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Items: 1 to 50 of 349

1.

The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats.

Mayo BJ, Secombe KR, Wignall AD, Bateman E, Thorpe D, Pietra C, Keefe DM, Bowen JM.

Cancer Chemother Pharmacol. 2020 Feb 14. doi: 10.1007/s00280-020-04040-0. [Epub ahead of print]

PMID:
32060615
2.

Intestinal accumulation of silica particles in a rat model of dextran sulfate sodium-induced colitis.

Tam SYJ, Coller JK, Wignall A, Gibson RJ, Khatri A, Barbé C, Bowen JM.

Ann Gastroenterol. 2019 Nov-Dec;32(6):584-592. doi: 10.20524/aog.2019.0411. Epub 2019 Aug 3.

3.

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines.

Bowen JM, Gibson RJ, Coller JK, Blijlevens N, Bossi P, Al-Dasooqi N, Bateman EH, Chiang K, de Mooij C, Mayo B, Stringer AM, Tissing W, Wardill HR, van Sebille YZA, Ranna V, Vaddi A, Keefe DM, Lalla RV, Cheng KKF, Elad S; Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO).

Support Care Cancer. 2019 Oct;27(10):4011-4022. doi: 10.1007/s00520-019-04892-0. Epub 2019 Jul 8.

PMID:
31286233
4.

Highlight article: Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity.

Van Sebille YZ, Gibson RJ, Wardill HR, Carney TJ, Bowen JM.

Exp Biol Med (Maywood). 2019 Oct;244(14):1178-1185. doi: 10.1177/1535370219855334. Epub 2019 Jun 11. No abstract available.

PMID:
31184924
5.

Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.

Wardill HR, Choo JM, Dmochowska N, Mavrangelos C, Campaniello MA, Bowen JM, Rogers GB, Hughes PA.

Inflamm Bowel Dis. 2019 Jun 18;25(7):1196-1207. doi: 10.1093/ibd/izz011.

PMID:
30794280
6.

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model.

Gibson RJ, van Sebille YZA, Wardill HR, Wignall A, Shirren J, Ball IA, Williams N, Wanner K, Bowen JM.

Chemotherapy. 2018;63(5):284-292. doi: 10.1159/000495470. Epub 2019 Feb 7.

7.

Unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression: a meta-analysis of randomized controlled trials over 2 decades

Sehatzadeh S, Daskalakis ZJ, Yap B, Tu HA, Palimaka S, Bowen JM, O’Reilly DJ.

J Psychiatry Neurosci. 2019 May 1;44(3):151-163.

8.

Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model.

Secombe KR, Ball IA, Shirren J, Wignall AD, Finnie J, Keefe D, Avogadri-Connors F, Olek E, Martin D, Moran S, Bowen JM.

Cancer Chemother Pharmacol. 2019 Mar;83(3):531-543. doi: 10.1007/s00280-018-3756-8. Epub 2018 Dec 10.

PMID:
30535958
9.

Economic analysis of pharmacist-administered influenza vaccines in Ontario, Canada.

O'Reilly DJ, Blackhouse G, Burns S, Bowen JM, Burke N, Mehltretter J, Waite NM, Houle SK.

Clinicoecon Outcomes Res. 2018 Oct 24;10:655-663. doi: 10.2147/CEOR.S167500. eCollection 2018.

10.

Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy.

Korver SK, Gibson RJ, Bowen JM, Coller JK.

Cancer Chemother Pharmacol. 2019 Feb;83(2):217-236. doi: 10.1007/s00280-018-3729-y. Epub 2018 Nov 24. Review.

PMID:
30474704
11.

Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.

Fakiha K, Coller JK, Logan RM, Gibson RJ, Bowen JM.

Support Care Cancer. 2019 Jun;27(6):2313-2320. doi: 10.1007/s00520-018-4511-8. Epub 2018 Oct 23.

PMID:
30350190
12.

Evaluation of Microbial Communities Associated With the Liquid and Solid Phases of the Rumen of Cattle Offered a Diet of Perennial Ryegrass or White Clover.

Bowen JM, McCabe MS, Lister SJ, Cormican P, Dewhurst RJ.

Front Microbiol. 2018 Oct 8;9:2389. doi: 10.3389/fmicb.2018.02389. eCollection 2018.

13.

Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats.

Lee AMC, Bowen JM, Su YW, Plews E, Chung R, Keefe DMK, Xian CJ.

J Cell Biochem. 2019 Mar;120(3):4180-4191. doi: 10.1002/jcb.27705. Epub 2018 Sep 27.

PMID:
30260048
14.

