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Switching in Cerebellar Stellate Cell Excitability in Response to a Pair of Inhibitory/Excitatory Presynaptic Inputs: A Dynamical System Perspective.

Farjami S, Alexander RPD, Bowie D, Khadra A.

Neural Comput. 2020 Jan 17:1-33. doi: 10.1162/neco_a_01261. [Epub ahead of print]


Amyloid Arthropathy: A Rare Mimic of Rheumatic Disease.

Bowie D, Bardi M, Hemmati I.

J Rheumatol. 2019 Nov;46(11):1540-1541. doi: 10.3899/jrheum.181197. No abstract available.


Cerebellar Stellate Cell Excitability Is Coordinated by Shifts in the Gating Behavior of Voltage-Gated Na+ and A-Type K+ Channels.

Alexander RPD, Mitry J, Sareen V, Khadra A, Bowie D.

eNeuro. 2019 Jun 5;6(3). pii: ENEURO.0126-19.2019. doi: 10.1523/ENEURO.0126-19.2019. Print 2019 May/Jun.


Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.

Dawe GB, Kadir MF, Venskutonytė R, Perozzo AM, Yan Y, Alexander RPD, Navarrete C, Santander EA, Arsenault M, Fuentes C, Aurousseau MRP, Frydenvang K, Barrera NP, Kastrup JS, Edwardson JM, Bowie D.

Neuron. 2019 Jun 5;102(5):976-992.e5. doi: 10.1016/j.neuron.2019.03.046. Epub 2019 Apr 30.


Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins.

Bowie D.

J Biol Chem. 2018 Nov 30;293(48):18789-18802. doi: 10.1074/jbc.TM118.003794. Epub 2018 Oct 17. Review.


Shared and unique aspects of ligand- and voltage-gated ion-channel gating.

Bowie D.

J Physiol. 2018 May 15;596(10):1829-1832. doi: 10.1113/JP275877. No abstract available.


Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation.

Brown PMGE, McGuire H, Bowie D.

J Gen Physiol. 2018 Jan 2;150(1):67-82. doi: 10.1085/jgp.201711895. Epub 2017 Dec 8.


Functional Validation of Heteromeric Kainate Receptor Models.

Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC.

Biophys J. 2017 Nov 21;113(10):2173-2177. doi: 10.1016/j.bpj.2017.08.047. Epub 2017 Sep 19.


¿Somos iguales? Using a structural violence framework to understand gender and health inequities from an intersectional perspective in the Peruvian Amazon.

Shannon GD, Motta A, Cáceres CF, Skordis-Worrall J, Bowie D, Prost A.

Glob Health Action. 2017 Jan - Dec;10(sup2):1330458. doi: 10.1080/16549716.2017.1330458.


Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.

Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G.

J Biol Chem. 2017 Aug 11;292(32):13258-13270. doi: 10.1074/jbc.M117.779165. Epub 2017 Jun 21.


Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid.

Krogsgaard-Larsen N, Delgar CG, Koch K, Brown PM, Møller C, Han L, Huynh TH, Hansen SW, Nielsen B, Bowie D, Pickering DS, Kastrup JS, Frydenvang K, Bunch L.

J Med Chem. 2017 Jan 12;60(1):441-457. doi: 10.1021/acs.jmedchem.6b01516. Epub 2016 Dec 22.


Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.

Dawe GB, Musgaard M, Aurousseau MRP, Nayeem N, Green T, Biggin PC, Bowie D.

Neuron. 2016 Mar 16;89(6):1264-1276. doi: 10.1016/j.neuron.2016.01.038. Epub 2016 Feb 25.


Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.

Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D.

J Physiol. 2016 Apr 1;594(7):1821-40. doi: 10.1113/JP271690. Epub 2016 Feb 2.


Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation.

Cueva Vargas JL, Osswald IK, Unsain N, Aurousseau MR, Barker PA, Bowie D, Di Polo A.

J Neurosci. 2015 Sep 2;35(35):12088-102. doi: 10.1523/JNEUROSCI.1273-15.2015.


Coupling cellular metabolism to neuronal signalling.

Bowie D, Attwell D.

J Physiol. 2015 Aug 15;593(16):3413-5. doi: 10.1113/JP271075. No abstract available.


α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.

Accardi MV, Brown PM, Miraucourt LS, Orser BA, Bowie D.

