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A lumped-element model of the chinchilla middle ear.

Bowers P, Rosowski JJ.

J Acoust Soc Am. 2019 Apr;145(4):1975. doi: 10.1121/1.5094897.


The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies.

Bowers PM, Boyle WJ, Damoiseaux R.

Methods Mol Biol. 2018;1827:479-489. doi: 10.1007/978-1-4939-8648-4_24.


Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T, Lee C, Li H, Li R, Royer R, Timshel PN, Walters RK, Willoughby EA, Yengo L; 23andMe Research Team; COGENT (Cognitive Genomics Consortium); Social Science Genetic Association Consortium, Alver M, Bao Y, Clark DW, Day FR, Furlotte NA, Joshi PK, Kemper KE, Kleinman A, Langenberg C, Mägi R, Trampush JW, Verma SS, Wu Y, Lam M, Zhao JH, Zheng Z, Boardman JD, Campbell H, Freese J, Harris KM, Hayward C, Herd P, Kumari M, Lencz T, Luan J, Malhotra AK, Metspalu A, Milani L, Ong KK, Perry JRB, Porteous DJ, Ritchie MD, Smart MC, Smith BH, Tung JY, Wareham NJ, Wilson JF, Beauchamp JP, Conley DC, Esko T, Lehrer SF, Magnusson PKE, Oskarsson S, Pers TH, Robinson MR, Thom K, Watson C, Chabris CF, Meyer MN, Laibson DI, Yang J, Johannesson M, Koellinger PD, Turley P, Visscher PM, Benjamin DJ, Cesarini D.

Nat Genet. 2018 Jul 23;50(8):1112-1121. doi: 10.1038/s41588-018-0147-3.


CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans.

Brunquell J, Raynes R, Bowers P, Morris S, Snyder A, Lugano D, Deonarine A, Westerheide SD.

Aging Cell. 2018 Oct;17(5):e12813. doi: 10.1111/acel.12813. Epub 2018 Jul 12.


The importance of correctly characterising the English spelling system when devising and evaluating methods of reading instruction: Comment on Taylor, Davis, and Rastle (2017).

Bowers JS, Bowers PN.

Q J Exp Psychol (Hove). 2018 Jul;71(7):1497-1500. doi: 10.1177/1747021818759477. Epub 2018 May 9.


Limits on normal cochlear 'third' windows provided by previous investigations of additional sound paths into and out of the cat inner ear.

Rosowski JJ, Bowers P, Nakajima HH.

Hear Res. 2018 Mar;360:3-13. doi: 10.1016/j.heares.2017.11.003. Epub 2017 Nov 10. Review.


Energy-efficient waveform for electrical stimulation of the cochlear nerve.

Yip M, Bowers P, Noel V, Chandrakasan A, Stankovic KM.

Sci Rep. 2017 Oct 19;7(1):13582. doi: 10.1038/s41598-017-13671-y.


Recannulation of the axillary artery in aortic and complex cardiac surgery.

Bowers PJT, Mathur MN.

J Card Surg. 2017 Jul;32(7):422-425. doi: 10.1111/jocs.13163. Epub 2017 Jun 19.


Middle-ear and inner-ear contribution to bone conduction in chinchilla: The development of Carhart's notch.

Chhan D, Bowers P, McKinnon ML, Rosowski JJ.

Hear Res. 2016 Oct;340:144-152. doi: 10.1016/j.heares.2016.02.015. Epub 2016 Feb 24.


A Randomized, Open-Label, Multicenter, Phase III Study of Epoetin Alfa Versus Best Standard of Care in Anemic Patients With Metastatic Breast Cancer Receiving Standard Chemotherapy.

Leyland-Jones B, Bondarenko I, Nemsadze G, Smirnov V, Litvin I, Kokhreidze I, Abshilava L, Janjalia M, Li R, Lakshmaiah KC, Samkharadze B, Tarasova O, Mohapatra RK, Sparyk Y, Polenkov S, Vladimirov V, Xiu L, Zhu E, Kimelblatt B, Deprince K, Safonov I, Bowers P, Vercammen E.

