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An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes.

Chatonnet A, Brazzolotto X, Hotelier T, Lenfant N, Marchot P, Bourne Y.

Chem Biol Interact. 2019 May 14;308:179-184. doi: 10.1016/j.cbi.2019.05.016. [Epub ahead of print]


Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.

Debarnot C, Monneau YR, Roig-Zamboni V, Delauzun V, Le Narvor C, Richard E, Hénault J, Goulet A, Fadel F, Vivès RR, Priem B, Bonnaffé D, Lortat-Jacob H, Bourne Y.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6760-6765. doi: 10.1073/pnas.1818333116. Epub 2019 Mar 14.


Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.

Barre A, Bourne Y, Van Damme EJM, Rougé P.

Int J Mol Sci. 2019 Jan 10;20(2). pii: E254. doi: 10.3390/ijms20020254. Review.


Genetic and enzymatic characterization of 3-O-sulfotransferase SNPs associated with Plasmodium falciparum parasitaemia.

Nguyen NT, Vivès RR, Torres M, Delauzun V, Saesen E, Roig-Zamboni V, Lortat-Jacob H, Rihet P, Bourne Y.

Glycobiology. 2018 Jul 1;28(7):534-541. doi: 10.1093/glycob/cwy038.


Glycosylate and move! The glycosyltransferase Maf is involved in bacterial flagella formation.

Sulzenbacher G, Roig-Zamboni V, Lebrun R, Guérardel Y, Murat D, Mansuelle P, Yamakawa N, Qian XX, Vincentelli R, Bourne Y, Wu LF, Alberto F.

Environ Microbiol. 2018 Jan;20(1):228-240. doi: 10.1111/1462-2920.13975. Epub 2017 Dec 4.


Structure of human lysosomal acid α-glucosidase-a guide for the treatment of Pompe disease.

Roig-Zamboni V, Cobucci-Ponzano B, Iacono R, Ferrara MC, Germany S, Bourne Y, Parenti G, Moracci M, Sulzenbacher G.

Nat Commun. 2017 Oct 24;8(1):1111. doi: 10.1038/s41467-017-01263-3.


Structural and functional insights into the periplasmic detector domain of the GacS histidine kinase controlling biofilm formation in Pseudomonas aeruginosa.

Ali-Ahmad A, Fadel F, Sebban-Kreuzer C, Ba M, Pélissier GD, Bornet O, Guerlesquin F, Bourne Y, Bordi C, Vincent F.

Sci Rep. 2017 Sep 12;7(1):11262. doi: 10.1038/s41598-017-11361-3.


Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors.

Molgó J, Marchot P, Aráoz R, Benoit E, Iorga BI, Zakarian A, Taylor P, Bourne Y, Servent D.

J Neurochem. 2017 Aug;142 Suppl 2:41-51. doi: 10.1111/jnc.13995. Epub 2017 Mar 21. Review.


Structural insights into a family 39 glycoside hydrolase from the gut symbiont Bacteroides cellulosilyticus WH2.

Ali-Ahmad A, Garron ML, Zamboni V, Lenfant N, Nurizzo D, Henrissat B, Berrin JG, Bourne Y, Vincent F.

J Struct Biol. 2017 Mar;197(3):227-235. doi: 10.1016/j.jsb.2016.11.004. Epub 2016 Nov 24.


NMR assignments of the GacS histidine-kinase periplasmic detection domain from Pseudomonas aeruginosa PAO1.

Ali-Ahmad A, Bornet O, Fadel F, Bourne Y, Vincent F, Bordi C, Guerlesquin F, Sebban-Kreuzer C.

Biomol NMR Assign. 2017 Apr;11(1):25-28. doi: 10.1007/s12104-016-9714-7. Epub 2016 Oct 6.


Relationships of human α/β hydrolase fold proteins and other organophosphate-interacting proteins.

Lenfant N, Bourne Y, Marchot P, Chatonnet A.

Chem Biol Interact. 2016 Nov 25;259(Pt B):343-351. doi: 10.1016/j.cbi.2016.04.027. Epub 2016 Apr 21. Review.


Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.

Bourne Y, Sharpless KB, Taylor P, Marchot P.

J Am Chem Soc. 2016 Feb 10;138(5):1611-21. doi: 10.1021/jacs.5b11384. Epub 2016 Jan 28.


Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.

Bourne Y, Sulzenbacher G, Radić Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P.

Structure. 2015 Jun 2;23(6):1106-15. doi: 10.1016/j.str.2015.04.009. Epub 2015 May 21.


Structural basis for carbohydrate binding properties of a plant chitinase-like agglutinin with conserved catalytic machinery.

Sulzenbacher G, Roig-Zamboni V, Peumans WJ, Henrissat B, van Damme EJ, Bourne Y.

