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Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation.

Wallace JG, Bellissimo CJ, Yeo E, Fei Xia Y, Petrik JJ, Surette MG, Bowdish DME, Sloboda DM.

Sci Rep. 2019 Nov 26;9(1):17621. doi: 10.1038/s41598-019-54098-x.


Starving the Gut: A Deficit of Butyrate in the Intestinal Ecosystem of Children With Intestinal Failure.

Dowhaniuk JK, Szamosi J, Chorlton S, Owens J, Mileski H, Clause RF, Pernica JM, Bowdish DME, Surette MG, Ratcliffe EM.

JPEN J Parenter Enteral Nutr. 2019 Oct 22. doi: 10.1002/jpen.1715. [Epub ahead of print]


IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity.

Karimi Y, Giles EC, Vahedi F, Chew MV, Nham T, Loukov D, Lee AJ, Bowdish DM, Ashkar AA.

Innate Immun. 2019 Oct 15:1753425919878839. doi: 10.1177/1753425919878839. [Epub ahead of print] No abstract available.


Loss of Microbial Topography Precedes Infection in Infants.

Surette MG, Bowdish DME.

Am J Respir Crit Care Med. 2019 Sep 15;200(6):660-662. doi: 10.1164/rccm.201903-0687ED. No abstract available.


TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice.

Breznik JA, Naidoo A, Foley KP, Schulz C, Lau TC, Loukov D, Sloboda DM, Bowdish DME, Schertzer JD.

Physiol Rep. 2018 Dec;6(23):e13937. doi: 10.14814/phy2.13937.


Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

Lamarche D, Johnstone J, Zytaruk N, Clarke F, Hand L, Loukov D, Szamosi JC, Rossi L, Schenck LP, Verschoor CP, McDonald E, Meade MO, Marshall JC, Bowdish DME, Karachi T, Heels-Ansdell D, Cook DJ, Surette MG; PROSPECT Investigators; Canadian Critical Care Trials Group; Canadian Critical Care Translational Biology Group.

Respir Res. 2018 Dec 7;19(1):245. doi: 10.1186/s12931-018-0950-5.


Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice.

Cavallari JF, Anhê FF, Foley KP, Denou E, Chan RW, Bowdish DME, Schertzer JD.

Physiol Rep. 2018 Nov;6(22):e13930. doi: 10.14814/phy2.13930.


Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis.

Krishnan S, Prise IE, Wemyss K, Schenck LP, Bridgeman HM, McClure FA, Zangerle-Murray T, O'Boyle C, Barbera TA, Mahmood F, Bowdish DME, Zaiss DMW, Grainger JR, Konkel JE.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10738-10743. doi: 10.1073/pnas.1802320115. Epub 2018 Oct 2.


The Aging Lung: Is Lung Health Good Health for Older Adults?

Bowdish DME.

Chest. 2019 Feb;155(2):391-400. doi: 10.1016/j.chest.2018.09.003. Epub 2018 Sep 22. Review.


Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis.

Hayes CL, Dong J, Galipeau HJ, Jury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, Libertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF.

Sci Rep. 2018 Sep 21;8(1):14184. doi: 10.1038/s41598-018-32366-6.


Probiotics to Prevent Respiratory Infections in Nursing Homes: A Pilot Randomized Controlled Trial.

Wang B, Hylwka T, Smieja M, Surrette M, Bowdish DME, Loeb M.

J Am Geriatr Soc. 2018 Jul;66(7):1346-1352. doi: 10.1111/jgs.15396. Epub 2018 May 9.


Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.

Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi JC, Verschoor CP, Loukov D, Schenck LP, Jury J, Foley KP, Schertzer JD, Larché MJ, Davidson DJ, Verdú EF, Surette MG, Bowdish DME.

Cell Host Microbe. 2018 Apr 11;23(4):570. doi: 10.1016/j.chom.2018.03.006. No abstract available.


Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier.

