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Items: 1 to 50 of 68

1.

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease.

Toublet FX, Lecoutey C, Lalut J, Hatat B, Davis A, Since M, Corvaisier S, Freret T, Sopkova de Oliveira Santos J, Claeysen S, Boulouard M, Dallemagne P, Rochais C.

Molecules. 2019 Jul 31;24(15). pii: E2786. doi: 10.3390/molecules24152786.

2.
3.

Characterizing age-related decline of recognition memory and brain activation profile in mice.

Belblidia H, Leger M, Abdelmalek A, Quiedeville A, Calocer F, Boulouard M, Jozet-Alves C, Freret T, Schumann-Bard P.

Exp Gerontol. 2018 Jun;106:222-231. doi: 10.1016/j.exger.2018.03.006. Epub 2018 Mar 8.

PMID:
29524468
4.

LP-211, a selective 5-HT7 receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats.

Beaudet G, Paizanis E, Zoratto F, Lacivita E, Leopoldo M, Freret T, Laviola G, Boulouard M, Adriani W.

Synapse. 2017 Dec;71(12). doi: 10.1002/syn.21995. Epub 2017 Aug 17.

PMID:
28752923
5.

Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse.

Freret T, Lelong-Boulouard V, Lecouflet P, Hamidouche K, Dauphin F, Boulouard M.

Psychopharmacology (Berl). 2017 Aug;234(15):2365-2374. doi: 10.1007/s00213-017-4664-z. Epub 2017 Jun 19.

PMID:
28631100
6.

Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate.

Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, Booij J, Lucassen PJ, Reneman L.

PLoS One. 2017 Feb 27;12(2):e0172776. doi: 10.1371/journal.pone.0172776. eCollection 2017.

7.

Deletion of the serotonin receptor type 7 disrupts the acquisition of allocentric but not egocentric navigation strategies in mice.

Beaudet G, Jozet-Alves C, Asselot R, Schumann-Bard P, Freret T, Boulouard M, Paizanis E.

Behav Brain Res. 2017 Mar 1;320:179-185. doi: 10.1016/j.bbr.2016.12.006. Epub 2016 Dec 8.

PMID:
27939340
8.

Long-Lasting Effects of Chronic Intermittent Alcohol Exposure in Adolescent Mice on Object Recognition and Hippocampal Neuronal Activity.

Beaudet G, Valable S, Bourgine J, Lelong-Boulouard V, Lanfumey L, Freret T, Boulouard M, Paizanis E.

Alcohol Clin Exp Res. 2016 Dec;40(12):2591-2603. doi: 10.1111/acer.13256. Epub 2016 Nov 1.

PMID:
27801508
9.

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.

Yahiaoui S, Hamidouche K, Ballandonne C, Davis A, de Oliveira Santos JS, Freret T, Boulouard M, Rochais C, Dallemagne P.

Eur J Med Chem. 2016 Oct 4;121:283-293. doi: 10.1016/j.ejmech.2016.05.048. Epub 2016 May 26.

PMID:
27266998
10.

Effects of acute administration of melatonin on attentional, executive, and working memory processes in rats.

Liet C, Amenouche F, Freret T, Boulouard M, Mauvieux B, Lelong-Boulouard V, Bocca ML.

Fundam Clin Pharmacol. 2015 Oct;29(5):472-7. doi: 10.1111/fcp.12134. Epub 2015 Aug 11.

PMID:
26194194
11.

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances.

Quiedeville A, Boulouard M, Hamidouche K, Da Silva Costa-Aze V, Nee G, Rochais C, Dallemagne P, Fabis F, Freret T, Bouet V.

Behav Brain Res. 2015 Oct 15;293:10-7. doi: 10.1016/j.bbr.2015.07.020. Epub 2015 Jul 14.

PMID:
26187692
12.

Therapeutic Potential of 5-HT6 Receptor Agonists.

Karila D, Freret T, Bouet V, Boulouard M, Dallemagne P, Rochais C.

J Med Chem. 2015 Oct 22;58(20):7901-12. doi: 10.1021/acs.jmedchem.5b00179. Epub 2015 Jul 2. Review.

