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Items: 1 to 50 of 72

1.

New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.

Bousset L, Rambur A, Fouache A, Bunay J, Morel L, Lobaccaro JA, Baron S, Trousson A, de Joussineau C.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2545. doi: 10.3390/ijms19092545. Review.

2.

Spatio-temporal connectivity and host resistance influence evolutionary and epidemiological dynamics of the canola pathogen Leptosphaeria maculans.

Bousset L, Sprague SJ, Thrall PH, Barrett LG.

Evol Appl. 2018 Apr 17;11(8):1354-1370. doi: 10.1111/eva.12630. eCollection 2018 Sep.

3.

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces.

Fenyi A, Coens A, Bellande T, Melki R, Bousset L.

Sci Rep. 2018 Jul 17;8(1):10788. doi: 10.1038/s41598-018-28856-2.

4.

ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.

Peelaerts W, Bousset L, Baekelandt V, Melki R.

Cell Tissue Res. 2018 Jul;373(1):195-212. doi: 10.1007/s00441-018-2839-5. Epub 2018 Apr 27. Review.

PMID:
29704213
5.

α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.

Loria F, Vargas JY, Bousset L, Syan S, Salles A, Melki R, Zurzolo C.

Acta Neuropathol. 2017 Nov;134(5):789-808. doi: 10.1007/s00401-017-1746-2. Epub 2017 Jul 19.

6.

Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.

Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM.

Acta Neuropathol. 2017 Oct;134(4):629-653. doi: 10.1007/s00401-017-1722-x. Epub 2017 May 19.

PMID:
28527044
7.

Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.

Makky A, Bousset L, Polesel-Maris J, Melki R.

Sci Rep. 2016 Nov 30;6:37970. doi: 10.1038/srep37970.

8.

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M.

Acta Neuropathol Commun. 2016 Nov 4;4(1):117.

9.

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

Abounit S, Bousset L, Loria F, Zhu S, de Chaumont F, Pieri L, Olivo-Marin JC, Melki R, Zurzolo C.

EMBO J. 2016 Oct 4;35(19):2120-2138. Epub 2016 Aug 22.

10.

Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

Data Brief. 2016 Feb 12;7:221-8. doi: 10.1016/j.dib.2016.02.018. eCollection 2016 Jun.

11.

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1.

Brahic M, Bousset L, Bieri G, Melki R, Gitler AD.

Acta Neuropathol. 2016 Apr;131(4):539-48. doi: 10.1007/s00401-016-1538-0. Epub 2016 Jan 28.

12.

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.

Monsellier E, Bousset L, Melki R.

Sci Rep. 2016 Jan 13;6:19180. doi: 10.1038/srep19180.

13.

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

Bousset L, Brundin P, Böckmann A, Meier B, Melki R.

J Parkinsons Dis. 2016;6(1):143-51. doi: 10.3233/JPD-150691.

14.

α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.

Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.

EMBO J. 2015 Oct 1;34(19):2408-23. doi: 10.15252/embj.201591397. Epub 2015 Aug 31.

15.

Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.

Verasdonck J, Bousset L, Gath J, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2016 Apr;10(1):5-12. doi: 10.1007/s12104-015-9628-9. Epub 2015 Aug 30.

PMID:
26318307
16.

Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.

Ruiz-Arlandis G, Pieri L, Bousset L, Melki R.

Neuropathol Appl Neurobiol. 2016 Feb;42(2):137-52. doi: 10.1111/nan.12258. Epub 2015 Jul 20.

PMID:
26111612
17.

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.

PMID:
26061766
18.

Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects.

Garten M, Prévost C, Cadart C, Gautier R, Bousset L, Melki R, Bassereau P, Vanni S.

Phys Chem Chem Phys. 2015 Jun 28;17(24):15589-97. doi: 10.1039/c5cp00244c. Epub 2015 Mar 31.

PMID:
25824255
19.

Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation.

Monsellier E, Redeker V, Ruiz-Arlandis G, Bousset L, Melki R.

J Biol Chem. 2015 Jan 30;290(5):2560-76. doi: 10.1074/jbc.M114.603332. Epub 2014 Dec 10.

20.

The role of Galectin-3 in α-synuclein-induced microglial activation.

Boza-Serrano A, Reyes JF, Rey NL, Leffler H, Bousset L, Nilsson U, Brundin P, Venero JL, Burguillos MA, Deierborg T.