The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy-induced gastrointestinal toxicity.

Secombe KR, Coller JK, Gibson RJ, Wardill HR, Bowen JM.

Int J Cancer. 2019 May 15;144(10):2365-2376. doi: 10.1002/ijc.31836. Epub 2018 Oct 1. Review.

PMID:
30155890
15.

Colonic migrating motor complexes are inhibited in acute tri-nitro benzene sulphonic acid colitis.

Hofma BR, Wardill HR, Mavrangelos C, Campaniello MA, Dimasi D, Bowen JM, Smid SD, Bonder CS, Beckett EA, Hughes PA.

PLoS One. 2018 Jun 22;13(6):e0199394. doi: 10.1371/journal.pone.0199394. eCollection 2018.

16.

Vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), angiostatin, and endostatin are increased in radiotherapy-induced gastrointestinal toxicity.

Stansborough RL, Bateman EH, Al-Dasooqi N, Bowen JM, Wignall A, Keefe DM, Yeoh AS, Logan RM, Yeoh EEK, Stringer AM, Gibson RJ.

Int J Radiat Biol. 2018 Jul;94(7):645-655. doi: 10.1080/09553002.2018.1483588.

PMID:
29855218
17.

Role of toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production in chemotherapy-induced mucositis.

Khan S, Wardill HR, Bowen JM.

Cancer Chemother Pharmacol. 2018 Jul;82(1):31-37. doi: 10.1007/s00280-018-3605-9. Epub 2018 May 29. Review.

PMID:
29845394
18.

Matrix metalloproteinase expression is altered in the small and large intestine following fractionated radiation in vivo.

Stansborough RL, Al-Dasooqi N, Bateman EH, Bowen JM, Keefe DMK, Logan RM, Yeoh ASJ, Yeoh EEK, Stringer AM, Gibson RJ.

Support Care Cancer. 2018 Nov;26(11):3873-3882. doi: 10.1007/s00520-018-4255-5. Epub 2018 May 12.

PMID:
29754212
19.

Clinical outcomes and health care utilization pre- and post-laparoscopic radiofrequency ablation of symptomatic fibroids and laparoscopic myomectomy: a randomized trial of uterine-sparing techniques (TRUST) in Canada.

Rattray DD, Weins L, Regush LC, Bowen JM, O'Reilly D, Thiel JA.

Clinicoecon Outcomes Res. 2018 Apr 5;10:201-212. doi: 10.2147/CEOR.S155038. eCollection 2018.

20.

Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis.

Wardill HR, Van Sebille YZA, Ciorba MA, Bowen JM.

Curr Opin Support Palliat Care. 2018 Jun;12(2):187-197. doi: 10.1097/SPC.0000000000000338.

PMID:
29547491
21.

Spectrum of Aortic Disease in the Giant Cell Arteritis Population.

Kebed DT, Bois JP, Connolly HM, Scott CG, Bowen JM, Warrington KJ, Makol A, Greason KL, Schaff HV, Anavekar NS.

Am J Cardiol. 2018 Feb 15;121(4):501-508. doi: 10.1016/j.amjcard.2017.11.011. Epub 2017 Nov 23.

PMID:
29291886
22.

Advances in the understanding and management of mucositis during stem cell transplantation.

Bowen JM, Wardill HR.

Curr Opin Support Palliat Care. 2017 Dec;11(4):341-346. doi: 10.1097/SPC.0000000000000310. Review.

PMID:
28984677
23.

Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer.

Van Sebille YZA, Gibson RJ, Wardill HR, Ball IA, Keefe DMK, Bowen JM.

Int J Cancer. 2018 Jan 15;142(2):369-380. doi: 10.1002/ijc.31048. Epub 2017 Sep 28.

24.

Preliminary Results of the Adoption and Application of the Integrated Comprehensive Care Bundle Care Program When Treating Patients with Chronic Obstructive Pulmonary Disease.

Guertin JR, Bowen JM, Gosse C, Blackhouse G, O'Reilly DJ, Baltaga E, Cox G, Johnson D, Le Blanc B, Loncke J, Pugsley S, Sivakumaran R, Wheatley L, Smith K, Tarride JE.

Can Respir J. 2017;2017:7049483. doi: 10.1155/2017/7049483. Epub 2017 Aug 7.

25.

Theophylline-7β-d-Ribofuranoside (Theonosine), a New Theophylline Metabolite Generated in Human and Animal Lung Tissue.

Sitar DS, Bowen JM, He J, Tesoro A, Spino M.

Pharmaceutics. 2017 Aug 14;9(3). pii: E28. doi: 10.3390/pharmaceutics9030028.

