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Analysis of levoglucosan and its isomers in atmospheric samples by ion chromatography with electrospray lithium cationisation - Triple quadrupole tandem mass spectrometry.

Sanz Rodriguez E, Perron MMG, Strzelec M, Proemse BC, Bowie AR, Paull B.

J Chromatogr A. 2019 Sep 20:460557. doi: 10.1016/j.chroma.2019.460557. [Epub ahead of print]


Toll-like receptor 2-dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival.

Musilova J, Mulcahy ME, Kuijk MM, McLoughlin RM, Bowie AG.

J Biol Chem. 2019 Sep 26. pii: jbc.RA119.009302. doi: 10.1074/jbc.RA119.009302. [Epub ahead of print]


Regulation of the Phytoplankton Heme b Iron Pool During the North Atlantic Spring Bloom.

Louropoulou E, Gledhill M, Browning TJ, Desai DK, Barraqueta JM, Tonnard M, Sarthou G, Planquette H, Bowie AR, Schmitz RA, LaRoche J, Achterberg EP.

Front Microbiol. 2019 Jul 11;10:1566. doi: 10.3389/fmicb.2019.01566. eCollection 2019.


Pre-concentration of thorium and neodymium isotopes using Nobias chelating resin: Method development and application to chromatographic separation.

Pérez-Tribouillier H, Noble TL, Townsend AT, Bowie AR, Chase Z.

Talanta. 2019 Sep 1;202:600-609. doi: 10.1016/j.talanta.2019.03.086. Epub 2019 Mar 27.


Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.

Carty M, Kearney J, Shanahan KA, Hams E, Sugisawa R, Connolly D, Doran CG, Muñoz-Wolf N, Gürtler C, Fitzgerald KA, Lavelle EC, Fallon PG, Bowie AG.

Immunity. 2019 Jun 18;50(6):1412-1424.e6. doi: 10.1016/j.immuni.2019.04.005. Epub 2019 May 7.


Pyrogenic iron: The missing link to high iron solubility in aerosols.

Ito A, Myriokefalitakis S, Kanakidou M, Mahowald NM, Scanza RA, Hamilton DS, Baker AR, Jickells T, Sarin M, Bikkina S, Gao Y, Shelley RU, Buck CS, Landing WM, Bowie AR, Perron MMG, Guieu C, Meskhidze N, Johnson MS, Feng Y, Kok JF, Nenes A, Duce RA.

Sci Adv. 2019 May 1;5(5):eaau7671. doi: 10.1126/sciadv.aau7671. eCollection 2019 May.


Harnessing poxviral know-how for anti-cytokine therapies.

Bowie AG.

J Biol Chem. 2019 Mar 29;294(13):5228-5229. doi: 10.1074/jbc.H119.008151.


Critical evaluation of a seaFAST system for the analysis of trace metals in marine samples.

Wuttig K, Townsend AT, van der Merwe P, Gault-Ringold M, Holmes T, Schallenberg C, Latour P, Tonnard M, Rijkenberg MJA, Lannuzel D, Bowie AR.

Talanta. 2019 May 15;197:653-668. doi: 10.1016/j.talanta.2019.01.047. Epub 2019 Jan 18.


SARM: From immune regulator to cell executioner.

Carty M, Bowie AG.

Biochem Pharmacol. 2019 Mar;161:52-62. doi: 10.1016/j.bcp.2019.01.005. Epub 2019 Jan 8.


Examining Variation in Life Expectancy Estimates by ZIP Code Tabulation Area (ZCTA) in Hawaii's Four Main Counties, 2008-2012.

Holmes JR, Tootoo JL, Chosy EJ, Bowie AY, Starr RR.

Prev Chronic Dis. 2018 Sep 20;15:E114. doi: 10.5888/pcd15.180035. No abstract available.


Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.

Dunphy G, Flannery SM, Almine JF, Connolly DJ, Paulus C, Jønsson KL, Jakobsen MR, Nevels MM, Bowie AG, Unterholzner L.

Mol Cell. 2018 Sep 6;71(5):745-760.e5. doi: 10.1016/j.molcel.2018.07.034.


Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses.

Dempsey A, Keating SE, Carty M, Bowie AG.

J Biol Chem. 2018 Sep 28;293(39):14989-15001. doi: 10.1074/jbc.RA118.005089. Epub 2018 Aug 15.


Self-RNA sentinels signal viral invasion.

Bowie AG.

