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Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells.

Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ.

Immunity. 2018 May 15;48(5):1029-1045.e5. doi: 10.1016/j.immuni.2018.04.026.


Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma.

Vermeulen JF, Van Hecke W, Adriaansen EJM, Jansen MK, Bouma RG, Villacorta Hidalgo J, Fisch P, Broekhuizen R, Spliet WGM, Kool M, Bovenschen N.

Oncoimmunology. 2017 Nov 27;7(3):e1398877. doi: 10.1080/2162402X.2017.1398877. eCollection 2018.


Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.

Kok HM, van den Hoogen LL, van Roon JAG, Adriaansen EJM, Fritsch-Stork RDE, Nguyen TQ, Goldschmeding R, Radstake TRDJ, Bovenschen N.

Rheumatology (Oxford). 2017 Dec 1;56(12):2129-2134. doi: 10.1093/rheumatology/kex332.


Oncogenic role of cytomegalovirus in medulloblastoma?

Hortal AM, Vermeulen JF, Van Hecke W, Bovenschen N.

Cancer Lett. 2017 Nov 1;408:55-59. doi: 10.1016/j.canlet.2017.08.024. Epub 2017 Aug 24. Review.


Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis.

Kinashi H, Falke LL, Nguyen TQ, Bovenschen N, Aten J, Leask A, Ito Y, Goldschmeding R.

Kidney Int. 2017 Oct;92(4):850-863. doi: 10.1016/j.kint.2017.03.029. Epub 2017 May 23.


Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns.

Bengsch B, Ohtani T, Herati RS, Bovenschen N, Chang KM, Wherry EJ.

J Immunol Methods. 2018 Feb;453:3-10. doi: 10.1016/j.jim.2017.03.009. Epub 2017 Mar 19.


A novel proinflammatory role for granzyme A.

van Eck JA, Shan L, Meeldijk J, Hack CE, Bovenschen N.

Cell Death Dis. 2017 Feb 23;8(2):e2630. doi: 10.1038/cddis.2017.56. No abstract available.


Differences in T-cell infiltrates and survival between HPV+ and HPV- oropharyngeal squamous cell carcinoma.

Matlung SE, Wilhelmina van Kempen PM, Bovenschen N, van Baarle D, Willems SM.

Future Sci OA. 2016 Jan 7;2(1):FSO88. doi: 10.4155/fso.15.88. eCollection 2016 Mar. Review.


Granzymes A and K differentially potentiate LPS-induced cytokine response.

Wensink AC, Kok HM, Meeldijk J, Fermie J, Froelich CJ, Hack CE, Bovenschen N.

Cell Death Discov. 2016 Dec 12;2:16084. doi: 10.1038/cddiscovery.2016.84. eCollection 2016.


Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis.

Engelen-Lee J, Blokhuis AM, Spliet WGM, Pasterkamp RJ, Aronica E, Demmers JAA, Broekhuizen R, Nardo G, Bovenschen N, Van Den Berg LH.

Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):210-220. doi: 10.1080/21678421.2016.1245757. Epub 2016 Nov 29.


Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis.

Gerritsen KG, Bovenschen N, Nguyen TQ, Sprengers D, Koeners MP, van Koppen AN, Joles JA, Goldschmeding R, Kok RJ.

J Cell Commun Signal. 2016 Dec;10(4):295-303. Epub 2016 Sep 19.


No evidence for human cytomegalovirus infection in pediatric medulloblastomas.

Vermeulen JF, van Hecke W, Jansen MK, Spliet WG, Broekhuizen R, Bovenschen N.

Neuro Oncol. 2016 Oct;18(10):1461-2. doi: 10.1093/neuonc/now151. Epub 2016 Aug 12. No abstract available.


Biological responses of human solid tumor cells to X-ray irradiation within a 1.5-Tesla magnetic field generated by a magnetic resonance imaging-linear accelerator.