26.

Relationship between hyperbaric oxygen therapy and quality of life in participants with chronic diabetic foot ulcers: data from a randomized controlled trial.

Li G, Hopkins RB, Levine MAH, Jin X, Bowen JM, Thabane L, Goeree R, Fedorko L, O'Reilly DJ.

Acta Diabetol. 2017 Sep;54(9):823-831. doi: 10.1007/s00592-017-1012-z. Epub 2017 Jun 12.

PMID:
28603808
27.

What Influences the Cost Effectiveness of Dabigatran versus Warfarin for Stroke Prevention in Atrial Fibrillation: A Systematic Review.

Jegathisawaran J, Holbrook A, Bowen JM, Burke N, Campbell K, Tarride JE.

J Popul Ther Clin Pharmacol. 2017 May 2;24(2):e1-e20. doi: 10.22374/1710-6222.24.2.1710. Review.

PMID:
28594478
28.

Aortic Root Surgery in Marfan Syndrome: Medium-Term Outcome in a Single-Center Experience.

Attenhofer Jost CH, Connolly HM, Scott CG, Ammash NM, Bowen JM, Schaff HV.

J Heart Valve Dis. 2017 Jan;26(1):45-53.

PMID:
28544831
29.

Cancer treatment-related gastrointestinal symptoms.

Bowen JM.

Curr Opin Support Palliat Care. 2017 Jun;11(2):118-119. doi: 10.1097/SPC.0000000000000269. No abstract available.

PMID:
28460373
30.

Dacomitinib-induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats.

Van Sebille YZA, Gibson RJ, Wardill HR, Secombe KR, Ball IA, Keefe DMK, Finnie JW, Bowen JM.

Int J Cancer. 2017 Jun 15;140(12):2820-2829. doi: 10.1002/ijc.30699. Epub 2017 Mar 28.

31.

The 2017 international classification of the Ehlers-Danlos syndromes.

Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, Bloom L, Bowen JM, Brady AF, Burrows NP, Castori M, Cohen H, Colombi M, Demirdas S, De Backer J, De Paepe A, Fournel-Gigleux S, Frank M, Ghali N, Giunta C, Grahame R, Hakim A, Jeunemaitre X, Johnson D, Juul-Kristensen B, Kapferer-Seebacher I, Kazkaz H, Kosho T, Lavallee ME, Levy H, Mendoza-Londono R, Pepin M, Pope FM, Reinstein E, Robert L, Rohrbach M, Sanders L, Sobey GJ, Van Damme T, Vandersteen A, van Mourik C, Voermans N, Wheeldon N, Zschocke J, Tinkle B.

Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):8-26. doi: 10.1002/ajmg.c.31552.

PMID:
28306229
32.

Illustration of the Impact of Unmeasured Confounding Within an Economic Evaluation Based on Nonrandomized Data.

Guertin JR, Bowen JM, De Rose G, O'Reilly DJ, Tarride JE.

MDM Policy Pract. 2017 Mar 16;2(1):2381468317697711. doi: 10.1177/2381468317697711. eCollection 2017 Jan-Jun.

33.

Ehlers-Danlos syndrome, classical type.

Bowen JM, Sobey GJ, Burrows NP, Colombi M, Lavallee ME, Malfait F, Francomano CA.

Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):27-39. doi: 10.1002/ajmg.c.31548. Epub 2017 Feb 13. Review.

PMID:
28192633
34.

Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity.

Stansborough RL, Bateman EH, Al-Dasooqi N, Bowen JM, Keefe DMK, Yeoh ASJ, Logan RM, Yeoh EEK, Stringer AM, Gibson RJ.

Support Care Cancer. 2017 Jun;25(6):1973-1983. doi: 10.1007/s00520-017-3601-3. Epub 2017 Feb 7.

PMID:
28175996
35.

Development of a trigger tool to identify adverse events and harm in Emergency Medical Services.

Howard IL, Bowen JM, Al Shaikh LAH, Mate KS, Owen RC, Williams DM.

Emerg Med J. 2017 Jun;34(6):391-397. doi: 10.1136/emermed-2016-205746. Epub 2017 Feb 2.

PMID:
28153866
36.

Feasibility of an altruistic sperm donation program in Canada: results from a population-based model.

O'Reilly D, Bowen JM, Perampaladas K, Qureshi R, Xie F, Hughes E.

Reprod Health. 2017 Jan 14;14(1):8. doi: 10.1186/s12978-016-0275-0.

37.

Routine assessment of the gut microbiome to promote preclinical research reproducibility and transparency.

Wardill HR, Bowen JM, Van Sebille YZA, Gibson RJ.

