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Items: 1 to 50 of 236

1.

Opinion: Expansion fever and soft money plague the biomedical research enterprise.

Bourne HR.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8647-8651. doi: 10.1073/pnas.1813115115. No abstract available.

2.

Lost Dollars Threaten Research in Public Academic Health Centers.

Bourne HR, Vermillion EB.

FASEB J. 2017 Mar;31(3):855-863. doi: 10.1096/fj.201601352.

PMID:
28246298
3.

Alfred Gilman: Intrepid, committed scientist.

Bourne HR.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3414-6. doi: 10.1073/pnas.1602386113. Epub 2016 Mar 21. No abstract available.

4.

Is 6 years too long to get a Ph.D. in Biomedical Science?

Bourne HR.

FASEB J. 2015 Feb;29(2):357-60. doi: 10.1096/fj.15-0201ufm. No abstract available.

PMID:
25649813
5.

A fair deal for PhD students and postdocs.

Bourne HR.

Elife. 2013 Oct 1;2:e01139. doi: 10.7554/eLife.01139.

6.

A recipe for mediocrity and disaster, in five axioms.

Bourne HR.

Elife. 2013 Jul 16;2:e01138. doi: 10.7554/eLife.01138.

7.

The writing on the wall.

Bourne HR.

Elife. 2013 Mar 26;2:e00642. doi: 10.7554/eLife.00642.

8.

Iceberg alert for NIH.

Bourne HR, Lively MO.

Science. 2012 Jul 27;337(6093):390. doi: 10.1126/science.1226460. Epub 2012 Jul 5. No abstract available. Erratum in: Science. 2012 Aug 10;337(6095):646. Science. 2012 Sep 14;337(6100):1294.

9.

Ambition, surprise and delight: necessary lessons.

Bourne HR.

Nat Cell Biol. 2009 Sep;11(9):1046. doi: 10.1038/ncb0909-1046. No abstract available.

PMID:
19724256
10.

PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells.

Wong K, Van Keymeulen A, Bourne HR.

J Cell Biol. 2007 Dec 17;179(6):1141-8.

11.

G-proteins and GPCrs: from the beginning.

Bourne HR.

Ernst Schering Found Symp Proc. 2006;(2):1-21. Review.

PMID:
17703575
12.

Bound attractant at the leading vs. the trailing edge determines chemotactic prowess.

Herzmark P, Campbell K, Wang F, Wong K, El-Samad H, Groisman A, Bourne HR.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13349-54. Epub 2007 Aug 7.

13.

Polarity reveals intrinsic cell chirality.

Xu J, Van Keymeulen A, Wakida NM, Carlton P, Berns MW, Bourne HR.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9296-300. Epub 2007 May 17.

14.

Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification.

Onsum MD, Wong K, Herzmark P, Bourne HR, Arkin AP.

Phys Biol. 2006 Sep 25;3(3):190-9.

PMID:
17021383
15.

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM.

Nature. 2006 Jul 27;442(7101):457-60.

PMID:
16871217
16.

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.

Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR.

J Cell Biol. 2006 Jul 31;174(3):437-45. Epub 2006 Jul 24.

17.

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.

PLoS Biol. 2006 Feb;4(2):e38. Epub 2006 Jan 24.

18.

Rac and cell migration: CDM proteins integrate signals.

Bourne HR.

Nat Cell Biol. 2005 Aug;7(8):777-8. No abstract available.

PMID:
16056271
19.

Neutrophil microtubules suppress polarity and enhance directional migration.

Xu J, Wang F, Van Keymeulen A, Rentel M, Bourne HR.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6884-9. Epub 2005 Apr 28.

20.

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.

Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR.

Cell. 2003 Jul 25;114(2):201-14.

21.

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis.

Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne HR.

J Cell Biol. 2003 Feb 3;160(3):375-85. Epub 2003 Jan 27.

22.

Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.

23.
24.

A chemical compass.

Bourne HR, Weiner O.

Nature. 2002 Sep 5;419(6902):21. No abstract available.

PMID:
12214215
25.

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.

Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR.

Nat Cell Biol. 2002 Jul;4(7):509-13.

26.

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils.

Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR.

Nat Cell Biol. 2002 Jul;4(7):513-8.

PMID:
12080345
27.

