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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Böckmann A, Bousset L, Stahlberg H.

Elife. 2019 Dec 9;8. pii: e48907. doi: 10.7554/eLife.48907. [Epub ahead of print]


Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons.

Kawahata I, Bousset L, Melki R, Fukunaga K.

Int J Mol Sci. 2019 Oct 28;20(21). pii: E5358. doi: 10.3390/ijms20215358.


Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.

Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM.

Ann Neurol. 2019 Oct;86(4):593-606. doi: 10.1002/ana.25557. Epub 2019 Aug 15.


α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.

Alam P, Bousset L, Melki R, Otzen DE.

J Neurochem. 2019 Sep;150(5):522-534. doi: 10.1111/jnc.14808. Epub 2019 Aug 2. Review.


The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo.

Vijayakumar J, Perrois C, Heim M, Bousset L, Alberti S, Besse F.

Nat Commun. 2019 Jun 13;10(1):2593. doi: 10.1038/s41467-019-10554-w.


Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.

Fenyi A, Leclair-Visonneau L, Clairembault T, Coron E, Neunlist M, Melki R, Derkinderen P, Bousset L.

Neurobiol Dis. 2019 Sep;129:38-43. doi: 10.1016/j.nbd.2019.05.002. Epub 2019 May 9.


Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.

Celhay O, Bousset L, Guy L, Kemeny JL, Leoni V, Caccia C, Trousson A, Damon-Soubeyrant C, De Haze A, Sabourin L, Godfraind C, de Joussineau C, Pereira B, Morel L, Lobaccaro JM, Baron S.

Eur Urol Oncol. 2019 Mar;2(2):198-206. doi: 10.1016/j.euo.2018.08.001. Epub 2018 Aug 24.


Effect of tolytoxin on tunneling nanotube formation and function.

Dilsizoglu Senol A, Pepe A, Grudina C, Sassoon N, Reiko U, Bousset L, Melki R, Piel J, Gugger M, Zurzolo C.

Sci Rep. 2019 Apr 5;9(1):5741. doi: 10.1038/s41598-019-42161-6.


LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD.

Acta Neuropathol. 2019 Jun;137(6):961-980. doi: 10.1007/s00401-019-01995-0. Epub 2019 Mar 29.


Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms.

Masnata M, Sciacca G, Maxan A, Bousset L, Denis HL, Lauruol F, David L, Saint-Pierre M, Kordower JH, Melki R, Alpaugh M, Cicchetti F.

Acta Neuropathol. 2019 Jun;137(6):981-1001. doi: 10.1007/s00401-019-01973-6. Epub 2019 Feb 20.


Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.

Peralta Ramos JM, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A.

Front Immunol. 2019 Jan 29;10:80. doi: 10.3389/fimmu.2019.00080. eCollection 2019.


A method to measure redox potential (Eh) and pH in agar media and plants shows that fungal growth is affected by and affects pH and Eh.

Bousset L, Ermel M, Soglonou B, Husson O.

Fungal Biol. 2019 Feb;123(2):117-124. doi: 10.1016/j.funbio.2018.11.008. Epub 2018 Nov 27.


Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.

Gribaudo S, Tixador P, Bousset L, Fenyi A, Lino P, Melki R, Peyrin JM, Perrier AL.

Stem Cell Reports. 2019 Feb 12;12(2):230-244. doi: 10.1016/j.stemcr.2018.12.007. Epub 2019 Jan 10.


Clustering of Tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors.

Shrivastava AN, Redeker V, Pieri L, Bousset L, Renner M, Madiona K, Mailhes-Hamon C, Coens A, Buée L, Hantraye P, Triller A, Melki R.

EMBO J. 2019 Feb 1;38(3). pii: e99871. doi: 10.15252/embj.201899871. Epub 2019 Jan 10.


CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion.

Wiegand T, Hunkeler A, Däpp A, Verasdonck J, Cadalbert R, Bousset L, Melki R, Böckmann A, Meier BH.

