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Items: 1 to 50 of 244


Tumour budding predicts increased recurrence after curative resection for T2N0 colorectal cancer

Garfinkle R, Lee L, Boutros M, Cardin MJ, Spatz A, Morin N.

Can J Surg. 2019 Oct 1;62(5):334-339.


Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium.

Chaudhary V, Boutros M.

PLoS Genet. 2019 Sep 17;15(9):e1008351. doi: 10.1371/journal.pgen.1008351. eCollection 2019 Sep.


Image-Guided Adaptive Endorectal Brachytherapy in the Non-Operative Management of Patients with Rectal Cancer.

Garant A, Magnan S, Devic S, Martin AG, Boutros M, Vasilevsky CA, Ferland S, Bujold A, DesGroseilliers S, Sebajang H, Richard C, Vuong T.

Int J Radiat Oncol Biol Phys. 2019 Aug 30. pii: S0360-3016(19)33728-9. doi: 10.1016/j.ijrobp.2019.08.042. [Epub ahead of print]


Can we better predict readmission for dehydration following creation of a diverting loop ileostomy: development and validation of a prediction model and web-based risk calculator.

Alqahtani M, Garfinkle R, Zhao K, Vasilevsky CA, Morin N, Ghitulescu G, Faria J, Boutros M.

Surg Endosc. 2019 Aug 26. doi: 10.1007/s00464-019-07069-2. [Epub ahead of print]


Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing.

Chaudhary V, Hingole S, Frei J, Port F, Strutt D, Boutros M.

Development. 2019 Aug 9;146(15). pii: dev174789. doi: 10.1242/dev.174789.


Gene expression atlas of a developing tissue by single cell expression correlation analysis.

Bageritz J, Willnow P, Valentini E, Leible S, Boutros M, Teleman AA.

Nat Methods. 2019 Aug;16(8):750-756. doi: 10.1038/s41592-019-0492-x. Epub 2019 Jul 29.


Editorial overview: Functionalizing cancer genomes in the era of big data.

Rad R, Boutros M.

Curr Opin Genet Dev. 2019 Feb;54:iii-vi. doi: 10.1016/j.gde.2019.06.011. Epub 2019 Jul 20. No abstract available.


Prediction model and web-based risk calculator for postoperative ileus after loop ileostomy closure.

Garfinkle R, Filion KB, Bhatnagar S, Sigler G, Banks A, Letarte F, Liberman S, Brown CJ, Boutros M.

Br J Surg. 2019 Jul 17. doi: 10.1002/bjs.11235. [Epub ahead of print]


Detection of mutational patterns in cell-free DNA of colorectal cancer by custom amplicon sequencing.

Herrmann S, Zhan T, Betge J, Rauscher B, Belle S, Gutting T, Schulte N, Jesenofsky R, Härtel N, Gaiser T, Hofheinz RD, Ebert MP, Boutros M.

Mol Oncol. 2019 Aug;13(8):1669-1683. doi: 10.1002/1878-0261.12539. Epub 2019 Jul 19.


EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice.

Francis NK, Sylla P, Abou-Khalil M, Arolfo S, Berler D, Curtis NJ, Dolejs SC, Garfinkle R, Gorter-Stam M, Hashimoto DA, Hassinger TE, Molenaar CJL, Pucher PH, Schuermans V, Arezzo A, Agresta F, Antoniou SA, Arulampalam T, Boutros M, Bouvy N, Campbell K, Francone T, Haggerty SP, Hedrick TL, Stefanidis D, Truitt MS, Kelly J, Ket H, Dunkin BJ, Pietrabissa A.

Surg Endosc. 2019 Sep;33(9):2726-2741. doi: 10.1007/s00464-019-06882-z. Epub 2019 Jun 27.


Development and validation of a clinical risk calculator for mortality after colectomy for fulminant Clostridium difficile colitis.

