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Items: 40


Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography.

Li J, Zormpas-Petridis K, Boult JKR, Reeves EL, Heindl A, Vinci M, Lopes F, Cummings C, Springer CJ, Chesler L, Jones C, Bamber JC, Yuan Y, Sinkus R, Jamin Y, Robinson SP.

Cancer Res. 2019 Nov 15;79(22):5874-5883. doi: 10.1158/0008-5472.CAN-19-1595. Epub 2019 Oct 11.


SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma.

Carreno G, Boult JKR, Apps JR, Gonzalez-Meljem JM, Haston S, Guiho R, Stache C, Danielson LS, Koers A, Smith LS, Virasami A, Panousopoulos L, Buchfelder M, Jacques TS, Chesler L, Robinson S, Martinez-Barbera JP.

Endocr Relat Cancer. 2019 Jan 1. pii: ERC-18-0538.R1. doi: 10.1530/ERC-18-0538. [Epub ahead of print]


Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Al-Saffar NMS, Troy H, Wong Te Fong AC, Paravati R, Jackson LE, Gowan S, Boult JKR, Robinson SP, Eccles SA, Yap TA, Leach MO, Chung YL.

Br J Cancer. 2018 Oct;119(9):1118-1128. doi: 10.1038/s41416-018-0242-3. Epub 2018 Oct 31.


Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma.

Baker LCJ, Sikka A, Price JM, Boult JKR, Lepicard EY, Box G, Jamin Y, Spinks TJ, Kramer-Marek G, Leach MO, Eccles SA, Box C, Robinson SP.

Front Oncol. 2018 Jul 23;8:271. doi: 10.3389/fonc.2018.00271. eCollection 2018.


Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology.

Little RA, Jamin Y, Boult JKR, Naish JH, Watson Y, Cheung S, Holliday KF, Lu H, McHugh DJ, Irlam J, West CML, Betts GN, Ashton G, Reynolds AR, Maddineni S, Clarke NW, Parker GJM, Waterton JC, Robinson SP, O'Connor JPB.

Radiology. 2018 Sep;288(3):739-747. doi: 10.1148/radiol.2018171531. Epub 2018 Jun 5.


Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo.

Papaevangelou E, Boult JKR, Whitley GS, Robinson SP, Howe FA.

Angiogenesis. 2018 Nov;21(4):737-749. doi: 10.1007/s10456-018-9617-6. Epub 2018 May 2.


Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

Khan AA, Paget JT, McLaughlin M, Kyula JN, Wilkinson MJ, Pencavel T, Mansfield D, Roulstone V, Seth R, Halle M, Somaiah N, Boult JKR, Robinson SP, Pandha HS, Vile RG, Melcher AA, Harris PA, Harrington KJ.

Sci Transl Med. 2018 Jan 24;10(425). pii: eaar2041. doi: 10.1126/scitranslmed.aar2041.


Near-infrared photoimmunotherapy targeting EGFR-Shedding new light on glioblastoma treatment.

Burley TA, Mączyńska J, Shah A, Szopa W, Harrington KJ, Boult JKR, Mrozek-Wilczkiewicz A, Vinci M, Bamber JC, Kaspera W, Kramer-Marek G.

Int J Cancer. 2018 Jun 1;142(11):2363-2374. doi: 10.1002/ijc.31246. Epub 2018 Jan 19.


Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.

Jerome NP, Boult JKR, Orton MR, d'Arcy JA, Nerurkar A, Leach MO, Koh DM, Collins DJ, Robinson SP.

Eur Radiol. 2018 Apr;28(4):1642-1653. doi: 10.1007/s00330-017-5083-6. Epub 2017 Oct 16.


Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform.

Almeida GS, Panek R, Hallsworth A, Webber H, Papaevangelou E, Boult JK, Jamin Y, Chesler L, Robinson SP.

Br J Cancer. 2017 Sep 5;117(6):791-800. doi: 10.1038/bjc.2017.251. Epub 2017 Aug 8.


Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI.

Boult JKR, Box G, Vinci M, Perryman L, Eccles SA, Jones C, Robinson SP.

Neoplasia. 2017 Sep;19(9):684-694. doi: 10.1016/j.neo.2017.05.007. Epub 2017 Aug 4.


Monitoring the Vascular Response and Resistance to Sunitinib in Renal Cell Carcinoma In Vivo with Susceptibility Contrast MRI.

Robinson SP, Boult JKR, Vasudev NS, Reynolds AR.

Cancer Res. 2017 Aug 1;77(15):4127-4134. doi: 10.1158/0008-5472.CAN-17-0248. Epub 2017 May 31.


Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma.

