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Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies: Proceedings of workshops presented at Society of Toxicology and joint Teratology Society and Neurobehavioral Teratology Society meetings.

Li AA, Sheets LP, Raffaele K, Moser V, Hofstra A, Hoberman A, Makris SL, Garman R, Bolon B, Kaufmann W, Auer R, Lau E, Vidmar T, Bowers WJ.

Neurotoxicol Teratol. 2017 Sep;63:24-45. doi: 10.1016/ Epub 2017 Jul 27.


Gestational and Lactational Exposure to an Environmentally-Relevant Mixture of Brominated Flame Retardants: Effects on Neurodevelopment and Metabolism.

Tung EWY, Kawata A, Rigden M, Bowers WJ, Caldwell D, Holloway AC, Robaire B, Hales BF, Wade MG.

Birth Defects Res. 2017 Apr 17;109(7):497-512. doi: 10.1002/bdr2.1021. Epub 2017 Mar 24.


Developmental neurotoxicity of polybrominated diphenyl ethers mixture de71 in Sprague-Dawley rats.

Gill S, Hou Y, Li N, Pulido O, Bowers W.

J Toxicol Environ Health A. 2016;79(12):482-93. doi: 10.1080/15287394.2016.1182001.


Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene.

Chepelev NL, Long AS, Bowers WJ, Gagné R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL.

Environ Mol Mutagen. 2016 Jun;57(5):350-63. doi: 10.1002/em.22020. Epub 2016 May 19.


Behavioral and thyroid effects of in utero and lactational exposure of Sprague-Dawley rats to the polybrominated diphenyl ether mixture DE71.

Bowers WJ, Wall PM, Nakai JS, Yagminas A, Wade M, Li N.

Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):127-42. doi: 10.1016/ Epub 2015 Aug 10.


Electrosurgery in gastrointestinal endoscopy: terminology matters.

Song LM, Gostout CJ, Tucker RD, Morris ML, Bowers WJ, Cattau EL Jr.

Gastrointest Endosc. 2016 Jan;83(1):271-3. doi: 10.1016/j.gie.2015.08.002. Epub 2015 Aug 8. No abstract available.


Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment.

Chepelev NL, Moffat ID, Bowers WJ, Yauk CL.

Mutat Res Rev Mutat Res. 2015 Apr-Jun;764:64-89. doi: 10.1016/j.mrrev.2015.03.001. Epub 2015 Mar 21. Review.


Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.

Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, Zauderer M, Hayden MR.

Neurobiol Dis. 2015 Apr;76:46-56. doi: 10.1016/j.nbd.2015.01.002. Epub 2015 Feb 3.


Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies.

Evans EE, Jonason AS Jr, Bussler H, Torno S, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Mallow C, Kirk R, Howell A, Giralico S, Scrivens M, Klimatcheva K, Fisher TL, Bowers WJ, Paris M, Smith ES, Zauderer M.

Cancer Immunol Res. 2015 Jun;3(6):689-701. doi: 10.1158/2326-6066.CIR-14-0171. Epub 2015 Jan 22.


SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease.

Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, Bussler H, Torno S, Kirk R, Howell A, Evans EE, Paris M, Bowers WJ, John G, Zauderer M.

Neurobiol Dis. 2015 Jan;73:254-68. doi: 10.1016/j.nbd.2014.10.008. Epub 2014 Oct 18.


Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.

Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ, Tieu K.

Nat Commun. 2014 Nov 5;5:5244. doi: 10.1038/ncomms6244.


Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring.

Esteban J, Elabbas LE, Borg D, Herlin M, Åkesson A, Barber X, Hamscher G, Nau H, Bowers WJ, Nakai JS, Viluksela M, Håkansson H.

Toxicol Lett. 2014 Aug 17;229(1):41-51. doi: 10.1016/j.toxlet.2014.04.021. Epub 2014 Jun 2.


In utero and lactational exposure to a mixture of environmental contaminants detected in Canadian Arctic human populations alters retinoid levels in rat offspring with low margins of exposure.

Elabbas LE, Esteban J, Barber X, Hamscher G, Nau H, Bowers WJ, Nakai JS, Herlin M, Åkesson A, Viluksela M, Borg D, Håkansson H.

J Toxicol Environ Health A. 2014;77(5):223-45. doi: 10.1080/15287394.2013.861776.


Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies.

Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ.

Am J Pathol. 2013 Jun;182(6):2285-97. doi: 10.1016/j.ajpath.2013.02.030. Epub 2013 Apr 6.


