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Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD.

ACS Med Chem Lett. 2019 Nov 12;10(12):1628-1634. doi: 10.1021/acsmedchemlett.9b00365. eCollection 2019 Dec 12.


Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.

Cheung PW, Bouley R, Brown D.

Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:175-194. doi: 10.1146/annurev-pharmtox-010919-023654. Epub 2019 Sep 27.


Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice.

Nair AV, Yanhong W, Paunescu TG, Bouley R, Brown D.

PLoS One. 2019 Aug 6;14(8):e0219940. doi: 10.1371/journal.pone.0219940. eCollection 2019.


The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May.


Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2.

Bouley RA, Hinkovska-Galcheva V, Shayman JA, Tesmer JJG.

Biochemistry. 2019 Apr 2;58(13):1709-1717. doi: 10.1021/acs.biochem.8b01124. Epub 2019 Mar 13.


Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation.

Cheung PW, Terlouw A, Janssen SA, Brown D, Bouley R.

J Physiol. 2019 Mar;597(6):1627-1642. doi: 10.1113/JP277024. Epub 2018 Dec 21.


Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2.

Hinkovska-Galcheva V, Kelly R, Manthei KA, Bouley R, Yuan W, Schwendeman A, Tesmer JJG, Shayman JA.

J Lipid Res. 2018 Jul;59(7):1205-1218. doi: 10.1194/jlr.M084012. Epub 2018 May 3.


Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.

Waldschmidt HV, Bouley R, Kirchhoff PD, Lee P, Tesmer JJG, Larsen SD.

Bioorg Med Chem Lett. 2018 May 15;28(9):1507-1515. doi: 10.1016/j.bmcl.2018.03.082. Epub 2018 Mar 30.


Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport.

Arystarkhova E, Bouley R, Liu YB, Sweadner KJ.

PLoS One. 2017 Nov 20;12(11):e0188006. doi: 10.1371/journal.pone.0188006. eCollection 2017.


Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.

He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9559-E9568. doi: 10.1073/pnas.1712670114. Epub 2017 Oct 23.


Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

Bouley R, Waldschmidt HV, Cato MC, Cannavo A, Song J, Cheung JY, Yao XQ, Koch WJ, Larsen SD, Tesmer JJG.

Mol Pharmacol. 2017 Dec;92(6):707-717. doi: 10.1124/mol.117.110130. Epub 2017 Oct 25.


Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.

Cheung PW, Ueberdiek L, Day J, Bouley R, Brown D.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F404-F413. doi: 10.1152/ajprenal.00004.2017. Epub 2017 Apr 5.


Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2017 Feb 8;139(5):2102-2110. doi: 10.1021/jacs.6b12565. Epub 2017 Jan 27.


Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL.

Blood. 2017 Jan 26;129(4):405-414. doi: 10.1182/blood-2016-06-721571. Epub 2016 Nov 18.


EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.

Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HA, Brown D, Bouley R.

J Am Soc Nephrol. 2016 Oct;27(10):3105-3116. Epub 2016 Mar 9.


Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice.

Chang SY, Lo CS, Zhao XP, Liao MC, Chenier I, Bouley R, Ingelfinger JR, Chan JS, Zhang SL.

J Renin Angiotensin Aldosterone Syst. 2016 Sep 15;17(3). pii: 1470320316668737. doi: 10.1177/1470320316668737. Print 2016 Jul.


Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.

Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

J Med Chem. 2016 May 26;59(10):5011-21. doi: 10.1021/acs.jmedchem.6b00372. Epub 2016 May 5.


Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CA, Mobashery S, Chang M, Dantas G.

Nat Chem Biol. 2015 Nov;11(11):855-61. doi: 10.1038/nchembio.1911. Epub 2015 Sep 14.


Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium.

Wang H, Lee M, Peng Z, Blázquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S.

J Med Chem. 2015 May 28;58(10):4194-203. doi: 10.1021/jm501831g. Epub 2015 May 12.


Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor.

Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S.

PLoS One. 2015 Mar 23;10(3):e0121419. doi: 10.1371/journal.pone.0121419. eCollection 2015.


Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2.


Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.

Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ.

Physiol Rep. 2014 Dec 3;2(12). pii: e12226. doi: 10.14814/phy2.12226. Print 2014 Dec 1.


Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.

Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N.

Cell Rep. 2014 Oct 9;9(1):180-192. doi: 10.1016/j.celrep.2014.08.074. Epub 2014 Oct 2.


High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.

Nomura N, Nunes P, Bouley R, Nair AV, Shaw S, Ueda E, Pathomthongtaweechai N, Lu HA, Brown D.

Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C597-605. doi: 10.1152/ajpcell.00154.2014. Epub 2014 Jun 18.


Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD Jr, Hallows KR, Brown D, Bouley R, Vilardaga JP.

J Biol Chem. 2013 Sep 27;288(39):27849-60. doi: 10.1074/jbc.M112.445098. Epub 2013 Aug 9.


Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.

Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW.

Nat Commun. 2013;4:2189. doi: 10.1038/ncomms3189.


Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.

Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U.

Autophagy. 2013 Apr;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4.


Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.

Bouley R, Nunes P, Andriopoulos B Jr, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F553-64. doi: 10.1152/ajprenal.00438.2011. Epub 2012 Dec 12.


AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.

Yui N, Lu HJ, Bouley R, Brown D.

Biol Open. 2012 Feb 15;1(2):101-8. doi: 10.1242/bio.2011042. Epub 2011 Nov 4.


Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.

Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D.

Am J Physiol Cell Physiol. 2013 Jan 1;304(1):C38-48. doi: 10.1152/ajpcell.00109.2012. Epub 2012 Sep 26.


Corin: a key protein of an adaptive renal mechanism to respond to salt variation?

Bouley R.

Kidney Int. 2012 Jul;82(1):7-8. doi: 10.1038/ki.2012.123.


New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.

Brown D, Bouley R, Păunescu TG, Breton S, Lu HA.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1421-33. doi: 10.1152/ajpcell.00085.2012. Epub 2012 Mar 28. Review.


Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand.

Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R.

Endocrinology. 2011 Oct;152(10):3893-904. doi: 10.1210/en.2011-1049. Epub 2011 Aug 9.


Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase.

Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA.

Am J Physiol Renal Physiol. 2011 Aug;301(2):F309-18. doi: 10.1152/ajprenal.00001.2011. Epub 2011 Apr 20.


Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.

Testero SA, Bouley R, Fisher JF, Chang M, Mobashery S.

Bioorg Med Chem Lett. 2011 May 1;21(9):2675-8. doi: 10.1016/j.bmcl.2010.12.076. Epub 2010 Dec 29.


Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration.

Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D.

J Am Soc Nephrol. 2011 Jan;22(1):59-72. doi: 10.1681/ASN.2009121267. Epub 2010 Nov 11.


Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.

Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY.

J Am Soc Nephrol. 2010 Apr;21(4):666-77. doi: 10.1681/ASN.2009050511. Epub 2010 Feb 18.


Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression.

Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1575-86. doi: 10.1152/ajprenal.90762.2008. Epub 2009 Sep 23.


Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.

Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP.

Nat Chem Biol. 2009 Oct;5(10):734-42. doi: 10.1038/nchembio.206. Epub 2009 Aug 23.


Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays.

Van Hoek AN, Bouley R, Lu Y, Silberstein C, Brown D, Wax MB, Patil RV.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1396-404. doi: 10.1152/ajprenal.00018.2009. Epub 2009 Mar 18.


Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.

Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA.

Kidney Int. 2008 Dec;74(12):1557-67. doi: 10.1038/ki.2008.412. Epub 2008 Aug 27.


A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.

Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D.

Am J Physiol Cell Physiol. 2008 Dec;295(6):C1476-87. doi: 10.1152/ajpcell.00344.2008. Epub 2008 Sep 17.


NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells.

Hasler U, Leroy V, Jeon US, Bouley R, Dimitrov M, Kim JA, Brown D, Kwon HM, Martin PY, Féraille E.

J Biol Chem. 2008 Oct 17;283(42):28095-105. doi: 10.1074/jbc.M708350200. Epub 2008 Aug 14.


Phosphorylation events and the modulation of aquaporin 2 cell surface expression.

Brown D, Hasler U, Nunes P, Bouley R, Lu HA.

Curr Opin Nephrol Hypertens. 2008 Sep;17(5):491-8. doi: 10.1097/MNH.0b013e3283094eb1. Review.


Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.

Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D.

J Biol Chem. 2008 Sep 26;283(39):26643-61. doi: 10.1074/jbc.M801071200. Epub 2008 Jul 29.


Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.

Bouley R, Hasler U, Lu HA, Nunes P, Brown D.

Semin Nephrol. 2008 May;28(3):266-78. doi: 10.1016/j.semnephrol.2008.03.010. Review.


The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.

Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F290-4. doi: 10.1152/ajprenal.00072.2008. Epub 2008 Apr 23.


Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking.

Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D.

J Biol Chem. 2007 Sep 28;282(39):28721-32. Epub 2007 Jul 18.


Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.

Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA.

Am J Physiol Renal Physiol. 2007 May;292(5):F1303-13. Epub 2007 Feb 6.


Physical and functional connection between auxilin and dynamin during endocytosis.

Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ.

EMBO J. 2006 Sep 20;25(18):4163-74. Epub 2006 Aug 31.

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