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Items: 1 to 50 of 151

1.

A cell-free platform for the prenylation of natural products and application to cannabinoid production.

Valliere MA, Korman TP, Woodall NB, Khitrov GA, Taylor RE, Baker D, Bowie JU.

Nat Commun. 2019 Feb 4;10(1):565. doi: 10.1038/s41467-019-08448-y.

2.

Unfolding of a ClC chloride transporter retains memory of its evolutionary history.

Min D, Jefferson RE, Qi Y, Wang JY, Arbing MA, Im W, Bowie JU.

Nat Chem Biol. 2018 May;14(5):489-496. doi: 10.1038/s41589-018-0025-4. Epub 2018 Mar 26.

3.

Accurate computational design of multipass transmembrane proteins.

Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D.

Science. 2018 Mar 2;359(6379):1042-1046. doi: 10.1126/science.aaq1739.

PMID:
29496880
4.

Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.

Rothé B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB.

Structure. 2018 Feb 6;26(2):209-224.e6. doi: 10.1016/j.str.2017.12.002. Epub 2017 Dec 28.

5.

Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.

Cao Z, Hutchison JM, Sanders CR, Bowie JU.

J Am Chem Soc. 2017 Aug 9;139(31):10742-10749. doi: 10.1021/jacs.7b04819. Epub 2017 Jul 25.

6.

A molecular rheostat maintains ATP levels to drive a synthetic biochemistry system.

Opgenorth PH, Korman TP, Iancu L, Bowie JU.

Nat Chem Biol. 2017 Sep;13(9):938-942. doi: 10.1038/nchembio.2418. Epub 2017 Jul 3.

PMID:
28671683
7.

Applications of Single-Molecule Methods to Membrane Protein Folding Studies.

Jefferson RE, Min D, Corin K, Wang JY, Bowie JU.

J Mol Biol. 2018 Feb 16;430(4):424-437. doi: 10.1016/j.jmb.2017.05.021. Epub 2017 May 23. Review.

PMID:
28549924
8.

A synthetic biochemistry platform for cell free production of monoterpenes from glucose.

Korman TP, Opgenorth PH, Bowie JU.

Nat Commun. 2017 May 24;8:15526. doi: 10.1038/ncomms15526.

9.

Complete topology inversion can be part of normal membrane protein biogenesis.

Woodall NB, Hadley S, Yin Y, Bowie JU.

Protein Sci. 2017 Apr;26(4):824-833. doi: 10.1002/pro.3131. Epub 2017 Feb 25.

10.

An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.

Vinokur JM, Cummins MC, Korman TP, Bowie JU.

Sci Rep. 2016 Dec 22;6:39737. doi: 10.1038/srep39737.

11.

A simple DNA handle attachment method for single molecule mechanical manipulation experiments.

Min D, Arbing MA, Jefferson RE, Bowie JU.

Protein Sci. 2016 Aug;25(8):1535-44. doi: 10.1002/pro.2952. Epub 2016 Jun 6.

12.

A synthetic biochemistry module for production of bio-based chemicals from glucose.

Opgenorth PH, Korman TP, Bowie JU.

Nat Chem Biol. 2016 Jun;12(6):393-5. doi: 10.1038/nchembio.2062. Epub 2016 Apr 11.

PMID:
27065234
13.

Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme.

Sherkhanov S, Korman TP, Clarke SG, Bowie JU.

Sci Rep. 2016 Apr 7;6:24239. doi: 10.1038/srep24239.

14.

Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.

Spielmann M, Kakar N, Tayebi N, Leettola C, Nürnberg G, Sowada N, Lupiáñez DG, Harabula I, Flöttmann R, Horn D, Chan WL, Wittler L, Yilmaz R, Altmüller J, Thiele H, van Bokhoven H, Schwartz CE, Nürnberg P, Bowie JU, Ahmad J, Kubisch C, Mundlos S, Borck G.

Genome Res. 2016 Feb;26(2):183-91. doi: 10.1101/gr.199430.115. Epub 2016 Jan 11.

15.

Molecular dynamics simulation strategies for protein-micelle complexes.

Cheng X, Kim JK, Kim Y, Bowie JU, Im W.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1566-72. doi: 10.1016/j.bbamem.2015.12.012. Epub 2015 Dec 8.

16.

Mapping the energy landscape for second-stage folding of a single membrane protein.

Min D, Jefferson RE, Bowie JU, Yoon TY.