Abou Khalil M, Bhatnagar SR, Feldman L, Longtin Y, Vasilevsky CA, Carignan A, Morin N, Boutros M.

J Trauma Acute Care Surg. 2019 Oct;87(4):856-864. doi: 10.1097/TA.0000000000002412.


Interchangeability of cardiac output measurements between non-invasive photoplethysmography and bolus thermodilution: A systematic review and individual patient data meta-analysis.

Fischer MO, Joosten A, Desebbe O, Boutros M, Debroczi S, Broch O, Malbrain MLNG, Ameloot K, Hofer CK, Bubenek-Turconi ŞI, Monnet X, Diouf M, Lorne E.

Anaesth Crit Care Pain Med. 2019 Jun 4. pii: S2352-5568(19)30043-8. doi: 10.1016/j.accpm.2019.05.007. [Epub ahead of print] Review.



Garfinkle R, Boutros M.

Br J Surg. 2019 Jun;106(7):952. doi: 10.1002/bjs.11229. No abstract available.


MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.

Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Häussler RS, Hinsenkamp I, Bamberg L, Hessling B, Müller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M.

Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0.


Infantile and adult mortality in precarious conditions.

Barrabé A, Louvrier A, Allary R, Moussa M, Boutros M, Bénateau H.

J Stomatol Oral Maxillofac Surg. 2019 Apr 26. pii: S2468-7855(19)30121-1. doi: 10.1016/j.jormas.2019.04.010. [Epub ahead of print]


Context-dependent genetic interactions in cancer.

Henkel L, Rauscher B, Boutros M.

Curr Opin Genet Dev. 2019 Feb;54:73-82. doi: 10.1016/j.gde.2019.03.004. Epub 2019 Apr 23. Review.


Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis.

Garfinkle R, Savage P, Boutros M, Landry T, Reynier P, Morin N, Vasilevsky CA, Filion KB.

Surg Endosc. 2019 Aug;33(8):2430-2443. doi: 10.1007/s00464-019-06794-y. Epub 2019 Apr 17.


Immunosuppressed Patients with Crohn's Disease Are at Increased Risk of Postoperative Complications: Results from the ACS-NSQIP Database.

Abou Khalil M, Abou-Khalil J, Motter J, Vasilevsky CA, Morin N, Ghitulescu G, Boutros M.

J Gastrointest Surg. 2019 Jun;23(6):1188-1197. doi: 10.1007/s11605-019-04186-0. Epub 2019 Mar 18.


Is the Pathologic Response of T3 Rectal Cancer to High-Dose-Rate Endorectal Brachytherapy Comparable to External Beam Radiotherapy?

Garfinkle R, Lachance S, Vuong T, Mikhail A, Pelsser V, Gologan A, Morin NA, Vasilevsky CA, Boutros M.

Dis Colon Rectum. 2019 Mar;62(3):294-301. doi: 10.1097/DCR.0000000000001220.


Clinical relevance of gene expression in localized and metastatic prostate cancer exemplified by FABP5.

Nitschke K, Erben P, Waldbillig F, Abdelhadi A, Weis CA, Gottschalt M, Wahby S, Nuhn P, Boutros M, Michel MS, von Hardenberg J, Worst TS.

World J Urol. 2019 Jan 30. doi: 10.1007/s00345-019-02651-8. [Epub ahead of print]


Assessing the readability, quality and accuracy of online health information for patients with low anterior resection syndrome following surgery for rectal cancer.

Garfinkle R, Wong-Chong N, Petrucci A, Sylla P, Wexner SD, Bhatnagar S, Morin N, Boutros M.

Colorectal Dis. 2019 May;21(5):523-531. doi: 10.1111/codi.14548. Epub 2019 Feb 4.


Time-resolved mapping of genetic interactions to model rewiring of signaling pathways.

Heigwer F, Scheeder C, Miersch T, Schmitt B, Blass C, Pour Jamnani MV, Boutros M.

