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Changing predictor measurement procedures affected the performance of prediction models in clinical examples.

Luijken K, Wynants L, van Smeden M, Van Calster B, Steyerberg EW, Groenwold RHH; Collaborators, Timmerman D, Bourne T, Ukaegbu C.

J Clin Epidemiol. 2019 Nov 7. pii: S0895-4356(19)30747-4. doi: 10.1016/j.jclinepi.2019.11.001. [Epub ahead of print]


O-RADS US Risk Stratification and Management System: A Consensus Guideline from the ACR Ovarian-Adnexal Reporting and Data System Committee.

Andreotti RF, Timmerman D, Strachowski LM, Froyman W, Benacerraf BR, Bennett GL, Bourne T, Brown DL, Coleman BG, Frates MC, Goldstein SR, Hamper UM, Horrow MM, Hernanz-Schulman M, Reinhold C, Rose SL, Whitcomb BP, Wolfman WL, Glanc P.

Radiology. 2019 Nov 5:191150. doi: 10.1148/radiol.2019191150. [Epub ahead of print]


The association between vaginal bacterial composition and miscarriage: a nested case-control study.

Al-Memar M, Bobdiwala S, Fourie H, Manino R, Lee YS, Smith A, Marchesi JR, Timmerman D, Bourne T, Bennett PR, MacIntyre DA.

BJOG. 2019 Oct 1. doi: 10.1111/1471-0528.15972. [Epub ahead of print]


The natural history of pregnancy-related enhanced myometrial vascularity following miscarriage.

Grewal K, Al-Memar M, Fourie H, Stalder C, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2019 Sep 10. doi: 10.1002/uog.21872. [Epub ahead of print]


The IDEAL study: MRI for suspected deep endometriosis assessment prior to laparoscopy is equally reliable as radiological imaging as a complement to transvaginal ultrasonography.

Bielen D, Tomassetti C, Van Schoubroeck D, Vanbeckevoort D, De Wever L, Vanden Bosch T, D'Hooghe T, Bourne T, D'hoore A, Wolthuis A, Van Cleynenbreughel B, Meuleman C, Timmerman D.

Ultrasound Obstet Gynecol. 2019 Sep 10. doi: 10.1002/uog.21868. [Epub ahead of print]


Sex differences in fetal growth and immediate birth outcomes in a low-risk Caucasian population.

Galjaard S, Ameye L, Lees CC, Pexsters A, Bourne T, Timmerman D, Devlieger R.

Biol Sex Differ. 2019 Sep 9;10(1):48. doi: 10.1186/s13293-019-0261-7.


Intrauterine haematomas in the first trimester and pregnancy complications.

Al-Memar M, Vaulet T, Fourie H, Bobdiwala S, Farren J, Saso S, Bracewell-Milnes T, De Moor B, Sur S, Stalder C, Bennett P, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2019 Sep 4. doi: 10.1002/uog.20861. [Epub ahead of print]


Triaging women with a pregnancy of unknown location using a two-step triage protocol including the M6 model: a clinical implementation study.

Bobdiwala S, Christodoulou E, Farren J, Mitchell-Jones N, Kyriacou C, Al-Memar M, Ayim F, Chohan B, Kirk E, Abughazza O, Guruwadahyarhalli B, Guha S, Vathanan V, Bottomley C, Gould D, Stalder C, Timmerman D, Van Calster B, Bourne T.

Ultrasound Obstet Gynecol. 2019 Aug 6. doi: 10.1002/uog.20420. [Epub ahead of print]


Evaluation of machine learning methods with Fourier Transform features for classifying ovarian tumors based on ultrasound images.

Martínez-Más J, Bueno-Crespo A, Khazendar S, Remezal-Solano M, Martínez-Cendán JP, Jassim S, Du H, Al Assam H, Bourne T, Timmerman D.

PLoS One. 2019 Jul 26;14(7):e0219388. doi: 10.1371/journal.pone.0219388. eCollection 2019.


Niche definition and guidance for detailed niche evaluation.