PMID:
26099069
13.

Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis.

van der Marel K, Bouet V, Meerhoff GF, Freret T, Boulouard M, Dauphin F, Klomp A, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L.

Neuroscience. 2015 Nov 19;309:243-58. doi: 10.1016/j.neuroscience.2015.04.044. Epub 2015 Apr 28.

PMID:
25934041
14.

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P.

J Med Chem. 2015 Apr 9;58(7):3172-87. doi: 10.1021/acs.jmedchem.5b00115. Epub 2015 Mar 31.

PMID:
25793650
15.

Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors.

Beaudet G, Bouet V, Jozet-Alves C, Schumann-Bard P, Dauphin F, Paizanis E, Boulouard M, Freret T.

Front Behav Neurosci. 2015 Jan 14;8:448. doi: 10.3389/fnbeh.2014.00448. eCollection 2014. Review.

16.

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.

Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A, Mignani S, Cresteil T, Boulouard M, Claeysen S, Rochais C, Dallemagne P.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30. doi: 10.1073/pnas.1410315111. Epub 2014 Aug 25.

17.

Environmental Enrichment Duration Differentially Affects Behavior and Neuroplasticity in Adult Mice.

Leger M, Paizanis E, Dzahini K, Quiedeville A, Bouet V, Cassel JC, Freret T, Schumann-Bard P, Boulouard M.

Cereb Cortex. 2015 Nov;25(11):4048-61. doi: 10.1093/cercor/bhu119. Epub 2014 Jun 5.

PMID:
24904072
18.

Dual histamine H3R/serotonin 5-HT4R ligands with antiamnesic properties: pharmacophore-based virtual screening and polypharmacology.

Lepailleur A, Freret T, Lemaître S, Boulouard M, Dauphin F, Hinschberger A, Dulin F, Lesnard A, Bureau R, Rault S.

J Chem Inf Model. 2014 Jun 23;54(6):1773-84. doi: 10.1021/ci500157n. Epub 2014 Jun 10.

PMID:
24857631
19.

5-HT6 receptor antagonists as treatment for age-related cognitive decline.

Quiedeville A, Boulouard M, Da Silva Costa-Aze V, Dauphin F, Bouet V, Freret T.

Rev Neurosci. 2014;25(3):417-27. doi: 10.1515/revneuro-2014-0013.

PMID:
24622786
20.

Object recognition test in mice.

Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, Freret T.

Nat Protoc. 2013 Dec;8(12):2531-7. doi: 10.1038/nprot.2013.155. Epub 2013 Nov 21.

PMID:
24263092
21.

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: synthesis and antinociceptive evaluation.

Since M, Freret T, Nee G, Terme T, Vanelle P, Boulouard M.

Eur J Med Chem. 2013 Nov;69:728-34. doi: 10.1016/j.ejmech.2013.08.041. Epub 2013 Sep 13.

PMID:
24095764
22.

Modulation of 5-HT7 receptor: effect on object recognition performances in mice.

Freret T, Paizanis E, Beaudet G, Gusmao-Montaigne A, Nee G, Dauphin F, Bouet V, Boulouard M.

Psychopharmacology (Berl). 2014 Jan;231(2):393-400. doi: 10.1007/s00213-013-3247-x. Epub 2013 Aug 31.

PMID:
23995300
23.

Effects of perinatal exposure to waterborne fluoxetine on memory processing in the cuttlefish Sepia officinalis.

Di Poi C, Darmaillacq AS, Dickel L, Boulouard M, Bellanger C.

Aquat Toxicol. 2013 May 15;132-133:84-91. doi: 10.1016/j.aquatox.2013.02.004. Epub 2013 Feb 16.

PMID:
23474317
24.

Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging.

Paban V, Billard JM, Bouet V, Freret T, Boulouard M, Chambon C, Loriod B, Alescio-Lautier B.

Brain Struct Funct. 2013 Nov;218(6):1501-12. doi: 10.1007/s00429-012-0472-8. Epub 2012 Nov 10.

PMID:
23143343
25.

Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice.

Leger M, Quiedeville A, Paizanis E, Natkunarajah S, Freret T, Boulouard M, Schumann-Bard P.

