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Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague.

Bowen W, Batra L, Pulsifer AR, Yolcu ES, Lawrenz MB, Shirwan H.

Vaccine. 2019 Sep 10;37(38):5708-5716. doi: 10.1016/j.vaccine.2019.07.103. Epub 2019 Aug 12.


Downstream processing of irbesartan nanocrystalline suspension and mini-tablet development - Part II.

Meruva S, Thool P, Karki S, Bowen W, Ghosh I, Kumar S.

Int J Pharm. 2019 Sep 10;568:118509. doi: 10.1016/j.ijpharm.2019.118509. Epub 2019 Jul 10.


Quantum noise limited nanoparticle detection with exposed-core fiber.

Mauranyapin NP, Madsen LS, Booth L, Peng L, Warren-Smith SC, Schartner EP, Ebendorff-Heidepriem H, Bowen WP.

Opt Express. 2019 Jun 24;27(13):18601-18611. doi: 10.1364/OE.27.018601.


Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model.

Bhushan B, Banerjee S, Paranjpe S, Koral K, Mars WM, Stoops JW, Orr A, Bowen WC, Locker J, Michalopoulos GK.

Hepatology. 2019 May 7. doi: 10.1002/hep.30696. [Epub ahead of print]


Translating Marine Animal Tracking Data into Conservation Policy and Management.

Hays GC, Bailey H, Bograd SJ, Bowen WD, Campagna C, Carmichael RH, Casale P, Chiaradia A, Costa DP, Cuevas E, Nico de Bruyn PJ, Dias MP, Duarte CM, Dunn DC, Dutton PH, Esteban N, Friedlaender A, Goetz KT, Godley BJ, Halpin PN, Hamann M, Hammerschlag N, Harcourt R, Harrison AL, Hazen EL, Heupel MR, Hoyt E, Humphries NE, Kot CY, Lea JSE, Marsh H, Maxwell SM, McMahon CR, Notarbartolo di Sciara G, Palacios DM, Phillips RA, Righton D, Schofield G, Seminoff JA, Simpfendorfer CA, Sims DW, Takahashi A, Tetley MJ, Thums M, Trathan PN, Villegas-Amtmann S, Wells RS, Whiting SD, Wildermann NE, Sequeira AMM.

Trends Ecol Evol. 2019 May;34(5):459-473. doi: 10.1016/j.tree.2019.01.009. Epub 2019 Mar 14. Review.


Formulation and performance of Irbesartan nanocrystalline suspension and granulated or bead-layered dried powders - Part I.

Meruva S, Thool P, Shah S, Karki S, Bowen W, Ghosh I, Kumar S.

Int J Pharm. 2019 Sep 10;568:118189. doi: 10.1016/j.ijpharm.2019.03.007. Epub 2019 Mar 6.


A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4+ T and Natural Killer Cells.

Barsoumian HB, Batra L, Shrestha P, Bowen WS, Zhao H, Egilmez NK, Gomez-Gutierrez JG, Yolcu ES, Shirwan H.

Cancer Res. 2019 Feb 15;79(4):783-794. doi: 10.1158/0008-5472.CAN-18-2401.


Free spectral range electrical tuning of a high quality on-chip microcavity.

Bekker C, Baker CG, Kalra R, Cheng HH, Li BB, Prakash V, Bowen WP.

Opt Express. 2018 Dec 24;26(26):33649-33670. doi: 10.1364/OE.26.033649.


Precision ultrasound sensing on a chip.

Basiri-Esfahani S, Armin A, Forstner S, Bowen WP.

Nat Commun. 2019 Jan 10;10(1):132. doi: 10.1038/s41467-018-08038-4.


Evaluation of heavy metal pollution in the sediment of Poyang Lake based on stochastic geo-accumulation model (SGM).

Feng Y, Chenglin L, Bowen W.