Nat Immunol. 2018 Jan;19(1):4-5. doi: 10.1038/s41590-017-0010-1. No abstract available.


Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC.

QJM. 2018 Apr 1;111(4):217-224. doi: 10.1093/qjmed/hcx243.


Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors.

Sisquella X, Ofir-Birin Y, Pimentel MA, Cheng L, Abou Karam P, Sampaio NG, Penington JS, Connolly D, Giladi T, Scicluna BJ, Sharples RA, Waltmann A, Avni D, Schwartz E, Schofield L, Porat Z, Hansen DS, Papenfuss AT, Eriksson EM, Gerlic M, Hill AF, Bowie AG, Regev-Rudzki N.

Nat Commun. 2017 Dec 7;8(1):1985. doi: 10.1038/s41467-017-02083-1.


Alum Activates the Bovine NLRP3 Inflammasome.

Harte C, Gorman AL, McCluskey S, Carty M, Bowie AG, Scott CJ, Meade KG, Lavelle EC.

Front Immunol. 2017 Nov 9;8:1494. doi: 10.3389/fimmu.2017.01494. eCollection 2017.


Changes in Nutritional and Functional Status in Longer Stay Patients Admitted to a Geriatric Evaluation and Management Unit.

Whitley A, Skliros E, Graven C, McIntosh R, Lasry C, Newsome C, Bowie A.

J Nutr Health Aging. 2017;21(6):686-691. doi: 10.1007/s12603-016-0838-3.


Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.

J Virol. 2017 Jul 12;91(15). pii: e00545-17. doi: 10.1128/JVI.00545-17. Print 2017 Aug 1.


The integral role of iron in ocean biogeochemistry.

Tagliabue A, Bowie AR, Boyd PW, Buck KN, Johnson KS, Saito MA.

Nature. 2017 Mar 1;543(7643):51-59. doi: 10.1038/nature21058. Review.


IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

Almine JF, O'Hare CA, Dunphy G, Haga IR, Naik RJ, Atrih A, Connolly DJ, Taylor J, Kelsall IR, Bowie AG, Beard PM, Unterholzner L.

Nat Commun. 2017 Feb 13;8:14392. doi: 10.1038/ncomms14392.


A novel anti-viral role for STAT3 in IFN-α signalling responses.

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ.

Cell Mol Life Sci. 2017 May;74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17.


Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

Brady G, Boggan L, Bowie A, O'Neill LA.

J Biol Chem. 2016 Nov 25;291(48):25278. No abstract available.


Nutrient Cycling: Are Antarctic Krill a Previously Overlooked Source in the Marine Iron Cycle?

Ratnarajah L, Bowie AR.

Curr Biol. 2016 Oct 10;26(19):R884-R887. doi: 10.1016/j.cub.2016.08.044. Epub 2016 Oct 10.


Tracking post-infectious fatigue in clinic using routine Lab tests.

Harvey JM, Broderick G, Bowie A, Barnes ZM, Katz BZ, O'Gorman MRG, Vernon SD, Fletcher MA, Klimas NG, Taylor R.

BMC Pediatr. 2016 Apr 26;16:54. doi: 10.1186/s12887-016-0596-8.


The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

Carroll EC, Jin L, Mori A, Muñoz-Wolf N, Oleszycka E, Moran HBT, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC.

Immunity. 2016 Mar 15;44(3):597-608. doi: 10.1016/j.immuni.2016.02.004. Epub 2016 Mar 2.


Novel strategies for targeting innate immune responses to influenza.

Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN.

Mucosal Immunol. 2016 Sep;9(5):1173-82. doi: 10.1038/mi.2015.141. Epub 2016 Jan 27.


The ontogeny of fairness in seven societies.

Blake PR, McAuliffe K, Corbit J, Callaghan TC, Barry O, Bowie A, Kleutsch L, Kramer KL, Ross E, Vongsachang H, Wrangham R, Warneken F.

Nature. 2015 Dec 10;528(7581):258-61. doi: 10.1038/nature15703. Epub 2015 Nov 18.


A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.

Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN; East-German and Swiss Hepatitis C Virus Study Groups.

Hepatology. 2015 Nov;62(5):1375-87. doi: 10.1002/hep.28105. Epub 2015 Sep 28.


Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.

J Virol. 2015 Aug;89(16):8406-15.


Correction: The biogeochemical role of baleen whales and krill in Southern Ocean nutrient cycling.

