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Items: 1 to 50 of 81

1.

Flavonoids as positive allosteric modulators of α7 nicotinic receptors.

Nielsen BE, Bermudez I, Bouzat C.

Neuropharmacology. 2019 Sep 24;160:107794. doi: 10.1016/j.neuropharm.2019.107794. [Epub ahead of print]

PMID:
31560909
2.

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides.

Lasala M, Fabiani C, Corradi J, Antollini S, Bouzat C.

Front Cell Neurosci. 2019 Feb 8;13:37. doi: 10.3389/fncel.2019.00037. eCollection 2019.

3.

Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium.

Turani O, Hernando G, Corradi J, Bouzat C.

Mol Pharmacol. 2018 Nov;94(5):1270-1279. doi: 10.1124/mol.118.113357. Epub 2018 Sep 6.

PMID:
30190363
4.

Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress.

Bartos M, Gumilar F, Gallegos CE, Bras C, Dominguez S, Mónaco N, Esandi MDC, Bouzat C, Cancela LM, Minetti A.

Reprod Toxicol. 2018 Oct;81:108-114. doi: 10.1016/j.reprotox.2018.07.078. Epub 2018 Jul 29. Review.

PMID:
30009953
5.

A human-specific, truncated α7 nicotinic receptor subunit assembles with full-length α7 and forms functional receptors with different stoichiometries.

Lasala M, Corradi J, Bruzzone A, Esandi MDC, Bouzat C.

J Biol Chem. 2018 Jul 6;293(27):10707-10717. doi: 10.1074/jbc.RA117.001698. Epub 2018 May 21.

6.

Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of α7 nicotinic receptor, glutamate and oxidative stress.

Mónaco NM, Bartos M, Dominguez S, Gallegos C, Bras C, Esandi MDC, Bouzat C, Giannuzzi L, Minetti A, Gumilar F.

Neurotoxicology. 2018 Jul;67:37-45. doi: 10.1016/j.neuro.2018.04.011. Epub 2018 Apr 17.

PMID:
29678590
7.

Molecular function of the novel α7β2 nicotinic receptor.

Nielsen BE, Minguez T, Bermudez I, Bouzat C.

Cell Mol Life Sci. 2018 Jul;75(13):2457-2471. doi: 10.1007/s00018-017-2741-4. Epub 2018 Jan 8.

PMID:
29313059
8.

Molecular function of α7 nicotinic receptors as drug targets.

Bouzat C, Lasala M, Nielsen BE, Corradi J, Esandi MDC.

J Physiol. 2018 May 15;596(10):1847-1861. doi: 10.1113/JP275101. Epub 2017 Nov 29. Review.

9.

Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis.

Fernández Hurst N, Zanetti SR, Báez NS, Bibolini MJ, Bouzat C, Roth GA.

J Neuroimmunol. 2017 Dec 15;313:145-151. doi: 10.1016/j.jneuroim.2017.09.012. Epub 2017 Sep 30.

PMID:
28992974
10.

Nicotinic acetylcholine receptors at the single-channel level.

Bouzat C, Sine SM.

Br J Pharmacol. 2018 Jun;175(11):1789-1804. doi: 10.1111/bph.13770. Epub 2017 Apr 8. Review.

11.

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function.

Boffi JC, Marcovich I, Gill-Thind JK, Corradi J, Collins T, Lipovsek MM, Moglie M, Plazas PV, Craig PO, Millar NS, Bouzat C, Elgoyhen AB.

Mol Pharmacol. 2017 Mar;91(3):250-262. doi: 10.1124/mol.116.107482. Epub 2017 Jan 9. Erratum in: Mol Pharmacol. 2017 May;91(5):437.

12.

Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells.

Zanetti SR, Ziblat A, Torres NI, Zwirner NW, Bouzat C.

J Biol Chem. 2016 Aug 5;291(32):16541-52. doi: 10.1074/jbc.M115.710574. Epub 2016 Jun 9.

13.

Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.

Corradi J, Bouzat C.

Mol Pharmacol. 2016 Sep;90(3):288-99. doi: 10.1124/mol.116.104240. Epub 2016 May 9. Review.

PMID:
27190210
14.

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective.

Andersen ND, Nielsen BE, Corradi J, Tolosa MF, Feuerbach D, Arias HR, Bouzat C.

Neuropharmacology. 2016 Aug;107:189-200. doi: 10.1016/j.neuropharm.2016.02.032. Epub 2016 Feb 27.

PMID:
26926428
15.

5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems.

Corradi J, Thompson AJ, McGonigle I, Price KL, Bouzat C, Lummis SC.

ACS Chem Neurosci. 2015 Jul 15;6(7):1158-64. doi: 10.1021/acschemneuro.5b00080. Epub 2015 May 7.

