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Items: 1 to 50 of 113

1.

Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.

Gourley C, Balmaña J, Ledermann JA, Serra V, Dent R, Loibl S, Pujade-Lauraine E, Boulton SJ.

J Clin Oncol. 2019 May 3:JCO1802050. doi: 10.1200/JCO.18.02050. [Epub ahead of print]

PMID:
31050911
2.

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.

Garcia-Muse T, Galindo-Diaz U, Garcia-Rubio M, Martin JS, Polanowska J, O'Reilly N, Aguilera A, Boulton SJ.

Cell Rep. 2019 Jan 15;26(3):775-787.e5. doi: 10.1016/j.celrep.2018.12.074.

3.

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis.

Poetsch AR, Boulton SJ, Luscombe NM.

Genome Biol. 2018 Dec 7;19(1):215. doi: 10.1186/s13059-018-1582-2.

4.

DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.

Logan CV, Murray JE, Parry DA, Robertson A, Bellelli R, Tarnauskaitė Ž, Challis R, Cleal L, Borel V, Fluteau A, Santoyo-Lopez J; SGP Consortium, Aitman T, Barroso I, Basel D, Bicknell LS, Goel H, Hu H, Huff C, Hutchison M, Joyce C, Knox R, Lacroix AE, Langlois S, McCandless S, McCarrier J, Metcalfe KA, Morrissey R, Murphy N, Netchine I, O'Connell SM, Olney AH, Paria N, Rosenfeld JA, Sherlock M, Syverson E, White PC, Wise C, Yu Y, Zacharin M, Banerjee I, Reijns M, Bober MB, Semple RK, Boulton SJ, Rios JJ, Jackson AP.

Am J Hum Genet. 2018 Dec 6;103(6):1038-1044. doi: 10.1016/j.ajhg.2018.10.024. Epub 2018 Nov 29.

5.

POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.

Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G, Boulton SJ.

Mol Cell. 2018 Oct 4;72(1):112-126.e5. doi: 10.1016/j.molcel.2018.08.043. Epub 2018 Sep 11.

6.

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.

Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O'Connell SM, Stamp G, Flynn HR, Snijders AP, Lassailly F, Jackson A, Boulton SJ.

Mol Cell. 2018 May 17;70(4):707-721.e7. doi: 10.1016/j.molcel.2018.04.008. Epub 2018 May 10.

7.

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.

Kotsantis P, Petermann E, Boulton SJ.

Cancer Discov. 2018 May;8(5):537-555. doi: 10.1158/2159-8290.CD-17-1461. Epub 2018 Apr 13. Review.

8.

Beyond PARP-POLθ as an anticancer target.

Higgins GS, Boulton SJ.

Science. 2018 Mar 16;359(6381):1217-1218. doi: 10.1126/science.aar5149. No abstract available.

PMID:
29590065
9.

New Editor-in-Chief-welcome to Simon Boulton!

Nigg EA, Boulton SJ.

Chromosoma. 2018 Mar;127(1):1. doi: 10.1007/s00412-018-0661-1. Epub 2018 Jan 29. No abstract available.

PMID:
29376191
10.

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.

León-Ortiz AM, Panier S, Sarek G, Vannier JB, Patel H, Campbell PJ, Boulton SJ.

Mol Cell. 2018 Jan 18;69(2):292-305.e6. doi: 10.1016/j.molcel.2017.12.014.

11.

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.

Margalef P, Kotsantis P, Borel V, Bellelli R, Panier S, Boulton SJ.

Cell. 2018 Jan 25;172(3):439-453.e14. doi: 10.1016/j.cell.2017.11.047. Epub 2017 Dec 28.

12.

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S.

Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017.

13.

Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency.

Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Göhring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW.

Front Immunol. 2017 Oct 2;8:1250. doi: 10.3389/fimmu.2017.01250. eCollection 2017.

14.

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.

Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J.

Nature. 2017 Sep 20;549(7673):548-552. doi: 10.1038/nature24023.

15.

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.

Takaki T, Montagner M, Serres MP, Le Berre M, Russell M, Collinson L, Szuhai K, Howell M, Boulton SJ, Sahai E, Petronczki M.

Nat Commun. 2017 Jul 24;8:16013. doi: 10.1038/ncomms16013.

16.

Mechanisms of DNA-protein crosslink repair.

Stingele J, Bellelli R, Boulton SJ.

Nat Rev Mol Cell Biol. 2017 Sep;18(9):563-573. doi: 10.1038/nrm.2017.56. Epub 2017 Jun 28. Review.

PMID:
28655905
17.

Erratum: Molecular basis of telomere dysfunction in human genetic diseases.

Sarek G, Marzec P, Margalef P, Boulton SJ.

Nat Struct Mol Biol. 2017 Jun 6;24(6):553. doi: 10.1038/nsmb0617-553a. No abstract available.