Effects of developmental exposure to mixtures of environmental contaminants on the hepatic metabolism of estradiol-17β in immature female Sprague Dawley rats.

Desaulniers D, Leingartner K, Pelletier G, Xiao GH, Bowers WJ.

Int J Toxicol. 2012 Sep-Oct;31(5):454-66. doi: 10.1177/1091581812457431. Epub 2012 Aug 22.


Effects of environmentally relevant mixtures of persistent organic pollutants on the developmental neurobiology in rats.

Gill S, Bowers WJ, Nakai JS, Yagminas A, Mueller R, Pulido O.

Toxicol Pathol. 2013 Jan;41(1):38-47. doi: 10.1177/0192623312451370. Epub 2012 Aug 7.


Volar dislocation of the distal ulna in supination caused by apex volar malunion of the radial shaft: a report of 2 cases.

Bowers WH, Karl JW, Strauch RJ.

J Pediatr Orthop. 2012 Jul-Aug;32(5):473-6. doi: 10.1097/BPO.0b013e318259f425.


Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord.

García-Alías G, Petrosyan HA, Schnell L, Horner PJ, Bowers WJ, Mendell LM, Fawcett JW, Arvanian VL.

J Neurosci. 2011 Dec 7;31(49):17788-99. doi: 10.1523/JNEUROSCI.4308-11.2011.


Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system.

Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS.

PLoS One. 2011;6(11):e27728. doi: 10.1371/journal.pone.0027728. Epub 2011 Nov 21.


Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord.

Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL.

Eur J Neurosci. 2011 Oct;34(8):1256-67. doi: 10.1111/j.1460-9568.2011.07862.x. Epub 2011 Oct 13.


Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease.

Hunter JM, Bowers WJ, Maarouf CL, Mastrangelo MA, Daugs ID, Kokjohn TA, Kalback WM, Luehrs DC, Valla J, Beach TG, Roher AE.

J Alzheimers Dis. 2011;27(2):361-76. doi: 10.3233/JAD-2011-110608.


In utero and lactational exposure to Aroclor 1254 affects bone geometry, mineral density and biomechanical properties of rat offspring.

Elabbas LE, Herlin M, Finnilä MA, Rendel F, Stern N, Trossvik C, Bowers WJ, Nakai J, Tuukkanen J, Viluksela M, Heimeier RA, Akesson A, Håkansson H.

Toxicol Lett. 2011 Nov 10;207(1):82-8. doi: 10.1016/j.toxlet.2011.08.003. Epub 2011 Aug 11.


Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.

Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Knowlden SA, Wright TW, Bowers WJ.

Am J Pathol. 2011 Oct;179(4):2053-70. doi: 10.1016/j.ajpath.2011.07.001. Epub 2011 Aug 9.


Perinatal exposure to environmental contaminants detected in Canadian Arctic human populations changes bone geometry and biomechanical properties in rat offspring.

Elabbas LE, Finnilä MA, Herlin M, Stern N, Trossvik C, Bowers WJ, Nakai J, Tuukkanen J, Heimeier RA, Åkesson A, Håkansson H.

J Toxicol Environ Health A. 2011;74(19):1304-18. doi: 10.1080/15287394.2011.590103.


Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.

Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S.

Vaccine. 2011 Sep 16;29(40):7080-9. doi: 10.1016/j.vaccine.2011.07.008. Epub 2011 Jul 27.


Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system.

Montgomery SL, Bowers WJ.

J Neuroimmune Pharmacol. 2012 Mar;7(1):42-59. doi: 10.1007/s11481-011-9287-2. Epub 2011 Jul 5. Review.


Modulation of the effects of methylmercury on rat neurodevelopment by co-exposure with Labrador Tea (Rhododendron tomentosum ssp. subarcticum).

Black P, Niu L, Sachdeva M, Lean D, Poon R, Bowers WJ, Chan HM, Arnason JT, Pelletier G.

Food Chem Toxicol. 2011 Sep;49(9):2336-42. doi: 10.1016/j.fct.2011.06.035. Epub 2011 Jun 21.


Genetic therapy for the nervous system.

Bowers WJ, Breakefield XO, Sena-Esteves M.

Hum Mol Genet. 2011 Apr 15;20(R1):R28-41. doi: 10.1093/hmg/ddr110. Epub 2011 Mar 23. Review.


An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction.

Desai MK, Guercio BJ, Narrow WC, Bowers WJ.

Glia. 2011 Apr;59(4):627-40. doi: 10.1002/glia.21131. Epub 2011 Feb 3.