Ratnarajah L, Bowie AR, Lannuzel D, Meiners KM, Nicol S.

PLoS One. 2015 Apr 17;10(4):e0125134. doi: 10.1371/journal.pone.0125134. eCollection 2015. No abstract available.


Innate immune recognition of DNA: A recent history.

Dempsey A, Bowie AG.

Virology. 2015 May;479-480:146-52. doi: 10.1016/j.virol.2015.03.013. Epub 2015 Mar 26. Review.


DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease.

Cox DJ, Field RH, Williams DG, Baran M, Bowie AG, Cunningham C, Dunne A.

Glia. 2015 May;63(5):812-25. doi: 10.1002/glia.22786. Epub 2015 Jan 27.


The biogeochemical role of baleen whales and krill in Southern Ocean nutrient cycling.

Ratnarajah L, Bowie AR, Lannuzel D, Meiners KM, Nicol S.

PLoS One. 2014 Dec 3;9(12):e114067. doi: 10.1371/journal.pone.0114067. eCollection 2014. Erratum in: PLoS One. 2015;10(4):e0125134.


TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.


The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.

Connolly DJ, Bowie AG.

Biochem Pharmacol. 2014 Dec 1;92(3):405-14. doi: 10.1016/j.bcp.2014.08.031. Epub 2014 Sep 6.


Innate immune activation of NFκB and its antagonism by poxviruses.

Brady G, Bowie AG.

Cytokine Growth Factor Rev. 2014 Oct;25(5):611-20. doi: 10.1016/j.cytogfr.2014.07.004. Epub 2014 Jul 11. Review.


A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.

Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN.

J Biol Chem. 2014 Aug 15;289(33):23123-31. doi: 10.1074/jbc.M113.492934. Epub 2014 Jun 19.


Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation.

Bowie AG.

Nat Immunol. 2014 Jun;15(6):534-6. doi: 10.1038/ni.2894. No abstract available.


The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

Verstak B, Stack J, Ve T, Mangan M, Hjerrild K, Jeon J, Stahl R, Latz E, Gay N, Kobe B, Bowie AG, Mansell A.

J Leukoc Biol. 2014 Sep;96(3):427-36. doi: 10.1189/jlb.2A0913-487R. Epub 2014 May 8.


SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.

Gürtler C, Carty M, Kearney J, Schattgen SA, Ding A, Fitzgerald KA, Bowie AG.

J Immunol. 2014 May 15;192(10):4821-32. doi: 10.4049/jimmunol.1302980. Epub 2014 Apr 7.


Innate antiviral signalling in the central nervous system.

Carty M, Reinert L, Paludan SR, Bowie AG.

Trends Immunol. 2014 Feb;35(2):79-87. doi: 10.1016/ Epub 2013 Dec 6. Review.


Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.

Bowie AG.

Immunity. 2013 Sep 19;39(3):423-5. doi: 10.1016/j.immuni.2013.08.023.


Innate immune detection of microbial nucleic acids.

Gürtler C, Bowie AG.

Trends Microbiol. 2013 Aug;21(8):413-20. doi: 10.1016/j.tim.2013.04.004. Epub 2013 May 29. Review.


Immune sensing of DNA.

Paludan SR, Bowie AG.

Immunity. 2013 May 23;38(5):870-80. doi: 10.1016/j.immuni.2013.05.004. Review.


The history of Toll-like receptors - redefining innate immunity.

O'Neill LA, Golenbock D, Bowie AG.

Nat Rev Immunol. 2013 Jun;13(6):453-60. doi: 10.1038/nri3446. Epub 2013 May 17. Review.


Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

Mansur DS, Maluquer de Motes C, Unterholzner L, Sumner RP, Ferguson BJ, Ren H, Strnadova P, Bowie AG, Smith GL.

PLoS Pathog. 2013 Feb;9(2):e1003183. doi: 10.1371/journal.ppat.1003183. Epub 2013 Feb 28.


Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.

Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR.

J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23.


Innate sensing of bacterial cyclic dinucleotides: more than just STING.

Bowie AG.

Nat Immunol. 2012 Dec;13(12):1137-9. doi: 10.1038/ni.2469. No abstract available.


Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro.

Leow-Dyke S, Allen C, Denes A, Nilsson O, Maysami S, Bowie AG, Rothwell NJ, Pinteaux E.

J Neuroinflammation. 2012 Oct 3;9:230. doi: 10.1186/1742-2094-9-230.

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