J Struct Biol. 2015 May;190(2):115-21. doi: 10.1016/j.jsb.2015.01.013. Epub 2015 Feb 26.


Structural and biochemical characterization of the β-N-acetylglucosaminidase from Thermotoga maritima: toward rationalization of mechanistic knowledge in the GH73 family.

Lipski A, Hervé M, Lombard V, Nurizzo D, Mengin-Lecreulx D, Bourne Y, Vincent F.

Glycobiology. 2015 Mar;25(3):319-30. doi: 10.1093/glycob/cwu113. Epub 2014 Oct 24.


Structural and functional characterization of the Clostridium perfringens N-acetylmannosamine-6-phosphate 2-epimerase essential for the sialic acid salvage pathway.

Pélissier MC, Sebban-Kreuzer C, Guerlesquin F, Brannigan JA, Bourne Y, Vincent F.

J Biol Chem. 2014 Dec 19;289(51):35215-24. doi: 10.1074/jbc.M114.604272. Epub 2014 Oct 15.


The neuroligins and their ligands: from structure to function at the synapse.

Bourne Y, Marchot P.

J Mol Neurosci. 2014 Jul;53(3):387-96. doi: 10.1007/s12031-014-0234-6. Epub 2014 Feb 6.


Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins.

Lenfant N, Hotelier T, Bourne Y, Marchot P, Chatonnet A.

J Mol Neurosci. 2014 Jul;53(3):362-9. doi: 10.1007/s12031-013-0194-2. Epub 2014 Jan 5.


Molecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor region.

Bourne Y, Renault L, Essono S, Mondielli G, Lamourette P, Boquet D, Grassi J, Marchot P.

PLoS One. 2013 Oct 11;8(10):e77226. doi: 10.1371/journal.pone.0077226. eCollection 2013.


The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily.

Parsiegla G, Noguere C, Santell L, Lazarus RA, Bourne Y.

Biochemistry. 2012 Dec 21;51(51):10250-8. doi: 10.1021/bi300873f. Epub 2012 Dec 13.


ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions.

Lenfant N, Hotelier T, Velluet E, Bourne Y, Marchot P, Chatonnet A.

Nucleic Acids Res. 2013 Jan;41(Database issue):D423-9. doi: 10.1093/nar/gks1154. Epub 2012 Nov 27.


Proteins with an alpha/beta hydrolase fold: Relationships between subfamilies in an ever-growing superfamily.

Lenfant N, Hotelier T, Bourne Y, Marchot P, Chatonnet A.

Chem Biol Interact. 2013 Mar 25;203(1):266-8. doi: 10.1016/j.cbi.2012.09.003. Epub 2012 Sep 23.


Structural insights into antibody sequestering and neutralizing of Na+ channel α-type modulator from old world scorpion venom.

Fabrichny IP, Mondielli G, Conrod S, Martin-Eauclaire MF, Bourne Y, Marchot P.

J Biol Chem. 2012 Apr 20;287(17):14136-48. doi: 10.1074/jbc.M111.315382. Epub 2012 Feb 27.


Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state.

Bourne Y, Radić Z, Taylor P, Marchot P.

J Am Chem Soc. 2010 Dec 29;132(51):18292-300. doi: 10.1021/ja106820e. Epub 2010 Nov 19.


Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions.

Pelissier MC, Lesley SA, Kuhn P, Bourne Y.

J Biol Chem. 2010 Aug 27;285(35):27468-76. doi: 10.1074/jbc.M109.095182. Epub 2010 Jun 23.


Crystal structure of the GalNAc/Gal-specific agglutinin from the phytopathogenic ascomycete Sclerotinia sclerotiorum reveals novel adaptation of a beta-trefoil domain.

Sulzenbacher G, Roig-Zamboni V, Peumans WJ, Rougé P, Van Damme EJ, Bourne Y.

J Mol Biol. 2010 Jul 23;400(4):715-23. doi: 10.1016/j.jmb.2010.05.038. Epub 2010 May 24.


Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site.

Vincent F, Round A, Reynaud A, Bordi C, Filloux A, Bourne Y.

Environ Microbiol. 2010 Jun;12(6):1775-86. doi: 10.1111/j.1462-2920.2010.02264.x.


Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions.

Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P.

EMBO J. 2010 Jul 21;29(14):2461-71. doi: 10.1038/emboj.2010.123. Epub 2010 Jun 11.


Structure of a polyisoprenoid binding domain from Saccharophagus degradans implicated in plant cell wall breakdown.

Vincent F, Molin DD, Weiner RM, Bourne Y, Henrissat B.

FEBS Lett. 2010 Apr 16;584(8):1577-84. doi: 10.1016/j.febslet.2010.03.015. Epub 2010 Mar 16.


Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism.

Bourne Y, Radic Z, Aráoz R, Talley TT, Benoit E, Servent D, Taylor P, Molgó J, Marchot P.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6076-81. doi: 10.1073/pnas.0912372107. Epub 2010 Mar 11.


Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: a comparison with acetylcholinesterase.

Leone P, Comoletti D, Taylor P, Bourne Y, Marchot P.

Chem Biol Interact. 2010 Sep 6;187(1-3):49-55. doi: 10.1016/j.cbi.2010.01.030. Epub 2010 Jan 25.


Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis.

Diacovich L, Dumont A, Lafitte D, Soprano E, Guilhon AA, Bignon C, Gorvel JP, Bourne Y, Méresse S.

J Biol Chem. 2009 Nov 27;284(48):33151-60. doi: 10.1074/jbc.M109.034975. Epub 2009 Sep 28.


Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.

Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y.

EMBO J. 2009 Oct 7;28(19):3040-51. doi: 10.1038/emboj.2009.227. Epub 2009 Aug 20.


Glycosyltransferases, glycoside hydrolases: surprise, surprise!

Henrissat B, Sulzenbacher G, Bourne Y.

Curr Opin Struct Biol. 2008 Oct;18(5):527-33. doi: 10.1016/ Epub 2008 Oct 1. Review.


Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion.

Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P.

Neuron. 2007 Dec 20;56(6):979-91.


[Bacterial glycosidases for the production of universal blood].

Sulzenbacher G, Bourne Y, Henrissat B.

Med Sci (Paris). 2007 Aug-Sep;23(8-9):703-5. French. No abstract available.


Gene overexpression and biochemical characterization of the biotechnologically relevant chlorogenic acid hydrolase from Aspergillus niger.

Benoit I, Asther M, Bourne Y, Navarro D, Canaan S, Lesage-Meessen L, Herweijer M, Coutinho PM, Asther M, Record E.

Appl Environ Microbiol. 2007 Sep;73(17):5624-32. Epub 2007 Jul 13.


Bacterial glycosidases for the production of universal red blood cells.

Liu QP, Sulzenbacher G, Yuan H, Bennett EP, Pietz G, Saunders K, Spence J, Nudelman E, Levery SB, White T, Neveu JM, Lane WS, Bourne Y, Olsson ML, Henrissat B, Clausen H.

Nat Biotechnol. 2007 Apr;25(4):454-64. Epub 2007 Apr 1.


Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein.

Bourne Y, Hansen SB, Sulzenbacher G, Talley TT, Huxford T, Taylor P, Marchot P.

J Mol Neurosci. 2006;30(1-2):103-4.


Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica.

Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Bourne Y, Taylor P.

J Mol Neurosci. 2006;30(1-2):101-2.


Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding.

Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot P.

J Biol Chem. 2006 Sep 29;281(39):29256-67. Epub 2006 Jul 12.


Functional characterization of the glycosyltransferase domain of penicillin-binding protein 1a from Thermotoga maritima.

Offant J, Michoux F, Dermiaux A, Biton J, Bourne Y.

Biochim Biophys Acta. 2006 Jun;1764(6):1036-42. Epub 2006 Apr 4.


LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.

Sulzenbacher G, Canaan S, Bordat Y, Neyrolles O, Stadthagen G, Roig-Zamboni V, Rauzier J, Maurin D, Laval F, Daffé M, Cambillau C, Gicquel B, Bourne Y, Jackson M.

EMBO J. 2006 Apr 5;25(7):1436-44. Epub 2006 Mar 16.


Structural insights into AChE inhibition by monoclonal antibodies.

Renault L, Essono S, Juin M, Boquet D, Grassi J, Bourne Y, Marchot P.

Chem Biol Interact. 2005 Dec 15;157-158:397-400.


A. niger protein "EstA", perhaps a new electrotactin, defines a new class of fungal esterases within the alpha/beta hydrolase fold superfamily.

Bourne Y, Hasper AA, Chahinian H, Renault L, Juin M, de Graaff LH, Marchot P.

Chem Biol Interact. 2005 Dec 15;157-158:395-6.


Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.

Bourne Y, Radić Z, Kolb HC, Sharpless KB, Taylor P, Marchot P.

Chem Biol Interact. 2005 Dec 15;157-158:159-65. Epub 2005 Nov 2.


Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.

Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y.

EMBO J. 2005 Oct 19;24(20):3635-46. Epub 2005 Sep 29.


Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors.

Bourne Y, Talley TT, Hansen SB, Taylor P, Marchot P.

EMBO J. 2005 Apr 20;24(8):1512-22. Epub 2005 Mar 24. Erratum in: EMBO J. 2006 Jan 11;25(1):266.

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