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A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites.

Suarez C, Lentini G, Ramaswamy R, Maynadier M, Aquilini E, Berry-Sterkers L, Cipriano M, Chen AL, Bradley P, Striepen B, Boulanger MJ, Lebrun M.

Nat Commun. 2019 Sep 6;10(1):4041. doi: 10.1038/s41467-019-11979-z.


Structural characterization of Treponema pallidum Tp0225 reveals an unexpected leucine-rich repeat architecture.

Ramaswamy R, Houston S, Loveless B, Cameron CE, Boulanger MJ.

Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):489-495. doi: 10.1107/S2053230X19007726. Epub 2019 Jun 26.


Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii.

Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10548-E10555. doi: 10.1073/pnas.1811167115. Epub 2018 Oct 22.


Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE.

Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z.


Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission.

Canepa GE, Molina-Cruz A, Yenkoidiok-Douti L, Calvo E, Williams AE, Burkhardt M, Peng F, Narum D, Boulanger MJ, Valenzuela JG, Barillas-Mury C.

NPJ Vaccines. 2018 Jul 10;3:26. doi: 10.1038/s41541-018-0065-5. eCollection 2018.


A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.

Blank ML, Parker ML, Ramaswamy R, Powell CJ, English ED, Adomako-Ankomah Y, Pernas LF, Workman SD, Boothroyd JC, Boulanger MJ, Boyle JP.

Mol Microbiol. 2018 Jun;108(5):519-535. doi: 10.1111/mmi.13947. Epub 2018 Apr 11.


Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex.

Powell CJ, Jenkins ML, Parker ML, Ramaswamy R, Kelsen A, Warshaw DM, Ward GE, Burke JE, Boulanger MJ.

J Biol Chem. 2017 Nov 24;292(47):19469-19477. doi: 10.1074/jbc.M117.809632. Epub 2017 Sep 25.


Efficient invasion by Toxoplasma depends on the subversion of host protein networks.

Guérin A, Corrales RM, Parker ML, Lamarque MH, Jacot D, El Hajj H, Soldati-Favre D, Boulanger MJ, Lebrun M.

Nat Microbiol. 2017 Oct;2(10):1358-1366. doi: 10.1038/s41564-017-0018-1. Epub 2017 Aug 28.


The structure of Plasmodium falciparum 3D7_0606800 reveals a bi-lobed architecture that supports re-annotation as a Venus Flytrap protein.

Parker ML, Ramaswamy R, van Gordon K, Powell CJ, Bosch J, Boulanger MJ.

Protein Sci. 2017 Sep;26(9):1878-1885. doi: 10.1002/pro.3218. Epub 2017 Jul 26.


Toxoplasma gondii MAF1b Binds the Host Cell MIB Complex To Mediate Mitochondrial Association.

Kelly FD, Wei BM, Cygan AM, Parker ML, Boulanger MJ, Boothroyd JC.

mSphere. 2017 May 24;2(3). pii: e00183-17. doi: 10.1128/mSphere.00183-17. eCollection 2017 May-Jun.


The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains.

Parker ML, Houston S, Wetherell C, Cameron CE, Boulanger MJ.

PLoS One. 2016 Nov 10;11(11):e0166274. doi: 10.1371/journal.pone.0166274. eCollection 2016.


The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host Cells.

Parker ML, Houston S, Pětrošová H, Lithgow KV, Hof R, Wetherell C, Kao WC, Lin YP, Moriarty TJ, Ebady R, Cameron CE, Boulanger MJ.

PLoS Pathog. 2016 Sep 28;12(9):e1005919. doi: 10.1371/journal.ppat.1005919. eCollection 2016 Sep.


Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA.

Ramaswamy R, Goomeshi Nobary S, Eyford BA, Pearson TW, Boulanger MJ.

Protein Sci. 2016 Dec;25(12):2297-2302. doi: 10.1002/pro.3053. Epub 2016 Oct 13.


Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense.

Eyford BA, Kaufman L, Salama-Alber O, Loveless B, Pope ME, Burke RD, Matovu E, Boulanger MJ, Pearson TW.

PLoS Negl Trop Dis. 2016 Apr 7;10(4):e0004510. doi: 10.1371/journal.pntd.0004510. eCollection 2016 Apr.


Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate.

Adomako-Ankomah Y, English ED, Danielson JJ, Pernas LF, Parker ML, Boulanger MJ, Dubey JP, Boyle JP.

Genetics. 2016 May;203(1):283-98. doi: 10.1534/genetics.115.186270. Epub 2016 Feb 26.


Stability of the Plasmodium falciparum AMA1-RON2 Complex Is Governed by the Domain II (DII) Loop.

Delgadillo RF, Parker ML, Lebrun M, Boulanger MJ, Douguet D.

PLoS One. 2016 Jan 5;11(1):e0144764. doi: 10.1371/journal.pone.0144764. eCollection 2016.


Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair.

Parker ML, Penarete-Vargas DM, Hamilton PT, Guérin A, Dubey JP, Perlman SJ, Spano F, Lebrun M, Boulanger MJ.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):398-403. doi: 10.1073/pnas.1515898113. Epub 2015 Dec 28.


A ribosome-inactivating protein in a Drosophila defensive symbiont.

Hamilton PT, Peng F, Boulanger MJ, Perlman SJ.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):350-5. doi: 10.1073/pnas.1518648113. Epub 2015 Dec 28.


The Structure of Plasmodium falciparum Blood-Stage 6-Cys Protein Pf41 Reveals an Unexpected Intra-Domain Insertion Required for Pf12 Coordination.

Parker ML, Peng F, Boulanger MJ.

PLoS One. 2015 Sep 28;10(9):e0139407. doi: 10.1371/journal.pone.0139407. eCollection 2015.


An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity.

Parker ML, Boulanger MJ.

PLoS One. 2015 May 8;10(5):e0126206. doi: 10.1371/journal.pone.0126206. eCollection 2015.


Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex.

Pihan E, Delgadillo RF, Tonkin ML, Pugnière M, Lebrun M, Boulanger MJ, Douguet D.

J Comput Aided Mol Des. 2015 Jun;29(6):525-39. doi: 10.1007/s10822-015-9842-7. Epub 2015 Mar 31.


Systems-based analysis of the Sarcocystis neurona genome identifies pathways that contribute to a heteroxenous life cycle.

Blazejewski T, Nursimulu N, Pszenny V, Dangoudoubiyam S, Namasivayam S, Chiasson MA, Chessman K, Tonkin M, Swapna LS, Hung SS, Bridgers J, Ricklefs SM, Boulanger MJ, Dubey JP, Porcella SF, Kissinger JC, Howe DK, Grigg ME, Parkinson J.

MBio. 2015 Feb 10;6(1). pii: e02445-14. doi: 10.1128/mBio.02445-14.


The shear stress of host cell invasion: exploring the role of biomolecular complexes.

Tonkin ML, Boulanger MJ.

PLoS Pathog. 2015 Jan 28;11(1):e1004539. doi: 10.1371/journal.ppat.1004539. eCollection 2015 Jan. Review. No abstract available.


Post-translational modification of LipL32 during Leptospira interrogans infection.

Witchell TD, Eshghi A, Nally JE, Hof R, Boulanger MJ, Wunder EA Jr, Ko AI, Haake DA, Cameron CE.

PLoS Negl Trop Dis. 2014 Oct 30;8(10):e3280. doi: 10.1371/journal.pntd.0003280. eCollection 2014 Oct.


Structural and functional divergence of the aldolase fold in Toxoplasma gondii.

Tonkin ML, Halavaty AS, Ramaswamy R, Ruan J, Igarashi M, Ngô HM, Boulanger MJ.