Acta Neuropathol Commun. 2014 Nov 12;2:156. doi: 10.1186/s40478-014-0156-0.

21.

Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation.

Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S.

RNA. 2014 Dec;20(12):1955-62. doi: 10.1261/rna.047209.114. Epub 2014 Oct 21.

22.

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang ZY, Roybon L, Melki R, Li JY.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.

PMID:
25296989
23.

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.

24.

Dynamical properties of α-synuclein in soluble and fibrillar forms by Quasi Elastic Neutron Scattering.

Bousset L, Brewee C, Melki R, Migliardo F.

Biochim Biophys Acta. 2014 Jul;1844(7):1307-16. doi: 10.1016/j.bbapap.2014.04.010. Epub 2014 Apr 21.

PMID:
24768772
25.

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.

Bétemps D, Verchère J, Brot S, Morignat E, Bousset L, Gaillard D, Lakhdar L, Melki R, Baron T.

Acta Neuropathol Commun. 2014 Mar 13;2:29. doi: 10.1186/2051-5960-2-29.

26.

Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity.

Gath J, Bousset L, Habenstein B, Melki R, Böckmann A, Meier BH.

PLoS One. 2014 Mar 5;9(3):e90659. doi: 10.1371/journal.pone.0090659. eCollection 2014.

27.

Quantitative resistance affects the speed of frequency increase but not the diversity of the virulence alleles overcoming a major resistance gene to Leptosphaeria maculans in oilseed rape.

Delourme R, Bousset L, Ermel M, Duffé P, Besnard AL, Marquer B, Fudal I, Linglin J, Chadœuf J, Brun H.

Infect Genet Evol. 2014 Oct;27:490-9. doi: 10.1016/j.meegid.2013.12.019. Epub 2014 Jan 3.

PMID:
24394446
28.

Alpha-synuclein transfers from neurons to oligodendrocytes.

Reyes JF, Rey NL, Bousset L, Melki R, Brundin P, Angot E.

Glia. 2014 Mar;62(3):387-98. doi: 10.1002/glia.22611. Epub 2013 Dec 31.

29.

The conformation of the prion domain of Sup35p in isolation and in the full-length protein.

Luckgei N, Schütz AK, Bousset L, Habenstein B, Sourigues Y, Gardiennet C, Meier BH, Melki R, Böckmann A.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12741-4. doi: 10.1002/anie.201304699. Epub 2013 Oct 9. No abstract available.

PMID:
24123863
30.

Yet another polymorph of α-synuclein: solid-state sequential assignments.

Gath J, Bousset L, Habenstein B, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2014 Oct;8(2):395-404. doi: 10.1007/s12104-013-9526-y. Epub 2013 Oct 10.

PMID:
24114178
31.

Structural and functional characterization of two alpha-synuclein strains.

Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R.

Nat Commun. 2013;4:2575. doi: 10.1038/ncomms3575.

32.

Solid-state NMR sequential assignments of the amyloid core of full-length Sup35p.

Schütz AK, Habenstein B, Luckgei N, Bousset L, Sourigues Y, Nielsen AB, Melki R, Böckmann A, Meier BH.

Biomol NMR Assign. 2014 Oct;8(2):349-56. doi: 10.1007/s12104-013-9515-1. Epub 2013 Aug 14.

PMID:
23943018
33.

Solid-state NMR sequential assignments of the amyloid core of Sup35pNM.

Luckgei N, Schütz AK, Habenstein B, Bousset L, Sourigues Y, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2014 Oct;8(2):365-70. doi: 10.1007/s12104-013-9518-y. Epub 2013 Aug 10.

PMID:
23934139
34.

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Rey NL, Petit GH, Bousset L, Melki R, Brundin P.

Acta Neuropathol. 2013 Oct;126(4):555-73. doi: 10.1007/s00401-013-1160-3. Epub 2013 Aug 8.

35.

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors.

Shrivastava AN, Kowalewski JM, Renner M, Bousset L, Koulakoff A, Melki R, Giaume C, Triller A.

Glia. 2013 Oct;61(10):1673-86. doi: 10.1002/glia.22548. Epub 2013 Aug 6.

PMID:
23922225
36.

Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.

Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PØ.

J Biol Chem. 2013 Sep 27;288(39):27752-63. doi: 10.1074/jbc.M113.483248. Epub 2013 Aug 6.

37.

[Infectious properties of protein aggregates involved in neurodegenerative diseases].