Nat Chem Biol. 2015 Dec;11(12):981-7. doi: 10.1038/nchembio.1939. Epub 2015 Oct 19.

17.

Dual-topology insertion of a dual-topology membrane protein.

Woodall NB, Yin Y, Bowie JU.

Nat Commun. 2015 Aug 26;6:8099. doi: 10.1038/ncomms9099.

18.

Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network.

Nam HJ, Kim I, Bowie JU, Kim S.

Sci Rep. 2015 Apr 29;5:9576. doi: 10.1038/srep09576.

19.

Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.

Vinokur JM, Korman TP, Sawaya MR, Collazo M, Cascio D, Bowie JU.

Protein Sci. 2015 Feb;24(2):212-20. doi: 10.1002/pro.2607. Epub 2014 Dec 26.

20.

Bacteriorhodopsin folds through a poorly organized transition state.

Schlebach JP, Woodall NB, Bowie JU, Park C.

J Am Chem Soc. 2014 Nov 26;136(47):16574-81. doi: 10.1021/ja508359n. Epub 2014 Nov 17.

21.

Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3.

Leettola CN, Knight MJ, Cascio D, Hoffman S, Bowie JU.

BMC Struct Biol. 2014 Jul 7;14:17. doi: 10.1186/1472-6807-14-17.

22.

A synthetic biochemistry molecular purge valve module that maintains redox balance.

Opgenorth PH, Korman TP, Bowie JU.

Nat Commun. 2014 Jun 17;5:4113. doi: 10.1038/ncomms5113.

PMID:
24936528
23.

Improving the tolerance of Escherichia coli to medium-chain fatty acid production.

Sherkhanov S, Korman TP, Bowie JU.

Metab Eng. 2014 Sep;25:1-7. doi: 10.1016/j.ymben.2014.06.003. Epub 2014 Jun 13.

PMID:
24932721
24.

Evidence of a novel mevalonate pathway in archaea.

Vinokur JM, Korman TP, Cao Z, Bowie JU.

Biochemistry. 2014 Jul 1;53(25):4161-8. doi: 10.1021/bi500566q. Epub 2014 Jun 18.

25.

A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates.

Korman TP, Sahachartsiri B, Li D, Vinokur JM, Eisenberg D, Bowie JU.

Protein Sci. 2014 May;23(5):576-85. doi: 10.1002/pro.2436. Epub 2014 Mar 12.

26.

An energetic scale for equilibrium H/D fractionation factors illuminates hydrogen bond free energies in proteins.

Cao Z, Bowie JU.

Protein Sci. 2014 May;23(5):566-75. doi: 10.1002/pro.2435. Epub 2014 Mar 17.

27.

Measuring membrane protein stability under native conditions.

Chang YC, Bowie JU.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):219-24. doi: 10.1073/pnas.1318576111. Epub 2013 Dec 23.

28.

Membrane proteins can have high kinetic stability.

Jefferson RE, Blois TM, Bowie JU.

J Am Chem Soc. 2013 Oct 9;135(40):15183-90. doi: 10.1021/ja407232b. Epub 2013 Sep 27.

29.

Measuring transmembrane helix interaction strengths in lipid bilayers using steric trapping.

Hong H, Chang YC, Bowie JU.

Methods Mol Biol. 2013;1063:37-56. doi: 10.1007/978-1-62703-583-5_3.

30.

Dieselzymes: development of a stable and methanol tolerant lipase for biodiesel production by directed evolution.

Korman TP, Sahachartsiri B, Charbonneau DM, Huang GL, Beauregard M, Bowie JU.

Biotechnol Biofuels. 2013 May 7;6(1):70. doi: 10.1186/1754-6834-6-70.

31.

Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins.

Nam HJ, Han SK, Bowie JU, Kim S.

PLoS Comput Biol. 2013;9(3):e1002997. doi: 10.1371/journal.pcbi.1002997. Epub 2013 Mar 21.

32.

Structural biology. Membrane protein twists and turns.

Bowie JU.

Science. 2013 Jan 25;339(6118):398-9. doi: 10.1126/science.1228655. No abstract available.

PMID:
23349275
33.

Crystal structure of Proteus mirabilis lipase, a novel lipase from the Proteus/psychrophilic subfamily of lipase family I.1.

Korman TP, Bowie JU.

