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Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses.

Sturgeon JP, Bourke CD, Prendergast AJ.

Pediatr Infect Dis J. 2019 Jul;38(7):741-748. doi: 10.1097/INF.0000000000002311.


Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation.

Bourke CD, Gough EK, Pimundu G, Shonhai A, Berejena C, Terry L, Baumard L, Choudhry N, Karmali Y, Bwakura-Dangarembizi M, Musiime V, Lutaakome J, Kekitiinwa A, Mutasa K, Szubert AJ, Spyer MJ, Deayton JR, Glass M, Geum HM, Pardieu C, Gibb DM, Klein N, Edens TJ, Walker AS, Manges AR, Prendergast AJ.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav0537. doi: 10.1126/scitranslmed.aav0537.


We can't afford to turn a blind eye to myopia.

Bourke CM, Loughman J, Fltcroft DI, Loskutova E, O'Brien C.

QJM. 2019 Mar 26. pii: hcz076. doi: 10.1093/qjmed/hcz076. [Epub ahead of print]


Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study.

Bwakura-Dangarembizi M, Amadi B, Bourke CD, Robertson RC, Mwapenya B, Chandwe K, Kapoma C, Chifunda K, Majo F, Ngosa D, Chakara P, Chulu N, Masimba F, Mapurisa I, Besa E, Mutasa K, Mwakamui S, Runodamoto T, Humphrey JH, Ntozini R, Wells JCK, Manges AR, Swann JR, Walker AS, Nathoo KJ, Kelly P, Prendergast AJ; HOPE-SAM study team.

BMJ Open. 2019 Feb 1;9(1):e023077. doi: 10.1136/bmjopen-2018-023077.


Transforming institutional racism at an Australian hospital.

Bourke CJ, Marrie H, Marrie A.

Aust Health Rev. 2018 Nov 21. doi: 10.1071/AH18062. [Epub ahead of print]


Lowering hospital walls to achieve health equity.

Matheson A, Bourke C, Verhoeven A, Khan MI, Nkunda D, Dahar Z, Ellison-Loschmann L.

BMJ. 2018 Sep 20;362:k3597. doi: 10.1136/bmj.k3597. No abstract available.


Integrated approach to oral health in aged care facilities using oral health practitioners and teledentistry in rural Queensland.

Tynan A, Deeth L, McKenzie D, Bourke C, Stenhouse S, Pitt J, Linneman H.

Aust J Rural Health. 2018 Apr 16. doi: 10.1111/ajr.12410. [Epub ahead of print]


Astrocyte dysfunction following molybdenum-associated purine loading could initiate Parkinson's disease with dementia.

Bourke CA.

NPJ Parkinsons Dis. 2018 Mar 20;4:7. doi: 10.1038/s41531-018-0045-5. eCollection 2018. Review.


Schistosomiasis in the first 1000 days.

Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ.

Lancet Infect Dis. 2018 Jun;18(6):e193-e203. doi: 10.1016/S1473-3099(17)30490-5. Epub 2017 Nov 20. Review. Erratum in: Lancet Infect Dis. 2018 Feb 1;:.


Occupational therapists are well placed to develop, support and embed carer programmes.

Allchin B, Sanders B, Bourke C.

Aust Occup Ther J. 2016 Dec;63(6):438. doi: 10.1111/1440-1630.12341. No abstract available.


Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram.

Neigh GN, Nemeth CL, Kelly SD, Hardy EE, Bourke C, Stowe ZN, Owens MJ.

Physiol Behav. 2017 Apr 1;172:24-30. doi: 10.1016/j.physbeh.2016.07.009. Epub 2016 Jul 13.


Immune Dysfunction as a Cause and Consequence of Malnutrition.

Bourke CD, Berkley JA, Prendergast AJ.

Trends Immunol. 2016 Jun;37(6):386-398. doi: 10.1016/ Epub 2016 May 26. Review.


Molybdenum Deficiency Produces Motor Nervous Effects That Are Consistent with Amyotrophic Lateral Sclerosis.

Bourke CA.

Front Neurol. 2016 Mar 8;7:28. doi: 10.3389/fneur.2016.00028. eCollection 2016. Review. No abstract available.


No change in neuropsychological dysfunction or emotional processing during treatment of major depression with cognitive-behaviour therapy or schema therapy.

Porter RJ, Bourke C, Carter JD, Douglas KM, McIntosh VV, Jordan J, Joyce PR, Frampton CM.

