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Items: 30


Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.

Otten C, Knox J, Boulday G, Eymery M, Haniszewski M, Neuenschwander M, Radetzki S, Vogt I, Hähn K, De Luca C, Cardoso C, Hamad S, Igual Gil C, Roy P, Albiges-Rizo C, Faurobert E, von Kries JP, Campillos M, Tournier-Lasserve E, Derry WB, Abdelilah-Seyfried S.

EMBO Mol Med. 2018 Oct;10(10). pii: e9155. doi: 10.15252/emmm.201809155.


The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity.

Lisowska J, Rödel CJ, Manet S, Miroshnikova YA, Boyault C, Planus E, De Mets R, Lee HH, Destaing O, Mertani H, Boulday G, Tournier-Lasserve E, Balland M, Abdelilah-Seyfried S, Albiges-Rizo C, Faurobert E.

J Cell Sci. 2018 Aug 13;131(15). pii: jcs216093. doi: 10.1242/jcs.216093.


Network-based analysis of omics data: the LEAN method.

Gwinner F, Boulday G, Vandiedonck C, Arnould M, Cardoso C, Nikolayeva I, Guitart-Pla O, Denis CV, Christophe OD, Beghain J, Tournier-Lasserve E, Schwikowski B.

Bioinformatics. 2017 Mar 1;33(5):701-709. doi: 10.1093/bioinformatics/btw676.


Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.

Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier-Lasserve E, Dejana E, Lampugnani MG.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8421-6. doi: 10.1073/pnas.1501352112. Epub 2015 Jun 24.


Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes.

Schulz GB, Wieland E, Wüstehube-Lausch J, Boulday G, Moll I, Tournier-Lasserve E, Fischer A.

Stroke. 2015 May;46(5):1337-43. doi: 10.1161/STROKEAHA.114.007512. Epub 2015 Mar 19.


Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins.

Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, Duchene J, Mickoleit M, Dietrich AC, Ramspacher C, Steed E, Manet-Dupé S, Benz A, Hassel D, Vermot J, Huisken J, Tournier-Lasserve E, Felbor U, Sure U, Albiges-Rizo C, Abdelilah-Seyfried S.

Dev Cell. 2015 Jan 26;32(2):181-90. doi: 10.1016/j.devcel.2014.12.016.


Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.

Hervé D, Philippi A, Belbouab R, Zerah M, Chabrier S, Collardeau-Frachon S, Bergametti F, Essongue A, Berrou E, Krivosic V, Sainte-Rose C, Houdart E, Adam F, Billiemaz K, Lebret M, Roman S, Passemard S, Boulday G, Delaforge A, Guey S, Dray X, Chabriat H, Brouckaert P, Bryckaert M, Tournier-Lasserve E.

Am J Hum Genet. 2014 Mar 6;94(3):385-94. doi: 10.1016/j.ajhg.2014.01.018. Epub 2014 Feb 27. Erratum in: Am J Hum Genet. 2014 Apr 3;94(4):642.


CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling.

Faurobert E, Rome C, Lisowska J, Manet-Dupé S, Boulday G, Malbouyres M, Balland M, Bouin AP, Kéramidas M, Bouvard D, Coll JL, Ruggiero F, Tournier-Lasserve E, Albiges-Rizo C.

J Cell Biol. 2013 Aug 5;202(3):545-61. doi: 10.1083/jcb.201303044.


CCM3 Mutations Are Associated with Early-Onset Cerebral Hemorrhage and Multiple Meningiomas.

Riant F, Bergametti F, Fournier HD, Chapon F, Michalak-Provost S, Cecillon M, Lejeune P, Hosseini H, Choe C, Orth M, Bernreuther C, Boulday G, Denier C, Labauge P, Tournier-Lasserve E.

Mol Syndromol. 2013 Apr;4(4):165-72. doi: 10.1159/000350042. Epub 2013 Apr 3.


EndMT contributes to the onset and progression of cerebral cavernous malformations.

Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, Ferrarini L, Orsenigo F, Papa E, Boulday G, Tournier-Lasserve E, Chapon F, Richichi C, Retta SF, Lampugnani MG, Dejana E.

Nature. 2013 Jun 27;498(7455):492-6. doi: 10.1038/nature12207. Epub 2013 Jun 9.


Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.

Boulday G, Rudini N, Maddaluno L, Blécon A, Arnould M, Gaudric A, Chapon F, Adams RH, Dejana E, Tournier-Lasserve E.

J Exp Med. 2011 Aug 29;208(9):1835-47. doi: 10.1084/jem.20110571. Epub 2011 Aug 22.


CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E.

J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. doi: 10.1242/jcs.059329.


Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.

Riant F, Bergametti F, Ayrignac X, Boulday G, Tournier-Lasserve E.

FEBS J. 2010 Mar;277(5):1070-5. doi: 10.1111/j.1742-4658.2009.07535.x. Epub 2010 Jan 22. Review.


Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations.

Boulday G, Blécon A, Petit N, Chareyre F, Garcia LA, Niwa-Kawakita M, Giovannini M, Tournier-Lasserve E.

Dis Model Mech. 2009 Mar-Apr;2(3-4):168-77. doi: 10.1242/dmm.001263. Epub 2009 Feb 2.


Organ-specific differences in the function of MCP-1 and CXCR3 during cardiac and skin allograft rejection.

Haskova Z, Izawa A, Contreras AG, Flynn E, Boulday G, Briscoe DM.

Transplantation. 2007 Jun 27;83(12):1595-601.


[The adaptor protein Lnk modulates endothelial cell activation].

Fitau J, Boulday G, Coulon F, Charreau B.

Nephrol Ther. 2005 Oct;1(4):228-33. Epub 2005 Aug 26. French.


Association of rapamycin and co-stimulation blockade using anti-B7 antibodies in renal allotransplantation in baboons.

Boulday G, Ashton-Chess J, Bernard P, Karam G, Vié H, Moreau A, Minault D, Lorré K, Soulillou JP, Blancho G.

Nephrol Dial Transplant. 2004 Jul;19(7):1752-60. Epub 2004 Apr 6.


The effect of mitoxantrone on anti-pig immunization in baboons.

Petzold T, Barreau N, Ashton-Chess J, Edan G, Boulday G, Roussel JC, Le Berre L, Minault D, Soulillou JP, Blancho G.

Xenotransplantation. 2003 Sep;10(5):422-31.


Rapid selection of differentially expressed genes in TNF[alpha]-activated endothelial cells.

Nagasaka T, Boulday G, Fraser CC, Coupel S, Coulon F, Tesson L, Heslan JM, Soulillou JP, Charreau B.

Mol Med. 2002 Sep;8(9):559-67.


Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells.

Boulday G, Coulon F, Fraser CC, Soulillou JP, Charreau B.

Transplantation. 2002 Nov 15;74(9):1352-4.


CD97-decay-accelerating factor interaction is not involved in leukocyte adhesion to endothelial cells.

Boulday G, Hamann J, Soulillou JP, Charreau B.

Transplantation. 2002 Feb 15;73(3):429-36.


Early induction of TIMP-1 in endothelial cells in response to human xenoreactive IgG.

Boulday G, Coupel S, Coulon F, Soulillou J, Charreau B.

Transplant Proc. 2001 Feb-Mar;33(1-2):701-2. No abstract available.


Effect of blockade of the costimulation pathway by anti-B7 antibodies in renal allotransplantation in baboons.

Boulday G, Bremand L, Karam G, Leteissier E, Moreau A, Petzold T, Lorré K, De Waele P, Nagasaka T, Soulillou J, Blancho G.

Transplant Proc. 2001 Feb-Mar;33(1-2):241-2. No abstract available.


Identification and characterization of novel porcine molecules specifically regulated on endothelial cells by human complement activation.

Boulday G, Coulon F, de Martin R, Soulillou JP, Charrreau B.

Transplant Proc. 2000 Aug;32(5):977-8. No abstract available.


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