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Items: 44

1.

Dehydroamino acids: chemical multi-tools for late-stage diversification.

Bogart JW, Bowers AA.

Org Biomol Chem. 2019 Apr 10;17(15):3653-3669. doi: 10.1039/c8ob03155j. Review.

2.

Inter-Modular Linkers play a crucial role in governing the biosynthesis of non-ribosomal peptides.

Farag S, Bleich RM, Shank EA, Isayev O, Bowers AA, Tropsha A.

Bioinformatics. 2019 Oct 1;35(19):3584-3591. doi: 10.1093/bioinformatics/btz127.

PMID:
30785185
3.

Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecular Formal Aza-Diels-Alder Reaction.

Bogart JW, Bowers AA.

J Am Chem Soc. 2019 Feb 6;141(5):1842-1846. doi: 10.1021/jacs.8b11852. Epub 2019 Jan 22.

4.

Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides.

Fleming SR, Bartges TE, Vinogradov AA, Kirkpatrick CL, Goto Y, Suga H, Hicks LM, Bowers AA.

J Am Chem Soc. 2019 Jan 16;141(2):758-762. doi: 10.1021/jacs.8b11521. Epub 2019 Jan 8.

5.

Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition.

Gutgsell AR, Ghodge SV, Bowers AA, Neher SB.

J Biol Chem. 2019 Feb 22;294(8):2678-2689. doi: 10.1074/jbc.RA118.005932. Epub 2018 Dec 27.

PMID:
30591589
6.

The substrate lends a hand.

Bowers AA.

Nat Chem Biol. 2018 Oct;14(10):907-908. doi: 10.1038/s41589-018-0135-z. No abstract available.

PMID:
30224692
7.

Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology.

Grubbs KJ, Bleich RM, Santa Maria KC, Allen SE, Farag S; AgBiome Team, Shank EA, Bowers AA.

mSystems. 2017 Nov 14;2(6). pii: e00040-17. doi: 10.1128/mSystems.00040-17. eCollection 2017 Nov-Dec.

8.

Biosynthesis: Methylating mushrooms.

Bowers AA.

Nat Chem Biol. 2017 Jul 18;13(8):821-822. doi: 10.1038/nchembio.2437. No abstract available.

PMID:
28853736
9.

Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.

Grove TL, Himes PM, Hwang S, Yumerefendi H, Bonanno JB, Kuhlman B, Almo SC, Bowers AA.

J Am Chem Soc. 2017 Aug 30;139(34):11734-11744. doi: 10.1021/jacs.7b01283. Epub 2017 Aug 21.

10.

P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides.

Gober JG, Ghodge SV, Bogart JW, Wever WJ, Watkins RR, Brustad EM, Bowers AA.

ACS Chem Biol. 2017 Jul 21;12(7):1726-1731. doi: 10.1021/acschembio.7b00358. Epub 2017 Jun 1.

PMID:
28535034
11.

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.

Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A.

Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1.

12.

Identification of Pyridine Synthase Recognition Sequences Allows a Modular Solid-Phase Route to Thiopeptide Variants.

Wever WJ, Bogart JW, Bowers AA.

J Am Chem Soc. 2016 Oct 19;138(41):13461-13464. doi: 10.1021/jacs.6b05389. Epub 2016 Oct 5.

PMID:
27575591
13.

Post-translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A.

Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA.

J Am Chem Soc. 2016 May 4;138(17):5487-90. doi: 10.1021/jacs.5b13529. Epub 2016 Apr 22.

14.

Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis.

Himes PM, Allen SE, Hwang S, Bowers AA.

ACS Chem Biol. 2016 Jun 17;11(6):1737-44. doi: 10.1021/acschembio.6b00042. Epub 2016 Apr 25.

PMID:
27019323
15.

Dynamic Docking of Conformationally Constrained Macrocycles: Methods and Applications.

Allen SE, Dokholyan NV, Bowers AA.

ACS Chem Biol. 2016 Jan 15;11(1):10-24. doi: 10.1021/acschembio.5b00663. Epub 2015 Dec 4. Review.

PMID:
26575401
16.

Inhibition of Cell Differentiation in Bacillus subtilis by Pseudomonas protegens.

Powers MJ, Sanabria-Valentín E, Bowers AA, Shank EA.

J Bacteriol. 2015 Jul;197(13):2129-2138. doi: 10.1128/JB.02535-14. Epub 2015 Mar 30.

17.

Chemoenzymatic synthesis of thiazolyl peptide natural products featuring an enzyme-catalyzed formal [4 + 2] cycloaddition.

Wever WJ, Bogart JW, Baccile JA, Chan AN, Schroeder FC, Bowers AA.

J Am Chem Soc. 2015 Mar 18;137(10):3494-7. doi: 10.1021/jacs.5b00940. Epub 2015 Mar 10.

18.

Enzymatic basis of "hybridity" in thiomarinol biosynthesis.

Dunn ZD, Wever WJ, Economou NJ, Bowers AA, Li B.

Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5137-41. doi: 10.1002/anie.201411667. Epub 2015 Feb 26.

19.

Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis.

Bleich R, Watrous JD, Dorrestein PC, Bowers AA, Shank EA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3086-91. doi: 10.1073/pnas.1414272112. Epub 2015 Feb 23.

20.

Correction: Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics.

Li B, Wever WJ, Walsh CT, Bowers AA.

Nat Prod Rep. 2015 Feb;32(2):348-9. doi: 10.1039/c4np90047b. No abstract available.

PMID:
25598489
21.

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics.

Li B, Wever WJ, Walsh CT, Bowers AA.

Nat Prod Rep. 2014 Jul;31(7):905-23. doi: 10.1039/c3np70106a. Review. Erratum in: Nat Prod Rep. 2015 Feb;32(2):348-9.

22.

Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.

Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):6025-8. doi: 10.1016/j.bmcl.2013.06.012. Epub 2013 Jun 18.

23.

The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli.

Du X, Wojtowicz D, Bowers AA, Levens D, Benham CJ, Przytycka TM.

Nucleic Acids Res. 2013 Jul;41(12):5965-77. doi: 10.1093/nar/gkt308. Epub 2013 Apr 25.

24.

Visible light mediated activation and O-glycosylation of thioglycosides.

Wever WJ, Cinelli MA, Bowers AA.

Org Lett. 2013 Jan 4;15(1):30-3. doi: 10.1021/ol302941q. Epub 2012 Dec 20.

PMID:
23256636
25.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

26.

A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus.

Li B, Forseth RR, Bowers AA, Schroeder FC, Walsh CT.

Chembiochem. 2012 Nov 26;13(17):2521-6. doi: 10.1002/cbic.201200536. Epub 2012 Oct 24.

27.

Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

Bowers AA, Acker MG, Young TS, Walsh CT.

J Am Chem Soc. 2012 Jun 27;134(25):10313-6. doi: 10.1021/ja302820x. Epub 2012 Jun 15.

28.

Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.

Bowers AA, Walsh CT, Acker MG.

J Am Chem Soc. 2010 Sep 8;132(35):12182-4. doi: 10.1021/ja104524q.

29.

Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

Walsh CT, Acker MG, Bowers AA.

J Biol Chem. 2010 Sep 3;285(36):27525-31. doi: 10.1074/jbc.R110.135970. Epub 2010 Jun 3. Review.

30.

Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.

Bowers AA, Acker MG, Koglin A, Walsh CT.

J Am Chem Soc. 2010 Jun 2;132(21):7519-27. doi: 10.1021/ja102339q.

31.

Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.

Acker MG, Bowers AA, Walsh CT.

J Am Chem Soc. 2009 Dec 9;131(48):17563-5. doi: 10.1021/ja908777t.

32.

Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors.

Newkirk TL, Bowers AA, Williams RM.

Nat Prod Rep. 2009 Oct;26(10):1293-320. doi: 10.1039/b817886k. Epub 2009 Aug 3. Review. No abstract available.

PMID:
19779641
33.
34.

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.

Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, Williams RM.

Org Lett. 2009 Mar 19;11(6):1301-4. doi: 10.1021/ol900078k.

35.

Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.

Bowers AA, Greshock TJ, West N, Estiu G, Schreiber SL, Wiest O, Williams RM, Bradner JE.

J Am Chem Soc. 2009 Mar 4;131(8):2900-5. doi: 10.1021/ja807772w.

37.

Heterobivalent library expansion by "living radical" processes: thiocarbonyl addition/elimination, and nitroxide-based reactions with fluorous deconvolution.

Crich D, Grant D, Bowers AA.

J Am Chem Soc. 2007 Oct 10;129(40):12106-7. Epub 2007 Sep 19. No abstract available.

PMID:
17880090
38.

Electrochemical generation of glycosyl triflate pools.

Nokami T, Shibuya A, Tsuyama H, Suga S, Bowers AA, Crich D, Yoshida J.

J Am Chem Soc. 2007 Sep 5;129(35):10922-8. Epub 2007 Aug 14.

40.
42.

On the regioselectivity of the Hanessian-Hullar reaction in 4,6-O-benzylidene protected galactopyranosides.

Crich D, Yao Q, Bowers AA.

Carbohydr Res. 2006 Jul 24;341(10):1748-52. Epub 2006 Mar 13.

43.

Word and tone working memory deficits in schizophrenia.

Wexler BE, Stevens AA, Bowers AA, Sernyak MJ, Goldman-Rakic PS.

Arch Gen Psychiatry. 1998 Dec;55(12):1093-6.

PMID:
9862552
44.

Functional MR imaging of regional brain responses to pleasant and unpleasant odors.

Fulbright RK, Skudlarski P, Lacadie CM, Warrenburg S, Bowers AA, Gore JC, Wexler BE.

AJNR Am J Neuroradiol. 1998 Oct;19(9):1721-6.

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