J Clin Oncol. 2016 Apr 10;34(11):1197-207. doi: 10.1200/JCO.2015.63.5649. Epub 2016 Feb 8.


Authors' reply to comments made about our article 'Food for thought'.

Gabbay MB, Goodall M, Capewell S, Bowers P, Kennedy LA, Byrne P, Barton GR, Martindale AM; Lay Health trainer Intervention Study (LHtIST) research group.

J Public Health (Oxf). 2015 Dec;37(4):749-50. doi: 10.1093/pubmed/fdu111. Epub 2014 Dec 23. No abstract available.


A general approach to antibody thermostabilization.

McConnell AD, Zhang X, Macomber JL, Chau B, Sheffer JC, Rahmanian S, Hare E, Spasojevic V, Horlick RA, King DJ, Bowers PM.

MAbs. 2014;6(5):1274-82. doi: 10.4161/mabs.29680.


Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.

Bowers PM, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, Do M, Neben TY, Horlick RA, Stanfield RL, Wilson IA, King DJ.

J Biol Chem. 2014 Nov 28;289(48):33557-67. doi: 10.1074/jbc.M114.607176. Epub 2014 Oct 15.


Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans.

Brunquell J, Bowers P, Westerheide SD.

Mech Ageing Dev. 2014 Nov-Dec;141-142:1-4. doi: 10.1016/j.mad.2014.08.002. Epub 2014 Aug 26.


Mammalian cell display and somatic hypermutation in vitro for human antibody discovery.

King DJ, Bowers PM, Kehry MR, Horlick RA.

Curr Drug Discov Technol. 2014 Mar;11(1):56-64. Review.


Mammalian cell display for the discovery and optimization of antibody therapeutics.

Bowers PM, Horlick RA, Kehry MR, Neben TY, Tomlinson GL, Altobell L, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell AD, Chau B, Berkebile AD, Hare E, Verdino P, King DJ.

Methods. 2014 Jan 1;65(1):44-56. doi: 10.1016/j.ymeth.2013.06.010. Epub 2013 Jun 20.


Simultaneous surface display and secretion of proteins from mammalian cells facilitate efficient in vitro selection and maturation of antibodies.

Horlick RA, Macomber JL, Bowers PM, Neben TY, Tomlinson GL, Krapf IP, Dalton JL, Verdino P, King DJ.

J Biol Chem. 2013 Jul 5;288(27):19861-9. doi: 10.1074/jbc.M113.452482. Epub 2013 May 20.


Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation.

Bowers PM, Neben TY, Tomlinson GL, Dalton JL, Altobell L, Zhang X, Macomber JL, Wu BF, Toobian RM, McConnell AD, Verdino P, Chau B, Horlick RA, King DJ.

J Biol Chem. 2013 Mar 15;288(11):7688-96. doi: 10.1074/jbc.M112.445502. Epub 2013 Jan 25.


An integrated approach to extreme thermostabilization and affinity maturation of an antibody.

McConnell AD, Spasojevich V, Macomber JL, Krapf IP, Chen A, Sheffer JC, Berkebile A, Horlick RA, Neben S, King DJ, Bowers PM.

Protein Eng Des Sel. 2013 Feb;26(2):151-64. doi: 10.1093/protein/gzs090. Epub 2012 Nov 19.


High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation.

McConnell AD, Do M, Neben TY, Spasojevic V, MacLaren J, Chen AP, Altobell L 3rd, Macomber JL, Berkebile AD, Horlick RA, Bowers PM, King DJ.

PLoS One. 2012;7(11):e49458. doi: 10.1371/journal.pone.0049458. Epub 2012 Nov 14.


Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies.

Bowers PM, Horlick RA, Neben TY, Toobian RM, Tomlinson GL, Dalton JL, Jones HA, Chen A, Altobell L 3rd, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell A, Chau B, Holland T, Berkebile AD, Neben SS, Boyle WJ, King DJ.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20455-60. doi: 10.1073/pnas.1114010108. Epub 2011 Dec 7.


A randomized controlled study comparing once-weekly to every-2-week and every-4-week dosing of epoetin alfa in CKD patients with anemia.

Pergola PE, Gartenberg G, Fu M, Sun S, Wolfson M, Bowers P.