Jordans IPM, de Leeuw RL, Stegwee SI, Amso NN, Barri Soldevila PN, van den Bosch T, Bourne T, Brölmann HAM, Donnez O, Dueholm M, Hehenkamp WJK, Jastrow N, Jurkovic D, Mashiach R, Naji O, Streuli I, Timmerman D, van der Voet LF, Huirne JAF.

Acta Obstet Gynecol Scand. 2019 Oct;98(10):1351-1352. doi: 10.1111/aogs.13623. Epub 2019 May 9. No abstract available.


Early-pregnancy events and subsequent antenatal, delivery and neonatal outcomes: prospective cohort study.

Al-Memar M, Vaulet T, Fourie H, Nikolic G, Bobdiwala S, Saso S, Farren J, Pipi M, Van Calster B, de Moor B, Stalder C, Bennett P, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2019 Oct;54(4):530-537. doi: 10.1002/uog.20262.


Social gradients in health and social care costs: Analysis of linked electronic health records in Kent, UK.

Jayatunga W, Asaria M, Belloni A, George A, Bourne T, Sadique Z.

Public Health. 2019 Apr;169:188-194. doi: 10.1016/j.puhe.2019.02.007. Epub 2019 Mar 12.


Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma.

Ngo T, Corrales A, Bourne T, Elmojahid S, Lam KS, Díaz E.

Front Mol Biosci. 2019 Feb 19;6:5. doi: 10.3389/fmolb.2019.00005. eCollection 2019.


Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study.

Froyman W, Landolfo C, De Cock B, Wynants L, Sladkevicius P, Testa AC, Van Holsbeke C, Domali E, Fruscio R, Epstein E, Dos Santos Bernardo MJ, Franchi D, Kudla MJ, Chiappa V, Alcazar JL, Leone FPG, Buonomo F, Hochberg L, Coccia ME, Guerriero S, Deo N, Jokubkiene L, Kaijser J, Coosemans A, Vergote I, Verbakel JY, Bourne T, Van Calster B, Valentin L, Timmerman D.

Lancet Oncol. 2019 Mar;20(3):448-458. doi: 10.1016/S1470-2045(18)30837-4. Epub 2019 Feb 5.


Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes.

Brown RG, Al-Memar M, Marchesi JR, Lee YS, Smith A, Chan D, Lewis H, Kindinger L, Terzidou V, Bourne T, Bennett PR, MacIntyre DA.

Transl Res. 2019 May;207:30-43. doi: 10.1016/j.trsl.2018.12.005. Epub 2018 Dec 27.


Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis.

Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, Coomarasamy A.

Hum Reprod Update. 2019 Mar 1;25(2):202-223. doi: 10.1093/humupd/dmy044.


A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol.

May J, Duncan C, Mol B, Bhattacharya S, Daniels J, Middleton L, Hewitt C, Coomarasamy A, Jurkovic D, Bourne T, Bottomley C, Peace-Gadsby A, Doust A, Tong S, Horne AW.

Trials. 2018 Nov 20;19(1):643. doi: 10.1186/s13063-018-3008-6.


The psychological impact of early pregnancy loss.

Farren J, Mitchell-Jones N, Verbakel JY, Timmerman D, Jalmbrant M, Bourne T.

Hum Reprod Update. 2018 Nov 1;24(6):731-749. doi: 10.1093/humupd/dmy025. Review.


Ovarian-Adnexal Reporting Lexicon for Ultrasound: A White Paper of the ACR Ovarian-Adnexal Reporting and Data System Committee.

Andreotti RF, Timmerman D, Benacerraf BR, Bennett GL, Bourne T, Brown DL, Coleman BG, Frates MC, Froyman W, Goldstein SR, Hamper UM, Horrow MM, Hernanz-Schulman M, Reinhold C, Strachowski LM, Glanc P.

J Am Coll Radiol. 2018 Oct;15(10):1415-1429. doi: 10.1016/j.jacr.2018.07.004. Epub 2018 Aug 24. Erratum in: J Am Coll Radiol. 2019 Mar;16(3):403-406.


Diagnostic protocols for the management of pregnancy of unknown location: a systematic review and meta-analysis.

Bobdiwala S, Saso S, Verbakel JY, Al-Memar M, Van Calster B, Timmerman D, Bourne T.

