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Items: 1 to 50 of 71

1.

Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial.

Pitchford LM, Driver PM, Fuller JC Jr, Akers WS, Abumrad NN, Amarnath V, Milne GL, Chen SC, Ye F, Roberts LJ 2nd, Shoemaker MB, Oates JA, Rathmacher JA, Boutaud O.

BMC Pharmacol Toxicol. 2020 Jan 6;21(1):3. doi: 10.1186/s40360-020-0382-y.

2.

Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions.

Davies SS, May-Zhang LS, Boutaud O, Amarnath V, Kirabo A, Harrison DG.

Pharmacol Ther. 2020 Jan;205:107418. doi: 10.1016/j.pharmthera.2019.107418. Epub 2019 Oct 16. Review.

PMID:
31629006
3.

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus.

Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA Jr, Dikalov SI, Zaika AI.

Cell Mol Gastroenterol Hepatol. 2019;7(2):480-482.e7. doi: 10.1016/j.jcmgh.2018.10.017. Epub 2018 Nov 8. No abstract available.

4.

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.

Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O.

BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7.

5.

Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension.

Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A.

Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H639-H646. doi: 10.1152/ajpheart.00595.2018. Epub 2019 Jan 4. Erratum in: Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H939.

PMID:
30608177
6.

Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.

Salisbury-Ruf CT, Bertram CC, Vergeade A, Lark DS, Shi Q, Heberling ML, Fortune NL, Okoye GD, Jerome WG, Wells QS, Fessel J, Moslehi J, Chen H, Roberts LJ 2nd, Boutaud O, Gamazon ER, Zinkel SS.

Elife. 2018 Oct 3;7. pii: e40907. doi: 10.7554/eLife.40907.

7.

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.

Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA.

Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22.

8.

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.

Giménez-Bastida JA, Boeglin WE, Boutaud O, Malkowski MG, Schneider C.

FASEB J. 2019 Jan;33(1):1033-1041. doi: 10.1096/fj.201801018R. Epub 2018 Aug 10.

9.

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2.

Boer RE, Giménez-Bastida JA, Boutaud O, Jana S, Schneider C, Sulikowski GA.

Org Lett. 2018 Jul 6;20(13):4020-4022. doi: 10.1021/acs.orglett.8b01578. Epub 2018 Jun 19.

10.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA.

Cancer Prev Res (Phila). 2016 Nov;9(11):855-865. Epub 2016 Aug 23.

11.

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.

Woodling NS, Colas D, Wang Q, Minhas P, Panchal M, Liang X, Mhatre SD, Brown H, Ko N, Zagol-Ikapitte I, van der Hart M, Khroyan TV, Chuluun B, Priyam PG, Milne GL, Rassoulpour A, Boutaud O, Manning-Boğ AB, Heller HC, Andreasson KI.

Brain. 2016 Jul;139(Pt 7):2063-81. doi: 10.1093/brain/aww117. Epub 2016 May 13.

12.

Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain.

Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ 2nd, Boutaud O.

Mitochondrion. 2016 May;28:88-95. doi: 10.1016/j.mito.2016.04.002. Epub 2016 Apr 13.

13.

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers.

Zagol-Ikapite I, Sosa IR, Oram D, Judd A, Amarnath K, Amarnath V, Stec D, Oates JA, Boutaud O.

J Lipid Res. 2015 Nov;56(11):2196-205. doi: 10.1194/jlr.P063271. Epub 2015 Sep 16.

14.

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease.

Friedman EA, Ogletree ML, Haddad EV, Boutaud O.

Thromb Res. 2015 Sep;136(3):493-503. doi: 10.1016/j.thromres.2015.05.027. Epub 2015 May 28. Review.

15.

Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ 2nd, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT.

J Mol Cell Cardiol. 2015 Feb;79:295-302. doi: 10.1016/j.yjmcc.2014.11.013. Epub 2014 Nov 18.

16.

Protein modification by adenine propenal.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ.

Chem Res Toxicol. 2014 Oct 20;27(10):1732-42. doi: 10.1021/tx500218g. Epub 2014 Sep 24.

17.

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

Woodling NS, Wang Q, Priyam PG, Larkin P, Shi J, Johansson JU, Zagol-Ikapitte I, Boutaud O, Andreasson KI.

J Neurosci. 2014 Apr 23;34(17):5882-94. doi: 10.1523/JNEUROSCI.0410-14.2014.

18.

Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA.

Biochemistry. 2014 Apr 22;53(15):2436-41. doi: 10.1021/bi401673b. Epub 2014 Apr 11.

19.

Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues.

Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ 2nd, Oates JA, Porter NA, Boutaud O.

ACS Med Chem Lett. 2013 Aug 8;4(8):710-714.

20.

12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.

Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M.

Thromb Haemost. 2013 Sep;110(3):569-81. doi: 10.1160/TH13-01-0014. Epub 2013 Jun 20. Erratum in: Thromb Haemost. 2014 Aug;112(2):426.

21.

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation.

Yin H, Vergeade A, Shi Q, Zackert WE, Gruenberg KC, Bokiej M, Amin T, Ying W, Masterson TS, Zinkel SS, Oates JA, Boutaud O, Roberts LJ 2nd.

Biochem Biophys Res Commun. 2012 Jun 29;423(2):224-8. doi: 10.1016/j.bbrc.2012.05.058. Epub 2012 May 23.

22.

Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome.

Smith JP, Haddad EV, Taylor MB, Oram D, Blakemore D, Chen Q, Boutaud O, Oates JA.

Hypertension. 2012 Mar;59(3):719-25. doi: 10.1161/HYPERTENSIONAHA.111.181404. Epub 2012 Feb 6.

