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PGxCorpus, a manually annotated corpus for pharmacogenomics.

Legrand J, Gogdemir R, Bousquet C, Dalleau K, Devignes MD, Digan W, Lee CJ, Ndiaye NC, Petitpain N, Ringot P, Smaïl-Tabbone M, Toussaint Y, Coulet A.

Sci Data. 2020 Jan 2;7(1):3. doi: 10.1038/s41597-019-0342-9.


eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y.

JCI Insight. 2019 Nov 1;4(21). pii: 121951. doi: 10.1172/jci.insight.121951.


Pharmacology and social media: Potentials and biases of web forums for drug mention analysis-case study of France.

Audeh B, Calvier FE, Bellet F, Beyens MN, Pariente A, Lillo-Le Louet A, Bousquet C.

Health Informatics J. 2019 Sep 30:1460458219865128. doi: 10.1177/1460458219865128. [Epub ahead of print]


Ontological and Non-Ontological Resources for Associating Medical Dictionary for Regulatory Activities Terms to SNOMED Clinical Terms With Semantic Properties.

Bousquet C, Souvignet J, Sadou É, Jaulent MC, Declerck G.

Front Pharmacol. 2019 Sep 10;10:975. doi: 10.3389/fphar.2019.00975. eCollection 2019.


Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression.

Laplagne C, Domagala M, Le Naour A, Quemerais C, Hamel D, Fournié JJ, Couderc B, Bousquet C, Ferrand A, Poupot M.

Int J Mol Sci. 2019 Sep 23;20(19). pii: E4719. doi: 10.3390/ijms20194719. Review.


Qualitative and Quantitative Analysis of Web Forums for Adverse Events Detection: "Strontium Ranelate" Case Study.

Karapetiantz P, Audeh B, Faille J, Lillo-Le Louët A, Bousquet C.

Stud Health Technol Inform. 2019 Aug 21;264:964-968. doi: 10.3233/SHTI190367.


Automated Control of Codes Accuracy in Case-Mix Databases by Evaluating Coherence with Available Information in the Electronic Health Record.

Chaux R, Treussier I, Audeh B, Pereira S, Hengoat T, Paviot BT, Bousquet C.

Stud Health Technol Inform. 2019 Aug 21;264:551-555. doi: 10.3233/SHTI190283.


An Iconic Approach to the Browsing of Medical Terminologies.

Lamy JB, Thuy VB, Lillo-Le Louët A, Bousquet C.

Stud Health Technol Inform. 2019 Aug 21;264:213-217. doi: 10.3233/SHTI190214.


The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release.

Saponaro C, Gmyr V, Thévenet J, Moerman E, Delalleau N, Pasquetti G, Coddeville A, Quenon A, Daoudi M, Hubert T, Vantyghem MC, Bousquet C, Martineau Y, Kerr-Conte J, Staels B, Pattou F, Bonner C.

Cell Rep. 2019 Aug 6;28(6):1447-1454.e4. doi: 10.1016/j.celrep.2019.07.009.


[Informativity of French web forums for the evaluation of side effects of baclofen].

Karapetiantz P, Lillo-Le Louët A, Bousquet C.

Therapie. 2019 Dec;74(6):569-578. doi: 10.1016/j.therap.2019.05.003. Epub 2019 May 31. French.


Computational Advances in Drug Safety: Systematic and Mapping Review of Knowledge Engineering Based Approaches.

Natsiavas P, Malousi A, Bousquet C, Jaulent MC, Koutkias V.

Front Pharmacol. 2019 May 17;10:415. doi: 10.3389/fphar.2019.00415. eCollection 2019.


Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome.

Alard A, Marboeuf C, Fabre B, Jean C, Martineau Y, Lopez F, Vende P, Poncet D, Schneider RJ, Bousquet C, Pyronnet S.

Front Genet. 2019 Mar 29;10:254. doi: 10.3389/fgene.2019.00254. eCollection 2019.


Semantic Queries Expedite MedDRA Terms Selection Thanks to a Dedicated User Interface: A Pilot Study on Five Medical Conditions.

Souvignet J, Declerck G, Trombert-Paviot B, Asfari H, Jaulent MC, Bousquet C.

Front Pharmacol. 2019 Feb 6;10:50. doi: 10.3389/fphar.2019.00050. eCollection 2019.


Modeling Keyword Search Strategy: Analysis of Pharmacovigilance Specialists' Search of MedDRA Terms.

