P, Beiske K, Delattre O, Couturier J.

Br J Cancer. 2011 Dec 6;105(12):1940-8. doi: 10.1038/bjc.2011.472. Epub 2011 Nov 10.

26.

Wilms tumor incidence in children with 2q terminal deletions: a cohort study.

Jones EA, Stewart A, Stiller C, Douglas F, Bown N.

Am J Med Genet A. 2011 Sep;155A(9):2221-3. doi: 10.1002/ajmg.a.34117. Epub 2011 Aug 3.

PMID:
21815249
27.

ABL1 fusion genes in hematological malignancies: a review.

De Braekeleer E, Douet-Guilbert N, Rowe D, Bown N, Morel F, Berthou C, Férec C, De Braekeleer M.

Eur J Haematol. 2011 May;86(5):361-71. doi: 10.1111/j.1600-0609.2011.01586.x. Epub 2011 Mar 23. Review.

PMID:
21435002
28.

A multilocus technique for risk evaluation of patients with neuroblastoma.

Ambros IM, Brunner B, Aigner G, Bedwell C, Beiske K, Bénard J, Bown N, Combaret V, Couturier J, Defferrari R, Gross N, Jeison M, Lunec J, Marques B, Martinsson T, Mazzocco K, Noguera R, Schleiermacher G, Speleman F, Stallings R, Tonini GP, Tweddle DA, Valent A, Vicha A, Roy NV, Villamon E, Ziegler A, Preuner S, Drobics M, Ladenstein R, Amann G, Schuit RJ, Pötschger U, Ambros PF.

Clin Cancer Res. 2011 Feb 15;17(4):792-804. doi: 10.1158/1078-0432.CCR-10-0830.

29.

Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas.

Bedwell C, Rowe D, Moulton D, Jones G, Bown N, Bacon CM.

Haematologica. 2011 Feb;96(2):343-6. doi: 10.3324/haematol.2010.031484. Epub 2010 Nov 25. No abstract available.

30.

Cryptic EWSR1-FLI1 fusions in Ewing sarcoma: potential pitfalls in the diagnostic use of fluorescence in situ hybridization probes.

Newby R, Rowe D, Paterson L, Farquharson MA, MacDuff E, Coupe A, Hale J, Dildey P, Bown N.

Cancer Genet Cytogenet. 2010 Jul 1;200(1):60-4. doi: 10.1016/j.cancergencyto.2010.03.005.

PMID:
20513536
31.

Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia.

Konn ZJ, Martineau M, Bown N, Richards S, Swansbury J, Talley P, Wright SL, Harrison CJ.

Genes Chromosomes Cancer. 2010 Mar;49(3):253-9. doi: 10.1002/gcc.20736.

PMID:
19998443
32.

Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia.

Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J.

Haematologica. 2010 Apr;95(4):679-83. doi: 10.3324/haematol.2009.011726. Epub 2009 Nov 30.

33.

Extraosseous pericardial Ewing's sarcoma.

Azribi F, Razak AR, Bough G, Lee D, Rowe D, Bown N, Dildey P, Clark S, Plummer R.

J Clin Oncol. 2010 Feb 1;28(4):e48-50. doi: 10.1200/JCO.2009.23.7487. Epub 2009 Nov 16. No abstract available.

PMID:
19917868
34.

A population-based cytogenetic study of adults with acute lymphoblastic leukemia.

Moorman AV, Chilton L, Wilkinson J, Ensor HM, Bown N, Proctor SJ.

Blood. 2010 Jan 14;115(2):206-14. doi: 10.1182/blood-2009-07-232124. Epub 2009 Nov 6. Erratum in: Blood. 2010 Aug 12;116(6):1017.

PMID:
19897583
35.

Post cardiac transplantation lymphoproliferative disorder presenting as t(8;14) Burkitt leukaemia/lymphoma treated with low intensity chemotherapy and rituximab.

Windebank K, Walwyn T, Kirk R, Parry G, Hasan A, Bown N, Wilkins B.

Pediatr Blood Cancer. 2009 Sep;53(3):392-6. doi: 10.1002/pbc.22070.

PMID:
19459198
36.

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

Sulong S, Moorman AV, Irving JA, Strefford JC, Konn ZJ, Case MC, Minto L, Barber KE, Parker H, Wright SL, Stewart AR, Bailey S, Bown NP, Hall AG, Harrison CJ.

Blood. 2009 Jan 1;113(1):100-7. doi: 10.1182/blood-2008-07-166801. Epub 2008 Oct 6.