Wang L, Hoogcarspel SJ, Wen Z, van Vulpen M, Molkentine DP, Kok J, Lin SH, Broekhuizen R, Ang KK, Bovenschen N, Raaymakers BW, Frank SJ.

Bioelectromagnetics. 2016 Oct;37(7):471-80. doi: 10.1002/bem.21991. Epub 2016 Jul 19.


Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors.

van Kempen PM, Noorlag R, Swartz JE, Bovenschen N, Braunius WW, Vermeulen JF, Van Cann EM, Grolman W, Willems SM.

Cancer Immunol Immunother. 2016 May;65(5):575-85. doi: 10.1007/s00262-016-1819-4. Epub 2016 Mar 18.


Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease.

van der Burgh R, Meeldijk J, Jongeneel L, Frenkel J, Bovenschen N, van Gijn M, Boes M.

Oncotarget. 2016 Apr 12;7(15):19265-71. doi: 10.18632/oncotarget.8086.


Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme Inhibitors.

Vermeulen JF, van Hecke W, Spliet WG, Villacorta Hidalgo J, Fisch P, Broekhuizen R, Bovenschen N.

PLoS One. 2016 Mar 10;11(3):e0151465. doi: 10.1371/journal.pone.0151465. eCollection 2016.


Granzyme M and K release in human experimental endotoxemia.

Wensink AC, Wiewel MA, Jongeneel LH, Boes M, van der Poll T, Hack CE, Bovenschen N.

Immunobiology. 2016 Jul;221(7):773-7. doi: 10.1016/j.imbio.2016.02.006. Epub 2016 Feb 24.


Bioluminescent reporters to monitor killer cell-mediated delivery of granzymes inside target cells.

de Poot SA, van Erp EA, Meeldijk J, Broekhuizen R, Goldschmeding R, Olthof MC, Steeghs EM, Bovenschen N.

Blood. 2015 Dec 24;126(26):2893-5. doi: 10.1182/blood-2015-07-657841. Epub 2015 Nov 13. No abstract available.


Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting.

Meyer S, Nederend M, Jansen JH, Reiding KR, Jacobino SR, Meeldijk J, Bovenschen N, Wuhrer M, Valerius T, Ubink R, Boross P, Rouwendal G, Leusen JH.

MAbs. 2016;8(1):87-98. doi: 10.1080/19420862.2015.1106658. Epub 2015 Oct 14. Erratum in: MAbs. 2017 Jan;9(1):165.


Granzymes regulate proinflammatory cytokine responses.

Wensink AC, Hack CE, Bovenschen N.

J Immunol. 2015 Jan 15;194(2):491-7. doi: 10.4049/jimmunol.1401214. Review.


Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes.

Wensink AC, Kemp V, Fermie J, García Laorden MI, van der Poll T, Hack CE, Bovenschen N.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5974-9. doi: 10.1073/pnas.1317347111. Epub 2014 Apr 7.


Granzyme M: behind enemy lines.

de Poot SA, Bovenschen N.

Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014 Jan 10. Review.


Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation.

Bovenschen N, Spijkers SN, Wensink AC, Schellens IM, van Domselaar R, van Baarle D.

Clin Immunol. 2014 Jan;150(1):1-11. doi: 10.1016/j.clim.2013.11.005. Epub 2013 Nov 18.


Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.

de Poot SA, Lai KW, van der Wal L, Plasman K, Van Damme P, Porter AC, Gevaert K, Bovenschen N.

Cell Death Differ. 2014 Mar;21(3):416-26. doi: 10.1038/cdd.2013.155. Epub 2013 Nov 1.


Accessory cells of the microenvironment protect multiple myeloma from T-cell cytotoxicity through cell adhesion-mediated immune resistance.

de Haart SJ, van de Donk NW, Minnema MC, Huang JH, Aarts-Riemens T, Bovenschen N, Yuan H, Groen RW, McMillin DW, Jakubikova J, Lokhorst HM, Martens AC, Mitsiades CS, Mutis T.