Clin J Am Soc Nephrol. 2010 Apr;5(4):598-606. doi: 10.2215/CJN.06770909. Epub 2010 Feb 25.


Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes.

Glaspy J, Crawford J, Vansteenkiste J, Henry D, Rao S, Bowers P, Berlin JA, Tomita D, Bridges K, Ludwig H.

Br J Cancer. 2010 Jan 19;102(2):301-15. doi: 10.1038/sj.bjc.6605498. Epub 2010 Jan 5.


A randomized controlled study of weekly and biweekly dosing of epoetin alfa in CKD Patients with anemia.

Pergola PE, Gartenberg G, Fu M, Wolfson M, Rao S, Bowers P.

Clin J Am Soc Nephrol. 2009 Nov;4(11):1731-40. doi: 10.2215/CJN.03470509. Epub 2009 Sep 17.


A comparative study of the effects of disposable and Volkmann spoon curettes in the treatment of basal cell carcinoma.

Julian C, Bowers PW, Pritchard C.

Br J Dermatol. 2009 Dec;161(6):1407-9. doi: 10.1111/j.1365-2133.2009.09425.x. Epub 2009 Aug 14. No abstract available. Erratum in: Br J Dermatol. 2009 Dec;161(6):1424.


Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly.

Roessler E, Pei W, Ouspenskaia MV, Karkera JD, Veléz JI, Banerjee-Basu S, Gibney G, Lupo PJ, Mitchell LE, Towbin JA, Bowers P, Belmont JW, Goldmuntz E, Baxevanis AD, Feldman B, Muenke M.

Mol Genet Metab. 2009 Sep-Oct;98(1-2):225-34. doi: 10.1016/j.ymgme.2009.05.005. Epub 2009 May 27.


Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.

Roessler E, Ouspenskaia MV, Karkera JD, Vélez JI, Kantipong A, Lacbawan F, Bowers P, Belmont JW, Towbin JA, Goldmuntz E, Feldman B, Muenke M.

Am J Hum Genet. 2008 Jul;83(1):18-29. doi: 10.1016/j.ajhg.2008.05.012. Epub 2008 Jun 5.


Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans.

Karkera JD, Lee JS, Roessler E, Banerjee-Basu S, Ouspenskaia MV, Mez J, Goldmuntz E, Bowers P, Towbin J, Belmont JW, Baxevanis AD, Schier AF, Muenke M.

Am J Hum Genet. 2007 Nov;81(5):987-94. Epub 2007 Sep 28.


Functional linkages can reveal protein complexes for structure determination.

Kim SM, Bowers PM, Pal D, Strong M, Terwilliger TC, Kaufmann M, Eisenberg D.

Structure. 2007 Sep;15(9):1079-89.


Efficacy and safety of epoetin alfa in critically ill patients.

Corwin HL, Gettinger A, Fabian TC, May A, Pearl RG, Heard S, An R, Bowers PJ, Burton P, Klausner MA, Corwin MJ; EPO Critical Care Trials Group.

N Engl J Med. 2007 Sep 6;357(10):965-76.


Hair analysis in sled dogs (Canis lupus familiaris) illustrates a linkage of mercury exposure along the Yukon River with human subsistence food systems.

Dunlap KL, Reynolds AJ, Bowers PM, Duffy LK.

Sci Total Environ. 2007 Oct 15;385(1-3):80-5. Epub 2007 Aug 17.


Natural history of anemia associated with interferon/ribavirin therapy for patients with HIV/HCV coinfection.

Henry DH, Slim J, Lamarca A, Bowers P, Leitz G; HIV/HCV Coinfection Natural History Study Group.

AIDS Res Hum Retroviruses. 2007 Jan;23(1):1-9.


The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.

Goulding CW, Bowers PM, Segelke B, Lekin T, Kim CY, Terwilliger TC, Eisenberg D.

J Mol Biol. 2007 Jan 12;365(2):275-83. Epub 2006 Oct 3.


An exploratory study of total mercury levels in archaeological caribou hair from northwest Alaska.

Gerlach SC, Duffy LK, Murray MS, Bowers PM, Adams R, Verbrugge DA.