Sci Total Environ. 2019 Apr 1;659:1-6. doi: 10.1016/j.scitotenv.2018.12.311. Epub 2018 Dec 23.


Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives.

Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD.

J Pharmacol Exp Ther. 2019 Feb;368(2):272-281. doi: 10.1124/jpet.118.253484. Epub 2018 Dec 7.


Creating a Culture of Health at Johns Hopkins Medicine.

Safeer R, Bowen W.

Am J Health Promot. 2018 Nov;32(8):1821-1823. doi: 10.1177/0890117118804149d. No abstract available.


A Comparative Study of Fluorescence Assays in Screening for BRD4.

Hansson P, Boyd H, Dale IL, Dahl G, Nicolaus F, Bowen W, Doering K, Dunsmore C, Cotton G, Lindmark H.

Assay Drug Dev Technol. 2018 Oct;16(7):372-383. doi: 10.1089/adt.2018.850. Epub 2018 Oct 9.


Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation.

Koral K, Haynes M, Bowen WC, Orr A, Mars W, Michalopoulos GK.

Am J Pathol. 2018 Sep;188(9):2074-2086. doi: 10.1016/j.ajpath.2018.06.005. Epub 2018 Jul 3.


Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice.

Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK.

Am J Pathol. 2018 Oct;188(10):2223-2235. doi: 10.1016/j.ajpath.2018.06.009. Epub 2018 Jul 20.


TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling.

Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK.

Hepatology. 2019 Apr;69(4):1702-1718. doi: 10.1002/hep.30109. Epub 2018 Dec 31.


Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.

Headen DM, Woodward KB, Coronel MM, Shrestha P, Weaver JD, Zhao H, Tan M, Hunckler MD, Bowen WS, Johnson CT, Shea L, Yolcu ES, García AJ, Shirwan H.

Nat Mater. 2018 Aug;17(8):732-739. doi: 10.1038/s41563-018-0099-0. Epub 2018 Jun 4.


Modelling of Cavity Optomechanical Magnetometers.

Yu Y, Forstner S, Rubinsztein-Dunlop H, Bowen WP.

Sensors (Basel). 2018 May 14;18(5). pii: E1558. doi: 10.3390/s18051558.


Hepatitis C Virus Mimics Effects of Glypican-3 on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes.

Xue Y, Mars WM, Bowen W, Singhi AD, Stoops J, Michalopoulos GK.

Am J Pathol. 2018 Jun;188(6):1469-1477. doi: 10.1016/j.ajpath.2018.02.013. Epub 2018 Mar 22.


Current challenges for cancer vaccine adjuvant development.

Bowen WS, Svrivastava AK, Batra L, Barsoumian H, Shirwan H.

Expert Rev Vaccines. 2018 Mar;17(3):207-215. doi: 10.1080/14760584.2018.1434000. Epub 2018 Feb 8. Review.


Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model.

Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H, Michalopoulos GK, Bhave VS.

Gene Expr. 2018 Mar 21;18(1):51-62. doi: 10.3727/105221617X15124876321401. Epub 2017 Dec 6.


Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.

Bowen WH, Burne RA, Wu H, Koo H.

Trends Microbiol. 2018 Mar;26(3):229-242. doi: 10.1016/j.tim.2017.09.008. Epub 2017 Oct 30. Review.


Using the CDC Worksite Health ScoreCard to Assess Employer Health Promotion Efforts: A Case Study at Johns Hopkins Medicine.

Safeer R, Bowen W, Maung Z, Lucik M.

J Occup Environ Med. 2018 Feb;60(2):e98-e105. doi: 10.1097/JOM.0000000000001206.


Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography.

Free RD, DeRocher K, Stock SR, Keane D, Scott-Anne K, Bowen WH, Joester D.

J Synchrotron Radiat. 2017 Sep 1;24(Pt 5):1056-1064. doi: 10.1107/S1600577517008724. Epub 2017 Aug 18.


Precision measurement: Sensing past the quantum limit.