Psychol Med. 2016 Jan;46(2):393-404. doi: 10.1017/S0033291715001907. Epub 2015 Oct 8.


Occupational therapy influence on a carer peer support model in a clinical mental health service.

Bourke C, Sanders B, Allchin B, Lentin P, Lang S.

Aust Occup Ther J. 2015 Oct;62(5):299-305. doi: 10.1111/1440-1630.12235. Epub 2015 Sep 22.


Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.

Stehouwer JS, Birnbaum MS, Voll RJ, Owens MJ, Plott SJ, Bourke CH, Wassef MA, Kilts CD, Goodman MM.

Bioorg Med Chem. 2015 Aug 1;23(15):4286-302. doi: 10.1016/j.bmc.2015.06.036. Epub 2015 Jun 19.


Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.

Ehrlich DE, Neigh GN, Bourke CH, Nemeth CL, Hazra R, Ryan SJ, Rowson S, Jairam N, Sholar CA, Rainnie DG, Stowe ZN, Owens MJ.

Neuropharmacology. 2015 Oct;97:251-8. doi: 10.1016/j.neuropharm.2015.05.012. Epub 2015 May 30.


Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.

Sanin DE, Prendergast CT, Bourke CD, Mountford AP.

PLoS Pathog. 2015 May 14;11(5):e1004841. doi: 10.1371/journal.ppat.1004841. eCollection 2015 May.


Iatrogenic Congenital Diaphragmatic Hernia following Prenatal Pleuroamniotic Shunting.

Thomas JT, Petersen S, Hurrion E, Gray PH, Bourke C, Kumar S, Gardener G.

Fetal Diagn Ther. 2016;40(4):310-312. Epub 2015 Apr 16.


A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model.

Fukushige M, Mitchell KM, Bourke CD, Woolhouse ME, Mutapi F.

Front Immunol. 2015 Feb 27;6:85. doi: 10.3389/fimmu.2015.00085. eCollection 2015.


Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE, Mutapi F.

Front Immunol. 2015 Feb 18;6:51. doi: 10.3389/fimmu.2015.00051. eCollection 2015.


Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.

Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ, Mountford AP.

Int J Parasitol. 2015 Mar;45(4):215-24. doi: 10.1016/j.ijpara.2014.11.002. Epub 2015 Jan 6.


Striatal dopamine receptor plasticity in neurotensin deficient mice.

Chastain LG, Qu H, Bourke CH, Iuvone PM, Dobner PR, Nemeroff CB, Kinkead B.

Behav Brain Res. 2015 Mar 1;280:160-71. doi: 10.1016/j.bbr.2014.11.014. Epub 2014 Nov 15.


CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1.

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 Aug 7;8(8):e3049. doi: 10.1371/journal.pntd.0003049. eCollection 2014 Aug.


SSRI or CRF antagonism partially ameliorate depressive-like behavior after adolescent social defeat.

Bourke CH, Glasper ER, Neigh GN.

Behav Brain Res. 2014 Aug 15;270:295-9. doi: 10.1016/j.bbr.2014.05.035. Epub 2014 May 24.


Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 May 8;8(5):e2846. doi: 10.1371/journal.pntd.0002846. eCollection 2014 May.


Circulating CD14brightCD16+ 'intermediate' monocytes exhibit enhanced parasite pattern recognition in human helminth infection.

Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP.

PLoS Negl Trop Dis. 2014 Apr 24;8(4):e2817. doi: 10.1371/journal.pntd.0002817. eCollection 2014 Apr.


Prenatal antidepressant exposure: clinical and preclinical findings.

Bourke CH, Stowe ZN, Owens MJ.

Pharmacol Rev. 2014 Feb 24;66(2):435-65. doi: 10.1124/pr.111.005207. Print 2014. Review.


The effect of arm position on the ultrasonographic measurements of the acromion-greater tuberosity distance.

Kumar P, Bourke C, Flanders J, Gorman T, Patel H.

Physiother Theory Pract. 2014 Apr;30(3):171-7. doi: 10.3109/09593985.2013.834490. Epub 2013 Sep 16.


Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats.

Bourke CH, Stowe ZN, Neigh GN, Olson DE, Owens MJ.

Neurotoxicol Teratol. 2013 Sep-Oct;39:100-9. doi: 10.1016/ Epub 2013 Jul 30.


Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model.

Malviya SA, Kelly SD, Greenlee MM, Eaton DC, Duke BJ, Bourke CH, Neigh GN.