PMID:
18838613
37.

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

Case M, Matheson E, Minto L, Hassan R, Harrison CJ, Bown N, Bailey S, Vormoor J, Hall AG, Irving JA.

Cancer Res. 2008 Aug 15;68(16):6803-9. doi: 10.1158/0008-5472.CAN-08-0101.

38.

FIP1L1-PDGFRA positive chronic eosinophilic leukaemia and associated central nervous system involvement.

Williams C, Kalra S, Nath U, Bown N, Wilson V, Wilkins BS, Neylon AJ.

J Clin Pathol. 2008 May;61(5):677-80. doi: 10.1136/jcp.2007.052100. Epub 2008 Feb 6.

PMID:
18256119
39.

Long-term immune reconstitution after anti-CD52-treated or anti-CD34-treated hematopoietic stem cell transplantation for severe T-lymphocyte immunodeficiency.

Slatter MA, Brigham K, Dickinson AM, Harvey HL, Barge D, Jackson A, Bown N, Flood TJ, Cant AJ, Abinun M, Gennery AR.

J Allergy Clin Immunol. 2008 Feb;121(2):361-7. Epub 2007 Dec 20.

PMID:
18086494
40.

Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: a study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group.

Roberts P, Burchill SA, Brownhill S, Cullinane CJ, Johnston C, Griffiths MJ, McMullan DJ, Bown NP, Morris SP, Lewis IJ.

Genes Chromosomes Cancer. 2008 Mar;47(3):207-20.

PMID:
18064647
41.

The lure of 'patient choice'.

Bryant LD, Bown N, Bekker HL, House A.

Br J Gen Pract. 2007 Oct;57(543):822-6.

42.

Quantitative assessment of mixed chimerism in allogeneic stem cell transplant patients: a comparison of molecular genetic and cytogenetic approaches.

Routledge D, Jackson A, Bourn D, Bown N, Cole M, Slatter MA, Gennery AR, Curtis A.

J Pediatr Hematol Oncol. 2007 Jun;29(6):428-31.

PMID:
17551410
43.

Donor lymphocyte infusions for post-transplant relapse of refractory anemia with excess blasts and monosomy 7.

Skinner R, Velangi M, Bown N.

Pediatr Blood Cancer. 2008 Mar;50(3):670-2.

PMID:
17253642
44.

High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays.

Carr J, Bown NP, Case MC, Hall AG, Lunec J, Tweddle DA.

Cancer Genet Cytogenet. 2007 Jan 15;172(2):127-38.

PMID:
17213021
45.

Population-based demographic study of karyotypes in 1709 patients with adult acute myeloid leukemia.

Sanderson RN, Johnson PR, Moorman AV, Roman E, Willett E, Taylor PR, Proctor SJ, Bown N, Ogston S, Bowen DT.

Leukemia. 2006 Mar;20(3):444-50.

PMID:
16424877
46.

Acquired isodisomy for chromosome 13 is common in AML, and associated with FLT3-itd mutations.

Griffiths M, Mason J, Rindl M, Akiki S, McMullan D, Stinton V, Powell H, Curtis A, Bown N, Craddock C.

Leukemia. 2005 Dec;19(12):2355-8. No abstract available.

PMID:
16239911
47.

Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma.

Langdon JA, Lamont JM, Scott DK, Dyer S, Prebble E, Bown N, Grundy RG, Ellison DW, Clifford SC.

Genes Chromosomes Cancer. 2006 Jan;45(1):47-60.

PMID:
16149064
48.

Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis.

Irving JA, Bloodworth L, Bown NP, Case MC, Hogarth LA, Hall AG.

Cancer Res. 2005 Apr 15;65(8):3053-8.

49.

Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma.

Vandesompele J, Baudis M, De Preter K, Van Roy N, Ambros P, Bown N, Brinkschmidt C, Christiansen H, Combaret V, Lastowska M, Nicholson J, O'Meara A, Plantaz D, Stallings R, Brichard B, Van den Broecke C, De Bie S, De Paepe A, Laureys G, Speleman F.

J Clin Oncol. 2005 Apr 1;23(10):2280-99.

50.

No correlation between trisomy 13 and FLT3 duplication in acute myeloid leukemia.

Powell H, Curtis A, Bown N, Taylor P.

Cancer Genet Cytogenet. 2005 Jan 1;156(1):92-3. No abstract available.

PMID:
15588866

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