Elife. 2018 Dec 28;7. pii: e40174. doi: 10.7554/eLife.40174.


WEADE: A workflow for enrichment analysis and data exploration.

Trost N, Rempel E, Ermakova O, Tamirisa S, Pârcălăbescu L, Boutros M, Lohmann JU, Lohmann I.

PLoS One. 2018 Sep 28;13(9):e0204016. doi: 10.1371/journal.pone.0204016. eCollection 2018.


A Comparison of Pathologic Outcomes of Open, Laparoscopic, and Robotic Resections for Rectal Cancer Using the ACS-NSQIP Proctectomy-Targeted Database: a Propensity Score Analysis.

Garfinkle R, Abou-Khalil M, Bhatnagar S, Wong-Chong N, Azoulay L, Morin N, Vasilevsky CA, Boutros M.

J Gastrointest Surg. 2019 Feb;23(2):348-356. doi: 10.1007/s11605-018-3974-8. Epub 2018 Sep 27.


Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content.

Mattila J, Kokki K, Hietakangas V, Boutros M.

Dev Cell. 2018 Oct 8;47(1):112-121.e3. doi: 10.1016/j.devcel.2018.08.011. Epub 2018 Sep 13.


Decoding the Regulatory Logic of the Drosophila Male Stem Cell System.

Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I.

Cell Rep. 2018 Sep 11;24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013.


Machine learning and image-based profiling in drug discovery.

Scheeder C, Heigwer F, Boutros M.

Curr Opin Syst Biol. 2018 Aug;10:43-52. doi: 10.1016/j.coisb.2018.05.004. Review.


Outcomes of Ileal Pouch Excision: an American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) Analysis.

Lachance S, Abou-Khalil M, Vasilevsky CA, Ghitulescu G, Morin N, Faria J, Boutros M.

J Gastrointest Surg. 2018 Dec;22(12):2142-2149. doi: 10.1007/s11605-018-3844-4. Epub 2018 Jul 31.


Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM.

PLoS One. 2018 Jun 28;13(6):e0199679. doi: 10.1371/journal.pone.0199679. eCollection 2018.


The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling.

Klingenberg M, Groß M, Goyal A, Polycarpou-Schwarz M, Miersch T, Ernst AS, Leupold J, Patil N, Warnken U, Allgayer H, Longerich T, Schirmacher P, Boutros M, Diederichs S.

Hepatology. 2018 Nov;68(5):1817-1832. doi: 10.1002/hep.30102. Epub 2018 Oct 12.


CRISPR/Cas9 for cancer research and therapy.

Zhan T, Rindtorff N, Betge J, Ebert MP, Boutros M.

Semin Cancer Biol. 2019 Apr;55:106-119. doi: 10.1016/j.semcancer.2018.04.001. Epub 2018 Apr 16. Review.


The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division.

Dix CL, Matthews HK, Uroz M, McLaren S, Wolf L, Heatley N, Win Z, Almada P, Henriques R, Boutros M, Trepat X, Baum B.

Dev Cell. 2018 Apr 9;45(1):132-145.e3. doi: 10.1016/j.devcel.2018.03.009.


Systematic characterization of pan-cancer mutation clusters.

Buljan M, Blattmann P, Aebersold R, Boutros M.

Mol Syst Biol. 2018 Mar 23;14(3):e7974. doi: 10.15252/msb.20177974.


A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment.

Shen J, Najafi S, Stäble S, Fabian J, Koeneke E, Kolbinger FR, Wrobel JK, Meder B, Distel M, Heimburg T, Sippl W, Jung M, Peterziel H, Kranz D, Boutros M, Westermann F, Witt O, Oehme I.

Cell Death Differ. 2018 Dec;25(12):2053-2070. doi: 10.1038/s41418-018-0080-0. Epub 2018 Mar 7.


RNA Interference (RNAi) Screening in Drosophila.