J Mol Biol. 2015 Feb 27;427(4):840-852. doi: 10.1016/j.jmb.2014.09.019. Epub 2014 Oct 2.


A conserved apicomplexan microneme protein contributes to Toxoplasma gondii invasion and virulence.

Huynh MH, Boulanger MJ, Carruthers VB.

Infect Immun. 2014 Oct;82(10):4358-68. doi: 10.1128/IAI.01877-14. Epub 2014 Aug 4.


Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria.

Srinivasan P, Ekanem E, Diouf A, Tonkin ML, Miura K, Boulanger MJ, Long CA, Narum DL, Miller LH.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10311-6. doi: 10.1073/pnas.1409928111. Epub 2014 Jun 23.


Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites.

Lamarque MH, Roques M, Kong-Hap M, Tonkin ML, Rugarabamu G, Marq JB, Penarete-Vargas DM, Boulanger MJ, Soldati-Favre D, Lebrun M.

Nat Commun. 2014 Jun 17;5:4098. doi: 10.1038/ncomms5098.


The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold.

Tonkin ML, Beck JR, Bradley PJ, Boulanger MJ.

J Biol Chem. 2014 May 16;289(20):13962-73. doi: 10.1074/jbc.M114.548891. Epub 2014 Mar 27.


Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).

Simhadri C, Daze KD, Douglas SF, Quon TT, Dev A, Gignac MC, Peng F, Heller M, Boulanger MJ, Wulff JE, Hof F.

J Med Chem. 2014 Apr 10;57(7):2874-83. doi: 10.1021/jm401487x. Epub 2014 Mar 26.


The multifunctional role of the pallilysin-associated Treponema pallidum protein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation.

Houston S, Russell S, Hof R, Roberts AK, Cullen P, Irvine K, Smith DS, Borchers CH, Tonkin ML, Boulanger MJ, Cameron CE.

Mol Microbiol. 2014 Feb;91(3):618-34. doi: 10.1111/mmi.12482. Epub 2014 Jan 7.


Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1.

Poukchanski A, Fritz HM, Tonkin ML, Treeck M, Boulanger MJ, Boothroyd JC.

PLoS One. 2013 Aug 5;8(8):e70637. doi: 10.1371/journal.pone.0070637. Print 2013.


Improving biophysical properties of a bispecific antibody scaffold to aid developability: quality by molecular design.

Von Kreudenstein TS, Escobar-Carbrera E, Lario PI, D'Angelo I, Brault K, Kelly J, Durocher Y, Baardsnes J, Woods RJ, Xie MH, Girod PA, Suits MD, Boulanger MJ, Poon DK, Ng GY, Dixit SB.

MAbs. 2013 Sep-Oct;5(5):646-54. doi: 10.4161/mabs.25632. Epub 2013 Jul 8.


Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41.

Tonkin ML, Arredondo SA, Loveless BC, Serpa JJ, Makepeace KA, Sundar N, Petrotchenko EV, Miller LH, Grigg ME, Boulanger MJ.

J Biol Chem. 2013 May 3;288(18):12805-17. doi: 10.1074/jbc.M113.455667. Epub 2013 Mar 19.


Purification, crystallization and X-ray diffraction analysis of Trypanosoma congolense insect-stage surface antigen (TcCISSA).

Tonkin ML, Workman SD, Eyford BA, Loveless BC, Fudge JL, Pearson TW, Boulanger MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1503-6. doi: 10.1107/S1744309112042686. Epub 2012 Nov 14.


Integrated bioinformatic and targeted deletion analyses of the SRS gene superfamily identify SRS29C as a negative regulator of Toxoplasma virulence.

Wasmuth JD, Pszenny V, Haile S, Jansen EM, Gast AT, Sher A, Boyle JP, Boulanger MJ, Parkinson J, Grigg ME.

MBio. 2012 Nov 13;3(6). pii: e00321-12. doi: 10.1128/mBio.00321-12.