Nazli A, Dizzell S, Zahoor MA, Ferreira VH, Kafka J, Woods MW, Ouellet M, Ashkar AA, Tremblay MJ, Bowdish DM, Kaushic C.

Cell Mol Immunol. 2019 Feb;16(2):178-194. doi: 10.1038/cmi.2017.168. Epub 2018 Mar 19.


Exercise reduces depression and inflammation but intensity matters.

Paolucci EM, Loukov D, Bowdish DME, Heisz JJ.

Biol Psychol. 2018 Mar;133:79-84. doi: 10.1016/j.biopsycho.2018.01.015. Epub 2018 Feb 3.


Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes.

Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME.

Mol Biol Evol. 2018 Feb 1;35(2):440-450. doi: 10.1093/molbev/msx298.


Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and pain.

Loukov D, Karampatos S, Maly MR, Bowdish DME.

Osteoarthritis Cartilage. 2018 Feb;26(2):255-263. doi: 10.1016/j.joca.2017.10.018. Epub 2017 Nov 8.


DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.

Verschoor CP, McEwen LM, Kobor MS, Loeb MB, Bowdish DME.

Exp Gerontol. 2018 May;105:47-52. doi: 10.1016/j.exger.2017.10.010. Epub 2017 Oct 12.


Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.

Verschoor CP, Lelic A, Parsons R, Evelegh C, Bramson JL, Johnstone J, Loeb MB, Bowdish DME.

J Infect Dis. 2017 Jul 15;216(2):191-197. doi: 10.1093/infdis/jix257.


Streptococcus pneumoniae Colonization Is Required To Alter the Nasal Microbiota in Cigarette Smoke-Exposed Mice.

Shen P, Whelan FJ, Schenck LP, McGrath JJC, Vanderstocken G, Bowdish DME, Surette MG, Stämpfli MR.

Infect Immun. 2017 Sep 20;85(10). pii: e00434-17. doi: 10.1128/IAI.00434-17. Print 2017 Oct.


The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study.

Verschoor CP, McEwen LM, Kohli V, Wolfson C, Bowdish DM, Raina P, Kobor MS, Balion C.

BMC Genet. 2017 Jun 21;18(1):57. doi: 10.1186/s12863-017-0525-3.


A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J.

J Immunol. 2017 May 15;198(10):3775-3789. doi: 10.4049/jimmunol.1700373.


Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.

Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi JC, Verschoor CP, Loukov D, Schenck LP, Jury J, Foley KP, Schertzer JD, Larché MJ, Davidson DJ, Verdú EF, Surette MG, Bowdish DME.

Cell Host Microbe. 2017 Apr 12;21(4):455-466.e4. doi: 10.1016/j.chom.2017.03.002. Erratum in: Cell Host Microbe. 2018 Apr 11;23 (4):570.


The unique immunological features of heparin-induced thrombocytopenia.

Staibano P, Arnold DM, Bowdish DM, Nazy I.

Br J Haematol. 2017 Apr;177(2):198-207. doi: 10.1111/bjh.14603. Epub 2017 Apr 3. Review.


The sil Locus in Streptococcus Anginosus Group: Interspecies Competition and a Hotspot of Genetic Diversity.

Mendonca ML, Szamosi JC, Lacroix AM, Fontes ME, Bowdish DM, Surette MG.

Front Microbiol. 2017 Jan 10;7:2156. doi: 10.3389/fmicb.2016.02156. eCollection 2016.


On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier.

Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H, Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DME, Lionakis MS, Jones SA, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM.

Immunity. 2017 Jan 17;46(1):133-147. doi: 10.1016/j.immuni.2016.12.010. Epub 2017 Jan 10.


The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes.

Himbert S, Alsop RJ, Rose M, Hertz L, Dhaliwal A, Moran-Mirabal JM, Verschoor CP, Bowdish DM, Kaestner L, Wagner C, Rheinstädter MC.

Sci Rep. 2017 Jan 3;7:39661. doi: 10.1038/srep39661.