16.

Unraveling mechanisms underlying partial agonism in 5-HT3A receptors.

Corradi J, Bouzat C.

J Neurosci. 2014 Dec 10;34(50):16865-76. doi: 10.1523/JNEUROSCI.1970-14.2014.

17.

Neurotransmitter GABA activates muscle but not α7 nicotinic receptors.

Dionisio L, Bergé I, Bravo M, Esandi Mdel C, Bouzat C.

Mol Pharmacol. 2015;87(3):391-400. doi: 10.1124/mol.114.095539. Epub 2014 Dec 9.

PMID:
25492812
18.

Corticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor.

Baier CJ, Franco DL, Gallegos CE, Mongiat LA, Dionisio L, Bouzat C, Caviedes P, Barrantes FJ.

Neuroscience. 2014 Aug 22;274:369-82. doi: 10.1016/j.neuroscience.2014.05.049. Epub 2014 Jun 4.

PMID:
24905439
19.

Caenorhabditis elegans neuromuscular junction: GABA receptors and ivermectin action.

Hernando G, Bouzat C.

PLoS One. 2014 Apr 17;9(4):e95072. doi: 10.1371/journal.pone.0095072. eCollection 2014.

20.

Stoichiometry for activation of neuronal α7 nicotinic receptors.

Andersen N, Corradi J, Sine SM, Bouzat C.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20819-24. doi: 10.1073/pnas.1315775110. Epub 2013 Dec 2.

21.

Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors.

Arias HR, De Rosa MJ, Bergé I, Feuerbach D, Bouzat C.

Biochemistry. 2013 Nov 26;52(47):8480-8. doi: 10.1021/bi4012572. Epub 2013 Nov 11.

PMID:
24164482
22.

GABAA receptor plasticity in Jurkat T cells.

Dionisio L, Arias V, Bouzat C, Esandi Mdel C.

Biochimie. 2013 Dec;95(12):2376-84. doi: 10.1016/j.biochi.2013.08.023. Epub 2013 Sep 4.

PMID:
24012548
23.

Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function.

Hernando G, Bergé I, Rayes D, Bouzat C.

Mol Pharmacol. 2012 Sep;82(3):550-60. doi: 10.1124/mol.112.079962. Epub 2012 Jun 25.

PMID:
22734069
24.

New insights into the structural bases of activation of Cys-loop receptors.

Bouzat C.

J Physiol Paris. 2012 Jan;106(1-2):23-33. doi: 10.1016/j.jphysparis.2011.09.012. Epub 2011 Oct 2. Review.

PMID:
21995938
25.

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.

daCosta CJ, Free CR, Corradi J, Bouzat C, Sine SM.

J Neurosci. 2011 Sep 28;31(39):13870-9. doi: 10.1523/JNEUROSCI.2652-11.2011.

26.

Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptors.

Andersen N, Corradi J, Bartos M, Sine SM, Bouzat C.

J Neurosci. 2011 Mar 9;31(10):3662-9. doi: 10.1523/JNEUROSCI.5940-10.2011.

27.

Effects of static magnetic fields on nicotinic cholinergic receptor function.

Tolosa MF, Bouzat C, Cravero WR.

Bioelectromagnetics. 2011 Sep;32(6):434-42. doi: 10.1002/bem.20657. Epub 2011 Feb 22.

PMID:
21344459
28.

A novel mechanism of modulation of 5-HT₃A receptors by hydrocortisone.

Corradi J, Andersen N, Bouzat C.

Biophys J. 2011 Jan 5;100(1):42-51. doi: 10.1016/j.bpj.2010.10.046.

29.

An intrinsic GABAergic system in human lymphocytes.

Dionisio L, José De Rosa M, Bouzat C, Esandi Mdel C.

Neuropharmacology. 2011 Feb-Mar;60(2-3):513-9. doi: 10.1016/j.neuropharm.2010.11.007. Epub 2010 Nov 18.

PMID:
21093461
30.

A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function.

Jones AK, Rayes D, Al-Diwani A, Maynard TP, Jones R, Hernando G, Buckingham SD, Bouzat C, Sattelle DB.

J Biol Chem. 2011 Jan 28;286(4):2550-8. doi: 10.1074/jbc.M110.177238. Epub 2010 Oct 21.

31.

Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.

Bartos M, Corradi J, Bouzat C.

Mol Neurobiol. 2009 Dec;40(3):236-52. doi: 10.1007/s12035-009-8084-x. Epub 2009 Oct 28. Review.

PMID:
19859835
32.

Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors.

Corradi J, Gumilar F, Bouzat C.

Biophys J. 2009 Sep 2;97(5):1335-45. doi: 10.1016/j.bpj.2009.06.018.