Bousset L, Melki R.

Biol Aujourdhui. 2013;207(1):55-9. doi: 10.1051/jbio/2013004. Epub 2013 May 23. Review. French.

PMID:
23694725
38.

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.

Lesage S, Anheim M, Letournel F, Bousset L, Honoré A, Rozas N, Pieri L, Madiona K, Dürr A, Melki R, Verny C, Brice A; French Parkinson's Disease Genetics Study Group.

Ann Neurol. 2013 Apr;73(4):459-71. doi: 10.1002/ana.23894.

PMID:
23526723
39.

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport.

Freundt EC, Maynard N, Clancy EK, Roy S, Bousset L, Sourigues Y, Covert M, Melki R, Kirkegaard K, Brahic M.

Ann Neurol. 2012 Oct;72(4):517-24. doi: 10.1002/ana.23747.

40.
41.

A native-like conformation for the C-terminal domain of the prion Ure2p within its fibrillar form.

Habenstein B, Bousset L, Sourigues Y, Kabani M, Loquet A, Meier BH, Melki R, Böckmann A.

Angew Chem Int Ed Engl. 2012 Aug 6;51(32):7963-6. doi: 10.1002/anie.201202093. Epub 2012 Jul 3. No abstract available.

PMID:
22760922
42.

Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface.

Trevino RS, Lauckner JE, Sourigues Y, Pearce MM, Bousset L, Melki R, Kopito RR.

J Biol Chem. 2012 Aug 24;287(35):29722-8. doi: 10.1074/jbc.M112.372474. Epub 2012 Jun 29.

43.

Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells.

Pieri L, Madiona K, Bousset L, Melki R.

Biophys J. 2012 Jun 20;102(12):2894-905. doi: 10.1016/j.bpj.2012.04.050. Epub 2012 Jun 19.

44.

Disentangling the genetic origins of a plant pathogen during disease spread using an original molecular epidemiology approach.

Xhaard C, Barrès B, Andrieux A, Bousset L, Halkett F, Frey P.

Mol Ecol. 2012 May;21(10):2383-98. doi: 10.1111/j.1365-294X.2012.05556.x. Epub 2012 Apr 10.

PMID:
22490255
45.

Hsc70 protein interaction with soluble and fibrillar alpha-synuclein.

Pemberton S, Madiona K, Pieri L, Kabani M, Bousset L, Melki R.

J Biol Chem. 2011 Oct 7;286(40):34690-9. doi: 10.1074/jbc.M111.261321. Epub 2011 Aug 10.

46.

Extensive de novo solid-state NMR assignments of the 33 kDa C-terminal domain of the Ure2 prion.

Habenstein B, Wasmer C, Bousset L, Sourigues Y, Schütz A, Loquet A, Meier BH, Melki R, Böckmann A.

J Biomol NMR. 2011 Nov;51(3):235-43. doi: 10.1007/s10858-011-9530-4. Epub 2011 Jul 31.

PMID:
21805376
47.

Solid-state NMR sequential assignments of α-synuclein.

Gath J, Habenstein B, Bousset L, Melki R, Meier BH, Böckmann A.

Biomol NMR Assign. 2012 Apr;6(1):51-5. doi: 10.1007/s12104-011-9324-3. Epub 2011 Jul 9.

PMID:
21744165
48.

Absence of isolation by distance patterns at the regional scale in the fungal plant pathogen Leptosphaeria maculans.

Travadon R, Sache I, Dutech C, Stachowiak A, Marquer B, Bousset L.

Fungal Biol. 2011 Jul;115(7):649-59. doi: 10.1016/j.funbio.2011.03.009. Epub 2011 Apr 23.

PMID:
21724171
49.

A mutation within the C-terminal domain of Sup35p that affects [PSI+] prion propagation.

Kabani M, Cosnier B, Bousset L, Rousset JP, Melki R, Fabret C.

Mol Microbiol. 2011 Aug;81(3):640-58. doi: 10.1111/j.1365-2958.2011.07719.x. Epub 2011 Jun 16.

50.

Wheat-germ cell-free production of prion proteins for solid-state NMR structural studies.

Noirot C, Habenstein B, Bousset L, Melki R, Meier BH, Endo Y, Penin F, Böckmann A.

N Biotechnol. 2011 Apr 30;28(3):232-8. doi: 10.1016/j.nbt.2010.06.016. Epub 2010 Jul 4.

PMID:
20609396

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