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Items: 49

1.

Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy.

Mahne AE, Mauze S, Joyce-Shaikh B, Xia J, Bowman EP, Beebe AM, Cua DJ, Jain R.

Cancer Res. 2017 Mar 1;77(5):1108-1118. doi: 10.1158/0008-5472.CAN-16-0797. Epub 2016 Oct 20.

2.

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.

Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM, Cua DJ.

Nat Med. 2015 Jul;21(7):719-29. doi: 10.1038/nm.3895. Epub 2015 Jun 29. Review.

PMID:
26121196
3.

Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial.

Papp K, Thaçi D, Reich K, Riedl E, Langley RG, Krueger JG, Gottlieb AB, Nakagawa H, Bowman EP, Mehta A, Li Q, Zhou Y, Shames R.

Br J Dermatol. 2015 Oct;173(4):930-9. doi: 10.1111/bjd.13932. Epub 2015 Oct 15. Erratum in: Br J Dermatol. 2016 Jun;174(6):1426.

PMID:
26042589
4.

Clinical improvement in psoriasis with specific targeting of interleukin-23.

Kopp T, Riedl E, Bangert C, Bowman EP, Greisenegger E, Horowitz A, Kittler H, Blumenschein WM, McClanahan TK, Marbury T, Zachariae C, Xu D, Hou XS, Mehta A, Zandvliet AS, Montgomery D, van Aarle F, Khalilieh S.

Nature. 2015 May 14;521(7551):222-6. doi: 10.1038/nature14175. Epub 2015 Mar 9.

PMID:
25754330
5.

Crosstalk among IL-23 and DNAX activating protein of 12 kDa-dependent pathways promotes osteoclastogenesis.

Shin HS, Sarin R, Dixit N, Wu J, Gershwin E, Bowman EP, Adamopoulos IE.

J Immunol. 2015 Jan 1;194(1):316-24. doi: 10.4049/jimmunol.1401013. Epub 2014 Dec 1.

6.

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis.

Adamopoulos IE, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, Mcclanahan T, De Waal Malefyt R, Gershwin ME, Bowman EP.

Ann Rheum Dis. 2015 Jun;74(6):1284-92. doi: 10.1136/annrheumdis-2013-204782. Epub 2014 Feb 23.

7.

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.

Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, Vives F, Moon C, Penaflor E, Turner S, Ayanoglu G, Chang C, Basham B, Mumm JB, Pierce RH, Yearley JH, McClanahan TK, Phillips JH, Cua DJ, Bowman EP, Kastelein RA, LaFace D.

Mucosal Immunol. 2014 Jul;7(4):842-56. doi: 10.1038/mi.2013.101. Epub 2013 Nov 27.

PMID:
24280935
8.

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.

Cayatte C, Joyce-Shaikh B, Vega F, Boniface K, Grein J, Murphy E, Blumenschein WM, Chen S, Malinao MC, Basham B, Pierce RH, Bowman EP, McKenzie BS, Elson CO, Faubion WA, Malefyt Rde W, Kastelein RA, Cua D, McClanahan TK, Beaumont M.

Clin Transl Gastroenterol. 2012 Feb 16;3:e10. doi: 10.1038/ctg.2012.2.

9.

Interferon-γ signaling inhibition ameliorates angiotensin II-induced cardiac damage.

Markó L, Kvakan H, Park JK, Qadri F, Spallek B, Binger KJ, Bowman EP, Kleinewietfeld M, Fokuhl V, Dechend R, Müller DN.

Hypertension. 2012 Dec;60(6):1430-6. doi: 10.1161/HYPERTENSIONAHA.112.199265. Epub 2012 Oct 29.

PMID:
23108651
10.

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.

Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, Gorman DM, Bowman EP, McClanahan TK, Yearley JH, Eberl G, Buckley CD, Kastelein RA, Pierce RH, Laface DM, Cua DJ.

Nat Med. 2012 Jul 1;18(7):1069-76. doi: 10.1038/nm.2817.

PMID:
22772566
11.

Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model.

Joshi A, Pancari G, Cope L, Bowman EP, Cua D, Proctor RA, McNeely T.