PLoS One. 2012;7(10):e48043. doi: 10.1371/journal.pone.0048043. Epub 2012 Oct 22.

26.

New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.

Lohou E, Sopkova-de Oliveira Santos J, Schumann-Bard P, Boulouard M, Stiebing S, Rault S, Collot V.

Bioorg Med Chem. 2012 Sep 1;20(17):5296-304. doi: 10.1016/j.bmc.2012.06.025. Epub 2012 Jul 3.

PMID:
22831803
27.

Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.

Danglot L, Freret T, Le Roux N, Narboux Nême N, Burgo A, Hyenne V, Roumier A, Contremoulins V, Dauphin F, Bizot JC, Vodjdani G, Gaspar P, Boulouard M, Poncer JC, Galli T, Simmler MC.

J Neurosci. 2012 Jun 27;32(26):9007-22. doi: 10.1523/JNEUROSCI.3084-11.2012.

28.

5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice.

Da Silva Costa-Aze V, Quiedeville A, Boulouard M, Dauphin F.

Psychopharmacology (Berl). 2012 Jul;222(1):99-115. doi: 10.1007/s00213-011-2627-3. Epub 2012 Feb 25.

PMID:
22367167
29.

A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat.

Hotte M, Dauphin F, Freret T, Boulouard M, Levallet G.

PLoS One. 2012;7(2):e32244. doi: 10.1371/journal.pone.0032244. Epub 2012 Feb 16.

30.

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Freret T, Bouet V, Quiedeville A, Nee G, Dallemagne P, Rochais C, Boulouard M.

Behav Brain Res. 2012 Apr 21;230(1):304-8. doi: 10.1016/j.bbr.2012.02.012. Epub 2012 Feb 14.

PMID:
22348892
31.

Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression.

Leconte C, Léger M, Boulouard M, Tixier E, Fréret T, Bernaudin M, Schumann-Bard P.

Behav Brain Res. 2012 Apr 21;230(1):78-84. doi: 10.1016/j.bbr.2012.01.054. Epub 2012 Feb 7.

PMID:
22326698
32.

Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment.

Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J, Gsell W, Reneman L.

Psychopharmacology (Berl). 2012 May;221(2):329-39. doi: 10.1007/s00213-011-2580-1. Epub 2011 Dec 24.

PMID:
22205158
33.

Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice.

Leger M, Bouet V, Freret T, Darmaillacq AS, Dacher M, Dauphin F, Boulouard M, Schumann-Bard P.

Behav Brain Res. 2012 Mar 1;228(1):22-9. doi: 10.1016/j.bbr.2011.11.022. Epub 2011 Nov 28.

PMID:
22138509
34.

Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigations.

Letourneur A, Freret T, Roussel S, Boulouard M, Divoux D, Toutain J, Bernaudin M, Schumann-Bard P, Bouet V, Touzani O.

Exp Neurol. 2012 Jan;233(1):264-72. doi: 10.1016/j.expneurol.2011.10.014. Epub 2011 Oct 25.

PMID:
22051176
35.

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan.

Freret T, Billard JM, Schumann-Bard P, Dutar P, Dauphin F, Boulouard M, Bouet V.

Neurobiol Aging. 2012 May;33(5):1005.e1-10. doi: 10.1016/j.neurobiolaging.2011.09.028. Epub 2011 Oct 27.

PMID:
22035592
36.

On the importance of long-term functional assessment after stroke to improve translation from bench to bedside.

Freret T, Schumann-Bard P, Boulouard M, Bouet V.

Exp Transl Stroke Med. 2011 Jun 18;3:6. doi: 10.1186/2040-7378-3-6.

37.

Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors.

Besnard S, Machado ML, Vignaux G, Boulouard M, Coquerel A, Bouet V, Freret T, Denise P, Lelong-Boulouard V.

Hippocampus. 2012 Apr;22(4):814-26. doi: 10.1002/hipo.20942. Epub 2011 Apr 27.

PMID:
21538662
38.

Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals.

Bouet V, Freret T, Dutar P, Billard JM, Boulouard M.

