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Items: 32


Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model.

Boutajangout A, Lindberg H, Awwad A, Paul A, Baitalmal R, Almokyad I, Höidén-Guthenberg I, Gunneriusson E, Frejd FY, Härd T, Löfblom J, Ståhl S, Wisniewski T.

Front Aging Neurosci. 2019 Mar 22;11:64. doi: 10.3389/fnagi.2019.00064. eCollection 2019.


Virtual screening of a natural compound library at orthosteric and allosteric binding sites of the neurotensin receptor.

Rejwan Ali M, Sadoqi M, Boutajangout A, Mezei M.

J Biomol Struct Dyn. 2019 Oct;37(17):4494-4506. doi: 10.1080/07391102.2018.1552200. Epub 2019 Jan 9.


Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model.

Goñi F, Martá-Ariza M, Herline K, Peyser D, Boutajangout A, Mehta P, Drummond E, Prelli F, Wisniewski T.

Alzheimers Res Ther. 2018 Jan 29;10(1):10. doi: 10.1186/s13195-018-0337-3.


Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies.

Ali MR, Sadoqi M, Møller SG, Boutajangout A, Mezei M.

J Mol Graph Model. 2017 Sep;76:36-42. doi: 10.1016/j.jmgm.2017.06.027. Epub 2017 Jun 29.


The Cox-2 Inhibitor Meloxicam Ameliorates Neuroinflammation and Depressive Behavior in Adult Mice after Splenectomy.

Haile M, Boutajangout A, Chung K, Chan J, Stolper T, Vincent N, Batchan M, D'Urso J, Lin Y, Kline R, Yaghmoor F, Jahfal S, Kamal R, Aljohani W, Blanck T, Bekker A, Wisniewski T.

J Neurophysiol Neurol Disord. 2016;3. pii: 101. Epub 2016 Aug 5.


TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia.

Greco SH, Tomkötter L, Vahle AK, Rokosh R, Avanzi A, Mahmood SK, Deutsch M, Alothman S, Alqunaibit D, Ochi A, Zambirinis C, Mohaimin T, Rendon M, Levie E, Pansari M, Torres-Hernandez A, Daley D, Barilla R, Pachter HL, Tippens D, Malik H, Boutajangout A, Wisniewski T, Miller G.

PLoS One. 2015 Jul 14;10(7):e0132786. doi: 10.1371/journal.pone.0132786. eCollection 2015.


The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.

Yaghmoor F, Noorsaeed A, Alsaggaf S, Aljohani W, Scholtzova H, Boutajangout A, Wisniewski T.

J Alzheimers Dis Parkinsonism. 2014 Nov;4(5). pii: 160.


Tau-based therapeutic approaches for Alzheimer's disease - a mini-review.

Boutajangout A, Wisniewski T.

Gerontology. 2014;60(5):381-5. doi: 10.1159/000358875. Epub 2014 Apr 8. Review.


The innate immune system in Alzheimer's disease.

Boutajangout A, Wisniewski T.

Int J Cell Biol. 2013;2013:576383. doi: 10.1155/2013/576383. Epub 2013 Oct 2. Review.


Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology.

Liu S, Breitbart A, Sun Y, Mehta PD, Boutajangout A, Scholtzova H, Wisniewski T.

J Neurochem. 2014 Feb;128(4):577-91. doi: 10.1111/jnc.12484. Epub 2013 Nov 6.


Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds.

Joseph-Mathurin N, Dorieux O, Trouche SG, Boutajangout A, Kraska A, Fontès P, Verdier JM, Sigurdsson EM, Mestre-Francés N, Dhenain M.

Neurobiol Aging. 2013 Nov;34(11):2613-22. doi: 10.1016/j.neurobiolaging.2013.05.013. Epub 2013 Jun 22.


Inhaled nitric oxide improves short term memory and reduces the inflammatory reaction in a mouse model of mild traumatic brain injury.

Liu P, Li YS, Quartermain D, Boutajangout A, Ji Y.

Brain Res. 2013 Jul 19;1522:67-75. doi: 10.1016/j.brainres.2013.05.032. Epub 2013 Jun 4.


Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging.

Wadghiri YZ, Li J, Wang J, Hoang DM, Sun Y, Xu H, Tsui W, Li Y, Boutajangout A, Wang A, de Leon M, Wisniewski T.