Hum Vaccin Immunother. 2012 Mar;8(3):336-46. doi: 10.4161/hv.18946. Epub 2012 Feb 13.

12.

CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues.

Sisirak V, Vey N, Vanbervliet B, Duhen T, Puisieux I, Homey B, Bowman EP, Trinchieri G, Dubois B, Kaiserlian D, Lira SA, Puisieux A, Blay JY, Caux C, Bendriss-Vermare N.

Blood. 2011 Nov 10;118(19):5130-40. doi: 10.1182/blood-2010-07-295626. Epub 2011 Sep 21.

13.

IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass.

Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, Chou CC, Pierce RH, Yao W, Lane NE, Laface D, Bowman EP.

J Immunol. 2011 Jul 15;187(2):951-9. doi: 10.4049/jimmunol.1003986. Epub 2011 Jun 13.

14.

Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis.

Chao CC, Chen SJ, Adamopoulos IE, Davis N, Hong K, Vu A, Kwan S, Fayadat-Dilman L, Asio A, Bowman EP.

Autoimmunity. 2011 May;44(3):243-52. doi: 10.3109/08916934.2010.517815. Epub 2010 Oct 7.

PMID:
20925596
15.

Structural, cellular, and molecular evaluation of bone erosion in experimental models of rheumatoid arthritis: assessment by μCT, histology, and serum biomarkers.

Chao CC, Chen SJ, Adamopoulos IE, Judo M, Asio A, Ayanoglu G, Bowman EP.

Autoimmunity. 2010 Dec;43(8):642-53. doi: 10.3109/08916931003610992. Epub 2010 Apr 12.

PMID:
20380588
16.

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.

Joyce-Shaikh B, Bigler ME, Chao CC, Murphy EE, Blumenschein WM, Adamopoulos IE, Heyworth PG, Antonenko S, Bowman EP, McClanahan TK, Phillips JH, Cua DJ.

J Exp Med. 2010 Mar 15;207(3):579-89. doi: 10.1084/jem.20090516. Epub 2010 Mar 8.

17.

Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors.

Adamopoulos IE, Chao CC, Geissler R, Laface D, Blumenschein W, Iwakura Y, McClanahan T, Bowman EP.

Arthritis Res Ther. 2010;12(1):R29. doi: 10.1186/ar2936. Epub 2010 Feb 18.

18.

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

Hillyer P, Larché MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM.

Rheumatology (Oxford). 2009 Dec;48(12):1581-9. doi: 10.1093/rheumatology/kep293. Epub 2009 Oct 8.

19.

Immune regulation of bone loss by Th17 cells.

Adamopoulos IE, Bowman EP.

Arthritis Res Ther. 2008;10(5):225. doi: 10.1186/ar2502. Epub 2008 Oct 17. Review.

20.

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.

Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR.

J Exp Med. 2008 Apr 14;205(4):799-810. doi: 10.1084/jem.20071258. Epub 2008 Apr 7.

21.

Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.

Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, Bowman EP, Krueger JG.

J Invest Dermatol. 2008 May;128(5):1207-11. doi: 10.1038/sj.jid.5701213. Epub 2008 Jan 17.

22.

Development, cytokine profile and function of human interleukin 17-producing helper T cells.

Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R.

Nat Immunol. 2007 Sep;8(9):950-7. Epub 2007 Aug 5.

PMID:
17676044
23.

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.

Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K, de Waal Malefyt R, Kastelein RA, McClanahan TK, Bowman EP.

J Exp Med. 2006 Nov 27;203(12):2577-87. Epub 2006 Oct 30.

24.

Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection.

Chackerian AA, Chen SJ, Brodie SJ, Mattson JD, McClanahan TK, Kastelein RA, Bowman EP.

Infect Immun. 2006 Nov;74(11):6092-9. Epub 2006 Aug 21.

25.

A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease.

Faaij CM, Lankester AC, Spierings E, Hoogeboom M, Bowman EP, Bierings M, Révész T, Egeler RM, van Tol MJ, Annels NE.

Br J Haematol. 2006 Jun;133(5):538-49.

PMID:
16681643
26.

Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy.

Bowman EP, Chackerian AA, Cua DJ.