J Biomol NMR. 2018 Dec;72(3-4):171-177. doi: 10.1007/s10858-018-0218-x. Epub 2018 Dec 10.


2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson's disease.

Camacho R, Täuber D, Hansen C, Shi J, Bousset L, Melki R, Li JY, Scheblykin IG.

Commun Biol. 2018 Oct 2;1:157. doi: 10.1038/s42003-018-0156-x. eCollection 2018.


New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.

Bousset L, Rambur A, Fouache A, Bunay J, Morel L, Lobaccaro JA, Baron S, Trousson A, de Joussineau C.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2545. doi: 10.3390/ijms19092545. Review.


Spatio-temporal connectivity and host resistance influence evolutionary and epidemiological dynamics of the canola pathogen Leptosphaeria maculans.

Bousset L, Sprague SJ, Thrall PH, Barrett LG.

Evol Appl. 2018 Apr 17;11(8):1354-1370. doi: 10.1111/eva.12630. eCollection 2018 Sep.


Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.

Fenyi A, Coens A, Bellande T, Melki R, Bousset L.

Sci Rep. 2018 Jul 17;8(1):10788. doi: 10.1038/s41598-018-28856-2.


ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.

Peelaerts W, Bousset L, Baekelandt V, Melki R.

Cell Tissue Res. 2018 Jul;373(1):195-212. doi: 10.1007/s00441-018-2839-5. Epub 2018 Apr 27. Review.


α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Loria F, Vargas JY, Bousset L, Syan S, Salles A, Melki R, Zurzolo C.

Acta Neuropathol. 2017 Nov;134(5):789-808. doi: 10.1007/s00401-017-1746-2. Epub 2017 Jul 19.


Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.

Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.

Acta Neuropathol. 2017 Oct;134(4):629-653. doi: 10.1007/s00401-017-1722-x. Epub 2017 May 19.


Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.

Makky A, Bousset L, Polesel-Maris J, Melki R.

Sci Rep. 2016 Nov 30;6:37970. doi: 10.1038/srep37970.


Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M.

Acta Neuropathol Commun. 2016 Nov 4;4(1):117.


Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

Abounit S, Bousset L, Loria F, Zhu S, de Chaumont F, Pieri L, Olivo-Marin JC, Melki R, Zurzolo C.

EMBO J. 2016 Oct 4;35(19):2120-2138. Epub 2016 Aug 22.


Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

Data Brief. 2016 Feb 12;7:221-8. doi: 10.1016/j.dib.2016.02.018. eCollection 2016 Jun.


Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.

Brahic M, Bousset L, Bieri G, Melki R, Gitler AD.

Acta Neuropathol. 2016 Apr;131(4):539-48. doi: 10.1007/s00401-016-1538-0. Epub 2016 Jan 28.


α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.

Monsellier E, Bousset L, Melki R.

Sci Rep. 2016 Jan 13;6:19180. doi: 10.1038/srep19180.


An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

Bousset L, Brundin P, Böckmann A, Meier B, Melki R.

J Parkinsons Dis. 2016;6(1):143-51. doi: 10.3233/JPD-150691.


α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

EMBO J. 2015 Oct 1;34(19):2408-23. doi: 10.15252/embj.201591397. Epub 2015 Aug 31.


Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.

Verasdonck J, Bousset L, Gath J, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2016 Apr;10(1):5-12. doi: 10.1007/s12104-015-9628-9. Epub 2015 Aug 30.


Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.

Ruiz-Arlandis G, Pieri L, Bousset L, Melki R.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):137-52. doi: 10.1111/nan.12258. Epub 2015 Jul 20.


α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.


Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects.

Garten M, Prévost C, Cadart C, Gautier R, Bousset L, Melki R, Bassereau P, Vanni S.

Phys Chem Chem Phys. 2015 Jun 28;17(24):15589-97. doi: 10.1039/c5cp00244c. Epub 2015 Mar 31.


Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation.

Monsellier E, Redeker V, Ruiz-Arlandis G, Bousset L, Melki R.