PLoS One. 2013;8(2):e57097. doi: 10.1371/journal.pone.0057097. Epub 2013 Feb 27.


Cognitive and sensorimotor tasks for assessing functional impairments in mouse models of Alzheimer's disease and related disorders.

Boutajangout A, Li YS, Quartermain D, Sigurdsson EM.

Methods Mol Biol. 2012;849:529-40. doi: 10.1007/978-1-61779-551-0_35.


Meloxicam improves object recognition memory and modulates glial activation after splenectomy in mice.

Kamer AR, Galoyan SM, Haile M, Kline R, Boutajangout A, Li YS, Bekker A.

Eur J Anaesthesiol. 2012 Jul;29(7):332-7. doi: 10.1097/EJA.0b013e3283534f56.


Tau as a therapeutic target for Alzheimer's disease.

Boutajangout A, Sigurdsson EM, Krishnamurthy PK.

Curr Alzheimer Res. 2011 Sep;8(6):666-77. Review.


Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain.

Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM.

J Neurochem. 2011 Aug;118(4):658-67. doi: 10.1111/j.1471-4159.2011.07337.x. Epub 2011 Jul 1.


Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.

Boutajangout A, Quartermain D, Sigurdsson EM.

J Neurosci. 2010 Dec 8;30(49):16559-66. doi: 10.1523/JNEUROSCI.4363-10.2010.


Vaccination as a therapeutic approach to Alzheimer's disease.

Wisniewski T, Boutajangout A.

Mt Sinai J Med. 2010 Jan-Feb;77(1):17-31. doi: 10.1002/msj.20156. Review.


Immunotherapeutic approaches for Alzheimer's disease in transgenic mouse models.

Wisniewski T, Boutajangout A.

Brain Struct Funct. 2010 Mar;214(2-3):201-18. doi: 10.1007/s00429-009-0236-2. Epub 2009 Dec 10. Review.


Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine.

Boutajangout A, Goni F, Knudsen E, Schreiber F, Asuni A, Quartermain D, Frangione B, Chabalgoity A, Wisniewski T, Sigurdsson EM.

J Alzheimers Dis. 2009;18(4):961-72. doi: 10.3233/JAD-2009-1204.


Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology.

Scholtzova H, Kascsak RJ, Bates KA, Boutajangout A, Kerr DJ, Meeker HC, Mehta PD, Spinner DS, Wisniewski T.

J Neurosci. 2009 Feb 11;29(6):1846-54. doi: 10.1523/JNEUROSCI.5715-08.2009.


Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.

Asuni AA, Boutajangout A, Scholtzova H, Knudsen E, Li YS, Quartermain D, Frangione B, Wisniewski T, Sigurdsson EM.

Eur J Neurosci. 2006 Nov;24(9):2530-42.


Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease.

Boutajangout A, Boom A, Leroy K, Brion JP.

FEBS Lett. 2004 Oct 8;576(1-2):183-9.


Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

Boutajangout A, Authelet M, Blanchard V, Touchet N, Tremp G, Pradier L, Brion JP.

Neurobiol Dis. 2004 Feb;15(1):47-60.


Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

Leroy K, Boutajangout A, Richardson J, Octave JN, Lovestone S, Anderton BH, Brion JP.

Neurosci Lett. 2003 Dec 26;353(3):226-30.


The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies.

Hanger DP, Gibb GM, de Silva R, Boutajangout A, Brion JP, Revesz T, Lees AJ, Anderton BH.

FEBS Lett. 2002 Nov 20;531(3):538-42.


The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.

Leroy K, Boutajangout A, Authelet M, Woodgett JR, Anderton BH, Brion JP.

Acta Neuropathol. 2002 Feb;103(2):91-9. Epub 2001 Nov 29.


Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

Boutajangout A, Leroy K, Touchet N, Authelet M, Blanchard V, Tremp G, Pradier L, Brion JP.

Neurosci Lett. 2002 Jan 18;318(1):29-33.


Immunohistochemical localization of WE-14 in the developing porcine sympathoadrenal cell lineage.

Barkatullah SC, Pogue KM, Depreitere J, Boutajangout A, Liang F, DePotter W, Curry WJ.

Histochem Cell Biol. 2001 Sep;116(3):255-62.


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