Receptor activation: what does the rhodopsin structure tell us?

Meng EC, Bourne HR.

Trends Pharmacol Sci. 2001 Nov;22(11):587-93. Review.

PMID:
11698103
28.

Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?

Rondard P, Iiri T, Srinivasan S, Meng E, Fujita T, Bourne HR.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6150-5. Epub 2001 May 8.

29.

An activation switch in the ligand binding pocket of the C5a receptor.

Gerber BO, Meng EC, Dotsch V, Baranski TJ, Bourne HR.

J Biol Chem. 2001 Feb 2;276(5):3394-400. Epub 2000 Nov 2.

30.

Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products.

Rickert P, Weiner OD, Wang F, Bourne HR, Servant G.

Trends Cell Biol. 2000 Nov;10(11):466-73. Review.

31.

Structure. Rhodopsin sees the light.

Bourne HR, Meng EC.

Science. 2000 Aug 4;289(5480):733-4.

PMID:
10950717
32.

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR.

Science. 2000 Feb 11;287(5455):1037-40.

33.

Localization of a peripheral membrane protein: Gbetagamma targets Galpha(Z).

Fishburn CS, Pollitt SK, Bourne HR.

Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1085-90.

34.

A necessary hero.

Bourne HR.

Curr Biol. 1999 Dec 2;9(23):R870-1. No abstract available.

35.

Spatial control of actin polymerization during neutrophil chemotaxis.

Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR.

Nat Cell Biol. 1999 Jun;1(2):75-81.

36.

Gbetagamma and palmitate target newly synthesized Galphaz to the plasma membrane.

Fishburn CS, Herzmark P, Morales J, Bourne HR.

J Biol Chem. 1999 Jun 25;274(26):18793-800.

37.

Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.

Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson RA, Bourne HR.

J Biol Chem. 1999 Jun 11;274(24):17033-41.

38.

C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.

Baranski TJ, Herzmark P, Lichtarge O, Gerber BO, Trueheart J, Meng EC, Iiri T, Sheikh SP, Bourne HR.

J Biol Chem. 1999 May 28;274(22):15757-65.

39.

Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis.

Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR.

Mol Biol Cell. 1999 Apr;10(4):1163-78.

40.

The expanding spectrum of G protein diseases.

Farfel Z, Bourne HR, Iiri T.

N Engl J Med. 1999 Apr 1;340(13):1012-20. Review. No abstract available.

PMID:
10099144
41.

Galphai is not required for chemotaxis mediated by Gi-coupled receptors.

Neptune ER, Iiri T, Bourne HR.

J Biol Chem. 1999 Jan 29;274(5):2824-8. Erratum in: J Biol Chem 1999 Mar 12;274(11):7598.

42.

A Gsalpha mutant designed to inhibit receptor signaling through Gs.

Iiri T, Bell SM, Baranski TJ, Fujita T, Bourne HR.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):499-504.

43.

Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling.

Apanovitch DM, Iiri T, Karasawa T, Bourne HR, Dohlman HG.

J Biol Chem. 1998 Oct 30;273(44):28597-602.

44.

G-protein diseases furnish a model for the turn-on switch.

Iiri T, Farfel Z, Bourne HR.

Nature. 1998 Jul 2;394(6688):35-8.

PMID:
9665125
45.

Plasma membrane localization of G alpha z requires two signals.

Morales J, Fishburn CS, Wilson PT, Bourne HR.

Mol Biol Cell. 1998 Jan;9(1):1-14.

46.

Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs.

Neptune ER, Bourne HR.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14489-94.

47.

G proteins propel surprise.

Iiri T, Bourne HR.

Nat Genet. 1998 Jan;18(1):8-10. No abstract available.

PMID:
9425887
48.

Pieces of the true grail: a G protein finds its target.

Bourne HR.

Science. 1997 Dec 12;278(5345):1898-9. No abstract available.

PMID:
9417637
49.

G proteins. The arginine finger strikes again.

Bourne HR.

Nature. 1997 Oct 16;389(6652):673-4. No abstract available.

PMID:
9338774
50.

Conditional activation defect of a human Gsalpha mutant.

Iiri T, Farfel Z, Bourne HR.

Proc Natl Acad Sci U S A. 1997 May 27;94(11):5656-61.

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