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Items: 1 to 50 of 88

1.

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.

Carty M, Kearney J, Shanahan KA, Hams E, Sugisawa R, Connolly D, Doran CG, Muñoz-Wolf N, Gürtler C, Fitzgerald KA, Lavelle EC, Fallon PG, Bowie AG.

Immunity. 2019 Jun 18;50(6):1412-1424.e6. doi: 10.1016/j.immuni.2019.04.005. Epub 2019 May 7.

PMID:
31076360
2.

Harnessing poxviral know-how for anti-cytokine therapies.

Bowie AG.

J Biol Chem. 2019 Mar 29;294(13):5228-5229. doi: 10.1074/jbc.H119.008151.

3.

SARM: From immune regulator to cell executioner.

Carty M, Bowie AG.

Biochem Pharmacol. 2019 Mar;161:52-62. doi: 10.1016/j.bcp.2019.01.005. Epub 2019 Jan 8.

PMID:
30633870
4.

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.

Dunphy G, Flannery SM, Almine JF, Connolly DJ, Paulus C, Jønsson KL, Jakobsen MR, Nevels MM, Bowie AG, Unterholzner L.

Mol Cell. 2018 Sep 6;71(5):745-760.e5. doi: 10.1016/j.molcel.2018.07.034.

5.

Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses.

Dempsey A, Keating SE, Carty M, Bowie AG.

J Biol Chem. 2018 Sep 28;293(39):14989-15001. doi: 10.1074/jbc.RA118.005089. Epub 2018 Aug 15.

PMID:
30111593
6.

Self-RNA sentinels signal viral invasion.

Bowie AG.

Nat Immunol. 2018 Jan;19(1):4-5. doi: 10.1038/s41590-017-0010-1. No abstract available.

PMID:
29242544
7.

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC.

QJM. 2018 Apr 1;111(4):217-224. doi: 10.1093/qjmed/hcx243.

8.

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors.

Sisquella X, Ofir-Birin Y, Pimentel MA, Cheng L, Abou Karam P, Sampaio NG, Penington JS, Connolly D, Giladi T, Scicluna BJ, Sharples RA, Waltmann A, Avni D, Schwartz E, Schofield L, Porat Z, Hansen DS, Papenfuss AT, Eriksson EM, Gerlic M, Hill AF, Bowie AG, Regev-Rudzki N.

Nat Commun. 2017 Dec 7;8(1):1985. doi: 10.1038/s41467-017-02083-1.

9.

Alum Activates the Bovine NLRP3 Inflammasome.

Harte C, Gorman AL, McCluskey S, Carty M, Bowie AG, Scott CJ, Meade KG, Lavelle EC.

Front Immunol. 2017 Nov 9;8:1494. doi: 10.3389/fimmu.2017.01494. eCollection 2017.

10.

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.

J Virol. 2017 Jul 12;91(15). pii: e00545-17. doi: 10.1128/JVI.00545-17. Print 2017 Aug 1.

11.

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

Almine JF, O'Hare CA, Dunphy G, Haga IR, Naik RJ, Atrih A, Connolly DJ, Taylor J, Kelsall IR, Bowie AG, Beard PM, Unterholzner L.

Nat Commun. 2017 Feb 13;8:14392. doi: 10.1038/ncomms14392.

12.

A novel anti-viral role for STAT3 in IFN-α signalling responses.

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ.

Cell Mol Life Sci. 2017 May;74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17.

PMID:
27988795
13.

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

Carroll EC, Jin L, Mori A, Muñoz-Wolf N, Oleszycka E, Moran HBT, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC.

Immunity. 2016 Mar 15;44(3):597-608. doi: 10.1016/j.immuni.2016.02.004. Epub 2016 Mar 2.

14.

Novel strategies for targeting innate immune responses to influenza.

Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN.

Mucosal Immunol. 2016 Sep;9(5):1173-82. doi: 10.1038/mi.2015.141. Epub 2016 Jan 27.

15.

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.

Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN; East-German and Swiss Hepatitis C Virus Study Groups.

Hepatology. 2015 Nov;62(5):1375-87. doi: 10.1002/hep.28105. Epub 2015 Sep 28.

PMID:
26250868
16.

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.

J Virol. 2015 Aug;89(16):8406-15.

17.

Innate immune recognition of DNA: A recent history.

Dempsey A, Bowie AG.

Virology. 2015 May;479-480:146-52. doi: 10.1016/j.virol.2015.03.013. Epub 2015 Mar 26. Review.

18.

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease.

Cox DJ, Field RH, Williams DG, Baran M, Bowie AG, Cunningham C, Dunne A.

Glia. 2015 May;63(5):812-25. doi: 10.1002/glia.22786. Epub 2015 Jan 27.

19.

TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.

20.

The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.

Connolly DJ, Bowie AG.

Biochem Pharmacol. 2014 Dec 1;92(3):405-14. doi: 10.1016/j.bcp.2014.08.031. Epub 2014 Sep 6.

PMID:
25199457
21.

Innate immune activation of NFκB and its antagonism by poxviruses.

Brady G, Bowie AG.

Cytokine Growth Factor Rev. 2014 Oct;25(5):611-20. doi: 10.1016/j.cytogfr.2014.07.004. Epub 2014 Jul 11. Review.

PMID:
25081317
22.

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.

Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN.

J Biol Chem. 2014 Aug 15;289(33):23123-31. doi: 10.1074/jbc.M113.492934. Epub 2014 Jun 19.

23.

Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation.

Bowie AG.

Nat Immunol. 2014 Jun;15(6):534-6. doi: 10.1038/ni.2894. No abstract available.

PMID:
24840992
24.