PLoS One. 2012;7(12):e52890. doi: 10.1371/journal.pone.0052890. Epub 2012 Dec 26.

34.

Network rewiring is an important mechanism of gene essentiality change.

Kim J, Kim I, Han SK, Bowie JU, Kim S.

Sci Rep. 2012;2:900. doi: 10.1038/srep00900. Epub 2012 Nov 29.

35.

Structural differences between thermophilic and mesophilic membrane proteins.

Meruelo AD, Han SK, Kim S, Bowie JU.

Protein Sci. 2012 Nov;21(11):1746-53. doi: 10.1002/pro.2157.

36.

Shifting hydrogen bonds may produce flexible transmembrane helices.

Cao Z, Bowie JU.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8121-6. doi: 10.1073/pnas.1201298109. Epub 2012 May 7.

37.

Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.

Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU.

Structure. 2011 Dec 7;19(12):1826-36. doi: 10.1016/j.str.2011.09.018.

38.

Revisiting the folding kinetics of bacteriorhodopsin.

Schlebach JP, Cao Z, Bowie JU, Park C.

Protein Sci. 2012 Jan;21(1):97-106. doi: 10.1002/pro.766. Epub 2011 Dec 5.

39.

Crystallizing membrane proteins using lipidic bicelles.

Ujwal R, Bowie JU.

Methods. 2011 Dec;55(4):337-41. doi: 10.1016/j.ymeth.2011.09.020. Epub 2011 Sep 29. Review.

40.

Thermodynamic stability of bacteriorhodopsin mutants measured relative to the bacterioopsin unfolded state.

Cao Z, Schlebach JP, Park C, Bowie JU.

Biochim Biophys Acta. 2012 Apr;1818(4):1049-54. doi: 10.1016/j.bbamem.2011.08.019. Epub 2011 Aug 22.

41.

A human sterile alpha motif domain polymerizome.

Knight MJ, Leettola C, Gingery M, Li H, Bowie JU.

Protein Sci. 2011 Oct;20(10):1697-706. doi: 10.1002/pro.703. Epub 2011 Aug 18.

42.

The molecular basis of the Caskin1 and Mint1 interaction with CASK.

Stafford RL, Ear J, Knight MJ, Bowie JU.

J Mol Biol. 2011 Sep 9;412(1):3-13. doi: 10.1016/j.jmb.2011.07.005. Epub 2011 Jul 12.

43.

Dramatic destabilization of transmembrane helix interactions by features of natural membrane environments.

Hong H, Bowie JU.

J Am Chem Soc. 2011 Jul 27;133(29):11389-98. doi: 10.1021/ja204524c. Epub 2011 Jul 5.

44.

TMKink: a method to predict transmembrane helix kinks.

Meruelo AD, Samish I, Bowie JU.

Protein Sci. 2011 Jul;20(7):1256-64. doi: 10.1002/pro.653. Epub 2011 Jun 2.

45.

Crystal structure of the central coiled-coil domain from human liprin-β2.

Stafford RL, Tang MY, Sawaya MR, Phillips ML, Bowie JU.

Biochemistry. 2011 May 10;50(18):3807-15. doi: 10.1021/bi200141e. Epub 2011 Apr 15.

46.

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation.

Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM.

EMBO J. 2011 Feb 2;30(3):569-81. doi: 10.1038/emboj.2010.336. Epub 2011 Jan 7.

47.

Probing membrane protein unfolding with pulse proteolysis.

Schlebach JP, Kim MS, Joh NH, Bowie JU, Park C.

J Mol Biol. 2011 Mar 4;406(4):545-51. doi: 10.1016/j.jmb.2010.12.018. Epub 2010 Dec 28. Review.

48.

Membrane protein folding: how important are hydrogen bonds?

Bowie JU.

Curr Opin Struct Biol. 2011 Feb;21(1):42-9. doi: 10.1016/j.sbi.2010.10.003. Epub 2010 Nov 12. Review.

49.

Method to measure strong protein-protein interactions in lipid bilayers using a steric trap.

Hong H, Blois TM, Cao Z, Bowie JU.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19802-7. doi: 10.1073/pnas.1010348107. Epub 2010 Nov 1.

50.

Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.

Knight MJ, Joubert MK, Plotkowski ML, Kropat J, Gingery M, Sakane F, Merchant SS, Bowie JU.

Biochemistry. 2010 Nov 9;49(44):9667-76. doi: 10.1021/bi101261x.

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