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Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis.

Kim JE, Roh E, Lee MH, Yu DH, Kim DJ, Lim TG, Jung SK, Peng C, Cho YY, Dickinson S, Alberts D, Bowden GT, Einspahr J, Stratton SP, Curiel-Lewandrowski C, Bode AM, Lee KW, Dong Z.

Oncogene. 2016 Aug 4;35(31):4091-101. doi: 10.1038/onc.2015.471. Epub 2015 Dec 21.


Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.

Lee MH, Lim DY, Kim MO, Lee SY, Shin SH, Kim JY, Kim SH, Kim DJ, Jung SK, Yao K, Kundu JK, Lee HS, Lee CJ, Dickinson SE, Alberts D, Bowden GT, Stratton S, Curiel C, Einspahr J, Bode AM, Surh YJ, Cho YY, Dong Z.

Carcinogenesis. 2015 Nov;36(11):1372-80. doi: 10.1093/carcin/bgv110. Epub 2015 Aug 12.


Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin.

Bermudez Y, Stratton SP, Curiel-Lewandrowski C, Warneke J, Hu C, Bowden GT, Dickinson SE, Dong Z, Bode AM, Saboda K, Brooks CA, Petricoin EF 3rd, Hurst CA, Alberts DS, Einspahr JG.

Cancer Prev Res (Phila). 2015 Aug;8(8):720-8. doi: 10.1158/1940-6207.CAPR-14-0407. Epub 2015 Jun 1.


The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses.

Dickinson SE, Rusche JJ, Bec SL, Horn DJ, Janda J, Rim SH, Smith CL, Bowden GT.

Mol Carcinog. 2015 Nov;54(11):1513-20. doi: 10.1002/mc.22224. Epub 2014 Oct 12. Erratum in: Mol Carcinog. 2016 Jul;55(7):1210.


A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes.

Dickinson SE, Olson ER, Levenson C, Janda J, Rusche JJ, Alberts DS, Bowden GT.

Arch Biochem Biophys. 2014 Sep 15;558:143-52. doi: 10.1016/ Epub 2014 Jul 5.


Stability of sulforaphane for topical formulation.

Franklin SJ, Dickinson SE, Karlage KL, Bowden GT, Myrdal PB.

Drug Dev Ind Pharm. 2014 Apr;40(4):494-502. doi: 10.3109/03639045.2013.768634. Epub 2013 Apr 23.


Sunlight UV-induced skin cancer relies upon activation of the p38α signaling pathway.

Liu K, Yu D, Cho YY, Bode AM, Ma W, Yao K, Li S, Li J, Bowden GT, Dong Z, Dong Z.

Cancer Res. 2013 Apr 1;73(7):2181-8. doi: 10.1158/0008-5472.CAN-12-3408. Epub 2013 Feb 4.


Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma.

Einspahr JG, Calvert V, Alberts DS, Curiel-Lewandrowski C, Warneke J, Krouse R, Stratton SP, Liotta L, Longo C, Pellacani G, Prasad A, Sagerman P, Bermudez Y, Deng J, Bowden GT, Petricoin EF 3rd.

Cancer Prev Res (Phila). 2012 Mar;5(3):403-13. doi: 10.1158/1940-6207.CAPR-11-0427. Erratum in: Cancer Prev Res (Phila). 2012 Aug;5(8):1072. Pellicani, Giovanni [corrected to Pellacani, Giovanni].


Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.

Li J, Mottamal M, Li H, Liu K, Zhu F, Cho YY, Sosa CP, Zhou K, Bowden GT, Bode AM, Dong Z.

Carcinogenesis. 2012 Feb;33(2):459-65. doi: 10.1093/carcin/bgr281. Epub 2011 Dec 1.


Activation of p38 MAP kinase and JNK pathways by UVA irradiation.

Zhang J, Bowden GT.

Photochem Photobiol Sci. 2012 Jan;11(1):54-61. doi: 10.1039/c1pp05133d. Epub 2011 Aug 22.


7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.