Curr Opin Infect Dis. 2006 Jun;19(3):245-52. Review.

PMID:
16645485
27.

Regulation of myeloid cell function through the CD200 receptor.

Jenmalm MC, Cherwinski H, Bowman EP, Phillips JH, Sedgwick JD.

J Immunol. 2006 Jan 1;176(1):191-9.

28.

Misdiagnosis of Asperger syndrome as personality disorder.

Bowman EP.

Autism. 2004 Mar;8(1):112-3. No abstract available.

PMID:
15074310
29.

CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.

Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC.

J Clin Invest. 2003 Apr;111(7):1001-10.

30.

Immune surveillance and effector functions of CCR10(+) skin homing T cells.

Hudak S, Hagen M, Liu Y, Catron D, Oldham E, McEvoy LM, Bowman EP.

J Immunol. 2002 Aug 1;169(3):1189-96.

31.

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.

Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL.

J Exp Med. 2002 May 6;195(9):1145-54.

32.

CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.

Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A.

Nat Med. 2002 Feb;8(2):157-65.

PMID:
11821900
33.

The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells.

Bowman EP, Kuklin NA, Youngman KR, Lazarus NH, Kunkel EJ, Pan J, Greenberg HB, Butcher EC.

J Exp Med. 2002 Jan 21;195(2):269-75.

34.

Developmental switches in chemokine response profiles during B cell differentiation and maturation.

Bowman EP, Campbell JJ, Soler D, Dong Z, Manlongat N, Picarella D, Hardy RR, Butcher EC.

J Exp Med. 2000 Apr 17;191(8):1303-18.

35.

Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.

Bowman EP, Campbell JJ, Druey KM, Scheschonka A, Kehrl JH, Butcher EC.

J Biol Chem. 1998 Oct 23;273(43):28040-8.

36.

6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7.

Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, Wu L, Zlotnik A, Butcher EC.

J Cell Biol. 1998 May 18;141(4):1053-9.

37.

ADP-ribosylation factor functions synergistically with a 50-kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D.

Lambeth JD, Kwak JY, Bowman EP, Perry D, Uhlinger DJ, Lopez I.

J Biol Chem. 1995 Feb 10;270(6):2431-4.

38.

Neutrophil phospholipase D: inhibition by Rho-GDP dissociation inhibitor and stimulation by small GTPase GDP dissociation stimulator.

Bowman EP, Uhlinger DJ, Lambeth JD.

Methods Enzymol. 1995;256:246-56. No abstract available.

PMID:
7476438
39.
42.

Chemical synthesis, initial conformational studies, and activity of rat steroidogenesis activator peptide and a truncated analog.

Glass DB, Robertson DG, Xu TS, Bowman EP, Lambeth JD.

Endocr Res. 1991;17(1-2):307-26.

PMID:
1879380
43.

Asperger's syndrome and autism: the case for a connection.

Bowman EP.

Br J Psychiatry. 1988 Mar;152:377-82.

PMID:
3167373
44.

Selective toxicity of deoxyadenosine analogues in human melanoma cell lines.

Parsons PG, Bowman EP, Blakley RL.

Biochem Pharmacol. 1986 Nov 15;35(22):4025-9.

PMID:
2430574
45.

A comparison of cobalamin binding by liver and kidney in rat and man.

Scott JS, Bowman EP, Cooksley WG.

Clin Sci (Lond). 1985 Mar;68(3):357-64.

PMID:
2982531
46.

Biofeedback as an adjunct to psychotherapy in the treatment of vaginismus.

Barnes J, Bowman EP, Cullen J.

Biofeedback Self Regul. 1984 Sep;9(3):281-9.

PMID:
6525355
48.

Day patient versus in-patient: factors determining selection of acutely ill patients for hospital treatment.

Bowman EP, Shelley RK, Sheehy-Skeffington A, Sinanan K.

Br J Psychiatry. 1983 Jun;142:584-7.

PMID:
6882981
49.

Sexual and contraceptive attitudes and behaviour of single attenders at a Dublin family planning clinic.

Bowman EP.

J Biosoc Sci. 1977 Oct;9(4):429-45. No abstract available.

PMID:
914890

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