J Neurosci. 2015 Jul 1;35(26):9676-88. doi: 10.1523/JNEUROSCI.0513-15.2015.


Discovery of novel small-molecule antagonists for GluK2.

Schiavini P, Dawe GB, Bowie D, Moitessier N.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2416-20. doi: 10.1016/j.bmcl.2015.04.008. Epub 2015 Apr 10.


Binding mode of an α-amino acid-linked quinoxaline-2,3-dione analogue at glutamate receptor subtype GluK1.

Demmer CS, Møller C, Brown PM, Han L, Pickering DS, Nielsen B, Bowie D, Frydenvang K, Kastrup JS, Bunch L.

ACS Chem Neurosci. 2015 Jun 17;6(6):845-54. doi: 10.1021/acschemneuro.5b00038. Epub 2015 Apr 9.


Retour aux sources: defining the structural basis of glutamate receptor activation.

Dawe GB, Aurousseau MR, Daniels BA, Bowie D.

J Physiol. 2015 Jan 1;593(1):97-110. doi: 10.1113/jphysiol.2014.277921. Epub 2014 Oct 21. Review.


Ionotropic glutamate receptors: alive and kicking.

Bowie D.

J Physiol. 2015 Jan 1;593(1):25-7. doi: 10.1113/jphysiol.2014.284448. No abstract available.


Ionotropic glutamate receptors made crystal clear.

Bowie D.

Trends Neurosci. 2014 Dec;37(12):687-8. doi: 10.1016/j.tins.2014.10.001. Epub 2014 Oct 22. Review.


Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons.

Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA.

J Neurosci. 2014 Aug 6;34(32):10624-34. doi: 10.1523/JNEUROSCI.0335-14.2014.


PACAP is essential for the adaptive thermogenic response of brown adipose tissue to cold exposure.

Diané A, Nikolic N, Rudecki AP, King SM, Bowie DJ, Gray SL.

J Endocrinol. 2014 Sep;222(3):327-39. doi: 10.1530/JOE-14-0316. Epub 2014 Jul 23.


Estimating the prevalence of COPD in Canada: Reported diagnosis versus measured airflow obstruction.

Evans J, Chen Y, Camp PG, Bowie DM, McRae L.

Health Rep. 2014 Mar;25(3):3-11.


Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.

Accardi MV, Daniels BA, Brown PM, Fritschy JM, Tyagarajan SK, Bowie D.

Nat Commun. 2014;5:3168. doi: 10.1038/ncomms4168.


Defining the structural relationship between kainate-receptor deactivation and desensitization.

Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D.

Nat Struct Mol Biol. 2013 Sep;20(9):1054-61. doi: 10.1038/nsmb.2654. Epub 2013 Aug 18.


Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.

Daniels BA, Andrews ED, Aurousseau MR, Accardi MV, Bowie D.

J Physiol. 2013 Aug 15;591(16):3873-85. doi: 10.1113/jphysiol.2013.253666. Epub 2013 May 27.


Chemical-genetic identification of the biochemical targets of polyalkyl guanidinium biocides.

Bowie D, Parvizi P, Duncan D, Nelson CJ, Fyles TM.

Org Biomol Chem. 2013 Jul 14;11(26):4359-66. doi: 10.1039/c3ob40593a. Epub 2013 May 21.


Automating single subunit counting of membrane proteins in mammalian cells.

McGuire H, Aurousseau MR, Bowie D, Blunck R.

J Biol Chem. 2012 Oct 19;287(43):35912-21. doi: 10.1074/jbc.M112.402057. Epub 2012 Aug 28.


Thinking of Co²⁺-staining explant tissue or cultured cells? How to make it reliable and specific.

Aurousseau MR, Osswald IK, Bowie D.

Eur J Neurosci. 2012 Apr;35(8):1201-7. doi: 10.1111/j.1460-9568.2012.08042.x. Review.


Ligand-gated ion channels: from genes to behaviour.

Bowie D.

J Physiol. 2012 Jan 1;590(1):9-11. doi: 10.1113/jphysiol.2011.224592. No abstract available.


Redefining the classification of AMPA-selective ionotropic glutamate receptors.

Bowie D.

J Physiol. 2012 Jan 1;590(1):49-61. doi: 10.1113/jphysiol.2011.221689. Epub 2011 Nov 21. Review.


Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation.

Maclean DM, Bowie D.