BJOG. 2019 Jan;126(2):190-198. doi: 10.1111/1471-0528.15442. Epub 2018 Sep 20.


Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model.

Saso S, Tziraki M, Clancy NT, Song L, Bracewell-Milnes T, Jones BP, Al-Memar M, Yazbek J, Thum MY, Sayasneh A, Bourne T, Smith JR, Elson DS, Ghaem-Maghami S.

Future Sci OA. 2018 Aug 1;4(7):FSO324. doi: 10.4155/fsoa-2018-0017. eCollection 2018 Jul.


Efficacy of an Inhaled IL-13 Antibody Fragment in a Model of Chronic Asthma.

Lightwood D, Tservistas M, Zehentleitner M, Sarkar K, Turner A, Bracher M, Smith B, Lamour S, Bourne T, Shaw S, Gozzard N, Palframan RT.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):610-619. doi: 10.1164/rccm.201712-2382OC.


Sonographic classification and reporting system for diagnosing adenomyosis.

Van den Bosch T, de Bruijn AM, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, Bourne T, Timmerman D, Huirne JAF.

Ultrasound Obstet Gynecol. 2019 May;53(5):576-582. doi: 10.1002/uog.19096. No abstract available.


Caesarean scar pregnancy in the UK: a national cohort study.

Harb HM, Knight M, Bottomley C, Overton C, Tobias A, Gallos ID, Shehmar M, Farquharson R, Horne A, Latthe P, Edi-Osagie E, MacLean M, Marston E, Zamora J, Dawood F, Small R, Ross J, Bourne T, Coomarasamy A, Jurkovic D.

BJOG. 2018 Dec;125(13):1663-1670. doi: 10.1111/1471-0528.15255. Epub 2018 Jun 5.


Use of biomedical photonics in gynecological surgery: a uterine transplantation model.

Saso S, Clancy NT, Jones BP, Bracewell-Milnes T, Al-Memar M, Cannon EM, Ahluwalia S, Yazbek J, Thum MY, Bourne T, Elson DS, Smith JR, Ghaem-Maghami S.

Future Sci OA. 2018 Feb 6;4(4):FSO286. doi: 10.4155/fsoa-2017-0129. eCollection 2018 Apr.


Sonographic examination of uterine niche in non-pregnant women: a modified Delphi procedure.

Jordans IPM, de Leeuw RA, Stegwee SI, Amso NN, Barri-Soldevila PN, van den Bosch T, Bourne T, Brölmann HAM, Donnez O, Dueholm M, Hehenkamp WJK, Jastrow N, Jurkovic D, Mashiach R, Naji O, Streuli I, Timmerman D, van der Voet LF, Huirne JAF.

Ultrasound Obstet Gynecol. 2019 Jan;53(1):107-115. doi: 10.1002/uog.19049.


Ambulatory versus inpatient management of severe nausea and vomiting of pregnancy: a randomised control trial with patient preference arm.

Mitchell-Jones N, Farren JA, Tobias A, Bourne T, Bottomley C.

BMJ Open. 2017 Dec 5;7(12):e017566. doi: 10.1136/bmjopen-2017-017566.


Evaluation of tramline sign for prenatal diagnosis of abnormally invasive placenta using three-dimensional ultrasound and Crystal Vue rendering technology.

Dall'Asta A, Shah H, Masini G, Paramasivam G, Yazbek J, Bourne T, Lees CC.

Ultrasound Obstet Gynecol. 2018 Sep;52(3):403-404. doi: 10.1002/uog.18975. No abstract available.


We need to change the culture around complaints procedures.

Bourne T.

BMJ. 2017 Nov 22;359:j5313. doi: 10.1136/bmj.j5313. No abstract available.


Doctors' perception of support and the processes involved in complaints investigations and how these relate to welfare and defensive practice: a cross-sectional survey of the UK physicians.

Bourne T, De Cock B, Wynants L, Peters M, Van Audenhove C, Timmerman D, Van Calster B, Jalmbrant M.

BMJ Open. 2017 Nov 21;7(11):e017856. doi: 10.1136/bmjopen-2017-017856.