Investigating terephthalate biodegradation: structural characterization of a putative decarboxylating cis-dihydrodiol dehydrogenase.

Bains J, Wulff JE, Boulanger MJ.

J Mol Biol. 2012 Oct 26;423(3):284-93. doi: 10.1016/j.jmb.2012.07.022. Epub 2012 Aug 11.


Purification, crystallization and preliminary X-ray diffraction analysis of inner membrane complex (IMC) subcompartment protein 1 (ISP1) from Toxoplasma gondii.

Tonkin ML, Brown S, Beck JR, Bradley PJ, Boulanger MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):832-4. doi: 10.1107/S174430911202297X. Epub 2012 Jun 28.


Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding.

Murray JI, Tonkin ML, Whiting AL, Peng F, Farnell B, Cullen JT, Hof F, Boulanger MJ.

BMC Struct Biol. 2012 Jul 2;12:16. doi: 10.1186/1472-6807-12-16.


Structural and functional insights into the malaria parasite moving junction complex.

Vulliez-Le Normand B, Tonkin ML, Lamarque MH, Langer S, Hoos S, Roques M, Saul FA, Faber BW, Bentley GA, Boulanger MJ, Lebrun M.

PLoS Pathog. 2012;8(6):e1002755. doi: 10.1371/journal.ppat.1002755. Epub 2012 Jun 21.


The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.

Bromba CM, Mason JW, Brant MG, Chan T, Lunke MD, Petric M, Boulanger MJ, Wulff JE.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7137-41. doi: 10.1016/j.bmcl.2011.09.076. Epub 2011 Sep 24.


Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.

Tonkin ML, Roques M, Lamarque MH, Pugnière M, Douguet D, Crawford J, Lebrun M, Boulanger MJ.

Science. 2011 Jul 22;333(6041):463-7. doi: 10.1126/science.1204988.


Elucidating the reaction mechanism of the benzoate oxidation pathway encoded aldehyde dehydrogenase from Burkholderia xenovorans LB400.

Bains J, Leon R, Temke KG, Boulanger MJ.

Protein Sci. 2011 Jun;20(6):1048-59. doi: 10.1002/pro.639. Epub 2011 May 4.


Structural characterization and epitope mapping of the glutamic acid/alanine-rich protein from Trypanosoma congolense: defining assembly on the parasite cell surface.

Loveless BC, Mason JW, Sakurai T, Inoue N, Razavi M, Pearson TW, Boulanger MJ.

J Biol Chem. 2011 Jun 10;286(23):20658-65. doi: 10.1074/jbc.M111.218941. Epub 2011 Apr 6.


The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites.

Lamarque M, Besteiro S, Papoin J, Roques M, Vulliez-Le Normand B, Morlon-Guyot J, Dubremetz JF, Fauquenoy S, Tomavo S, Faber BW, Kocken CH, Thomas AW, Boulanger MJ, Bentley GA, Lebrun M.

PLoS Pathog. 2011 Feb 10;7(2):e1001276. doi: 10.1371/journal.ppat.1001276.


A product analog bound form of 3-oxoadipate-enol-lactonase (PcaD) reveals a multifunctional role for the divergent cap domain.

Bains J, Kaufman L, Farnell B, Boulanger MJ.

J Mol Biol. 2011 Mar 11;406(5):649-58. doi: 10.1016/j.jmb.2011.01.007. Epub 2011 Jan 13. Review.


Bifunctional role of the Treponema pallidum extracellular matrix binding adhesin Tp0751.

Houston S, Hof R, Francescutti T, Hawkes A, Boulanger MJ, Cameron CE.

Infect Immun. 2011 Mar;79(3):1386-98. doi: 10.1128/IAI.01083-10. Epub 2010 Dec 13.


Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion.

Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF.

Oncogene. 2011 Mar 24;30(12):1422-35. doi: 10.1038/onc.2010.535. Epub 2010 Dec 6.


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