J Physiol. 2011 Nov 15;589(Pt 22):5383-90. doi: 10.1113/jphysiol.2011.219485. Epub 2011 Oct 3.


Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.

Lachance-Touchette P, Brown P, Meloche C, Kinirons P, Lapointe L, Lacasse H, Lortie A, Carmant L, Bedford F, Bowie D, Cossette P.

Eur J Neurosci. 2011 Jul;34(2):237-49. doi: 10.1111/j.1460-9568.2011.07767.x. Epub 2011 Jun 30.


Choosing the right pain relief for patients with soft-tissue injuries.

Bowie D.

Emerg Nurse. 2011 May;19(2):28-30. Review.


Cations but not anions regulate the responsiveness of kainate receptors.

Maclean DM, Wong AY, Fay AM, Bowie D.

J Neurosci. 2011 Feb 9;31(6):2136-44. doi: 10.1523/JNEUROSCI.4314-10.2011.


Geographical variations in the prevalence of atopic sensitization in six study sites across Canada.

Chan-Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich-Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J.

Allergy. 2010 Nov;65(11):1404-13. doi: 10.1111/j.1398-9995.2010.02399.x.


Canadian Thoracic Society Asthma Committee commentary on long-acting beta-2 agonist use for asthma in Canada.

Lougheed MD, Lemiere C, Dell S, Ducharme F, Fitzgerald JM, Leigh R, Licskai C, Rowe BH, Bowie D, Becker A, Boulet LP.

Can Respir J. 2010 Mar-Apr;17(2):57-60. No abstract available.


Canadian Thoracic Society Asthma Management Continuum--2010 Consensus Summary for children six years of age and over, and adults.

Lougheed MD, Lemière C, Dell SD, Ducharme FM, Fitzgerald JM, Leigh R, Licskai C, Rowe BH, Bowie D, Becker A, Boulet LP; Canadian Thoracic Society Asthma Committee.

Can Respir J. 2010 Jan-Feb;17(1):15-24.


Sore throat progressing to embolic sepsis: a case of Lemierre's syndrome.

Dirks J, Bowie D.

Can Respir J. 2010 Jan-Feb;17(1):e20-2.


Multiorgan failure from 1-benzylpiperazine ingestion--legal high or lethal high?

Gee P, Jerram T, Bowie D.

Clin Toxicol (Phila). 2010 Mar;48(3):230-3. doi: 10.3109/15563651003592948.


Neurophysiology of inhibitory and excitatory amino acid receptors.

Bowie D, McKinney RA.

J Physiol. 2010 Jan 1;588(Pt 1):29-32. doi: 10.1113/jphysiol.2009.185561. No abstract available.


Ion-dependent gating of kainate receptors.

Bowie D.

J Physiol. 2010 Jan 1;588(Pt 1):67-81. doi: 10.1113/jphysiol.2009.178863. Epub 2009 Oct 12. Review.


Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

Lebrun-Julien F, Duplan L, Pernet V, Osswald I, Sapieha P, Bourgeois P, Dickson K, Bowie D, Barker PA, Di Polo A.

J Neurosci. 2009 Apr 29;29(17):5536-45. doi: 10.1523/JNEUROSCI.0831-09.2009.


Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists.

Fay AM, Corbeil CR, Brown P, Moitessier N, Bowie D.

Mol Pharmacol. 2009 May;75(5):1096-107. doi: 10.1124/mol.108.054254. Epub 2009 Feb 18.


Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis.

Zhao B, Wong AY, Murshid A, Bowie D, Presley JF, Bedford FK.

Cell Signal. 2008 Oct;20(10):1769-79. doi: 10.1016/j.cellsig.2008.06.011. Epub 2008 Jun 24.


Ionotropic glutamate receptors & CNS disorders.

Bowie D.

CNS Neurol Disord Drug Targets. 2008 Apr;7(2):129-43. Review.


Na+/Cl- dipole couples agonist binding to kainate receptor activation.

Wong AY, MacLean DM, Bowie D.

J Neurosci. 2007 Jun 20;27(25):6800-9.


Airflow obstruction in young adults in Canada.

Al-Hazmi M, Wooldrage K, Anthonisen NR, Becklake MR, Bowie D, Chan-Yeung M, Dimich-Ward H, Ernst P, Manfreda J, Sears MR, Siersted HC, Sweet L, Van Til L.

Can Respir J. 2007 May-Jun;14(4):221-7.

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