Baker CG, Bowen WP.

Nature. 2017 Jul 12;547(7662):164-165. doi: 10.1038/547164a. No abstract available.


Erratum: Quantum enhanced feedback cooling of a mechanical oscillator using nonclassical light.

Schäfermeier C, Kerdoncuff H, Hoff UB, Fu H, Huck A, Bilek J, Harris GI, Bowen WP, Gehring T, Andersen UL.

Nat Commun. 2017 Feb 3;8:14489. doi: 10.1038/ncomms14489. No abstract available.


Design and Investigation of a [18F]-Labeled Benzamide Derivative as a High Affinity Dual Sigma Receptor Subtype Radioligand for Prostate Tumor Imaging.

Yang D, Comeau A, Bowen WD, Mach RH, Ross BD, Hong H, Van Dort ME.

Mol Pharm. 2017 Mar 6;14(3):770-780. doi: 10.1021/acs.molpharmaceut.6b01020. Epub 2017 Feb 14.


Enzymology and Ultrastructure of the in situ Pellicle in Caries-Active and Caries-Inactive Patients.

Kirsch J, Hannig C, Pötschke S, Basche S, Bowen WH, Rupf S, Trautmann S, Umanskaya N, Hannig M.

Caries Res. 2017;51(2):109-118. doi: 10.1159/000452226. Epub 2017 Jan 26.


Nondestructive Profilometry of Optical Nanofibers.

Madsen LS, Baker C, Rubinsztein-Dunlop H, Bowen WP.

Nano Lett. 2016 Dec 14;16(12):7333-7337. Epub 2016 Nov 21.


Quantum enhanced feedback cooling of a mechanical oscillator using nonclassical light.

Schäfermeier C, Kerdoncuff H, Hoff UB, Fu H, Huck A, Bilek J, Harris GI, Bowen WP, Gehring T, Andersen UL.

Nat Commun. 2016 Nov 29;7:13628. doi: 10.1038/ncomms13628.


Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation.

Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK.

Hepatology. 2016 Nov;64(5):1711-1724. doi: 10.1002/hep.28721. Epub 2016 Oct 1.


Ethical issues and best practice in clinically based genomic research: Exeter Stakeholders Meeting Report.

Carrieri D, Bewshea C, Walker G, Ahmad T, Bowen W, Hall A, Kelly S; 7th of October 2015 Exeter Stakeholders Meeting.

J Med Ethics. 2016 Nov;42(11):695-697. doi: 10.1136/medethics-2016-103530. Epub 2016 Sep 27.


High bandwidth on-chip capacitive tuning of microtoroid resonators.

Baker CG, Bekker C, McAuslan DL, Sheridan E, Bowen WP.

Opt Express. 2016 Sep 5;24(18):20400-12. doi: 10.1364/OE.24.020400.


Nonlinear optomechanical measurement of mechanical motion.

Brawley GA, Vanner MR, Larsen PE, Schmid S, Boisen A, Bowen WP.

Nat Commun. 2016 Mar 21;7:10988. doi: 10.1038/ncomms10988.


Key Questions in Marine Megafauna Movement Ecology.

Hays GC, Ferreira LC, Sequeira AMM, Meekan MG, Duarte CM, Bailey H, Bailleul F, Bowen WD, Caley MJ, Costa DP, Eguíluz VM, Fossette S, Friedlaender AS, Gales N, Gleiss AC, Gunn J, Harcourt R, Hazen EL, Heithaus MR, Heupel M, Holland K, Horning M, Jonsen I, Kooyman GL, Lowe CG, Madsen PT, Marsh H, Phillips RA, Righton D, Ropert-Coudert Y, Sato K, Shaffer SA, Simpfendorfer CA, Sims DW, Skomal G, Takahashi A, Trathan PN, Wikelski M, Womble JN, Thums M.

Trends Ecol Evol. 2016 Jun;31(6):463-475. doi: 10.1016/j.tree.2016.02.015. Epub 2016 Mar 12.


Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma.

Nicholson H, Mesangeau C, McCurdy CR, Bowen WD.

J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. doi: 10.1124/jpet.115.228387. Epub 2015 Nov 16.


Evidence-Based Management Of Acute Hand Injuries In The Emergency Department.

Bowen WT, Slaven EM.

Emerg Med Pract. 2014 Dec;16(12):1-25; quiz 26-7. Epub 2014 Dec 1. Review.


Dental caries - not just holes in teeth! A perspective.

Bowen WH.

Mol Oral Microbiol. 2016 Jun;31(3):228-33. doi: 10.1111/omi.12132. Epub 2015 Oct 12. Review.


Enzymes in the in-situ pellicle of children with different caries activity.

Grychtol S, Viergutz G, Pötschke S, Bowen WH, Hoth-Hannig W, Leis B, Umanskaya N, Hannig M, Hannig C.

Eur J Oral Sci. 2015 Oct;123(5):319-326. doi: 10.1111/eos.12207. Epub 2015 Aug 28.


Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM.

Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.


A novel approach to quantifying the spatiotemporal behavior of instrumented grey seals used to sample the environment.

Baker LL, Mills Flemming JE, Jonsen ID, Lidgard DC, Iverson SJ, Bowen WD.

Mov Ecol. 2015 Jul 8;3(1):20. doi: 10.1186/s40462-015-0047-4. eCollection 2015.


Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity.

Nicholson H, Comeau A, Mesangeau C, McCurdy CR, Bowen WD.

J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. doi: 10.1124/jpet.115.224105. Epub 2015 Jun 1.


Offspring size at weaning affects survival to recruitment and reproductive performance of primiparous gray seals.

Bowen WD, den Heyer CE, McMillan JI, Iverson SJ.

Ecol Evol. 2015 Apr;5(7):1412-24. doi: 10.1002/ece3.1450. Epub 2015 Mar 4.


In memoriam: Dr John A. Gray III.

Bowen WH.

J Dent Res. 2015 Mar;94(3):393-4. No abstract available.


The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.

Miller JH, Avilés-Reyes A, Scott-Anne K, Gregoire S, Watson GE, Sampson E, Progulske-Fox A, Koo H, Bowen WH, Lemos JA, Abranches J.

Infect Immun. 2015 May;83(5):2001-10. doi: 10.1128/IAI.03022-14. Epub 2015 Mar 2.


Advances in laser scanning imaging cytometry for high-content screening.

Wylie PG, Onley DJ, Hammerstein AF, Bowen WP.

Assay Drug Dev Technol. 2015 Mar;13(2):66-78. doi: 10.1089/adt.2014.607. Epub 2015 Feb 5. Review.


Characterization of TRIF selectivity in the AGP class of lipid A mimetics: role of secondary lipid chains.

Khalaf JK, Bowen WS, Bazin HG, Ryter KT, Livesay MT, Ward JR, Evans JT, Johnson DA.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):547-53. doi: 10.1016/j.bmcl.2014.12.024. Epub 2014 Dec 17.


Candida albicans and Streptococcus mutans: a potential synergistic alliance to cause virulent tooth decay in children.

Koo H, Bowen WH.

Future Microbiol. 2014;9(12):1295-7. doi: 10.2217/fmb.14.92. No abstract available.


Preparedness for epidemic disease or bioterrorism: minimum cost planning for the location and staffing of urban point-of-dispensing centers.

Bowen WM, Chen JY, Tukel OI.

J Emerg Manag. 2014 Sep-Oct;12(5):391-406. doi: 10.5055/jem.2014.0204.


Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.

Koral K, Paranjpe S, Bowen WC, Mars W, Luo J, Michalopoulos GK.

Hepatology. 2015 Feb;61(2):537-47. doi: 10.1002/hep.27444. Epub 2014 Dec 24.

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