Bacterial Binding, Phagocytosis, and Killing: Measurements Using Colony Forming Units.

Novakowski KE, Loukov D, Chawla V, Bowdish DM.

Methods Mol Biol. 2017;1519:297-309.


Composition and immunological significance of the upper respiratory tract microbiota.

Schenck LP, Surette MG, Bowdish DM.

FEBS Lett. 2016 Nov;590(21):3705-3720. doi: 10.1002/1873-3468.12455. Epub 2016 Nov 1. Review.


Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents.

Lelic A, Verschoor CP, Lau VW, Parsons R, Evelegh C, Bowdish DM, Bramson JL, Loeb MB.

J Infect Dis. 2016 Dec 15;214(12):1905-1910. Epub 2016 Oct 5.


Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner.

Mullarkey CE, Bailey MJ, Golubeva DA, Tan GS, Nachbagauer R, He W, Novakowski KE, Bowdish DM, Miller MS, Palese P.

mBio. 2016 Oct 4;7(5). pii: e01624-16. doi: 10.1128/mBio.01624-16.


Correction: Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children.

Verschoor CP, Singh P, Russell ML, Bowdish DM, Brewer A, Cyr L, Ward BJ, Loeb M.

PLoS One. 2016 Sep 22;11(9):e0163830. doi: 10.1371/journal.pone.0163830. eCollection 2016.


Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial.

Cook DJ, Johnstone J, Marshall JC, Lauzier F, Thabane L, Mehta S, Dodek PM, McIntyre L, Pagliarello J, Henderson W, Taylor RW, Cartin-Ceba R, Golan E, Herridge M, Wood G, Ovakim D, Karachi T, Surette MG, Bowdish DM, Lamarche D, Verschoor CP, Duan EH, Heels-Ansdell D, Arabi Y, Meade M; PROSPECT Investigators and the Canadian Critical Care Trials Group.

Trials. 2016 Aug 2;17:377. doi: 10.1186/s13063-016-1495-x.


Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination.

Bridle BW, Nguyen A, Salem O, Zhang L, Koshy S, Clouthier D, Chen L, Pol J, Swift SL, Bowdish DM, Lichty BD, Bramson JL, Wan Y.

J Immunol. 2016 Jun 1;196(11):4587-95. doi: 10.4049/jimmunol.1600106. Epub 2016 Apr 27.


Partitioning and correlating subgroup characteristics from Aligned Pattern Clusters.

Lee ES, Whelan FJ, Bowdish DM, Wong AK.

Bioinformatics. 2016 Aug 15;32(16):2427-34. doi: 10.1093/bioinformatics/btw211. Epub 2016 Apr 22.


Tumor necrosis factor drives increased splenic monopoiesis in old mice.

Loukov D, Naidoo A, Puchta A, Marin JL, Bowdish DM.

J Leukoc Biol. 2016 Jul;100(1):121-9. doi: 10.1189/jlb.3MA0915-433RR. Epub 2016 Apr 1.


Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide.

Fei F, Lee KM, McCarry BE, Bowdish DM.

Sci Rep. 2016 Mar 4;6:22637. doi: 10.1038/srep22637.


Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice.

Shen P, Morissette MC, Vanderstocken G, Gao Y, Hassan M, Roos A, Thayaparan D, Merlano M, Dorrington MG, Nikota JK, Bauer CMT, Kwiecien JM, Labiris R, Bowdish DME, Stevenson CS, Stämpfli MR.

Infect Immun. 2016 Apr 22;84(5):1536-1547. doi: 10.1128/IAI.01504-15. Print 2016 May.


A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function.

Novakowski KE, Huynh A, Han S, Dorrington MG, Yin C, Tu Z, Pelka P, Whyte P, Guarné A, Sakamoto K, Bowdish DM.

Immunol Cell Biol. 2016 Aug;94(7):646-55. doi: 10.1038/icb.2016.20. Epub 2016 Feb 18.