Differences in ultrasound features of papillations in unilocular-solid adnexal cysts: a retrospective international multicenter study.

Landolfo C, Valentin L, Franchi D, Van Holsbeke C, Fruscio R, Froyman W, Sladkevicius P, Kaijser J, Ameye L, Bourne T, Savelli L, Coosemans A, Testa A, Timmerman D.

Ultrasound Obstet Gynecol. 2018 Aug;52(2):269-278. doi: 10.1002/uog.18951.


Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study.

Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T.

Ultrasound Obstet Gynecol. 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. Erratum in: Ultrasound Obstet Gynecol. 2018 Nov;52(5):684.


Factors to consider in pregnancy of unknown location.

Bobdiwala S, Al-Memar M, Farren J, Bourne T.

Womens Health (Lond). 2017 Aug;13(2):27-33. doi: 10.1177/1745505717709677. Epub 2017 Jun 29. Review.


The first-trimester fetal central nervous system: a novel ultrasonographic perspective.

Shah H, Al-Memar M, de Bakker B, Fourie H, Lees C, Bourne T.

Am J Obstet Gynecol. 2017 Aug;217(2):220-221. doi: 10.1016/j.ajog.2017.05.053. Epub 2017 May 31. No abstract available.


Validation of the Performance of International Ovarian Tumor Analysis (IOTA) Methods in the Diagnosis of Early Stage Ovarian Cancer in a Non-Screening Population.

Froyman W, Wynants L, Landolfo C, Bourne T, Valentin L, Testa A, Sladkevicius P, Franchi D, Fischerova D, Savelli L, Van Calster B, Timmerman D.

Diagnostics (Basel). 2017 Jun 2;7(2). pii: E32. doi: 10.3390/diagnostics7020032.


Clinical Utility of Risk Models to Refer Patients with Adnexal Masses to Specialized Oncology Care: Multicenter External Validation Using Decision Curve Analysis.

Wynants L, Timmerman D, Verbakel JY, Testa A, Savelli L, Fischerova D, Franchi D, Van Holsbeke C, Epstein E, Froyman W, Guerriero S, Rossi A, Fruscio R, Leone FP, Bourne T, Valentin L, Van Calster B.

Clin Cancer Res. 2017 Sep 1;23(17):5082-5090. doi: 10.1158/1078-0432.CCR-16-3248. Epub 2017 May 16.


Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population.

Bourne T, Waltz M, Casper TC, Kavak K, Aaen G, Belman A, Benson L, Candee M, Chitnis T, Graves J, Greenberg B, Gorman M, Harris Y, Krupp L, Lotze T, Mar S, Ness J, Olsen C, Roalstad S, Rodriguez M, Rose J, Rubin J, Schreiner T, Tillema JM, Kahn I, Waldman A, Barcellos L, Waubant E, Weinstock-Guttman B; US Network of Pediatric MS Centers.

J Neurol Sci. 2017 Apr 15;375:371-375. doi: 10.1016/j.jns.2017.02.041. Epub 2017 Feb 20.


First International Consensus Report on Adnexal Masses: Management Recommendations.

Glanc P, Benacerraf B, Bourne T, Brown D, Coleman BG, Crum C, Dodge J, Levine D, Pavlik E, Timmerman D, Ueland FR, Wolfman W, Goldstein SR.

J Ultrasound Med. 2017 May;36(5):849-863. doi: 10.1002/jum.14197. Epub 2017 Mar 7.


Validation and updating of risk models based on multinomial logistic regression.

Van Calster B, Van Hoorde K, Vergouwe Y, Bobdiwala S, Condous G, Kirk E, Bourne T, Steyerberg EW.

Diagn Progn Res. 2017 Feb 8;1:2. doi: 10.1186/s41512-016-0002-x. eCollection 2017.


Flawed external validation study of the ADNEX model to diagnose ovarian cancer.

Van Calster B, Steyerberg EW, Bourne T, Timmerman D, Collins GS; TG6 of the STRATOS initiative.

Gynecol Oncol Rep. 2016 Sep 14;18:49-50. eCollection 2016 Nov. No abstract available.


Can risk factors, clinical history and symptoms be used to predict risk of ectopic pregnancy in women attending an early pregnancy assessment unit?