33.

Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation.

De Rosa MJ, Dionisio L, Agriello E, Bouzat C, Esandi Mdel C.

Life Sci. 2009 Sep 9;85(11-12):444-9. doi: 10.1016/j.lfs.2009.07.010. Epub 2009 Jul 24.

PMID:
19632243
34.

An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse.

Almedom RB, Liewald JF, Hernando G, Schultheis C, Rayes D, Pan J, Schedletzky T, Hutter H, Bouzat C, Gottschalk A.

EMBO J. 2009 Sep 2;28(17):2636-49. doi: 10.1038/emboj.2009.204. Epub 2009 Jul 16.

35.

Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.

Bartos M, Price KL, Lummis SC, Bouzat C.

J Biol Chem. 2009 Aug 7;284(32):21478-87. doi: 10.1074/jbc.M109.013797. Epub 2009 Jun 8.

36.

The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.

Spitzmaul G, Gumilar F, Dilger JP, Bouzat C.

Br J Pharmacol. 2009 Jul;157(5):804-17. doi: 10.1111/j.1476-5381.2009.00214.x. Epub 2009 Apr 30.

37.

Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors.

Rayes D, De Rosa MJ, Sine SM, Bouzat C.

J Neurosci. 2009 May 6;29(18):6022-32. doi: 10.1523/JNEUROSCI.0627-09.2009.

38.

Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.

Arias HR, Gumilar F, Rosenberg A, Targowska-Duda KM, Feuerbach D, Jozwiak K, Moaddel R, Wainer IW, Bouzat C.

Biochemistry. 2009 Jun 2;48(21):4506-18. doi: 10.1021/bi802206k.

39.

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.

Bouzat C, Bartos M, Corradi J, Sine SM.

J Neurosci. 2008 Jul 30;28(31):7808-19. doi: 10.1523/JNEUROSCI.0448-08.2008.

40.

Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states.

Gumilar F, Bouzat C.

Eur J Pharmacol. 2008 Apr 14;584(1):30-9. doi: 10.1016/j.ejphar.2008.01.023. Epub 2008 Feb 5.

PMID:
18314100
41.

Subunit-selective role of the M3 transmembrane domain of the nicotinic acetylcholine receptor in channel gating.

De Rosa MJ, Corradi J, Bouzat C.

Biochim Biophys Acta. 2008 Feb;1778(2):521-9. Epub 2007 Nov 4.

42.

Activation of single nicotinic receptor channels from Caenorhabditis elegans muscle.

Rayes D, Flamini M, Hernando G, Bouzat C.

Mol Pharmacol. 2007 May;71(5):1407-15. Epub 2007 Feb 21.

PMID:
17314321
43.

Role of pairwise interactions between M1 and M2 domains of the nicotinic receptor in channel gating.

Corradi J, Spitzmaul G, De Rosa MJ, Costabel M, Bouzat C.

Biophys J. 2007 Jan 1;92(1):76-86. Epub 2006 Oct 6.

44.

Molecular determinants of pyrantel selectivity in nicotinic receptors.

Bartos M, Rayes D, Bouzat C.

Mol Pharmacol. 2006 Oct;70(4):1307-18. Epub 2006 Jul 6.

PMID:
16825485
45.

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors.

Arias HR, Bhumireddy P, Bouzat C.

Int J Biochem Cell Biol. 2006;38(8):1254-76. Epub 2006 Feb 20. Review.

PMID:
16520081
46.

Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors.

Arias HR, Bhumireddy P, Spitzmaul G, Trudell JR, Bouzat C.

Biochemistry. 2006 Feb 21;45(7):2014-26.

PMID:
16475790
47.

Stoichiometry of the alpha9alpha10 nicotinic cholinergic receptor.

Plazas PV, Katz E, Gomez-Casati ME, Bouzat C, Elgoyhen AB.

J Neurosci. 2005 Nov 23;25(47):10905-12.

48.

Single-channel kinetic analysis of chimeric alpha7-5HT3A receptors.

Rayes D, Spitzmaul G, Sine SM, Bouzat C.

Mol Pharmacol. 2005 Nov;68(5):1475-83. Epub 2005 Aug 23.

PMID:
16118362
49.

Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor.

Plazas PV, De Rosa MJ, Gomez-Casati ME, Verbitsky M, Weisstaub N, Katz E, Bouzat C, Elgoyhen AB.

Br J Pharmacol. 2005 Aug;145(7):963-74.

50.

Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

De Rosa MJ, Esandi Mdel C, Garelli A, Rayes D, Bouzat C.

J Neuroimmunol. 2005 Mar;160(1-2):154-61. Epub 2004 Dec 25.

PMID:
15710468

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