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Elife. 2017 Dec 12;6. pii: e29353. doi: 10.7554/eLife.29353.

An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway.

Author information

1
DynaMo Center, Copenhagen Plant Science Center, Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark.
2
Department of Plant Sciences, University of California, Davis, Davis, United States.

Abstract

To optimize fitness a plant should monitor its metabolism to appropriately control growth and defense. Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the available energy and nutrients. Recent work suggests that plants may measure defense metabolites to potentially provide a strategy ensuring fast reallocation of resources to coordinate plant growth and defense. There is little understanding of mechanisms enabling defense metabolite signaling. To identify mechanisms of defense metabolite signaling, we used glucosinolates, an important class of plant defense metabolites. We report novel signaling properties specific to one distinct glucosinolate, 3-hydroxypropylglucosinolate across plants and fungi. This defense metabolite, or derived compounds, reversibly inhibits root growth and development. 3-hydroxypropylglucosinolate signaling functions via genes in the ancient TOR pathway. If this event is not unique, this raises the possibility that other evolutionarily new plant metabolites may link to ancient signaling pathways.

KEYWORDS:

A. thaliana; TOR; defense metabolism; evolutionary biology; genomics; metabolite regulation; plant biology; signalling

PMID:
29231169
PMCID:
PMC5730369
DOI:
10.7554/eLife.29353
[Indexed for MEDLINE]
Free PMC Article

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