Gut. 2017 Oct;66(10):1869-1871. doi: 10.1136/gutjnl-2016-313486. Epub 2017 Jan 9. No abstract available.

PMID:
28069831
38.

The Integrated Comprehensive Care Program: A Novel Home Care Initiative After Major Thoracic Surgery.

Shargall Y, Hanna WC, Schneider L, Schieman C, Finley CJ, Tran A, Demay S, Gosse C, Bowen JM, Blackhouse G, Smith K.

Semin Thorac Cardiovasc Surg. 2016 Summer;28(2):574-582. doi: 10.1053/j.semtcvs.2015.12.003. Epub 2015 Dec 11.

PMID:
28043480
39.

Process mapping evaluation of medication reconciliation in academic teaching hospitals: a critical step in quality improvement.

Holbrook A, Bowen JM, Patel H, O'Brien C, You JJ, Tahavori R, Doleweerd J, Berezny T, Perri D, Nieuwstraten C, Troyan S, Patel A.

BMJ Open. 2016 Dec 30;6(12):e013663. doi: 10.1136/bmjopen-2016-013663.

40.

Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report.

Coller JK, Bowen JM, Ball IA, Wardill HR, van Sebille YZ, Stansborough RL, Lightwala Z, Wignall A, Shirren J, Secombe K, Gibson RJ.

Cancer Chemother Pharmacol. 2017 Feb;79(2):431-434. doi: 10.1007/s00280-016-3223-3. Epub 2016 Dec 23.

PMID:
28011980
41.

TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea.

Wardill HR, Bowen JM, Van Sebille YZ, Secombe KR, Coller JK, Ball IA, Logan RM, Gibson RJ.

Mol Cancer Ther. 2016 Nov;15(11):2767-2779. Epub 2016 Aug 22.

42.

Irinotecan-induced mucositis: the interactions and potential role of GLP-2 analogues.

Mayo BJ, Stringer AM, Bowen JM, Bateman EH, Keefe DM.

Cancer Chemother Pharmacol. 2017 Feb;79(2):233-249. doi: 10.1007/s00280-016-3165-9. Epub 2016 Oct 21. Review.

PMID:
27770239
43.

Irinotecan-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.

Campbell JM, Stephenson MD, Bateman E, Peters MD, Keefe DM, Bowen JM.

Pharmacogenomics J. 2017 Jan;17(1):21-28. doi: 10.1038/tpj.2016.58. Epub 2016 Aug 9. Review.

PMID:
27503581
44.
45.

Management of Hospital Formularies in Ontario: Challenges within a Local Health Integration Network.

Burke N, Bowen JM, Troyan S, Jegathisawaran J, Gosse C, Tonkin M, Kagoma S, Goeree R, Holbrook A.

Can J Hosp Pharm. 2016 May-Jun;69(3):187-93. Epub 2016 Jun 30.

46.

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction.

Wardill HR, Mander KA, Van Sebille YZ, Gibson RJ, Logan RM, Bowen JM, Sonis ST.

Int J Cancer. 2016 Dec 15;139(12):2635-2645. doi: 10.1002/ijc.30252. Epub 2016 Jul 15. Review.

47.

Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms.

Wardill HR, Gibson RJ, Van Sebille YZ, Secombe KR, Coller JK, White IA, Manavis J, Hutchinson MR, Staikopoulos V, Logan RM, Bowen JM.

Mol Cancer Ther. 2016 Jun;15(6):1376-86. doi: 10.1158/1535-7163.MCT-15-0990. Epub 2016 Mar 29.

48.

Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.

Campbell JM, Bateman E, Stephenson MD, Bowen JM, Keefe DM, Peters MD.

Cancer Chemother Pharmacol. 2016 Jul;78(1):27-39. doi: 10.1007/s00280-016-3043-5. Epub 2016 May 3. Review.

PMID:
27142726
49.

A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options.

Wardill HR, Gibson RJ, Van Sebille YZ, Secombe KR, Logan RM, Bowen JM.

Exp Biol Med (Maywood). 2016 Jul;241(13):1386-94. doi: 10.1177/1535370216640932. Epub 2016 Mar 31.

50.

Gastrointestinal toxicities of first and second-generation small molecule human epidermal growth factor receptor tyrosine kinase inhibitors in advanced nonsmall cell lung cancer.

Van Sebille YZ, Gibson RJ, Wardill HR, Bowen JM.

Curr Opin Support Palliat Care. 2016 Jun;10(2):152-6. doi: 10.1097/SPC.0000000000000210. No abstract available.

PMID:
27035390

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