Physiol Behav. 2013 Oct 2;122:187-92. doi: 10.1016/j.physbeh.2013.03.018. Epub 2013 Mar 26.


Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.

Bourke CH, Capello CF, Rogers SM, Yu ML, Boss-Williams KA, Weiss JM, Stowe ZN, Owens MJ.

Psychopharmacology (Berl). 2013 Jul;228(2):231-41. doi: 10.1007/s00213-013-3030-z. Epub 2013 Feb 24. Erratum in: Psychopharmacology (Berl). 2014 Dec;231(23):4583.


Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products.

Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP.

Parasite Immunol. 2013 May-Jun;35(5-6):147-56. doi: 10.1111/pim.12028.


Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala.

Flandreau EI, Bourke CH, Ressler KJ, Vale WW, Nemeroff CB, Owens MJ.

Psychoneuroendocrinology. 2013 Aug;38(8):1349-61. doi: 10.1016/j.psyneuen.2012.11.020. Epub 2012 Dec 23.


Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children.

Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F.

PLoS Negl Trop Dis. 2012;6(11):e1898. doi: 10.1371/journal.pntd.0001898. Epub 2012 Nov 8.


Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response.

Bourke CD, Mutapi F, Nausch N, Photiou DM, Poulsen LK, Kristensen B, Arnved J, Rønborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M, Bager P.

Clin Exp Allergy. 2012 Nov;42(11):1582-95. doi: 10.1111/j.1365-2222.2012.04063.x.


Translational reciprocity: bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain.

Neigh GN, Ritschel LA, Kilpela LS, Harrell CS, Bourke CH.

Neuroscience. 2013 Sep 26;249:139-53. doi: 10.1016/j.neuroscience.2012.09.075. Epub 2012 Oct 13. Review.


Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F.

J Infect Dis. 2013 Jul;208(1):159-69. doi: 10.1093/infdis/jis524. Epub 2012 Oct 8.


Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection.

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IY, Appleby LJ, Bourke CD, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2012;6(9):e1824. doi: 10.1371/journal.pntd.0001824. Epub 2012 Sep 27.


Long-term review of sutureless ward reduction in neonates with gastroschisis in the neonatal unit.

Choi WW, McBride CA, Bourke C, Borzi P, Choo K, Walker R, Nguyen T, Davies M, Donovan T, Cartwright D, Kimble RM.

J Pediatr Surg. 2012 Aug;47(8):1516-20. doi: 10.1016/j.jpedsurg.2012.01.010. Review.


Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T, Mutapi F.

Sci Rep. 2012;2:472. doi: 10.1038/srep00472. Epub 2012 Jun 26.


Motor neurone disease in molybdenum-deficient sheep fed the endogenous purine xanthosine: possible mechanism for Tribulus staggers.

Bourke CA.

Aust Vet J. 2012 Jul;90(7):272-4. doi: 10.1111/j.1751-0813.2012.00947.x.


Comparison of neuropsychological functioning and emotional processing in major depression and social anxiety disorder subjects, and matched healthy controls.

Bourke C, Porter RJ, Carter JD, McIntosh VV, Jordan J, Bell C, Carter F, Colhoun H, Joyce PR.

Aust N Z J Psychiatry. 2012 Oct;46(10):972-81. doi: 10.1177/0004867412451502. Epub 2012 Jun 18.


Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.

Bourke CH, Raees MQ, Malviya S, Bradburn CA, Binder EB, Neigh GN.

Psychoneuroendocrinology. 2013 Jan;38(1):84-93. doi: 10.1016/j.psyneuen.2012.05.001. Epub 2012 May 29.


Stress-induced sex differences: adaptations mediated by the glucocorticoid receptor.

Bourke CH, Harrell CS, Neigh GN.

Horm Behav. 2012 Aug;62(3):210-8. doi: 10.1016/j.yhbeh.2012.02.024. Epub 2012 Mar 3. Review.


Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection.

Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F.

Int Arch Allergy Immunol. 2012;158(3):288-98. doi: 10.1159/000332949. Epub 2012 Mar 6.


Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats.

Bourke CH, Neigh GN.

Behav Brain Res. 2012 Feb 1;227(1):270-5. doi: 10.1016/j.bbr.2011.11.001. Epub 2011 Nov 9.


The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production.

Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP.

Int J Parasitol. 2011 Nov;41(13-14):1335-45. doi: 10.1016/j.ijpara.2011.08.005. Epub 2011 Oct 14.


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