Ayim F, Tapp S, Guha S, Ameye L, Al-Memar M, Sayasneh A, Bottomley C, Gould D, Stalder C, Timmerman D, Bourne T.

Ultrasound Obstet Gynecol. 2016 Nov;48(5):656-662. doi: 10.1002/uog.16007.


Post-traumatic stress, anxiety and depression following miscarriage or ectopic pregnancy: a prospective cohort study.

Farren J, Jalmbrant M, Ameye L, Joash K, Mitchell-Jones N, Tapp S, Timmerman D, Bourne T.

BMJ Open. 2016 Nov 2;6(11):e011864. doi: 10.1136/bmjopen-2016-011864.


Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer.

Sundar S, Rick C, Dowling F, Au P, Snell K, Rai N, Champaneria R, Stobart H, Neal R, Davenport C, Mallett S, Sutton A, Kehoe S, Timmerman D, Bourne T, Van Calster B, Gentry-Maharaj A, Menon U, Deeks J; ROCkeTS study group.

BMJ Open. 2016 Aug 9;6(8):e010333. doi: 10.1136/bmjopen-2015-010333.


Evaluating the risk of ovarian cancer before surgery using the ADNEX model: a multicentre external validation study.

Sayasneh A, Ferrara L, De Cock B, Saso S, Al-Memar M, Johnson S, Kaijser J, Carvalho J, Husicka R, Smith A, Stalder C, Blanco MC, Ettore G, Van Calster B, Timmerman D, Bourne T.

Br J Cancer. 2016 Aug 23;115(5):542-8. doi: 10.1038/bjc.2016.227. Epub 2016 Aug 2.


Physiological and acoustic characteristics of the male music theatre voice.

Bourne T, Garnier M, Samson A.

J Acoust Soc Am. 2016 Jul;140(1):610. doi: 10.1121/1.4954751.


Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis.

Mitchell-Jones N, Gallos I, Farren J, Tobias A, Bottomley C, Bourne T.

BJOG. 2017 Jan;124(1):20-30. doi: 10.1111/1471-0528.14180. Epub 2016 Jul 14. Review.


Doctors' experiences and their perception of the most stressful aspects of complaints processes in the UK: an analysis of qualitative survey data.

Bourne T, Vanderhaegen J, Vranken R, Wynants L, De Cock B, Peters M, Timmerman D, Van Calster B, Jalmbrant M, Van Audenhove C.

BMJ Open. 2016 Jul 4;6(7):e011711. doi: 10.1136/bmjopen-2016-011711.


Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group.

Guerriero S, Condous G, van den Bosch T, Valentin L, Leone FP, Van Schoubroeck D, Exacoustos C, Installé AJ, Martins WP, Abrao MS, Hudelist G, Bazot M, Alcazar JL, Gonçalves MO, Pascual MA, Ajossa S, Savelli L, Dunham R, Reid S, Menakaya U, Bourne T, Ferrero S, Leon M, Bignardi T, Holland T, Jurkovic D, Benacerraf B, Osuga Y, Somigliana E, Timmerman D.

Ultrasound Obstet Gynecol. 2016 Sep;48(3):318-32. doi: 10.1002/uog.15955. Epub 2016 Jun 28.


Age-related differences in the sonographic characteristics of endometriomas.

Guerriero S, Van Calster B, Somigliana E, Ajossa S, Froyman W, De Cock B, Coosemans A, Fischerová D, Van Holsbeke C, Alcazar JL, Testa AC, Valentin L, Bourne T, Timmerman D.

Hum Reprod. 2016 Aug;31(8):1723-31. doi: 10.1093/humrep/dew113. Epub 2016 Jun 9.


The clinical performance of the M4 decision support model to triage women with a pregnancy of unknown location as at low or high risk of complications.

Bobdiwala S, Guha S, Van Calster B, Ayim F, Mitchell-Jones N, Al-Memar M, Mitchell H, Stalder C, Bottomley C, Kothari A, Timmerman D, Bourne T.

Hum Reprod. 2016 Jul;31(7):1425-35. doi: 10.1093/humrep/dew105. Epub 2016 May 10.

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