Marcilly R, Douze L, Bousquet C, Pelayo S.

Stud Health Technol Inform. 2019;257:298-302.


Captive-reared European hamsters follow an offensive strategy during risk-assessment.

Tissier ML, Bousquet CAH, Fleitz J, Habold C, Petit O, Handrich Y.

PLoS One. 2019 Jan 14;14(1):e0210158. doi: 10.1371/journal.pone.0210158. eCollection 2019.


From risk to care: the hepatitis C screening and diagnostic cascade in a primary health care clinic in Karachi, Pakistan-a cohort study.

Khalid GG, Kyaw KWY, Bousquet C, Auat R, Donchuk D, Trickey A, Hamid S, Qureshi H, Mazzeo V, Aslam K, Khowaja S, Van den Bergh R.

Int Health. 2020 Jan 1;12(1):19-27. doi: 10.1093/inthealth/ihy096.


Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma.

Neuzillet C, Tijeras-Raballand A, Ragulan C, Cros J, Patil Y, Martinet M, Erkan M, Kleeff J, Wilson J, Apte M, Tosolini M, Wilson AS, Delvecchio FR, Bousquet C, Paradis V, Hammel P, Sadanandam A, Kocher HM.

J Pathol. 2019 May;248(1):51-65. doi: 10.1002/path.5224. Epub 2019 Feb 22.


Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.

Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de La Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A.

Gut. 2019 Apr;68(4):693-707. doi: 10.1136/gutjnl-2018-317570. Epub 2018 Nov 10.


Comment on "Assessment of the Utility of Social Media for Broad-Ranging Statistical Signal Detection in Pharmacovigilance: Results from the WEB-RADR Project".

Bousquet C, Audeh B, Bellet F, Lillo-Le Louët A.

Drug Saf. 2018 Dec;41(12):1371-1373. doi: 10.1007/s40264-018-0747-y. No abstract available.


International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature.

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S.

Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review.


Evaluating Twitter as a complementary data source for pharmacovigilance.

Lardon J, Bellet F, Aboukhamis R, Asfari H, Souvignet J, Jaulent MC, Beyens MN, Lillo-LeLouët A, Bousquet C.

Expert Opin Drug Saf. 2018 Aug;17(8):763-774. doi: 10.1080/14740338.2018.1499724. Epub 2018 Jul 26.


Patients' Perception of Privacy of Personal Data, Shared in Online Communities: Are We in the Presence of a Paradox?

Lamas E, Coquedano C, Bousquet C, Ferrer M, Chekroun M, Zorrilla S, Salinas R.

Stud Health Technol Inform. 2018;251:237-240.


Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer.

Ogier C, Colombo PE, Bousquet C, Canterel-Thouennon L, Sicard P, Garambois V, Thomas G, Gaborit N, Jarlier M, Pirot N, Pugnière M, Vie N, Gongora C, Martineau P, Robert B, Pèlegrin A, Chardès T, Larbouret C.

Cancer Lett. 2018 Sep 28;432:227-236. doi: 10.1016/j.canlet.2018.06.023. Epub 2018 Jun 20.


Mining Patients' Narratives in Social Media for Pharmacovigilance: Adverse Effects and Misuse of Methylphenidate.

Chen X, Faviez C, Schuck S, Lillo-Le-Louët A, Texier N, Dahamna B, Huot C, Foulquié P, Pereira S, Leroux V, Karapetiantz P, Guenegou-Arnoux A, Katsahian S, Bousquet C, Burgun A.

Front Pharmacol. 2018 May 24;9:541. doi: 10.3389/fphar.2018.00541. eCollection 2018.


Descriptions of Adverse Drug Reactions Are Less Informative in Forums Than in the French Pharmacovigilance Database but Provide More Unexpected Reactions.

Karapetiantz P, Bellet F, Audeh B, Lardon J, Leprovost D, Aboukhamis R, Morlane-Hondère F, Grouin C, Burgun A, Katsahian S, Jaulent MC, Beyens MN, Lillo-Le Louët A, Bousquet C.

Front Pharmacol. 2018 May 1;9:439. doi: 10.3389/fphar.2018.00439. eCollection 2018.


Signal Detection for Baclofen in Web Forums: A Preliminary Study.

Karapetiantz P, Audeh B, Lillo-Le Louët A, Bousquet C.

Stud Health Technol Inform. 2018;247:421-425.


The Meaning of Patient Empowerment in the Digital Age: The Role of Online Patient-Communities.