Boult JKR, Apps JR, Hölsken A, Hutchinson JC, Carreno G, Danielson LS, Smith LM, Bäuerle T, Buslei R, Buchfelder M, Virasami AK, Koers A, Arthurs OJ, Jacques TS, Chesler L, Martinez-Barbera JP, Robinson SP.

Brain Pathol. 2018 Jul;28(4):475-483. doi: 10.1111/bpa.12525. Epub 2017 May 17.


Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging.

Boult JK, Borri M, Jury A, Popov S, Box G, Perryman L, Eccles SA, Jones C, Robinson SP.

NMR Biomed. 2016 Nov;29(11):1608-1617. doi: 10.1002/nbm.3594. Epub 2016 Sep 27.


Investigating the Vascular Phenotype of Subcutaneously and Orthotopically Propagated PC3 Prostate Cancer Xenografts Using Combined Carbogen Ultrasmall Superparamagnetic Iron Oxide MRI.

Burrell JS, Walker-Samuel S, Boult JK, Baker LC, Jamin Y, Halliday J, Waterton JC, Robinson SP.

Top Magn Reson Imaging. 2016 Oct;25(5):237-243. Review.


Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling.

Baker LCJ, Boult JKR, Thomas M, Koehler A, Nayak T, Tessier J, Ooi CH, Birzele F, Belousov A, Zajac M, Horn C, LeFave C, Robinson SP.

Br J Cancer. 2016 Sep 6;115(6):691-702. doi: 10.1038/bjc.2016.236. Epub 2016 Aug 16.


Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models.

O'Connor JP, Boult JK, Jamin Y, Babur M, Finegan KG, Williams KJ, Little RA, Jackson A, Parker GJ, Reynolds AR, Waterton JC, Robinson SP.

Cancer Res. 2016 Feb 15;76(4):787-95. doi: 10.1158/0008-5472.CAN-15-2062. Epub 2015 Dec 9.


Detecting microvascular changes in the mouse spleen using optical computed tomography.

McErlean CM, Boult JK, Collins DJ, Leach MO, Robinson SP, Doran SJ.

Microvasc Res. 2015 Sep;101:96-102. doi: 10.1016/j.mvr.2015.06.008. Epub 2015 Jun 30.


Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography.

Jamin Y, Boult JKR, Li J, Popov S, Garteiser P, Ulloa JL, Cummings C, Box G, Eccles SA, Jones C, Waterton JC, Bamber JC, Sinkus R, Robinson SP.

Cancer Res. 2015 Apr 1;75(7):1216-1224. doi: 10.1158/0008-5472.CAN-14-1997. Epub 2015 Feb 11.


Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.

Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JK, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Ellison DW, Wharton SB, Robson K, Michalski A, Hargrave D, Jacques TS, Pizer B, Bailey S, Swartling FJ, Weiss WA, Chesler L, Clifford SC.

Cancer Cell. 2015 Jan 12;27(1):72-84. doi: 10.1016/j.ccell.2014.11.002. Epub 2014 Dec 18.


Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

Lin G, Hill DK, Andrejeva G, Boult JK, Troy H, Fong AC, Orton MR, Panek R, Parkes HG, Jafar M, Koh DM, Robinson SP, Judson IR, Griffiths JR, Leach MO, Eykyn TR, Chung YL.

Br J Cancer. 2014 Jul 15;111(2):375-85. doi: 10.1038/bjc.2014.281. Epub 2014 Jun 3.


Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography.

Li J, Jamin Y, Boult JK, Cummings C, Waterton JC, Ulloa J, Sinkus R, Bamber JC, Robinson SP.

Br J Cancer. 2014 Apr 2;110(7):1727-32. doi: 10.1038/bjc.2014.76. Epub 2014 Feb 25.


Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data.

Hill DK, Orton MR, Mariotti E, Boult JK, Panek R, Jafar M, Parkes HG, Jamin Y, Miniotis MF, Al-Saffar NM, Beloueche-Babari M, Robinson SP, Leach MO, Chung YL, Eykyn TR.

PLoS One. 2013 Sep 4;8(9):e71996. doi: 10.1371/journal.pone.0071996. eCollection 2013.


Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

Baker LC, Boult JK, Jamin Y, Gilmour LD, Walker-Samuel S, Burrell JS, Ashcroft M, Howe FA, Griffiths JR, Raleigh JA, van der Kogel AJ, Robinson SP.

Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):160-7. doi: 10.1016/j.ijrobp.2013.04.051. Epub 2013 Jul 9.


A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib) treatment.

Boult JK, Terkelsen J, Walker-Samuel S, Bradley DP, Robinson SP.