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

Verstak B, Stack J, Ve T, Mangan M, Hjerrild K, Jeon J, Stahl R, Latz E, Gay N, Kobe B, Bowie AG, Mansell A.

J Leukoc Biol. 2014 Sep;96(3):427-36. doi: 10.1189/jlb.2A0913-487R. Epub 2014 May 8.

25.

SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.

Gürtler C, Carty M, Kearney J, Schattgen SA, Ding A, Fitzgerald KA, Bowie AG.

J Immunol. 2014 May 15;192(10):4821-32. doi: 10.4049/jimmunol.1302980. Epub 2014 Apr 7.

26.

Innate antiviral signalling in the central nervous system.

Carty M, Reinert L, Paludan SR, Bowie AG.

Trends Immunol. 2014 Feb;35(2):79-87. doi: 10.1016/j.it.2013.10.012. Epub 2013 Dec 6. Review.

PMID:
24316012
27.
28.

Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.

Bowie AG.

Immunity. 2013 Sep 19;39(3):423-5. doi: 10.1016/j.immuni.2013.08.023.

29.

Innate immune detection of microbial nucleic acids.

Gürtler C, Bowie AG.

Trends Microbiol. 2013 Aug;21(8):413-20. doi: 10.1016/j.tim.2013.04.004. Epub 2013 May 29. Review.

30.

Immune sensing of DNA.

Paludan SR, Bowie AG.

Immunity. 2013 May 23;38(5):870-80. doi: 10.1016/j.immuni.2013.05.004. Review.

31.

The history of Toll-like receptors - redefining innate immunity.

O'Neill LA, Golenbock D, Bowie AG.

Nat Rev Immunol. 2013 Jun;13(6):453-60. doi: 10.1038/nri3446. Epub 2013 May 17. Review.

PMID:
23681101
32.

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

Mansur DS, Maluquer de Motes C, Unterholzner L, Sumner RP, Ferguson BJ, Ren H, Strnadova P, Bowie AG, Smith GL.

PLoS Pathog. 2013 Feb;9(2):e1003183. doi: 10.1371/journal.ppat.1003183. Epub 2013 Feb 28.

33.

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.

Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR.

J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23.

34.

Innate sensing of bacterial cyclic dinucleotides: more than just STING.

Bowie AG.

Nat Immunol. 2012 Dec;13(12):1137-9. doi: 10.1038/ni.2469. No abstract available.

PMID:
23160208
35.

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro.

Leow-Dyke S, Allen C, Denes A, Nilsson O, Maysami S, Bowie AG, Rothwell NJ, Pinteaux E.

J Neuroinflammation. 2012 Oct 3;9:230. doi: 10.1186/1742-2094-9-230.

36.

The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.

Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA.

J Biol Chem. 2012 Oct 5;287(41):34709-21. doi: 10.1074/jbc.M112.350678. Epub 2012 Aug 13.

37.

Viral immune modulators perturb the human molecular network by common and unique strategies.

Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G.

Nature. 2012 Jul 26;487(7408):486-90. doi: 10.1038/nature11289.

PMID:
22810585
38.
39.

Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.

Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS.

Immunity. 2012 Apr 20;36(4):561-71. doi: 10.1016/j.immuni.2012.02.014. Epub 2012 Apr 5.

40.

The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.

O'Neill LA, Bowie AG.

Cell. 2011 Oct 14;147(2):259-61. doi: 10.1016/j.cell.2011.09.027.

41.

Cytosolic DNA sensors regulating type I interferon induction.

Keating SE, Baran M, Bowie AG.

Trends Immunol. 2011 Dec;32(12):574-81. doi: 10.1016/j.it.2011.08.004. Epub 2011 Sep 21. Review.

PMID:
21940216
42.

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, Bourke NM, Randow F, Smith GL, Bowie AG.

PLoS Pathog. 2011 Sep;7(9):e1002247. doi: 10.1371/journal.ppat.1002247. Epub 2011 Sep 8.

43.

Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake.

Paludan SR, Levy O, Bowie AG.

Nat Immunol. 2011 Aug 18;12(9):805-8. doi: 10.1038/ni.0911-805. No abstract available.

PMID:
21852774
44.

Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.

Flannery SM, Keating SE, Szymak J, Bowie AG.

J Biol Chem. 2011 Jul 8;286(27):23688-97. doi: 10.1074/jbc.M111.248351. Epub 2011 May 23.

45.

Innate DNA sensing moves to the nucleus.

Unterholzner L, Bowie AG.

Cell Host Microbe. 2011 May 19;9(5):351-3. doi: 10.1016/j.chom.2011.05.001.

46.

Recognition of herpesviruses by the innate immune system.

Paludan SR, Bowie AG, Horan KA, Fitzgerald KA.

Nat Rev Immunol. 2011 Feb;11(2):143-54. doi: 10.1038/nri2937. Review. Erratum in: Nat Rev Immunol. 2013 Aug;13(8):614.

47.

Evaluating the role of Toll-like receptors in diseases of the central nervous system.

Carty M, Bowie AG.

Biochem Pharmacol. 2011 Apr 1;81(7):825-37. doi: 10.1016/j.bcp.2011.01.003. Epub 2011 Jan 15. Review.

PMID:
21241665
48.

IFI16 is an innate immune sensor for intracellular DNA.

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG.

Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3.

49.

TRAF3: uncovering the real but restricted role in human.

Bowie AG.

Immunity. 2010 Sep 24;33(3):293-5. doi: 10.1016/j.immuni.2010.09.008.

50.

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.

Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock DT, Monie T, Bowie AG.

J Immunol. 2010 Oct 1;185(7):4261-71. doi: 10.4049/jimmunol.1002013. Epub 2010 Aug 27.

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