PMID:
28586326
18.

Clinical and Molecular Heterogeneity of RTEL1 Deficiency.

Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Göhring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW.

Front Immunol. 2017 May 1;8:449. doi: 10.3389/fimmu.2017.00449. eCollection 2017. Erratum in: Front Immunol. 2017 Oct 02;8:1250.

19.

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.

von Morgen P, Burdova K, Flower TG, O'Reilly NJ, Boulton SJ, Smerdon SJ, Macurek L, Hořejší Z.

Oncogene. 2017 Aug 24;36(34):4943-4950. doi: 10.1038/onc.2017.99. Epub 2017 Apr 24.

20.

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.

Hiraga SI, Ly T, Garzón J, Hořejší Z, Ohkubo YN, Endo A, Obuse C, Boulton SJ, Lamond AI, Donaldson AD.

EMBO Rep. 2017 Mar;18(3):403-419. doi: 10.15252/embr.201641983. Epub 2017 Jan 11.

21.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.

Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjær S, Tainer JA, Skehel JM, Groll M, Boulton SJ.

Mol Cell. 2016 Nov 17;64(4):688-703. doi: 10.1016/j.molcel.2016.09.031. Epub 2016 Oct 27.

22.

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling.

Taylor MRG, Špírek M, Jian Ma C, Carzaniga R, Takaki T, Collinson LM, Greene EC, Krejci L, Boulton SJ.

Mol Cell. 2016 Dec 1;64(5):926-939. doi: 10.1016/j.molcel.2016.10.020. Epub 2016 Nov 17.

23.

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility.

Frizzell A, Nguyen JH, Petalcorin MI, Turner KD, Boulton SJ, Freudenreich CH, Lahue RS.

Cell Rep. 2016 Aug 16;16(7):2047. doi: 10.1016/j.celrep.2016.07.072. No abstract available.

24.

Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science.

Khandpur S, Porter RM, Boulton SJ, Anstey A.

Br J Dermatol. 2017 Apr;176(4):902-909. doi: 10.1111/bjd.14935. Epub 2017 Feb 28. Review.

PMID:
27510322
25.

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding.

Sarek G, Vannier JB, Panier S, Petrini JHJ, Boulton SJ.

Mol Cell. 2016 Mar 3;61(5):788-789. doi: 10.1016/j.molcel.2016.02.016. Epub 2016 Mar 3. No abstract available.

26.

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.

Matsuzaki K, Borel V, Adelman CA, Schindler D, Boulton SJ.

Genes Dev. 2015 Dec 15;29(24):2532-46. doi: 10.1101/gad.272740.115. Epub 2015 Dec 4.

27.

Molecular basis of telomere dysfunction in human genetic diseases.

Sarek G, Marzec P, Margalef P, Boulton SJ.

Nat Struct Mol Biol. 2015 Nov;22(11):867-74. doi: 10.1038/nsmb.3093. Review. Erratum in: Nat Struct Mol Biol. 2017 Jun 6;24(6):553.

PMID:
26581521
28.

REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans.

Chung G, Rose AM, Petalcorin MI, Martin JS, Kessler Z, Sanchez-Pulido L, Ponting CP, Yanowitz JL, Boulton SJ.

Genes Dev. 2015 Sep 15;29(18):1969-79. doi: 10.1101/gad.266056.115.

29.

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.

Taylor MRG, Špírek M, Chaurasiya KR, Ward JD, Carzaniga R, Yu X, Egelman EH, Collinson LM, Rueda D, Krejci L, Boulton SJ.

Cell. 2015 Jul 16;162(2):271-286. doi: 10.1016/j.cell.2015.06.015.

30.

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs MR, Reynolds JJ, Winczura A, Blackford AN, Borel V, Miller ES, Zlatanou A, Nieminuszczy J, Ryan EL, Davies NJ, Stankovic T, Boulton SJ, Niedzwiedz W, Stewart GS.

Mol Cell. 2015 Aug 6;59(3):462-77. doi: 10.1016/j.molcel.2015.06.007. Epub 2015 Jul 9.

31.

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, Celie PHN, Schouten PC, van den Broek B, Salman A, Nieuwland M, de Rink I, de Ronde J, Jalink K, Boulton SJ, Chen J, van Gent DC, Bartek J, Jonkers J, Borst P, Rottenberg S.

Nature. 2015 May 28;521(7553):541-544. doi: 10.1038/nature14328. Epub 2015 Mar 23.

32.

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.

Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD.

Nature. 2015 Feb 12;518(7538):258-62. doi: 10.1038/nature14184. Epub 2015 Feb 2.

33.

TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.

Sarek G, Vannier JB, Panier S, Petrini JHJ, Boulton SJ.

