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Items: 27


Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants.

Bourke CD, Evans C.

Clin Infect Dis. 2019 Dec 13. pii: ciz1193. doi: 10.1093/cid/ciz1193. [Epub ahead of print] No abstract available.


Determinants of urogenital schistosomiasis among pregnant women and its association with pregnancy outcomes, neonatal deaths and child growth.

Murenjekwa W, Makasi R, Ntozini R, Chasekwa B, Mutasa K, Moulton LH, Tielsch JM, Humphrey JH, Smith LE, Prendergast AJ, Bourke CD; SHINE Trial Team.

J Infect Dis. 2019 Dec 13. pii: jiz664. doi: 10.1093/infdis/jiz664. [Epub ahead of print]


The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa.

Bourke CD, Prendergast AJ.

J Infect Dis. 2019 Oct 23. pii: jiz495. doi: 10.1093/infdis/jiz495. [Epub ahead of print] No abstract available.


Current Understanding of Innate Immune Cell Dysfunction in Childhood Undernutrition.

Bourke CD, Jones KDJ, Prendergast AJ.

Front Immunol. 2019 Jul 29;10:1728. doi: 10.3389/fimmu.2019.01728. eCollection 2019. Review.


Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses.

Sturgeon JP, Bourke CD, Prendergast AJ.

Pediatr Infect Dis J. 2019 Jul;38(7):741-748. doi: 10.1097/INF.0000000000002311.


Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation.

Bourke CD, Gough EK, Pimundu G, Shonhai A, Berejena C, Terry L, Baumard L, Choudhry N, Karmali Y, Bwakura-Dangarembizi M, Musiime V, Lutaakome J, Kekitiinwa A, Mutasa K, Szubert AJ, Spyer MJ, Deayton JR, Glass M, Geum HM, Pardieu C, Gibb DM, Klein N, Edens TJ, Walker AS, Manges AR, Prendergast AJ.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav0537. doi: 10.1126/scitranslmed.aav0537.


Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study.

Bwakura-Dangarembizi M, Amadi B, Bourke CD, Robertson RC, Mwapenya B, Chandwe K, Kapoma C, Chifunda K, Majo F, Ngosa D, Chakara P, Chulu N, Masimba F, Mapurisa I, Besa E, Mutasa K, Mwakamui S, Runodamoto T, Humphrey JH, Ntozini R, Wells JCK, Manges AR, Swann JR, Walker AS, Nathoo KJ, Kelly P, Prendergast AJ; HOPE-SAM study team.

BMJ Open. 2019 Feb 1;9(1):e023077. doi: 10.1136/bmjopen-2018-023077.


Schistosomiasis in the first 1000 days.

Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ.

Lancet Infect Dis. 2018 Jun;18(6):e193-e203. doi: 10.1016/S1473-3099(17)30490-5. Epub 2017 Nov 20. Review. Erratum in: Lancet Infect Dis. 2018 Feb 1;:.


Immune Dysfunction as a Cause and Consequence of Malnutrition.

Bourke CD, Berkley JA, Prendergast AJ.

Trends Immunol. 2016 Jun;37(6):386-398. doi: 10.1016/ Epub 2016 May 26. Review.


Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.

Sanin DE, Prendergast CT, Bourke CD, Mountford AP.

PLoS Pathog. 2015 May 14;11(5):e1004841. doi: 10.1371/journal.ppat.1004841. eCollection 2015 May.


A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model.

Fukushige M, Mitchell KM, Bourke CD, Woolhouse ME, Mutapi F.

Front Immunol. 2015 Feb 27;6:85. doi: 10.3389/fimmu.2015.00085. eCollection 2015.


Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE, Mutapi F.

Front Immunol. 2015 Feb 18;6:51. doi: 10.3389/fimmu.2015.00051. eCollection 2015.


Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.

Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ, Mountford AP.

Int J Parasitol. 2015 Mar;45(4):215-24. doi: 10.1016/j.ijpara.2014.11.002. Epub 2015 Jan 6.


CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1.

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 Aug 7;8(8):e3049. doi: 10.1371/journal.pntd.0003049. eCollection 2014 Aug.


Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 May 8;8(5):e2846. doi: 10.1371/journal.pntd.0002846. eCollection 2014 May.


Circulating CD14brightCD16+ 'intermediate' monocytes exhibit enhanced parasite pattern recognition in human helminth infection.

Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP.

PLoS Negl Trop Dis. 2014 Apr 24;8(4):e2817. doi: 10.1371/journal.pntd.0002817. eCollection 2014 Apr.


Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products.

Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP.

Parasite Immunol. 2013 May-Jun;35(5-6):147-56. doi: 10.1111/pim.12028.


Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children.

Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F.

PLoS Negl Trop Dis. 2012;6(11):e1898. doi: 10.1371/journal.pntd.0001898. Epub 2012 Nov 8.


Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response.

Bourke CD, Mutapi F, Nausch N, Photiou DM, Poulsen LK, Kristensen B, Arnved J, Rønborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M, Bager P.

Clin Exp Allergy. 2012 Nov;42(11):1582-95. doi: 10.1111/j.1365-2222.2012.04063.x.


Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F.

J Infect Dis. 2013 Jul;208(1):159-69. doi: 10.1093/infdis/jis524. Epub 2012 Oct 8.


Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection.

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IY, Appleby LJ, Bourke CD, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2012;6(9):e1824. doi: 10.1371/journal.pntd.0001824. Epub 2012 Sep 27.


Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T, Mutapi F.

Sci Rep. 2012;2:472. doi: 10.1038/srep00472. Epub 2012 Jun 26.


Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection.

Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F.

Int Arch Allergy Immunol. 2012;158(3):288-98. doi: 10.1159/000332949. Epub 2012 Mar 6.


The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production.

Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP.

Int J Parasitol. 2011 Nov;41(13-14):1335-45. doi: 10.1016/j.ijpara.2011.08.005. Epub 2011 Oct 14.


Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria.

Imai N, Rujeni N, Nausch N, Bourke CD, Appleby LJ, Cowan G, Gwisai R, Midzi N, Cavanagh D, Mduluza T, Taylor D, Mutapi F.

Parasitology. 2011 Oct;138(12):1519-33. doi: 10.1017/S0031182011001181. Epub 2011 Aug 4.


Schistosome infection intensity is inversely related to auto-reactive antibody levels.

Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse ME, Maizels RM, Mduluza T.

PLoS One. 2011 May 6;6(5):e19149. doi: 10.1371/journal.pone.0019149.


Acquired immune heterogeneity and its sources in human helminth infection.

Bourke CD, Maizels RM, Mutapi F.

Parasitology. 2011 Feb;138(2):139-59. doi: 10.1017/S0031182010001216. Epub 2010 Oct 15. Review.

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