CD4+ T cell effects on CD8+ T cell location defined using bioluminescence.

Azadniv M, Bowers WJ, Topham DJ, Crispe IN.

PLoS One. 2011 Jan 20;6(1):e16222. doi: 10.1371/journal.pone.0016222.


Trk retrograde signaling requires persistent, Pincher-directed endosomes.

Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):852-7. doi: 10.1073/pnas.1015981108. Epub 2010 Dec 27.


A Gas Pressure Scale Based on Primary Standard Piston Gauges.

Olson DA, Driver RG, Bowers WJ.

J Res Natl Inst Stand Technol. 2010 Dec 1;115(6):393-412. Print 2010 Nov-Dec.


Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM.

Nat Med. 2010 Sep;16(9):998-1000. doi: 10.1038/nm.2199. Epub 2010 Aug 22.


Environmental contaminants and human health in the Canadian Arctic.

Donaldson SG, Van Oostdam J, Tikhonov C, Feeley M, Armstrong B, Ayotte P, Boucher O, Bowers W, Chan L, Dallaire F, Dallaire R, Dewailly E, Edwards J, Egeland GM, Fontaine J, Furgal C, Leech T, Loring E, Muckle G, Nancarrow T, Pereg D, Plusquellec P, Potyrala M, Receveur O, Shearer RG.

Sci Total Environ. 2010 Oct 15;408(22):5165-234. doi: 10.1016/j.scitotenv.2010.04.059. Epub 2010 Aug 21. Review. Erratum in: Sci Total Environ. 2012 Aug 1;431:437-8.


Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.

Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ.

Am J Pathol. 2010 Sep;177(3):1422-35. doi: 10.2353/ajpath.2010.100087. Epub 2010 Aug 9.


Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.

Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS.

J Neurosci. 2010 Jul 14;30(28):9567-77. doi: 10.1523/JNEUROSCI.0942-10.2010.


Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform.

de Silva S, Lotta LT Jr, Burris CA, Bowers WJ.

Hum Gene Ther. 2010 Nov;21(11):1615-22. doi: 10.1089/hum.2010.022. Epub 2010 Oct 7.


Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.

Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ.

Mol Ther. 2010 Aug;18(8):1471-81. doi: 10.1038/mt.2010.111. Epub 2010 Jun 15.


Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.

de Silva S, Mastrangelo MA, Lotta LT Jr, Burris CA, Izsvák Z, Ivics Z, Bowers WJ.

Hum Gene Ther. 2010 Nov;21(11):1603-13. doi: 10.1089/hum.2010.062. Epub 2010 Oct 22.


An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies.

Ryan DA, Narrow WC, Federoff HJ, Bowers WJ.

J Neurosci Methods. 2010 Jul 15;190(2):171-9. doi: 10.1016/j.jneumeth.2010.05.001. Epub 2010 May 7.


GTPase activity plays a key role in the pathobiology of LRRK2.

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ.

PLoS Genet. 2010 Apr 8;6(4):e1000902. doi: 10.1371/journal.pgen.1000902.


A capacitive probe for measuring the clearance between the piston and the cylinder of a gas piston gauge.

Bowers WJ, Olson DA.

Rev Sci Instrum. 2010 Mar;81(3):035102. doi: 10.1063/1.3310092.


We are not done. Interview by Ann Kettering Sincox.

Forsberg A, Bowers W.

Mich Nurse. 2010 Mar-Apr;83(2):12-5. No abstract available.


Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.

Park KM, Bowers WJ.

Cell Signal. 2010 Jul;22(7):977-83. doi: 10.1016/j.cellsig.2010.01.010. Epub 2010 Jan 21. Review.


Herpes Virus Amplicon Vectors.

de Silva S, Bowers WJ.

Viruses. 2009 Dec 1;1(3):594-629.


A pilot study of personality pathology in patients with anorexia nervosa: modifiable factors related to outcome after hospitalization.

McCormick LM, Keel PK, Brumm MC, Watson DB, Forman-Hoffman VL, Bowers WA.

Eat Weight Disord. 2009 Jun-Sep;14(2-3):e113-20.


Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons.

Park KM, Yule DI, Bowers WJ.

Cell Signal. 2010 Mar;22(3):519-26. doi: 10.1016/j.cellsig.2009.11.006.


Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform.

de Silva S, Mastrangelo MA, Lotta LT Jr, Burris CA, Federoff HJ, Bowers WJ.

Gene Ther. 2010 Mar;17(3):424-31. doi: 10.1038/gt.2009.144. Epub 2009 Oct 29.

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