Lee DE, Lee KW, Byun S, Jung SK, Song N, Lim SH, Heo YS, Kim JE, Kang NJ, Kim BY, Bowden GT, Bode AM, Lee HJ, Dong Z.

J Biol Chem. 2011 Apr 22;286(16):14246-56. doi: 10.1074/jbc.M110.147348. Epub 2011 Mar 4.


p38 MAP kinase plays a functional role in UVB-induced mouse skin carcinogenesis.

Dickinson SE, Olson ER, Zhang J, Cooper SJ, Melton T, Criswell PJ, Casanova A, Dong Z, Hu C, Saboda K, Jacobs ET, Alberts DS, Bowden GT.

Mol Carcinog. 2011 Jun;50(6):469-78. doi: 10.1002/mc.20734. Epub 2011 Jan 25.


Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.

Sekulic A, Kim SY, Hostetter G, Savage S, Einspahr JG, Prasad A, Sagerman P, Curiel-Lewandrowski C, Krouse R, Bowden GT, Warneke J, Alberts DS, Pittelkow MR, DiCaudo D, Nickoloff BJ, Trent JM, Bittner M.

Cancer Prev Res (Phila). 2010 Oct;3(10):1277-83. doi: 10.1158/1940-6207.CAPR-10-0058. Epub 2010 Sep 28.


Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent.

Olson ER, Melton T, Dickinson SE, Dong Z, Alberts DS, Bowden GT.

Cancer Prev Res (Phila). 2010 Jul;3(7):876-84. doi: 10.1158/1940-6207.CAPR-09-0220. Epub 2010 Jun 15.


A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.

Stratton SP, Alberts DS, Einspahr JG, Sagerman PM, Warneke JA, Curiel-Lewandrowski C, Myrdal PB, Karlage KL, Nickoloff BJ, Brooks C, Saboda K, Yozwiak ML, Krutzsch MF, Hu C, Lluria-Prevatt M, Dong Z, Bowden GT, Bartels PH.

Cancer Prev Res (Phila). 2010 Feb;3(2):160-9. doi: 10.1158/1940-6207.CAPR-09-0183. Epub 2010 Jan 26.


Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.

Dickinson SE, Melton TF, Olson ER, Zhang J, Saboda K, Bowden GT.

Cancer Res. 2009 Sep 1;69(17):7103-10. doi: 10.1158/0008-5472.CAN-09-0770. Epub 2009 Aug 11.


Stabilization of quercetin paradoxically reduces its proapoptotic effect on UVB-irradiated human keratinocytes.

Olson ER, Melton T, Dong Z, Bowden GT.

Cancer Prev Res (Phila). 2008 Oct;1(5):362-8. doi: 10.1158/1940-6207.CAPR-08-0101.


Myricetin suppresses UVB-induced skin cancer by targeting Fyn.

Jung SK, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, Bode AM, Bowden GT, Lee HJ, Dong Z.

Cancer Res. 2008 Jul 15;68(14):6021-9. doi: 10.1158/0008-5472.CAN-08-0899.


UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes.

Zhang J, Bowden GT.

Mol Carcinog. 2008 Dec;47(12):974-83. doi: 10.1002/mc.20450.


Nucleolin stabilizes Bcl-X L messenger RNA in response to UVA irradiation.

Zhang J, Tsaprailis G, Bowden GT.

Cancer Res. 2008 Feb 15;68(4):1046-54. doi: 10.1158/0008-5472.CAN-07-1927.


Cross-validation of murine UV signal transduction pathways in human skin.

Einspahr JG, Bowden GT, Alberts DS, McKenzie N, Saboda K, Warneke J, Salasche S, Ranger-Moore J, Curiel-Lewandrowski C, Nagle RB, Nickoloff BJ, Brooks C, Dong Z, Stratton SP.

Photochem Photobiol. 2008 Mar-Apr;84(2):463-76. doi: 10.1111/j.1751-1097.2007.00287.x. Epub 2008 Jan 29.


Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.

Lee KW, Kang NJ, Heo YS, Rogozin EA, Pugliese A, Hwang MK, Bowden GT, Bode AM, Lee HJ, Dong Z.