Clin Cancer Res. 2013 Oct 15;19(20):5591-601. doi: 10.1158/1078-0432.CCR-12-3676. Epub 2013 Sep 4.


Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support.

Lok SI, van Mil A, Bovenschen N, van der Weide P, van Kuik J, van Wichen D, Peeters T, Siera E, Winkens B, Sluijter JP, Doevendans PA, da Costa Martins PA, de Jonge N, de Weger RA.

Circ Heart Fail. 2013 Jul;6(4):853-61. doi: 10.1161/CIRCHEARTFAILURE.112.000255. Epub 2013 May 2.


Granzyme M cannot induce cell death via cleavage of mouse FADD.

de Poot SA, Lai KW, Hovingh ES, Bovenschen N.

Apoptosis. 2013 Apr;18(4):533-4. doi: 10.1007/s10495-013-0810-1. No abstract available.


Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.

van Domselaar R, de Poot SA, Remmerswaal EB, Lai KW, ten Berge IJ, Bovenschen N.

Cell Death Differ. 2013 Mar;20(3):419-29. doi: 10.1038/cdd.2012.132. Epub 2012 Oct 26.


All human granzymes target hnRNP K that is essential for tumor cell viability.

van Domselaar R, Quadir R, van der Made AM, Broekhuizen R, Bovenschen N.

J Biol Chem. 2012 Jun 29;287(27):22854-64. doi: 10.1074/jbc.M112.365692. Epub 2012 May 11.


Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue.

Dolman ME, van Dorenmalen KM, Pieters EH, Sparidans RW, Lacombe M, Szokol B, Orfi L, Kéri G, Bovenschen N, Storm G, Hennink WE, Kok RJ.

Macromol Biosci. 2012 Jan;12(1):93-103. doi: 10.1002/mabi.201100277. Epub 2011 Oct 13.


Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.

Hollestelle MJ, Lai KW, van Deuren M, Lenting PJ, de Groot PG, Sprong T, Bovenschen N.

PLoS One. 2011;6(9):e24216. doi: 10.1371/journal.pone.0024216. Epub 2011 Sep 1.


Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.

de Koning PJ, Kummer JA, de Poot SA, Quadir R, Broekhuizen R, McGettrick AF, Higgins WJ, Devreese B, Worrall DM, Bovenschen N.

PLoS One. 2011;6(8):e22645. doi: 10.1371/journal.pone.0022645. Epub 2011 Aug 3.


Cell death-independent functions of granzymes: hit viruses where it hurts.

van Domselaar R, Bovenschen N.

Rev Med Virol. 2011 Sep;21(5):301-14. doi: 10.1002/rmv.697. Epub 2011 Jun 29. Review.


Human and mouse granzyme M display divergent and species-specific substrate specificities.

de Poot SA, Westgeest M, Hostetter DR, Van Damme P, Plasman K, Demeyer K, Broekhuizen R, Gevaert K, Craik CS, Bovenschen N.

Biochem J. 2011 Aug 1;437(3):431-42. doi: 10.1042/BJ20110210.


Cleavage of Notch1 by granzyme B disables its transcriptional activity.

van Tetering G, Bovenschen N, Meeldijk J, van Diest PJ, Vooijs M.

Biochem J. 2011 Jul 15;437(2):313-22. doi: 10.1042/BJ20110226.


Proteomic profiling of the human failing heart after left ventricular assist device support.

de Weger RA, Schipper ME, Siera-de Koning E, van der Weide P, van Oosterhout MF, Quadir R, Steenbergen-Nakken H, Lahpor JR, de Jonge N, Bovenschen N.

J Heart Lung Transplant. 2011 May;30(5):497-506. doi: 10.1016/j.healun.2010.11.011. Epub 2011 Jan 6.


LDL receptor polymorphisms revisited.