Lamas E, Salinas R, Coquedano C, Simon MP, Bousquet C, Ferrer M, Zorrilla S.

Stud Health Technol Inform. 2017;244:43-47.


The Adverse Drug Reactions from Patient Reports in Social Media Project: Five Major Challenges to Overcome to Operationalize Analysis and Efficiently Support Pharmacovigilance Process.

Bousquet C, Dahamna B, Guillemin-Lanne S, Darmoni SJ, Faviez C, Huot C, Katsahian S, Leroux V, Pereira S, Richard C, Schück S, Souvignet J, Lillo-Le Louët A, Texier N.

JMIR Res Protoc. 2017 Sep 21;6(9):e179. doi: 10.2196/resprot.6463.


Vigi4Med Scraper: A Framework for Web Forum Structured Data Extraction and Semantic Representation.

Audeh B, Beigbeder M, Zimmermann A, Jaillon P, Bousquet C.

PLoS One. 2017 Jan 25;12(1):e0169658. doi: 10.1371/journal.pone.0169658. eCollection 2017.


Focal Adhesion Kinase: A promising therapeutic target in pancreatic adenocarcinoma.

Decaup E, Rochotte J, Pyronnet S, Bousquet C, Jean C.

Clin Res Hepatol Gastroenterol. 2017 Jun;41(3):246-248. doi: 10.1016/j.clinre.2016.10.010. Epub 2016 Dec 6.


Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.

Leca J, Martinez S, Lac S, Nigri J, Secq V, Rubis M, Bressy C, Sergé A, Lavaut MN, Dusetti N, Loncle C, Roques J, Pietrasz D, Bousquet C, Garcia S, Granjeaud S, Ouaissi M, Bachet JB, Brun C, Iovanna JL, Zimmermann P, Vasseur S, Tomasini R.

J Clin Invest. 2016 Nov 1;126(11):4140-4156. doi: 10.1172/JCI87734. Epub 2016 Oct 4.


OntoADR a semantic resource describing adverse drug reactions to support searching, coding, and information retrieval.

Souvignet J, Declerck G, Asfari H, Jaulent MC, Bousquet C.

J Biomed Inform. 2016 Oct;63:100-107. doi: 10.1016/j.jbi.2016.06.010. Epub 2016 Jun 28.


[Automated grouping of terms associated to cardiac valve fibrosis in MedDRA].

Asfari H, Souvignet J, Lillo-Le Louët A, Trombert B, Jaulent MC, Bousquet C.

Therapie. 2016 Dec;71(6):541-552. doi: 10.1016/j.therap.2016.06.003. Epub 2016 Jul 21. French.


Inconsistencies Between Antiparkinsonian Drugs and ICD-10 Codes in Inpatients: A TOLBIAC Project Case Study.

Triki N, Bousquet C, Lardon J, Asfari H, Spiga R, Trombert-Paviot B.

Stud Health Technol Inform. 2016;228:364-8.


Lay Crowd-Sourced Expertise (LCE) and Its Influence on the New Role of Patients: Ethical and Societal Issues.

Lamas E, Salinas R, Ferrer M, Bousquet C, Vuillaume D.

Stud Health Technol Inform. 2016;228:80-4.


MedDRA® automated term groupings using OntoADR: evaluation with upper gastrointestinal bleedings.

Souvignet J, Asfari H, Lardon J, Del Tedesco E, Declerck G, Bousquet C.

Expert Opin Drug Saf. 2016 Sep;15(9):1153-61. doi: 10.1080/14740338.2016.1206075. Epub 2016 Jul 15.


Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts.

Moatassim-Billah S, Duluc C, Samain R, Jean C, Perraud A, Decaup E, Cassant-Sourdy S, Bakri Y, Selves J, Schmid H, Martineau Y, Mathonnet M, Pyronnet S, Bousquet C.

Oncotarget. 2016 Jul 5;7(27):41584-41598. doi: 10.18632/oncotarget.9296.


Good Signal Detection Practices: Evidence from IMI PROTECT.

Wisniewski AF, Bate A, Bousquet C, Brueckner A, Candore G, Juhlin K, Macia-Martinez MA, Manlik K, Quarcoo N, Seabroke S, Slattery J, Southworth H, Thakrar B, Tregunno P, Van Holle L, Kayser M, Norén GN.

Drug Saf. 2016 Jun;39(6):469-90. doi: 10.1007/s40264-016-0405-1.