Heigwer F, Port F, Boutros M.

Genetics. 2018 Mar;208(3):853-874. doi: 10.1534/genetics.117.300077.


Toward an integrated map of genetic interactions in cancer cells.

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M.

Mol Syst Biol. 2018 Feb 21;14(2):e7656. doi: 10.15252/msb.20177656.


β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells.

Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, Boutros M.

Sci Rep. 2018 Feb 16;8(1):3178. doi: 10.1038/s41598-018-20641-5.


Clinical and Economic Impact of an Enhanced Recovery Pathway for Open and Laparoscopic Rectal Surgery.

Garfinkle R, Boutros M, Ghitulescu G, Vasilevsky CA, Charlebois P, Liberman S, Stein B, Feldman LS, Lee L.

J Laparoendosc Adv Surg Tech A. 2018 Jul;28(7):811-818. doi: 10.1089/lap.2017.0677. Epub 2018 Feb 16.


ERAD-dependent control of the Wnt secretory factor Evi.

Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M.

EMBO J. 2018 Feb 15;37(4). pii: e97311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29.


Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation.

Billmann M, Chaudhary V, ElMaghraby MF, Fischer B, Boutros M.

Cell Syst. 2018 Jan 24;6(1):52-64.e4. doi: 10.1016/j.cels.2017.10.015. Epub 2017 Nov 30.


Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane.

Menck K, Sönmezer C, Worst TS, Schulz M, Dihazi GH, Streit F, Erdmann G, Kling S, Boutros M, Binder C, Gross JC.

J Extracell Vesicles. 2017 Sep 26;6(1):1378056. doi: 10.1080/20013078.2017.1378056. eCollection 2017.


The Authors Reply.

Garfinkle R, Boutros M.

Dis Colon Rectum. 2017 Dec;60(12):e641. doi: 10.1097/DCR.0000000000000952. No abstract available.


Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.

Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS.

Hepatology. 2018 Aug;68(2):707-722. doi: 10.1002/hep.29613. Epub 2018 Feb 1.


An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs.

Larribère L, Galach M, Novak D, Arévalo K, Volz HC, Stark HJ, Boukamp P, Boutros M, Utikal J.

Stem Cell Reports. 2017 Oct 10;9(4):1234-1245. doi: 10.1016/j.stemcr.2017.08.023. Epub 2017 Sep 28.


Incidence Rates and Predictors of Colectomy for Ulcerative Colitis in the Era of Biologics: Results from a Provincial Database.

Abou Khalil M, Boutros M, Nedjar H, Morin N, Ghitulescu G, Vasilevsky CA, Gordon P, Rahme E.

J Gastrointest Surg. 2018 Jan;22(1):124-132. doi: 10.1007/s11605-017-3530-y. Epub 2017 Aug 14.


Clinical practice guideline for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons (ASCRS) and Society of American Gastrointestinal and Endoscopic Surgeons (SAGES).

Carmichael JC, Keller DS, Baldini G, Bordeianou L, Weiss E, Lee L, Boutros M, McClane J, Steele SR, Feldman LS.

Surg Endosc. 2017 Sep;31(9):3412-3436. doi: 10.1007/s00464-017-5722-7. Epub 2017 Aug 3. No abstract available.


The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction.

Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F.

EMBO Mol Med. 2017 Sep;9(9):1279-1293. doi: 10.15252/emmm.201707565.


Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M.

FASEB J. 2017 Nov;31(11):4832-4844. doi: 10.1096/fj.201700144R. Epub 2017 Jul 21.


Cost of Ulcerative Colitis in Quebec, Canada: A Retrospective Cohort Study.

Dan A, Boutros M, Nedjar H, Kopylov U, Afif W, Khalil MA, Rahme E.

Inflamm Bowel Dis. 2017 Aug;23(8):1262-1271. doi: 10.1097/MIB.0000000000001147.


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