Bovenschen N.

Blood. 2010 Dec 16;116(25):5439-40. doi: 10.1182/blood-2010-09-306415. No abstract available.


Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

van Domselaar R, Philippen LE, Quadir R, Wiertz EJ, Kummer JA, Bovenschen N.

J Immunol. 2010 Dec 15;185(12):7605-13. doi: 10.4049/jimmunol.1001503. Epub 2010 Nov 8.


Orphan granzymes find a home.

Bovenschen N, Kummer JA.

Immunol Rev. 2010 May;235(1):117-27. doi: 10.1111/j.0105-2896.2010.00889.x. Review.


Proteomic profiling of proteases: tools for granzyme degradomics.

van Domselaar R, de Poot SA, Bovenschen N.

Expert Rev Proteomics. 2010 Jun;7(3):347-59. doi: 10.1586/epr.10.24. Review.


von Willebrand factor activation, granzyme-B and thrombocytopenia in meningococcal disease.

Hollestelle MJ, Sprong T, Bovenschen N, de Mast Q, van der Ven AJ, Joosten LA, Neeleman C, Hyseni A, Lenting PJ, de Groot PG, van Deuren M.

J Thromb Haemost. 2010 May;8(5):1098-106. doi: 10.1111/j.1538-7836.2010.03811.x. Epub 2010 Feb 16.


The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system.

de Koning PJ, Tesselaar K, Bovenschen N, Colak S, Quadir R, Volman TJ, Kummer JA.

Mol Immunol. 2010 Jan;47(4):903-11. doi: 10.1016/j.molimm.2009.10.001. Epub 2009 Nov 5.


Biology of granzyme M: a serine protease with unique features.

de Koning PJ, Kummer JA, Bovenschen N.

Crit Rev Immunol. 2009;29(4):307-15. Review.


Downregulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome.

de Koning PJ, Bovenschen N, Leusink FK, Broekhuizen R, Quadir R, van Gemert JT, Hordijk GJ, Chang WS, van der Tweel I, Tilanus MG, Kummer JA.

Int J Cancer. 2009 Oct 1;125(7):1542-50. doi: 10.1002/ijc.24507.


Serine protease inhibitor 8 is a novel immunohistochemical marker for neuroendocrine tumors of the pancreas.

de Koning PJ, Bovenschen N, Broekhuizen R, Lips CJ, Kummer JA.

Pancreas. 2009 May;38(4):461-7. doi: 10.1097/MPA.0b013e318194fcc2.


Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.

Bovenschen N, Quadir R, van den Berg AL, Brenkman AB, Vandenberghe I, Devreese B, Joore J, Kummer JA.

J Biol Chem. 2009 Feb 6;284(6):3504-12. doi: 10.1074/jbc.M806716200. Epub 2008 Dec 5.


CTGF inhibits BMP-7 signaling in diabetic nephropathy.

Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, Bovenschen N, Li Z, Xu L, Oliver N, Aten J, Joles JA, Vial C, Brandan E, Lyons KM, Goldschmeding R.

J Am Soc Nephrol. 2008 Nov;19(11):2098-107. doi: 10.1681/ASN.2007111261. Epub 2008 Jul 16.


NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.

Bovenschen N, de Koning PJ, Quadir R, Broekhuizen R, Damen JM, Froelich CJ, Slijper M, Kummer JA.

J Immunol. 2008 Jun 15;180(12):8184-91.


Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein.

Hu L, Bovenschen N, Havekes LM, van Vlijmen BJ, Tamsma JT.

J Thromb Haemost. 2007 Nov;5(11):2301-4. No abstract available.


Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis.

Kummer JA, Micheau O, Schneider P, Bovenschen N, Broekhuizen R, Quadir R, Strik MC, Hack CE, Tschopp J.

Cell Death Differ. 2007 Aug;14(8):1486-96. Epub 2007 May 4.

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