Cancer Res. 2008 Feb 1;68(3):946-55. doi: 10.1158/0008-5472.CAN-07-3140.


Differential localization of MT1-MMP in human prostate cancer tissue: role of IGF-1R in MT1-MMP expression.

Sroka IC, McDaniel K, Nagle RB, Bowden GT.

Prostate. 2008 Apr 1;68(5):463-76. doi: 10.1002/pros.20718.


Integrin A6 Cleavage in Mouse Skin Tumors.

Demetriou MC, Kwei KA, Powell MB, Nagle RB, Bowden GT, Cress AE.

Open Cancer J. 2008 Jan 1;2:1-4.


Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.

Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z.

Carcinogenesis. 2007 Sep;28(9):1918-27. Epub 2007 Aug 11.


Targeting Bcl-X(L) for prevention and therapy of skin cancer.

Zhang J, Bowden GT.

Mol Carcinog. 2007 Aug;46(8):665-70. Review.


Integrin alpha6 cleavage: a novel modification to modulate cell migration.

Pawar SC, Demetriou MC, Nagle RB, Bowden GT, Cress AE.

Exp Cell Res. 2007 Apr 1;313(6):1080-9. Epub 2007 Jan 17.


Involvement of oxidants and AP-1 in angiotensin II-activated NFAT3 transcription factor.

Tu VC, Sun H, Bowden GT, Chen QM.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1248-55. Epub 2006 Nov 15.


Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar.

Arbiser JL, Govindarajan B, Battle TE, Lynch R, Frank DA, Ushio-Fukai M, Perry BN, Stern DF, Bowden GT, Liu A, Klein E, Kolodziejski PJ, Eissa NT, Hossain CF, Nagle DG.

J Invest Dermatol. 2006 Jun;126(6):1396-402.


Inhibition of UVA-induced c-Jun N-terminal kinase activity results in caspase-dependent apoptosis in human keratinocytes.

Silvers AL, Finch JS, Bowden GT.

Photochem Photobiol. 2006 Mar-Apr;82(2):423-31.


Catalase reverses tumorigenicity in a malignant cell line by an epidermal growth factor receptor pathway.

Finch JS, Tome ME, Kwei KA, Bowden GT.

Free Radic Biol Med. 2006 Mar 1;40(5):863-75. Epub 2005 Nov 2.


90K/Mac-2 binding protein is expressed in prostate cancer and induces promatrilysin expression.

Bair EL, Nagle RB, Ulmer TA, Laferté S, Bowden GT.

Prostate. 2006 Feb 15;66(3):283-93.


An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.

Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF.

Neoplasia. 2005 Sep;7(9):873-82.


Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.

Bair EL, Chen ML, McDaniel K, Sekiguchi K, Cress AE, Nagle RB, Bowden GT.

Neoplasia. 2005 Apr;7(4):380-9.


The role of Rac1 in maintaining malignant phenotype of mouse skin tumor cells.

Kwei KA, Finch JS, Ranger-Moore J, Bowden GT.

Cancer Lett. 2006 Jan 18;231(2):326-38.


Transcriptional repression of catalase in mouse skin tumor progression.

Kwei KA, Finch JS, Thompson EJ, Bowden GT.

Neoplasia. 2004 Sep-Oct;6(5):440-8.


Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism.

Zhu M, Zhang Y, Cooper S, Sikorski E, Rohwer J, Bowden GT.

Mol Carcinog. 2004 Nov;41(3):179-86.


UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression.

Bachelor MA, Bowden GT.

Semin Cancer Biol. 2004 Apr;14(2):131-8. Review.


Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling.

Bowden GT.

Nat Rev Cancer. 2004 Jan;4(1):23-35. Review. No abstract available.


RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties.

Horn EJ, Albor A, Liu Y, El-Hizawi S, Vanderbeek GE, Babcock M, Bowden GT, Hennings H, Lozano G, Weinberg WC, Kulesz-Martin M.

Carcinogenesis. 2004 Feb;25(2):157-67. Epub 2003 Oct 24.


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