Mol Cell. 2015 Feb 19;57(4):622-635. doi: 10.1016/j.molcel.2014.12.024. Epub 2015 Jan 22. Erratum in: Mol Cell. 2016 Mar 3;61(5):788-9. Mol Cell. 2016 Mar 3;61(5):788-789.

34.

The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling.

Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ, Collis SJ.

Cell Cycle. 2014;13(21):3450-9. doi: 10.4161/15384101.2014.956529.

35.

A role for human mitochondrial complex II in the production of reactive oxygen species in human skin.

Anderson A, Bowman A, Boulton SJ, Manning P, Birch-Machin MA.

Redox Biol. 2014;2:1016-22. doi: 10.1016/j.redox.2014.08.005. Epub 2014 Aug 28.

36.

Skin manifestations of mitochondrial dysfunction: more important than previously thought.

Boulton SJ, Bowman A, Koohgoli R, Birch-Machin MA.

Exp Dermatol. 2015 Jan;24(1):12-3. doi: 10.1111/exd.12597. No abstract available.

PMID:
25403780
37.

Impact of hyperpigmentation on superoxide flux and melanoma cell metabolism at mitochondrial complex II.

Boulton SJ, Birch-Machin MA.

FASEB J. 2015 Jan;29(1):346-53. doi: 10.1096/fj.14-261982. Epub 2014 Oct 28.

PMID:
25351989
38.

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.

Staples CJ, Myers KN, Beveridge RD, Patil AA, Howard AE, Barone G, Lee AJ, Swanton C, Howell M, Maslen S, Skehel JM, Boulton SJ, Collis SJ.

J Cell Sci. 2014 Jul 1;127(Pt 13):2910-9. doi: 10.1242/jcs.147785. Epub 2014 May 9.

39.

Metabolism of DNA secondary structures at the eukaryotic replication fork.

León-Ortiz AM, Svendsen J, Boulton SJ.

DNA Repair (Amst). 2014 Jul;19:152-62. doi: 10.1016/j.dnarep.2014.03.016. Epub 2014 May 9.

PMID:
24815912
40.

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

Hořejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ.

Cell Rep. 2014 Apr 10;7(1):19-26. doi: 10.1016/j.celrep.2014.03.013. Epub 2014 Mar 20.

41.

RTEL1: functions of a disease-associated helicase.

Vannier JB, Sarek G, Boulton SJ.

Trends Cell Biol. 2014 Jul;24(7):416-25. doi: 10.1016/j.tcb.2014.01.004. Epub 2014 Feb 25. Review.

PMID:
24582487
42.

RTEL1 inhibits trinucleotide repeat expansions and fragility.

Frizzell A, Nguyen JH, Petalcorin MI, Turner KD, Boulton SJ, Freudenreich CH, Lahue RS.

Cell Rep. 2014 Mar 13;6(5):827-35. doi: 10.1016/j.celrep.2014.01.034. Epub 2014 Feb 20.

43.

Double-strand break repair: 53BP1 comes into focus.

Panier S, Boulton SJ.

Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11. Review.

PMID:
24326623
44.

RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.

Vannier JB, Sandhu S, Petalcorin MI, Wu X, Nabi Z, Ding H, Boulton SJ.

Science. 2013 Oct 11;342(6155):239-42. doi: 10.1126/science.1241779.

45.

A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.

Ballew BJ, Joseph V, De S, Sarek G, Vannier JB, Stracker T, Schrader KA, Small TN, O'Reilly R, Manschreck C, Harlan Fleischut MM, Zhang L, Sullivan J, Stratton K, Yeager M, Jacobs K, Giri N, Alter BP, Boland J, Burdett L, Offit K, Boulton SJ, Savage SA, Petrini JH.

PLoS Genet. 2013 Aug;9(8):e1003695. doi: 10.1371/journal.pgen.1003695. Epub 2013 Aug 29.

46.

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.

Adelman CA, Lolo RL, Birkbak NJ, Murina O, Matsuzaki K, Horejsi Z, Parmar K, Borel V, Skehel JM, Stamp G, D'Andrea A, Sartori AA, Swanton C, Boulton SJ.

Nature. 2013 Oct 17;502(7471):381-4. doi: 10.1038/nature12565. Epub 2013 Sep 4.

47.

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.

Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.

Mol Cell. 2013 Aug 22;51(4):423-39. doi: 10.1016/j.molcel.2013.08.006.

48.

Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.

Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan AR, Boulton SJ, Ganesan S.

J Biol Chem. 2013 Nov 8;288(45):32357-69. doi: 10.1074/jbc.M113.459164. Epub 2013 Aug 6.

49.

Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.

O'Neil NJ, Martin JS, Youds JL, Ward JD, Petalcorin MI, Rose AM, Boulton SJ.

PLoS Genet. 2013;9(7):e1003582. doi: 10.1371/journal.pgen.1003582. Epub 2013 Jul 18.

50.

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD, Boulton SJ.

Mol Cell. 2013 Mar 7;49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17.

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