Mycoplasma pneumoniae, a trigger for Weston Hurst syndrome.

Magun R, Verschoor CP, Bowdish DM, Provias J.

Neurol Neuroimmunol Neuroinflamm. 2016 Jan 21;3(1):e187. doi: 10.1212/NXI.0000000000000187. eCollection 2016 Feb.


Streptococcus pneumoniae Colonization Disrupts the Microbial Community within the Upper Respiratory Tract of Aging Mice.

Thevaranjan N, Whelan FJ, Puchta A, Ashu E, Rossi L, Surette MG, Bowdish DM.

Infect Immun. 2016 Mar 24;84(4):906-16. doi: 10.1128/IAI.01275-15. Print 2016 Apr.


TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity.

Puchta A, Naidoo A, Verschoor CP, Loukov D, Thevaranjan N, Mandur TS, Nguyen PS, Jordana M, Loeb M, Xing Z, Kobzik L, Larché MJ, Bowdish DM.

PLoS Pathog. 2016 Jan 14;12(1):e1005368. doi: 10.1371/journal.ppat.1005368. eCollection 2016 Jan.


Infection in an aging population.

Kline KA, Bowdish DM.

Curr Opin Microbiol. 2016 Feb;29:63-7. doi: 10.1016/j.mib.2015.11.003. Epub 2015 Dec 11. Review.


Class A Scavenger Receptor-Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity.

Nellimarla S, Baid K, Loo YM, Gale M Jr, Bowdish DM, Mossman KL.

J Immunol. 2015 Oct 15;195(8):3858-65. doi: 10.4049/jimmunol.1501028. Epub 2015 Sep 11.


An Introduction to Automated Flow Cytometry Gating Tools and Their Implementation.

Verschoor CP, Lelic A, Bramson JL, Bowdish DM.

Front Immunol. 2015 Jul 27;6:380. doi: 10.3389/fimmu.2015.00380. eCollection 2015. Review.


The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors.

Yap NV, Whelan FJ, Bowdish DM, Golding GB.

Front Immunol. 2015 Jul 6;6:342. doi: 10.3389/fimmu.2015.00342. eCollection 2015.


Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children.

Verschoor CP, Singh P, Russell ML, Bowdish DM, Brewer A, Cyr L, Ward BJ, Loeb M.

PLoS One. 2015 Jun 24;10(6):e0131531. doi: 10.1371/journal.pone.0131531. eCollection 2015. Erratum in: PLoS One. 2016;11(9):e0163830.


Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: protocol for a feasibility randomized pilot trial.

Johnstone J, Meade M, Marshall J, Heyland DK, Surette MG, Bowdish DM, Lauzier F, Thebane L, Cook DJ; PROSPECT Investigators and the Canadian Critical Care Trials Group.

Pilot Feasibility Stud. 2015 May 24;1:19. eCollection 2015.


Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age.

Stearns JC, Davidson CJ, McKeon S, Whelan FJ, Fontes ME, Schryvers AB, Bowdish DM, Kellner JD, Surette MG.

ISME J. 2015 May;9(5):1268. doi: 10.1038/ismej.2015.49. No abstract available.


Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly.

Verschoor CP, Loukov D, Naidoo A, Puchta A, Johnstone J, Millar J, Lelic A, Novakowski KE, Dorrington MG, Loeb M, Bramson JL, Bowdish DM.

Mol Immunol. 2015 May;65(1):148-56. doi: 10.1016/j.molimm.2015.01.015. Epub 2015 Feb 5.


Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age.

Stearns JC, Davidson CJ, McKeon S, Whelan FJ, Fontes ME, Schryvers AB, Bowdish DM, Kellner JD, Surette MG.

ISME J. 2015 May;9(5):1246-59. doi: 10.1038/ismej.2014.250. Epub 2015 Jan 9. Erratum in: ISME J. 2015 May;9(5):1268.

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