Mech Ageing Dev. 2011 May;132(5):240-8. doi: 10.1016/j.mad.2011.04.006. Epub 2011 Apr 17.

PMID:
21530571
39.

Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice.

Da Silva Costa-Aze V, Dauphin F, Boulouard M.

Behav Brain Res. 2011 Sep 12;222(1):134-40. doi: 10.1016/j.bbr.2011.03.046. Epub 2011 Apr 1.

PMID:
21443908
40.

Comparison of the effects of erythropoietin and its carbamylated derivative on behaviour and hippocampal neurogenesis in mice.

Leconte C, Bihel E, Lepelletier FX, Bouët V, Saulnier R, Petit E, Boulouard M, Bernaudin M, Schumann-Bard P.

Neuropharmacology. 2011 Feb-Mar;60(2-3):354-64. doi: 10.1016/j.neuropharm.2010.09.025. Epub 2010 Oct 7.

PMID:
20932982
41.

Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat.

Bouet V, Freret T, Ankri S, Bezault M, Renolleau S, Boulouard M, Jacotot E, Chauvier D, Schumann-Bard P.

Behav Brain Res. 2010 Sep 1;212(1):56-63. doi: 10.1016/j.bbr.2010.03.043. Epub 2010 Mar 27.

PMID:
20347879
42.

Review of 5-HT4R ligands: state of art and clinical applications.

Bureau R, Boulouard M, Dauphin F, Lezoualc'h F, Rault S.

Curr Top Med Chem. 2010;10(5):527-53. Review.

PMID:
20166943
43.

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice.

Bouet V, Boulouard M, Toutain J, Divoux D, Bernaudin M, Schumann-Bard P, Freret T.

Nat Protoc. 2009;4(10):1560-4. doi: 10.1038/nprot.2009.125. Epub 2009 Oct 1.

PMID:
19798088
44.

Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse.

Leconte C, Tixier E, Freret T, Toutain J, Saulnier R, Boulouard M, Roussel S, Schumann-Bard P, Bernaudin M.

Stroke. 2009 Oct;40(10):3349-55. doi: 10.1161/STROKEAHA.109.557314. Epub 2009 Jul 23.

PMID:
19628803
45.

The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse.

Bazin MA, El Kihel L, Boulouard M, Bouët V, Rault S.

Steroids. 2009 Nov;74(12):931-7. doi: 10.1016/j.steroids.2009.06.010. Epub 2009 Jul 3.

PMID:
19577585
46.

Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity in mice.

Berenguer I, El Aouad N, Andujar S, Romero V, Suvire F, Freret T, Bermejo A, Ivorra MD, Enriz RD, Boulouard M, Cabedo N, Cortes D.

Bioorg Med Chem. 2009 Jul 15;17(14):4968-80. doi: 10.1016/j.bmc.2009.05.079. Epub 2009 Jun 6.

PMID:
19540762
47.

Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.

Lemaître S, Lepailleur A, Bureau R, Butt-Gueulle S, Lelong-Boulouard V, Duchatelle P, Boulouard M, Dumuis A, Daveu C, Lezoualc'h F, Pfeiffer B, Dauphin F, Rault S.

Bioorg Med Chem. 2009 Mar 15;17(6):2607-22. doi: 10.1016/j.bmc.2008.11.045. Epub 2008 Nov 24.

PMID:
19261477
48.

Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test.

Freret T, Bouet V, Leconte C, Roussel S, Chazalviel L, Divoux D, Schumann-Bard P, Boulouard M.

Behav Neurosci. 2009 Feb;123(1):224-30. doi: 10.1037/a0014157.

PMID:
19170448
49.

Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat.

Levallet G, Hotte M, Boulouard M, Dauphin F.

Psychopharmacology (Berl). 2009 Jan;202(1-3):125-39. doi: 10.1007/s00213-008-1283-8. Epub 2008 Aug 15.

PMID:
18712363
50.

Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse.

Da Silva Costa V, Duchatelle P, Boulouard M, Dauphin F.

Neuropsychopharmacology. 2009 Jan;34(2):488-500. doi: 10.1038/npp.2008.94. Epub 2008 Jul 2.

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