PLoS One. 2013 Apr 26;8(4):e63024. doi: 10.1371/journal.pone.0063024. Print 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/37d4affb-9a93-44f3-8546-ad9cc07c7805.


Exploring ΔR(2) * and ΔR(1) as imaging biomarkers of tumor oxygenation.

Burrell JS, Walker-Samuel S, Baker LC, Boult JK, Jamin Y, Halliday J, Waterton JC, Robinson SP.

J Magn Reson Imaging. 2013 Aug;38(2):429-34. doi: 10.1002/jmri.23987. Epub 2013 Jan 4.


Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma.

Jamin Y, Tucker ER, Poon E, Popov S, Vaughan L, Boult JK, Webber H, Hallsworth A, Baker LC, Jones C, Koh DM, Pearson AD, Chesler L, Robinson SP.

Radiology. 2013 Jan;266(1):130-40. doi: 10.1148/radiol.12120128. Epub 2012 Nov 20.


MRI measurements of vessel calibre in tumour xenografts: comparison with vascular corrosion casting.

Burrell JS, Bradley RS, Walker-Samuel S, Jamin Y, Baker LC, Boult JK, Withers PJ, Halliday J, Waterton JC, Robinson SP.

Microvasc Res. 2012 Nov;84(3):323-9. doi: 10.1016/j.mvr.2012.08.001. Epub 2012 Aug 18.


False-negative MRI biomarkers of tumour response to targeted cancer therapeutics.

Boult JK, Jamin Y, Jacobs V, Gilmour LD, Walker-Samuel S, Halliday J, Elvin P, Ryan AJ, Waterton JC, Robinson SP.

Br J Cancer. 2012 Jun 5;106(12):1960-6. doi: 10.1038/bjc.2012.208. Epub 2012 May 17.


The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.

Baker LC, Boult JK, Walker-Samuel S, Chung YL, Jamin Y, Ashcroft M, Robinson SP.

Br J Cancer. 2012 May 8;106(10):1638-47. doi: 10.1038/bjc.2012.131. Epub 2012 Apr 12.


Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.

Burrell JS, Walker-Samuel S, Baker LC, Boult JK, Jamin Y, Ryan AJ, Waterton JC, Halliday J, Robinson SP.

Int J Cancer. 2012 Oct 15;131(8):1854-62. doi: 10.1002/ijc.27460. Epub 2012 Mar 22.


Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.

Boult JK, Walker-Samuel S, Jamin Y, Leiper JM, Whitley GS, Robinson SP.

J Pathol. 2011 Nov;225(3):344-52. doi: 10.1002/path.2904. Epub 2011 May 18.


Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts.

Walker-Samuel S, Boult JK, McPhail LD, Box G, Eccles SA, Robinson SP.

Int J Cancer. 2012 Mar 15;130(6):1284-93. doi: 10.1002/ijc.26112. Epub 2011 Aug 1.


Investigating temporal fluctuations in tumor vasculature with combined carbogen and ultrasmall superparamagnetic iron oxide particle (CUSPIO) imaging.

Burrell JS, Walker-Samuel S, Baker LC, Boult JK, Ryan AJ, Waterton JC, Halliday J, Robinson SP.

Magn Reson Med. 2011 Jul;66(1):227-34. doi: 10.1002/mrm.22779. Epub 2011 Feb 8.


Threshold for epileptiform activity is elevated in prion knockout mice.

Ratté S, Vreugdenhil M, Boult JK, Patel A, Asante EA, Collinge J, Jefferys JG.

Neuroscience. 2011 Apr 14;179:56-61. doi: 10.1016/j.neuroscience.2011.01.053. Epub 2011 Jan 28.


Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing.

Walker-Samuel S, Orton M, Boult JK, Robinson SP.

Magn Reson Med. 2011 Feb;65(2):438-47. doi: 10.1002/mrm.22572. Epub 2010 Nov 16.


The role of tumour-derived iNOS in tumour progression and angiogenesis.

Kostourou V, Cartwright JE, Johnstone AP, Boult JK, Cullis ER, Whitley G, Robinson SP.

Br J Cancer. 2011 Jan 4;104(1):83-90. doi: 10.1038/sj.bjc.6606034. Epub 2010 Dec 7.


Bayesian estimation of changes in transverse relaxation rates.

Walker-Samuel S, Orton M, McPhail LD, Boult JK, Box G, Eccles SA, Robinson SP.

Magn Reson Med. 2010 Sep;64(3):914-21. doi: 10.1002/mrm.22478.


Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network.

Boult JK, Tanière P, Hallissey MT, Campbell MJ, Tselepis C.

Br J Cancer. 2008 Jun 17;98(12):1985-92. doi: 10.1038/sj.bjc.6604398. Epub 2008 May 20.

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