J Biol Chem. 2015 Jan 30;290(5):2560-76. doi: 10.1074/jbc.M114.603332. Epub 2014 Dec 10.


The role of Galectin-3 in α-synuclein-induced microglial activation.

Boza-Serrano A, Reyes JF, Rey NL, Leffler H, Bousset L, Nilsson U, Brundin P, Venero JL, Burguillos MA, Deierborg T.

Acta Neuropathol Commun. 2014 Nov 12;2:156. doi: 10.1186/s40478-014-0156-0.


Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.

Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S.

RNA. 2014 Dec;20(12):1955-62. doi: 10.1261/rna.047209.114. Epub 2014 Oct 21.


Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang ZY, Roybon L, Melki R, Li JY.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.


Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.


Dynamical properties of α-synuclein in soluble and fibrillar forms by Quasi Elastic Neutron Scattering.

Bousset L, Brewee C, Melki R, Migliardo F.

Biochim Biophys Acta. 2014 Jul;1844(7):1307-16. doi: 10.1016/j.bbapap.2014.04.010. Epub 2014 Apr 21.


Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.

Bétemps D, Verchère J, Brot S, Morignat E, Bousset L, Gaillard D, Lakhdar L, Melki R, Baron T.

Acta Neuropathol Commun. 2014 Mar 13;2:29. doi: 10.1186/2051-5960-2-29.


Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity.

Gath J, Bousset L, Habenstein B, Melki R, Böckmann A, Meier BH.

PLoS One. 2014 Mar 5;9(3):e90659. doi: 10.1371/journal.pone.0090659. eCollection 2014.


Quantitative resistance affects the speed of frequency increase but not the diversity of the virulence alleles overcoming a major resistance gene to Leptosphaeria maculans in oilseed rape.

Delourme R, Bousset L, Ermel M, Duffé P, Besnard AL, Marquer B, Fudal I, Linglin J, Chadœuf J, Brun H.

Infect Genet Evol. 2014 Oct;27:490-9. doi: 10.1016/j.meegid.2013.12.019. Epub 2014 Jan 3.


Alpha-synuclein transfers from neurons to oligodendrocytes.

Reyes JF, Rey NL, Bousset L, Melki R, Brundin P, Angot E.

Glia. 2014 Mar;62(3):387-98. doi: 10.1002/glia.22611. Epub 2013 Dec 31.


The conformation of the prion domain of Sup35p in isolation and in the full-length protein.

Luckgei N, Schütz AK, Bousset L, Habenstein B, Sourigues Y, Gardiennet C, Meier BH, Melki R, Böckmann A.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12741-4. doi: 10.1002/anie.201304699. Epub 2013 Oct 9. No abstract available.


Yet another polymorph of α-synuclein: solid-state sequential assignments.

Gath J, Bousset L, Habenstein B, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2014 Oct;8(2):395-404. doi: 10.1007/s12104-013-9526-y. Epub 2013 Oct 10.


Structural and functional characterization of two alpha-synuclein strains.

Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R.

Nat Commun. 2013;4:2575. doi: 10.1038/ncomms3575.


Solid-state NMR sequential assignments of the amyloid core of full-length Sup35p.

Schütz AK, Habenstein B, Luckgei N, Bousset L, Sourigues Y, Nielsen AB, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2014 Oct;8(2):349-56. doi: 10.1007/s12104-013-9515-1. Epub 2013 Aug 14.


Solid-state NMR sequential assignments of the amyloid core of Sup35pNM.

Luckgei N, Schütz AK, Habenstein B, Bousset L, Sourigues Y, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2014 Oct;8(2):365-70. doi: 10.1007/s12104-013-9518-y. Epub 2013 Aug 10.


Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Rey NL, Petit GH, Bousset L, Melki R, Brundin P.

Acta Neuropathol. 2013 Oct;126(4):555-73. doi: 10.1007/s00401-013-1160-3. Epub 2013 Aug 8.

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