23.

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.

Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M.

Mol Pharmacol. 2012 Mar;81(3):420-30. doi: 10.1124/mol.111.075630. Epub 2011 Dec 9.

24.

On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry.

Chacon A, Zagol-Ikapitte I, Amarnath V, Reyzer ML, Oates JA, Caprioli RM, Boutaud O.

J Mass Spectrom. 2011 Aug;46(8):840-6. doi: 10.1002/jms.1958.

25.

Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies.

Zagol-Ikapitte I, Amarnath V, Jadhav S, Oates JA, Boutaud O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1098-104. doi: 10.1016/j.jchromb.2011.03.026. Epub 2011 Mar 21.

26.

Functional characterization of mutations in inherited human cPLA₂ deficiency.

Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O.

Biochemistry. 2011 Mar 15;50(10):1731-8. doi: 10.1021/bi101877n. Epub 2011 Feb 9.

27.

Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth.

Plunkett J, Doniger S, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, Oates J, Boutaud O, McGregor TL, McElroy JJ, Teramo K, Borecki I, Fay JC, Muglia LJ.

BMC Med Genomics. 2010 Dec 24;3:62. doi: 10.1186/1755-8794-3-62.

28.

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.

Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):435-42. doi: 10.1161/ATVBAHA.110.219527. Epub 2010 Dec 2.

29.

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure.

Boutaud O, Roberts LJ 2nd.

Free Radic Biol Med. 2011 Sep 1;51(5):1062-7. doi: 10.1016/j.freeradbiomed.2010.10.704. Epub 2010 Oct 27. Review.

30.

Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes.

Boutaud O, Oates JA.

Methods Mol Biol. 2010;644:67-90. doi: 10.1007/978-1-59745-364-6_7.

PMID:
20645166
31.

PGE2 decreases reactivity of human platelets by activating EP2 and EP4.

Smith JP, Haddad EV, Downey JD, Breyer RM, Boutaud O.

Thromb Res. 2010 Jul;126(1):e23-9. doi: 10.1016/j.thromres.2010.04.003. Epub 2010 May 8.

32.

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ 2nd, Davies SS.

Pharmaceutics. 2010 Mar;2(1):18-29.

33.

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.

Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ 2nd.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2699-704. doi: 10.1073/pnas.0910174107. Epub 2010 Feb 1.

34.

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte I, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts Ii LJ, Davies SS.

Pharmaceutics. 2010 Feb 1;2(1):18-29.

35.

Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs.

Mosoni L, Balage M, Vazeille E, Combaret L, Morand C, Zagol-Ikapitte I, Boutaud O, Marzani B, Papet I, Dardevet D.

Nutrition. 2010 Nov-Dec;26(11-12):1157-62. doi: 10.1016/j.nut.2009.09.016. Epub 2010 Jan 15.

PMID:
20080031
36.

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis.

Zagol-Ikapitte I, Amarnath V, Bala M, Roberts LJ 2nd, Oates JA, Boutaud O.

Chem Res Toxicol. 2010 Jan;23(1):240-50. doi: 10.1021/tx900407a.

37.

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA.

Org Biomol Chem. 2009 Dec 21;7(24):5103-12. doi: 10.1039/b912528k. Epub 2009 Oct 20.

38.

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin.

Carrier EJ, Amarnath V, Oates JA, Boutaud O.

Biochemistry. 2009 Nov 17;48(45):10775-81. doi: 10.1021/bi9015132.

39.

The enteropathy of prostaglandin deficiency.

Adler DH, Phillips JA 3rd, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA.

J Gastroenterol. 2009;44 Suppl 19:1-7. doi: 10.1007/s00535-008-2253-y. Epub 2009 Jan 16.

40.

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.

Potet F, Petersen CI, Boutaud O, Shuai W, Stepanovic SZ, Balser JR, Kupershmidt S.

J Mol Cell Cardiol. 2009 Feb;46(2):257-67. doi: 10.1016/j.yjmcc.2008.10.015. Epub 2008 Nov 5.

41.

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

Adler DH, Cogan JD, Phillips JA 3rd, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA.

J Clin Invest. 2008 Jun;118(6):2121-31. doi: 10.1172/JCI30473. Erratum in: J Clin Invest. 2009 Sep;119(9):2844.

42.

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase.

Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O, Oates JA.

Biochem Pharmacol. 2008 Apr 1;75(7):1472-81. doi: 10.1016/j.bcp.2007.12.005. Epub 2007 Dec 27.

44.

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ 2nd.

Biochemistry. 2006 Dec 26;45(51):15756-67. Epub 2006 Dec 6.

45.
46.

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42.

Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA.

J Neurochem. 2006 Feb;96(4):917-23. Epub 2006 Jan 12.

47.

Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity.

Zagol-Ikapitte I, Masterson TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA.

J Neurochem. 2005 Aug;94(4):1140-5. Epub 2005 Jun 30.

48.

Cyclooxygenase-dependent lipid-modification of brain proteins.

Boutaud O, Andreasson KI, Zagol-Ikapitte I, Oates JA.

Brain Pathol. 2005 Apr;15(2):139-42. Review.

PMID:
15912886
49.

Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine.

Zagol-Ikapitte I, Bernoud-Hubac N, Amarnath V, Roberts LJ 2nd, Boutaud O, Oates JA.

Biochemistry. 2004 May 11;43(18):5503-10.

PMID:
15122916
50.

Modification of proteins by isoketal-containing oxidized phospholipids.

Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ 2nd.

J Biol Chem. 2004 Apr 2;279(14):13447-51. Epub 2004 Jan 10.

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