Chemosphere. 2006 Dec;65(11):1909-14. Epub 2006 Jul 31. Review.


PRK and amblyopia.

Bowers PJ, Enzenauer RW.

Ophthalmology. 2006 Jun;113(6):1065; author reply 1065. No abstract available.


Everybody out!

Bowers PJ, Maguire ML, Silva PA, Kitchen R.

Nursing. 2006 Spring;36(5 Suppl E D):12-3.


A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.

Plant LD, Bowers PN, Liu Q, Morgan T, Zhang T, State MW, Chen W, Kittles RA, Goldstein SA.

J Clin Invest. 2006 Feb;116(2):430-5.


Utilizing logical relationships in genomic data to decipher cellular processes.

Bowers PM, O'Connor BD, Cokus SJ, Sprinzak E, Yeates TO, Eisenberg D.

FEBS J. 2005 Oct;272(20):5110-8. Review.


Angle-closure glaucoma after discontinuing donepezil hydrochloride (Aricept).

Enzenauer RW, Bowers PJ.

J Gerontol A Biol Sci Med Sci. 2005 Aug;60(8):1083. No abstract available.


Erythropoietic response to anemia in chronic hepatitis C patients receiving combination pegylated interferon/ribavirin.

Balan V, Schwartz D, Wu GY, Muir AJ, Ghalib R, Jackson J, Keeffe EB, Rossaro L, Burnett A, Goon BL, Bowers PJ, Leitz GJ; HCV Natural History Study Group.

Am J Gastroenterol. 2005 Feb;100(2):299-307.


Use of logic relationships to decipher protein network organization.

Bowers PM, Cokus SJ, Eisenberg D, Yeates TO.

Science. 2004 Dec 24;306(5705):2246-9.


Once-weekly epoetin alfa improves quality of life and increases hemoglobin in anemic HIV+ patients.

Saag MS, Bowers P, Leitz GJ, Levine AM; Community HIV Anemia Management Protocol Sites (CHAMPS) Study Group.

AIDS Res Hum Retroviruses. 2004 Oct;20(10):1037-45.


Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy.

Pockros PJ, Shiffman ML, Schiff ER, Sulkowski MS, Younossi Z, Dieterich DT, Wright TL, Mody SH, Tang KL, Goon BL, Bowers PJ, Leitz G, Afdhal NH; PROACTIVE Study Group.

Hepatology. 2004 Dec;40(6):1450-8.


Acute angle-closure glaucoma caused by vitreous prolapse after neodymium:YAG posterior capsulotomy.

Mihora LD, Bowers PJ Jr, Blank NM.

J Cataract Refract Surg. 2004 Nov;30(11):2445-7.


Naming-speed processes, timing, and reading: a conceptual review.

Wolf M, Bowers PG, Biddle K.

J Learn Disabil. 2000 Jul-Aug;33(4):387-407. Review.


Naming-speed processes and developmental reading disabilities: an introduction to the special issue on the double-deficit hypothesis.

Wolf M, Bowers PG.

J Learn Disabil. 2000 Jul-Aug;33(4):322-4. No abstract available.


Outcomes of laser in situ keratomileusis in a Refractive Surgery fellowship program.

Bowers PJ Jr, Zeldes SS, Price MO, McManis CL, Price FW Jr.

J Refract Surg. 2004 May-Jun;20(3):265-9.


Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study.

Afdhal NH, Dieterich DT, Pockros PJ, Schiff ER, Shiffman ML, Sulkowski MS, Wright T, Younossi Z, Goon BL, Tang KL, Bowers PJ; Proactive Study Group.

Gastroenterology. 2004 May;126(5):1302-11.


Prolinks: a database of protein functional linkages derived from coevolution.

Bowers PM, Pellegrini M, Thompson MJ, Fierro J, Yeates TO, Eisenberg D.

Genome Biol. 2004;5(5):R35. Epub 2004 Apr 16.


Everybody out! Will your facility's evacuation procedures withstand a disaster?

Bowers PJ, Maguire ML, Silva PA, Kitchen R.

Nurs Manage. 2004 Apr;35(4):50-4.


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