How social network structure affects decision-making in Drosophila melanogaster.

Pasquaretta C, Battesti M, Klenschi E, Bousquet CA, Sueur C, Mery F.

Proc Biol Sci. 2016 Mar 16;283(1826):20152954. doi: 10.1098/rspb.2015.2954.


Adverse Drug Reaction Identification and Extraction in Social Media: A Scoping Review.

Lardon J, Abdellaoui R, Bellet F, Asfari H, Souvignet J, Texier N, Jaulent MC, Beyens MN, Burgun A, Bousquet C.

J Med Internet Res. 2015 Jul 10;17(7):e171. doi: 10.2196/jmir.4304. Review.


Evaluation of Internet Social Networks using Net scoring Tool: A Case Study in Adverse Drug Reaction Mining.

Katsahian S, Simond Moreau E, Leprovost D, Lardon J, Bousquet C, Kerdelhué G, Abdellaoui R, Texier N, Burgun A, Boussadi A, Faviez C.

Stud Health Technol Inform. 2015;210:526-30.


Improvement of Diagnosis Coding by Analysing EHR and Using Rule Engine: Application to the Chronic Kidney Disease.

Lardon J, Asfari H, Souvignet J, Trombert-Paviot B, Bousquet C.

Stud Health Technol Inform. 2015;210:120-4.


Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.

Duluc C, Moatassim-Billah S, Chalabi-Dchar M, Perraud A, Samain R, Breibach F, Gayral M, Cordelier P, Delisle MB, Bousquet-Dubouch MP, Tomasini R, Schmid H, Mathonnet M, Pyronnet S, Martineau Y, Bousquet C.

EMBO Mol Med. 2015 Jun;7(6):735-53. doi: 10.15252/emmm.201404346.


Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.

Chalabi-Dchar M, Cassant-Sourdy S, Duluc C, Fanjul M, Lulka H, Samain R, Roche C, Breibach F, Delisle MB, Poupot M, Dufresne M, Shimaoka T, Yonehara S, Mathonnet M, Pyronnet S, Bousquet C.

Gastroenterology. 2015 Jun;148(7):1452-65. doi: 10.1053/j.gastro.2015.02.009. Epub 2015 Feb 13.


High-performance liquid chromatography method for the determination of hydrogen peroxide present or released in teeth bleaching kits and hair cosmetic products.

Gimeno P, Bousquet C, Lassu N, Maggio AF, Civade C, Brenier C, Lempereur L.

J Pharm Biomed Anal. 2015 Mar 25;107:386-93. doi: 10.1016/j.jpba.2015.01.018. Epub 2015 Jan 19.


Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling.

Secq V, Leca J, Bressy C, Guillaumond F, Skrobuk P, Nigri J, Lac S, Lavaut MN, Bui TT, Thakur AK, Callizot N, Steinschneider R, Berthezene P, Dusetti N, Ouaissi M, Moutardier V, Calvo E, Bousquet C, Garcia S, Bidaut G, Vasseur S, Iovanna JL, Tomasini R.

Cell Death Dis. 2015 Jan 15;6:e1592. doi: 10.1038/cddis.2014.557.


Imbalanced splicing in MAPK signaling sustains Ras-induced transformation.

Müller D, Martineau Y, Bousquet C, Pyronnet S.

Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):155-6. doi: 10.1016/j.clinre.2014.09.011. Epub 2014 Nov 20.


Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

Baer R, Cintas C, Dufresne M, Cassant-Sourdy S, Schönhuber N, Planque L, Lulka H, Couderc B, Bousquet C, Garmy-Susini B, Vanhaesebroeck B, Pyronnet S, Saur D, Guillermet-Guibert J.

Genes Dev. 2014 Dec 1;28(23):2621-35. doi: 10.1101/gad.249409.114.


Chocs anaphylactiques d'origine médicamenteuse : sous-notification et PMSI.

Asfari H, Bousquet C, Paviot BT, Bellet F, Mounier G, Marsille F, Beyens MN, Guy C.

Therapie. 2014 Nov-Dec;69(6):483-90. doi: 10.2515/therapie/2014057. French.


[Drug-related anaphylactic shocks: under-reporting and PMSI].

Asfari H, Bousquet C, Trombert Paviot B, Bellet F, Mounier G, Marsille F, Beyens MN, Guy C.

Therapie. 2014 Nov-Dec;69(6):483-90. doi: 10.2515/therapie/2014057. Epub 2014 Oct 1. French.


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